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  1. Article ; Online: The InSciEdRS View: A User-Friendly and Accessible Microscope with Easy-to-Follow Companion Curricula.

    Shams, Soaleha / Olson, Sidney / Ekker, Michael P / Salmi, Adam / Ekker, Stephen C / Pierret, Chris

    Zebrafish

    2024  Volume 21, Issue 2, Page(s) 101–108

    Abstract: Microscopes are essential for research and education in science. Unlike computers and online learning tools, however, microscopes are not currently a fixed element in K-12 classrooms, due to steep cost, needless complexity, and often requiring a ... ...

    Abstract Microscopes are essential for research and education in science. Unlike computers and online learning tools, however, microscopes are not currently a fixed element in K-12 classrooms, due to steep cost, needless complexity, and often requiring a prohibitive level of staff training to effectively deploy. In a collaboration with Area 10 Labs, Integrated Science Education Outreach (InSciEd Out) developed a state-of-the-art alternative microscope, the InSciEdRS View, to reduce the financial barrier, prohibitive per-student cost, unnecessary complexity, and extensive staff training. Utilizing a 1080p camera and a lunchbox-style case, this Wi-Fi- and USB-connectable microscope comes with all necessary components for visualization of microscopic specimens (10 × -50 × magnification). While built to handle the rigors of classroom use, its imaging capability and battery-operation can make it flexible for a laboratory or fieldwork as well. We further highlight here K-12 curricula that we have developed using larval zebrafish to enable teachers, science outreach leaders, and parents to support active hands-on science observations. The InSciEdRS View microscope and the InSciEd Out curricula are readily scalable, translatable, and accessible for traditional and neurodiverse students and integrating these in various settings can be an efficient way to achieve better outcomes in science education.
    MeSH term(s) Animals ; Humans ; Zebrafish ; Curriculum ; Students ; Microscopy
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2156020-1
    ISSN 1557-8542 ; 1545-8547
    ISSN (online) 1557-8542
    ISSN 1545-8547
    DOI 10.1089/zeb.2023.0093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Zebrafish in Education: Tackling Big Problems with Little Fish.

    Jackstadt, Madelyn M / Hutson, Lara / Liang, Jennifer O / Pickart, Michael A / Pierret, Chris / Franz-Odendaal, Tamara A

    Zebrafish

    2024  Volume 21, Issue 2, Page(s) 71–72

    MeSH term(s) Animals ; Zebrafish ; Perciformes
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Editorial
    ZDB-ID 2156020-1
    ISSN 1557-8542 ; 1545-8547
    ISSN (online) 1557-8542
    ISSN 1545-8547
    DOI 10.1089/zeb.2024.0141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Extension - A novel approach to inquiry learning with the 5E's.

    Indahl, Timothy C / Planchard, Megan / Hammerlund, Madeleine E M / Pierret, Chris

    Essays in education

    2022  Volume 27, Issue 1

    Language English
    Publishing date 2022-09-30
    Publishing country United States
    Document type Journal Article
    ISSN 1527-9359
    ISSN (online) 1527-9359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Exosomal microRNAs in breast cancer: towards theranostic applications.

    Gulati, Richa / Mitra, Tridip / Rajiv, Rohan / Rajan, Emilda Judith Ezhil / Pierret, Chris / Enninga, Elizabeth Ann L / Janardhanan, Rajiv

    Frontiers in molecular biosciences

    2024  Volume 11, Page(s) 1330144

    Abstract: Breast cancer is one of the top two reproductive cancers responsible for high rates of morbidity and mortality among women globally. Despite the advancements in the treatment of breast cancer, its early diagnosis remains a challenge. Recent evidence ... ...

    Abstract Breast cancer is one of the top two reproductive cancers responsible for high rates of morbidity and mortality among women globally. Despite the advancements in the treatment of breast cancer, its early diagnosis remains a challenge. Recent evidence indicates that despite the adroit use of numerous strategies to facilitate rapid and precision-oriented screening of breast cancer at the community level through the use of mammograms, Fine-needle aspiration cytology (FNAC) and biomarker tracking, no strategy has been unequivocally accepted as a gold standard for facilitating rapid screening for disease. This necessitates the need to identify novel strategies for the detection and triage of breast cancer lesions at higher rates of specificity, and sensitivity, whilst taking into account the epidemiologic and social-demographic features of the patients. Recent shreds of evidence indicate that exosomes could be a robust source of biomaterial for the rapid screening of breast cancer due to their high stability and their presence in body fluids. Increasing evidence indicates that the Exosomal microRNAs- play a significant role in modifying the tumour microenvironment of breast cancers, thereby potentially aiding in the proliferation, invasion and metastasis of breast cancer. In this review, we summarize the role of ExomiRs in the tumour microenvironment in breast cancer. These ExomiRs can also be used as candidate biomarkers for facilitating rapid screening and triaging of breast cancer patients for clinical intervention.
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2024.1330144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Endocrine disrupting chemicals: gestational diabetes and beyond.

    Mitra, Tridip / Gulati, Richa / Ramachandran, Krithika / Rajiv, Rohan / Enninga, Elizabeth Ann L / Pierret, Chris K / Kumari R, Sajeetha / Janardhanan, Rajiv

    Diabetology & metabolic syndrome

    2024  Volume 16, Issue 1, Page(s) 95

    Abstract: Gestational Diabetes Mellitus (GDM) has been on the rise for the last two decades along with the growing incidence of obesity. The ubiquitous use of Endocrine-Disrupting Chemicals (EDCs) worldwide has been associated with this increase in GDM incidence. ... ...

    Abstract Gestational Diabetes Mellitus (GDM) has been on the rise for the last two decades along with the growing incidence of obesity. The ubiquitous use of Endocrine-Disrupting Chemicals (EDCs) worldwide has been associated with this increase in GDM incidence. Epigenetic modifications such as DNA methylation, histone acetylation, and methylation have been associated with prenatal exposure to EDCs. EDC exposure can also drive a sustained disruption of the hypothalamus-pituitary-thyroid axis and various other signaling pathways such as thyroid signaling, PPARγ signaling, PI3K-AKT signaling. This disruption leads to impaired glucose metabolism, insulin resistance as well as β-cell dysfunction, which culminate into GDM. Persistent EDC exposure in pregnant women also increases adipogenesis, which results in gestational weight gain. Importantly, pregnant mothers transfer these EDCs to the fetus via the placenta, thus leading to other pregnancy-associated complications such as intrauterine growth restriction (IUGR), and large for gestational age neonates. Furthermore, this early EDC exposure of the fetus increases the susceptibility of the infant to metabolic diseases in early life. The transgenerational impact of EDCs is also associated with higher vascular tone, cognitive aberrations, and enhanced susceptibility to lifestyle disorders including reproductive health anomalies. The review focuses on the impact of environmental toxins in inducing epigenetic alterations and increasing the susceptibility to metabolic diseases during pregnancy needs to be extensively studied such that interventions can be developed to break this vicious cycle. Furthermore, the use of EDC-associated ExomiRs from the serum of patients can help in the early diagnosis of GDM, thereby leading to triaging of patients based on increasing risk factor of the clinicopathological condition.
    Language English
    Publishing date 2024-04-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2518786-7
    ISSN 1758-5996
    ISSN 1758-5996
    DOI 10.1186/s13098-024-01317-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: "Science for All": A Case Study of Digitizing Inquiry-Driven Professional Development.

    Indahl, Timothy C / Ekker, Michael P / Sindberg, Gregory M / Pierret, Chris

    Creative education

    2021  Volume 12, Issue 8, Page(s) 1773–1782

    Abstract: To adapt to the increasingly technology-driven environment of modern K-12 education Integrated Science Education Outreach (InSciEd Out) digitized an extensive professional development curriculum library that forms the core experience for teachers joining ...

    Abstract To adapt to the increasingly technology-driven environment of modern K-12 education Integrated Science Education Outreach (InSciEd Out) digitized an extensive professional development curriculum library that forms the core experience for teachers joining the program. In previous years the curriculum had been delivered solely in print form. The goals of this conversion were to better employ technology in the teacher training experience that mirrored best practice in their K-12 classrooms and to provide a more scalable product for InSciEd Out. The digitized professional development curriculum was delivered using Google Classroom accessed by teachers with Chromebooks. The digitization measurably improved flexibility for engagement in scientific experimentation and granted immediate access to course feedback for the program. Teachers who participated rated the course positively in general and specifically reported increased self-efficacy in technology use both in the internship and in the classroom.
    Language English
    Publishing date 2021-08-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2577618-6
    ISSN 2151-4771 ; 2151-4755
    ISSN (online) 2151-4771
    ISSN 2151-4755
    DOI 10.4236/ce.2021.128134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Exploring the Hawaiian Ala Wai Watershed with Zebrafish.

    Oglesby, Zachary / Rillorta, Alanna Nicole / Agos, Cheydon / Borges, Ku'uipo / Cabradilla, Saien / Garvin, Michael / Higuchi, Bryn / Kamaka, Elisabeth / Law, Chancen / Liu, Matthew / Matsumoto, Grace / Ng, Tiffany / Quiroz, Gemma / Ramiro, Chelsea / Saito, Jamie / Williams, Malia / Yamada, Asia / Yogi, Zane / Olson, Sidney /
    Shams, Soaleha / Withy, Kelley / Pierret, Chris

    Zebrafish

    2024  Volume 21, Issue 2, Page(s) 206–213

    Abstract: The Ala Wai Canal is an artificial waterway in the tourist district of Waikiki in Honolulu, HI. Originally built to collect runoff from industrial, residential, and green spaces dedicated to recreation, the Ala Wai Canal has since experienced potent ... ...

    Abstract The Ala Wai Canal is an artificial waterway in the tourist district of Waikiki in Honolulu, HI. Originally built to collect runoff from industrial, residential, and green spaces dedicated to recreation, the Ala Wai Canal has since experienced potent levels of toxicity due to this runoff entering the watershed and making it hazardous for both marine life and humans at current concentration, including
    MeSH term(s) Humans ; Animals ; Zebrafish ; Hawaii ; Water ; Water Pollutants, Chemical/toxicity ; Water Pollutants, Chemical/analysis ; Embryo, Nonmammalian/chemistry
    Chemical Substances Water (059QF0KO0R) ; Water Pollutants, Chemical
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2156020-1
    ISSN 1557-8542 ; 1545-8547
    ISSN (online) 1557-8542
    ISSN 1545-8547
    DOI 10.1089/zeb.2023.0092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: 75202 The New Normal

    Adriana Morales Gomez / Kit Knier / Joanna Yang Yowler / Chris Pierret / Linda M. Scholl

    Journal of Clinical and Translational Science, Vol 5, Pp 62-

    A Virtual Summer Foundations in Research

    2021  Volume 62

    Abstract: ABSTRACT IMPACT: The Summer Foundation on Research gave undergraduate students the opportunity to do research despite the new normal - COVID-19 pandemic. OBJECTIVES/GOALS: The COVID-19 pandemic prevented domestic and international undergraduate students ... ...

    Abstract ABSTRACT IMPACT: The Summer Foundation on Research gave undergraduate students the opportunity to do research despite the new normal - COVID-19 pandemic. OBJECTIVES/GOALS: The COVID-19 pandemic prevented domestic and international undergraduate students from attending in-person Mayo Clinic Summer Undergraduate Research Programs. Mayo decided to redesign this program as a virtual, 4-week Summer Foundations in Research (SFIR) program. The goal of this program was to give students a scientific research experience. METHODS/STUDY POPULATION: The SFIR included an Introduction to Experimental Design, Dialogue methodology for communicating science, scientific mentoring, asynchronous online modules and a Resiliency component. Evaluations of the program were undertaken to gather feedback for program improvement and to assess the educational and mental health impact on participants. These evaluations asked student to rate each section of the program. Additionally, students were encouraged to provide their own comments and feedback. Statistical analysis of quantitative data was performed using excel. The qualitative data was studied using the identification, analysis and interpretation of patterns method per the student’s comments on each of the questions addressed in the survey. RESULTS/ANTICIPATED RESULTS: These evaluations revealed positive outcomes across program components: 66% of the participants found the Resiliency component extremely worthwhile, 80% of participants liked the experimental design and 70% liked the educational courses. Qualitative data showed that mentor/mentee interactions were highly valued, and both participants and faculty suggested increasing the amount of time devoted to these interactions. Small group discussions gave students the opportunity to get to know other peers and encouraged further discussions about science and the community. Participants suggested minor improvements to the program, such as re-creating the online modules specific for undergraduate students, increasing 1-to-1 and small ...
    Keywords Medicine ; R
    Subject code 796
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: 55564 Interactive mindfulness and dialogue sessions are integral components of research training.

    Kit Knier / Adriana Morales Gomez / Joanna Yang Yowler / Chris Pierret / Linda M. Scholl

    Journal of Clinical and Translational Science, Vol 5, Pp 64-

    2021  Volume 65

    Abstract: ABSTRACT IMPACT: This work demonstrates the integration of interactive mindfulness and dialogue sessions in curricula is both desired by students and effective in conferring resilience, a protective factor that may aid in maintaining wellbeing of ... ...

    Abstract ABSTRACT IMPACT: This work demonstrates the integration of interactive mindfulness and dialogue sessions in curricula is both desired by students and effective in conferring resilience, a protective factor that may aid in maintaining wellbeing of trainees interested in pursuing graduate studies in biomedical research and science. OBJECTIVES/GOALS: To support student futures in the field of biomedicine, Mayo Clinic Graduate School of Biological Sciences utilized digital platforms to deliver a summer research program in the summer of 2020. One goal of this program, in addition to scholastic outcomes and research experience, was to support and improve the wellbeing of college student participants. METHODS/STUDY POPULATION: Following the cancellation of in-person summer research programs, students were invited to attend a digital Summer Foundations in Research program. The 4-week program included 4 small group dialogue sessions led by trained facilitators and 4 large group mindfulness seminars followed with 3 Q/A style small group sessions. Surveys were delivered on days 1, 27, and 3 months following the program. Wellbeing measures included Brief Resilience, Perceived Stress, and Satisfaction with Life Scales. Students were prompted to indicate how worthwhile they found course components and comment on why they rated each component the way they did. Wellbeing results were assessed using paired t-tests with Bonferroni correction for multiple comparisons. Thematic analysis was used to interpret qualitative results. RESULTS/ANTICIPATED RESULTS: Students improved across all wellbeing measures at the program conclusion, including resilience (mean difference(SE) pre- to post-program +0.22(0.06) p=0.0007), perceived stress (-1.71(0.66) p=0.0116), and life satisfaction (+1.57(0.52) p=0.0037). Gains in resilience were maintained 3 months out (pre-program to 3 month survey +0.28(0.06) p<0.0001). To our surprise, mindfulness was the highest rated component of the research program with 85% (121/142) of students rating the ...
    Keywords Medicine ; R
    Subject code 796
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online ; Conference proceedings: Education Platform at ZDM8.

    Lyman Gingerich, Jamie S / Pickart, Michael A / Pierret, Chris

    Zebrafish

    2016  Volume 13, Issue 2, Page(s) 142–143

    Abstract: Interest among the zebrafish community in education and science accessibility for all ages has increased. At the 8th Annual Zebrafish Disease Models Conference (ZDM8), a specifically designed session enabled professional scientists, educators, and ... ...

    Abstract Interest among the zebrafish community in education and science accessibility for all ages has increased. At the 8th Annual Zebrafish Disease Models Conference (ZDM8), a specifically designed session enabled professional scientists, educators, and students to have a venue to present their science, discuss ideas in education, and partner to navigate a scientific meeting as an educational experience. This meeting report describes the format of the Platform Session as well as challenges and future plans to leverage impact of conferences on the local communities.
    MeSH term(s) Animals ; Disease Models, Animal ; Science/education ; Zebrafish
    Language English
    Publishing date 2016-04
    Publishing country United States
    Document type Congresses
    ZDB-ID 2156020-1
    ISSN 1557-8542 ; 1545-8547
    ISSN (online) 1557-8542
    ISSN 1545-8547
    DOI 10.1089/zeb.2016.1239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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