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Article ; Online: Diet-Exercise-Induced Hypokalemic Metabolic Alkalosis.

Hoorn, Ewout J / Bovée, Dominique M / Geerse, Daniël A / Visser, Wesley J

2020 Volume 133, Issue 11, Page(s) e667–e669

MeSH term(s)	Alkalosis/diet therapy ; Alkalosis/etiology ; Diet/adverse effects ; Electrocardiography ; Endurance Training/adverse effects ; Female ; Humans ; Hypokalemia/etiology ; Hypokalemia/physiopathology ; Hypokalemia/therapy ; Long QT Syndrome/etiology ; Long QT Syndrome/physiopathology ; Middle Aged ; Potassium Chloride/therapeutic use ; Syncope/etiology ; Syncope/physiopathology
Chemical Substances	Potassium Chloride (660YQ98I10)
Language	English
Publishing date	2020-05-20
Publishing country	United States
Document type	Case Reports
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2020.04.019
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Article ; Online: The prognostic value of a trend in modified SOFA score for patients with hematological malignancies in the intensive care unit.

Demandt, Astrid M P / Geerse, Daniël A / Janssen, Bram J P / Winkens, Bjorn / Schouten, Harry C / van Mook, Walther N K A

European journal of haematology

2017 Volume 99, Issue 4, Page(s) 315–322

Abstract: Background: Patients with hematological malignancies admitted to an intensive care unit (ICU) have a poor prognosis. The Sequential Organ Failure Assessment (SOFA) score is used to monitor patients on the ICU. Little is known about the value of this ... ...

Abstract	Background: Patients with hematological malignancies admitted to an intensive care unit (ICU) have a poor prognosis. The Sequential Organ Failure Assessment (SOFA) score is used to monitor patients on the ICU. Little is known about the value of this score in hematology patients. Therefore, the prognostic value of the SOFA score and a modified hematological SOFA score (SOFAhem) was studied. Methods: Patients with hematological malignancies admitted to the ICU between 1999 and 2009 were analyzed in a retrospective cohort study. The SOFAhem score was defined as the original SOFA score omitting the coagulation and neurological parameters. Results: In 149 admissions, ICU mortality was 52%. Mortality was significantly associated with higher SOFA and SOFAhem scores on admission, and trend in SOFAhem scores. An unchanged and increased SOFAhem score compared to decreasing SOFAhem scores was associated with a higher mortality rate (53% resp 67% resp 25%). Conclusions: Trends in SOFA or SOFAhem score are both suitable as prognostic parameter. The trend in SOFAhem score seems to be independently related to mortality in hematological patients admitted to the ICU, and because of the higher odds ratios and lower P-values compared to the SOFA score, it is probably stronger related to mortality than the classical score, but its prognostic value should be tested in a larger cohort.
Language	English
Publishing date	2017-10
Publishing country	England
Document type	Journal Article
ZDB-ID	392482-8
ISSN	1600-0609 ; 0902-4441
ISSN (online)	1600-0609
ISSN	0902-4441
DOI	10.1111/ejh.12919
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Zs.A 323: Show issues

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Article ; Online: New-onset psoriasis during peritoneal dialysis.

Geerse, Daniël A / Suijkerbuijk, Joëlle / van Poppelen, Karen M / Litjens, Elisabeth J / Cornelis, Tom

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

2014 Volume 34, Issue 7, Page(s) 802–803

MeSH term(s)	Administration, Topical ; Betamethasone/therapeutic use ; Biopsy, Needle ; Female ; Follow-Up Studies ; Humans ; Immunohistochemistry ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/therapy ; Middle Aged ; Peritoneal Dialysis/adverse effects ; Peritoneal Dialysis/methods ; Psoriasis/diagnosis ; Psoriasis/drug therapy ; Psoriasis/etiology ; Psoriasis/physiopathology ; Severity of Illness Index ; Vitamin D/therapeutic use
Chemical Substances	Vitamin D (1406-16-2) ; Betamethasone (9842X06Q6M)
Language	English
Publishing date	2014-11-28
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	645010-6
ISSN	1718-4304 ; 0896-8608
ISSN (online)	1718-4304
ISSN	0896-8608
DOI	10.3747/pdi.2013.00249
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Zs.A 1936: Show issues

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Article ; Online: Diagnosis of acute myocardial infarction in hemodialysis patients may be feasible by comparing variation of cardiac troponins during acute presentation to baseline variation.

van Berkel, Miranda / Dekker, Marijke J E / Bogers, Hanneke / Geerse, Daniel A / Konings, Constantijn J A M / Scharnhorst, Volkher

Clinica chimica acta; international journal of clinical chemistry

2016 Volume 456, Page(s) 36–41

Abstract: Acute myocardial infarction (AMI) is defined as a dynamic change in cardiac troponin (cTn) with at least one cTn value exceeding the 99 th percentile of a reference population in combination with typical clinical symptoms. In hemodialysis (HD) patients, ... ...

Abstract	Acute myocardial infarction (AMI) is defined as a dynamic change in cardiac troponin (cTn) with at least one cTn value exceeding the 99 th percentile of a reference population in combination with typical clinical symptoms. In hemodialysis (HD) patients, a broad range of cTn concentrations is found, partially due to patient-specific comorbidities. Therefore, the 99 th percentile cannot be used in HD patients and decision algorithms to diagnose AMI should be based on temporal variations of troponin. In this study, relative and absolute variations of cTn in a large population of asymptomatic hemodialysis patients were established during a period of 15 months. Patients were stratified according to their history of coronary artery disease (CAD). An intra-individual long term variation of 23% for cTroponin I (cTnI) and 12% for cTroponin T (cTnT) was found for patients without a history of CAD. The corresponding reference change values (RCVs) were 69% and 39% respectively. For patients with a history of CAD this variation was 29% for cTnI and 10% for cTnT, with RCVs of 86% and 35% respectively. During follow up, 27 HD patients developed an acute myocardial infarction (AMI). During these events, irrespective of CAD history, cTnI increased>172% and cTnT increased>97% above baseline cTn as measured during clinically stable periods three months separate to the event. Therefore, if a HD patient has symptoms of an acute event and a cTn increase that exceeds the RCVs described here, AMI may be suspected. If the troponin increase exceeds 172% for cTnI or 97% for cTnT, AMI is likely.
MeSH term(s)	Acute Disease ; Adult ; Aged ; Aged, 80 and over ; Feasibility Studies ; Female ; Humans ; Male ; Middle Aged ; Myocardial Infarction/blood ; Myocardial Infarction/diagnosis ; Renal Dialysis ; Troponin I/blood ; Troponin T/blood ; Young Adult
Chemical Substances	Troponin I ; Troponin T
Language	English
Publishing date	2016-05-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80228-1
ISSN	1873-3492 ; 0009-8981
ISSN (online)	1873-3492
ISSN	0009-8981
DOI	10.1016/j.cca.2016.01.022
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Article ; Online: Sterile peritonitis associated with the use of amino-acid solution in eight peritoneal dialysis patients.

Geerse, Daniël A / Rutherford, Peter / Bogers, Johanna C A / Konings, Constantijn J A M

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

2011 Volume 31, Issue 1, Page(s) 90–91

MeSH term(s)	Amino Acids/administration & dosage ; Amino Acids/adverse effects ; Dialysis Solutions ; Humans ; Peritoneal Dialysis, Continuous Ambulatory ; Peritonitis/chemically induced
Chemical Substances	Amino Acids ; Dialysis Solutions
Language	English
Publishing date	2011-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	645010-6
ISSN	1718-4304 ; 0896-8608
ISSN (online)	1718-4304
ISSN	0896-8608
DOI	10.3747/pdi.2010.00264
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Article ; Online: Prognosis of patients with haematological malignancies admitted to the intensive care unit: Sequential Organ Failure Assessment (SOFA) trend is a powerful predictor of mortality.

Geerse, Daniël A / Span, Lambert F R / Pinto-Sietsma, Sara-Joan / van Mook, Walther N K A

European journal of internal medicine

2011 Volume 22, Issue 1, Page(s) 57–61

Abstract: Background: The prognosis of patients with haematological malignancies who are admitted to the ICU is generally poor. In order to optimize care, it is important to be able to determine which patients are most likely to benefit from continuation of ... ...

Abstract	Background: The prognosis of patients with haematological malignancies who are admitted to the ICU is generally poor. In order to optimize care, it is important to be able to determine which patients are most likely to benefit from continuation of treatment after ICU admission. Methods: Data of 86 patients with a haematological malignancy consecutively admitted to the ICU of Maastricht University Medical Centre were examined in a retrospective cohort study in order to identify clinically useful prognostic parameters. Results: ICU mortality was 56% and in-hospital mortality was 65%. Non-survivors had higher APACHE-II and SOFA scores compared with survivors (32±8.0 versus 25±6.5 and 11.5±3.1 versus 8.5±3.0, respectively). The mortality rate was significantly higher in patients with an increasing SOFA score (≥2 points) compared with patients with an unchanged or decreasing SOFA score (72% versus 58% and 21%, respectively). Mortality was also higher in patients requiring invasive mechanical ventilation or inotropic/vasopressor therapy. Conclusion: The mortality rate among patients with haematological malignancies who are admitted to the ICU is high and mainly associated with the severity of illness, as reflected by more severe and worsening organ failure and a need for mechanical ventilation or inotropic/vasopressor therapy. Several factors appear to be associated with a poor outcome, but no absolute predictors of mortality could be identified, although the results suggest that changes in the SOFA score during the stay in the ICU can be helpful in the decision making about the continuation or discontinuation of treatment.
MeSH term(s)	APACHE ; Adult ; Aged ; Female ; Hematologic Neoplasms/complications ; Hematologic Neoplasms/mortality ; Hospital Mortality/trends ; Hospitals, University ; Humans ; Intensive Care Units/trends ; Male ; Medical Records ; Middle Aged ; Multiple Organ Failure/etiology ; Multiple Organ Failure/mortality ; Netherlands/epidemiology ; Predictive Value of Tests ; Prognosis ; Respiration, Artificial/mortality ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Sensitivity and Specificity ; Severity of Illness Index ; Survival Rate
Language	English
Publishing date	2011-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1038679-8
ISSN	1879-0828 ; 0953-6205
ISSN (online)	1879-0828
ISSN	0953-6205
DOI	10.1016/j.ejim.2010.11.003
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Article ; Online: Adherence and Concordance between Serious Illness Care Planning Conversations and Oncology Clinician Documentation among Patients with Advanced Cancer.

Geerse, Olaf P / Lamas, Daniela J / Bernacki, Rachelle E / Sanders, Justin J / Paladino, Joanna / Berendsen, Annette J / Hiltermann, Thijo J N / Lindvall, Charlotta / Fromme, Erik K / Block, Susan D

Journal of palliative medicine

2020 Volume 24, Issue 1, Page(s) 53–62

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Advance Care Planning ; Communication ; Critical Care ; Critical Illness ; Documentation ; Humans ; Neoplasms/therapy
Language	English
Publishing date	2020-06-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1427361-5
ISSN	1557-7740 ; 1096-6218
ISSN (online)	1557-7740
ISSN	1096-6218
DOI	10.1089/jpm.2019.0615
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Zs.A 5440: Show issues

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Article ; Online: Moderate elevations of high-sensitivity cardiac troponin I and B-type natriuretic peptide in chronic hemodialysis patients are associated with mortality.

Geerse, Daniël A / van Berkel, Miranda / Vogels, Steffie / Kooman, Jeroen P / Konings, Constantijn J A M / Scharnhorst, Volkher

Clinical chemistry and laboratory medicine

2013 Volume 51, Issue 6, Page(s) 1321–1328

Abstract: Background: Several biomarkers are associated with mortality in hemodialysis patients. In particular, elevated cardiac troponin T and B-type natriuretic peptide (BNP) are strong predictors of mortality; however, less is known about cardiac troponin I ( ... ...

Abstract	Background: Several biomarkers are associated with mortality in hemodialysis patients. In particular, elevated cardiac troponin T and B-type natriuretic peptide (BNP) are strong predictors of mortality; however, less is known about cardiac troponin I (cTnI). Elevated troponin I is detected in many hemodialysis patients, but the association of moderate elevations with mortality is unclear. Methods: The relation between mortality and cTnI, using a high-sensitivity cTnI assay, as well as BNP and C-reactive protein (CRP) was evaluated in 206 chronic hemodialysis patients. Results: Median follow-up was 28 months with a total mortality of 35%. Mortality was significantly associated with elevated cTnI, BNP and CRP. Even patients with only moderate elevation of cTnI (0.01-0.10 μg/L) showed 2.5-fold increased mortality. Interestingly, hazard ratios for mortality for single (random) measurements were comparable to those for mean/median measurements. Subsequently, subgroup analysis based on combined markers was performed. Patients with both cTnI <0.01 μg/L and BNP in the first quartile had 100% survival. Patients with either cTnI <0.01 μg/L or BNP in the lowest quartile had significantly lower mortality (12% and 13%, respectively) than patients with BNP levels in the second quartile or higher and cTnI of 0.01-0.05 μg/L and patients with cTnI ≥0.05 μg/L (mortality 46 and 58%, respectively). Conclusions: A combination of moderate elevation of cTnI and BNP provided additional prognostic value. A single measurement of these biomarkers performed comparably to the mean/median of multiple measurements.
MeSH term(s)	Aged ; C-Reactive Protein/analysis ; C-Reactive Protein/metabolism ; Chronic Disease ; Female ; Humans ; Male ; Natriuretic Peptide, Brain/analysis ; Natriuretic Peptide, Brain/metabolism ; Prognosis ; Renal Dialysis/adverse effects ; Renal Dialysis/mortality ; Troponin I/analysis ; Troponin I/metabolism
Chemical Substances	Troponin I ; Natriuretic Peptide, Brain (114471-18-0) ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2013-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2012-0305
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Article ; Online: A Qualitative Study of Serious Illness Conversations in Patients with Advanced Cancer.

Geerse, Olaf P / Lamas, Daniela J / Sanders, Justin J / Paladino, Joanna / Kavanagh, Jane / Henrich, Natalie J / Berendsen, Annette J / Hiltermann, Thijo J N / Fromme, Erik K / Bernacki, Rachelle E / Block, Susan D

Journal of palliative medicine

2019 Volume 22, Issue 7, Page(s) 773–781

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Advance Care Planning ; Aged ; Critical Illness/psychology ; Female ; Humans ; Male ; Medical Oncology/methods ; Middle Aged ; Neoplasms/psychology ; Patient Care Planning ; Physician-Patient Relations ; Qualitative Research ; Quality of Life
Language	English
Publishing date	2019-02-06
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1427361-5
ISSN	1557-7740 ; 1096-6218
ISSN (online)	1557-7740
ISSN	1096-6218
DOI	10.1089/jpm.2018.0487
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Article ; Online: The Clinical Course of Minimal Change Nephrotic Syndrome With Onset in Adulthood or Late Adolescence: A Case Series.

Maas, Rutger J / Deegens, Jeroen K / Beukhof, Johan R / Reichert, Louis J / Ten Dam, Marc A / Beutler, Jaap J / van den Wall Bake, A Warmold L / Rensma, Pieter L / Konings, Constantijn J / Geerse, Daniel A / Feith, Geert W / Van Kuijk, Willi H / Wetzels, Jack F

American journal of kidney diseases : the official journal of the National Kidney Foundation

2017 Volume 69, Issue 5, Page(s) 637–646

Abstract: Background: Few studies have examined the treatment and outcome of adult-onset minimal change nephrotic syndrome (MCNS). We retrospectively studied 125 patients who had MCNS with onset in either adulthood or late adolescence. Presenting characteristics, ...

Abstract	Background: Few studies have examined the treatment and outcome of adult-onset minimal change nephrotic syndrome (MCNS). We retrospectively studied 125 patients who had MCNS with onset in either adulthood or late adolescence. Presenting characteristics, duration of initial treatment and response to treatment, relapse patterns, complications, and long-term outcome were studied. Study design: Case series. Setting & participants: Patients with new-onset nephrotic syndrome 16 years or older and a histologic diagnosis of MCNS in 1985 to 2011 were identified from pathology records of 10 participating centers. Outcomes: Partial and complete remission, treatment resistance, relapse, complications, renal survival. Results: Corticosteroids were given as initial treatment in 105 (84%) patients. After 16 weeks of corticosteroid treatment, 92 (88%) of these patients had reached remission. Median time to remission was 4 (IQR, 2-7) weeks. 7 (6%) patients initially received cyclophosphamide with or without corticosteroids, and all attained remission after a median of 4 (IQR, 3-11) weeks. 13 (10%) patients reached remission without immunosuppressive treatment. One or more relapses were observed in 57 (54%) patients who received initial corticosteroid treatment. Second-line cyclophosphamide resulted in stable remission in 57% of patients with relapsing MCNS. Acute kidney injury was observed in 50 (40%) patients. Recovery of kidney function occurred almost without exception. Arterial or venous thrombosis occurred in 11 (9%) patients. At the last follow-up, 113 (90%) patients were in remission and had preserved kidney function. 3 patients with steroid-resistant MCNS progressed to end-stage renal disease, which was associated with focal segmental glomerulosclerosis lesions on repeat biopsy. Limitations: Retrospective design, variable treatment protocols. Conclusions: The large majority of patients who had MCNS with onset in adulthood or late adolescence were treated with corticosteroids and reached remission, but many had relapses. Cyclophosphamide resulted in stable remission in many patients with relapses. Significant morbidity was observed due to acute kidney injury and other complications. Progression to end-stage renal disease occurred in a few patients and was explained by focal segmental glomerulosclerosis.
MeSH term(s)	Acute Kidney Injury/epidemiology ; Adolescent ; Adrenal Cortex Hormones/therapeutic use ; Adult ; Age of Onset ; Aged ; Aged, 80 and over ; Cyclophosphamide/therapeutic use ; Disease Progression ; Female ; Follow-Up Studies ; Glomerulosclerosis, Focal Segmental/epidemiology ; Glomerulosclerosis, Focal Segmental/physiopathology ; Humans ; Immunosuppressive Agents/therapeutic use ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/physiopathology ; Male ; Middle Aged ; Nephrosis, Lipoid/drug therapy ; Nephrosis, Lipoid/epidemiology ; Nephrosis, Lipoid/physiopathology ; Recovery of Function ; Recurrence ; Remission Induction ; Remission, Spontaneous ; Retrospective Studies ; Thrombosis/epidemiology ; Venous Thrombosis/epidemiology ; Young Adult
Chemical Substances	Adrenal Cortex Hormones ; Immunosuppressive Agents ; Cyclophosphamide (8N3DW7272P)
Language	English
Publishing date	2017-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	604539-x
ISSN	1523-6838 ; 0272-6386
ISSN (online)	1523-6838
ISSN	0272-6386
DOI	10.1053/j.ajkd.2016.10.032
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