Article ; Online: Vitamin D deficiency and rickets in children and adolescents with ichthyosiform erythroderma in type IV and V skin.
The British journal of dermatology
2012 Volume 166, Issue 3, Page(s) 608–615
Abstract: Background: Ichthyosiform erythroderma due to keratinizing disorders may suppress cutaneous vitamin D synthesis, leading to vitamin D deficiency and rickets.: Objectives: To determine the prevalence of vitamin D deficiency and rickets in children and ...
| Abstract | Background: Ichthyosiform erythroderma due to keratinizing disorders may suppress cutaneous vitamin D synthesis, leading to vitamin D deficiency and rickets. Objectives: To determine the prevalence of vitamin D deficiency and rickets in children and adolescents with congenital ichthyosis and other keratinizing disorders with erythroderma and scaling. Patients and methods: In this cross-sectional study, 45 children and adolescents with ichthyosiform erythroderma due to keratinizing disorders, and 66 controls (group 1: age and sex matched, with skin diseases other than keratinizing disorders; group 2: age and sex matched, healthy volunteers) were included. Evidence of rickets was determined clinically (physical examination and radiographs) and biochemically {serum calcium, phosphorus, alkaline phosphatase, 25-hydroxy vitamin D [25(OH)D] and parathyroid hormone (PTH)}. Results: All patients in the disease group had clinical, radiological or biochemical evidence of rickets [25(OH)D<20ngmL(-1) ], and analysis was done for all subjects with the available biochemical reports. The mean serum 25(OH)D levels of the disease group was 8·38±5·23ngmL(-1) and was significantly lower than in control group 1 (11·1±5·8ngmL(-1) ) (P<0·01) and control group 2 (13·5±6·9ngmL(-1) ) (P<0·001). The prevalence of vitamin D deficiency [25(OH)D<20ngmL(-1) ] was significantly higher in the disease group (n=38 of 39, 97·4%) than in control group 2 (n=12, 70·6%) (P<0·01), and total controls (n=56, 84·8%) (P=0·04). The frequency of hyperparathyroidism (PTH>65pgmL(-1) ) was also significantly higher in the disease group than in controls (P<0·01). Conclusions: Children and adolescents with various forms of ichthyosiform erythroderma, especially those with pigmented skin (types IV-VI), are at increased risk of developing vitamin D deficiency and clinical rickets. |
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| MeSH term(s) | Adolescent ; Alkaline Phosphatase/metabolism ; Calcium/metabolism ; Child ; Cross-Sectional Studies ; Female ; Humans ; Ichthyosiform Erythroderma, Congenital/blood ; Ichthyosiform Erythroderma, Congenital/complications ; Male ; Parathyroid Hormone/metabolism ; Phosphorus/metabolism ; Rickets/blood ; Rickets/etiology ; Vitamin D/analogs & derivatives ; Vitamin D/metabolism ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/etiology |
| Chemical Substances | Parathyroid Hormone ; Vitamin D (1406-16-2) ; Phosphorus (27YLU75U4W) ; 25-hydroxyvitamin D (A288AR3C9H) ; Alkaline Phosphatase (EC 3.1.3.1) ; Calcium (SY7Q814VUP) |
| Language | English |
| Publishing date | 2012-03 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 80076-4 |
| ISSN | 1365-2133 ; 0007-0963 |
| ISSN (online) | 1365-2133 |
| ISSN | 0007-0963 |
| DOI | 10.1111/j.1365-2133.2011.10672.x |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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