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  1. Article ; Online: Robert L. Pressey (1953-2023).

    Adams, Vanessa M / Álvarez-Romero, Jorge G / Ban, Natalie C / Mills, Morena / Visconti, Piero

    Nature ecology & evolution

    2023  Volume 7, Issue 12, Page(s) 1957–1958

    Language English
    Publishing date 2023-10-14
    Publishing country England
    Document type Editorial
    ISSN 2397-334X
    ISSN (online) 2397-334X
    DOI 10.1038/s41559-023-02240-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Thesis: Einfluss von Lesetermin und Mostbehandlung auf die Alterung von Weißwein, am Beispiel von Vitis vinifera L. cv. Riesling

    Adams, Simone

    (Geisenheimer Berichte ; 72)

    2013  

    Author's details Simone Adams
    Series title Geisenheimer Berichte ; 72
    Collection
    Language German
    Size 127 S., 240 mm x 160 mm, 201 g
    Publisher Forschungsanstalt Geisenheim
    Publishing place Geisenheim, Rheingau
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Gießen, Univ., Diss., 2012
    HBZ-ID HT018463728
    ISBN 978-3-934742-61-1 ; 3-934742-61-0
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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  3. Article ; Online: Structure-Function Studies of the Antibiotic Target l,l-Diaminopimelate Aminotransferase from

    Weatherhead, Anthony W / Crowther, Jennifer M / Horne, Christopher R / Meng, Yanxiang / Coombes, David / Currie, Michael J / Watkin, Serena A J / Adams, Lily E / Parthasarathy, Anutthaman / Dobson, Renwick C J / Hudson, André O

    Biochemistry

    2020  Volume 59, Issue 24, Page(s) 2274–2288

    Abstract: While humans lack the biosynthetic pathways ... ...

    Abstract While humans lack the biosynthetic pathways for
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Enzyme Inhibitors/chemistry ; Structure-Activity Relationship ; Transaminases/antagonists & inhibitors ; Transaminases/chemistry ; Transaminases/genetics ; Verrucomicrobia/enzymology ; Verrucomicrobia/genetics
    Chemical Substances Anti-Bacterial Agents ; Enzyme Inhibitors ; Transaminases (EC 2.6.1.-)
    Language English
    Publishing date 2020-06-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/acs.biochem.0c00185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Candidate genes affecting stomatal density in rice (Oryza sativa L.) identified by genome-wide association.

    Phetluan, Watchara / Wanchana, Samart / Aesomnuk, Wanchana / Adams, Julian / Pitaloka, Mutiara K / Ruanjaichon, Vinitchan / Vanavichit, Apichart / Toojinda, Theerayut / Gray, Julie E / Arikit, Siwaret

    Plant science : an international journal of experimental plant biology

    2023  Volume 330, Page(s) 111624

    Abstract: Stomata regulate photosynthesis and water loss. They have been an active subject of research for centuries, but our knowledge of the genetic components that regulate stomatal development in crops remains very limited in comparison to the model plant ... ...

    Abstract Stomata regulate photosynthesis and water loss. They have been an active subject of research for centuries, but our knowledge of the genetic components that regulate stomatal development in crops remains very limited in comparison to the model plant Arabidopsis thaliana. Leaf stomatal density was found to vary by over 2.5-fold across a panel of 235 rice accessions. Using GWAS, we successfully identified five different QTLs associated with stomatal density on chromosomes 2, 3, 9, and 12. Forty-two genes were identified within the haplotype blocks corresponding to these QTLs. Of these, nine genes contained haplotypes that were associated with different stomatal densities. These include a gene encoding a trehalose-6-phosphate synthase, an enzyme that has previously been associated with altered stomatal density in Arabidopsis, and genes encoding a B-BOX zinc finger family protein, a leucine-rich repeat family protein, and the 40 S ribosomal protein S3a, none of which have previously been linked to stomatal traits. We investigated further and show that a closely related B-BOX protein regulates stomatal development in Arabidopsis. The results of this study provide information on genetic associations with stomatal density in rice. The QTLs and candidate genes may be useful in future breeding programs for low or high stomatal density and, consequently, improved photosynthetic capacity, water use efficiency, or drought tolerance.
    MeSH term(s) Oryza/metabolism ; Genome-Wide Association Study ; Arabidopsis/genetics ; Arabidopsis/metabolism ; Plant Breeding ; Water/metabolism
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2023-02-01
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 742010-9
    ISSN 1873-2259 ; 0168-9452
    ISSN (online) 1873-2259
    ISSN 0168-9452
    DOI 10.1016/j.plantsci.2023.111624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Molecular docking and anti-ulcerative potential of Cucumis (L. Inodorous) on ibuprofen induced gastric ulceration in male wistar animals.

    Adebayo-Gege, Grace / Uthman, Zainab Shehu / Adams, Moses Dele / Florence, Tarfa / Haruna, Danazumi Umar / Audu, Ngabea Murtala / Lawan, Hamidu Jabba / Queen, Ozegbe / Chinedu, Onwuchekwa / Meraiyebu, Ajibola / Kafaru, Ojo

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 161, Page(s) 114531

    Abstract: Background: The use of NSAIDs have caused stomach injury by inhibiting endogenous mucosal prostaglandin production. Cucumis melo is reported to possess antiulcer potential. This study investigates the mechanism underlying the antiulcer potentials of ... ...

    Abstract Background: The use of NSAIDs have caused stomach injury by inhibiting endogenous mucosal prostaglandin production. Cucumis melo is reported to possess antiulcer potential. This study investigates the mechanism underlying the antiulcer potentials of Cucumis melo (CUM).
    Methods: Thirty-five male Wistar rat were randomly assigned to each of seven groups; A(control given water and rat pellets), B(gastric ulcer induced with ibuprofen 400 mg/kg), C (Misoprotol 200 μg/kg), D to G (pretreated with different variation of CUM extract; 25 %, 50 %, 75 % and 100 % at a dose of 1 ml/kg for 3 weeks prior to gastric ulcer induction). Ulcer score, ulcer index and percentage inhibition, total gastric acidity was measured. Antioxidant activities, Malondialdehyde, H
    Result: Total gastric acidity, ulcer score, ulcer index, MDA, TNF-α significantly decreased after CUM treatment when compared to group B. The percentage inhibition, antioxidant activities, PGE2 concentration was significantly increased in all treatment groups compared to group B. Interactions of selected compounds of CUM with Prostaglandin E2 at various docking pockets showed folic acid has highest binding affinity followed by delta7-avenasterol and codisterol to PGE2 receptor. this study shows that one of the mechanisms by which CUM exhibits its antiulcer potential by enhancing Prostaglandin synthesis and antioxidant capacity. Therefore, Cucumis melo can therefore be explored as novel antiulcer agents.
    MeSH term(s) Rats ; Male ; Animals ; Stomach Ulcer/chemically induced ; Stomach Ulcer/drug therapy ; Stomach Ulcer/metabolism ; Ibuprofen/metabolism ; Dinoprostone/metabolism ; Molecular Docking Simulation ; Antioxidants/metabolism ; Rats, Wistar ; Cucumis/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plant Extracts/chemistry ; Gastric Mucosa/metabolism
    Chemical Substances Ibuprofen (WK2XYI10QM) ; Dinoprostone (K7Q1JQR04M) ; Antioxidants ; Tumor Necrosis Factor-alpha ; Plant Extracts
    Language English
    Publishing date 2023-03-17
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.114531
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Methacarn preserves mucus integrity and improves visualization of amoebae in gills of Atlantic salmon (Salmo salar L.).

    Fernandez, Carolina / Mascolo, Dario / Monaghan, Sean J / Baily, Johanna L / Chalmers, Lynn / Paladini, Giuseppe / Adams, Alexandra / Bron, James E / Fridman, Sophie

    Journal of fish diseases

    2019  Volume 42, Issue 6, Page(s) 883–894

    Abstract: ... to (a) improve preservation of the mucous coat on Atlantic salmon, Salmo salar L., gills and (b) to examine ...

    Abstract Two aqueous fixation methods (modified Davidson's solution and modified Davidson's solution with 2% (w/v) Alcian blue) were compared against two non-aqueous fixation methods (methacarn solution and methacarn solution with 2% (w/v) Alcian blue) along with the standard buffered formalin fixation method to (a) improve preservation of the mucous coat on Atlantic salmon, Salmo salar L., gills and (b) to examine the interaction between the amoebae and mucus on the gill during an infection with amoebic gill disease. Aqueous fixatives demonstrated excellent cytological preservation but failed to deliver the preservation of the mucus when compared to the non-aqueous-based fixatives; qualitative and semi-quantitative analysis revealed a greater preservation of the gill mucus using the non-aqueous methacarn solution. A combination of this fixation method and an Alcian blue/Periodic acid-Schiff staining was tested in gills of Atlantic salmon infected with amoebic gill disease; lectin labelling was also used to confirm the mucus preservation in the methacarn-fixed tissue. Amoebae were observed closely associated with the mucus demonstrating that the techniques employed for preservation of the mucous coat can indeed avoid the loss of potential mucus-embedded parasites, thus providing a better understanding of the relationship between the mucus and parasite.
    MeSH term(s) Acetic Acid/chemistry ; Alcian Blue/chemistry ; Amoeba/pathogenicity ; Animals ; Chloroform/chemistry ; Fixatives/chemistry ; Formaldehyde/chemistry ; Gills/parasitology ; Gills/pathology ; Methanol/chemistry ; Mucus ; Periodic Acid-Schiff Reaction ; Salmo salar/anatomy & histology ; Salmo salar/parasitology ; Tissue Fixation/methods
    Chemical Substances Fixatives ; methacarn ; Formaldehyde (1HG84L3525) ; Chloroform (7V31YC746X) ; Alcian Blue (P4448TJR7J) ; Acetic Acid (Q40Q9N063P) ; Methanol (Y4S76JWI15)
    Language English
    Publishing date 2019-04-04
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 432109-1
    ISSN 1365-2761 ; 0140-7775
    ISSN (online) 1365-2761
    ISSN 0140-7775
    DOI 10.1111/jfd.12988
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Investigating the behaviour of Atlantic salmon (Salmo salar L.) post-smolts during their early marine migration through the Clyde Marine Region.

    Lilly, Jessie / Honkanen, Hannele M / Bailey, David M / Bean, Colin W / Forrester, Ruaidhri / Rodger, Jessica R / Adams, Colin E

    Journal of fish biology

    2022  Volume 101, Issue 5, Page(s) 1285–1300

    Abstract: It is thought that survival during migration is particularly poor for Atlantic salmon post-smolts immediately after entry into sea and particularly in the estuarine environment. Nonetheless, there is currently a lack of information on Atlantic salmon ... ...

    Abstract It is thought that survival during migration is particularly poor for Atlantic salmon post-smolts immediately after entry into sea and particularly in the estuarine environment. Nonetheless, there is currently a lack of information on Atlantic salmon post-smolt movement behaviour in estuaries in the UK. This study used acoustic tagging to estimate loss rates and compare the behaviour of Atlantic salmon post-smolts migrating from two distinctly different rivers draining into the Clyde Estuary, the River Endrick (n = 145) and the Gryffe (n = 102). Contrary to most literature, post-smolts undertook rapid migrations through the estuary, potentially decreasing their exposure to predators/anthropogenic stressors and reducing their estimated loss rates (river: 1%-3% km
    MeSH term(s) Animals ; Salmo salar ; Animal Migration ; Estuaries ; Rivers ; Salinity
    Language English
    Publishing date 2022-09-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 410564-3
    ISSN 1095-8649 ; 0022-1112
    ISSN (online) 1095-8649
    ISSN 0022-1112
    DOI 10.1111/jfb.15200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Immersion challenge model for Flavobacterium psychrophilum infection of Atlantic salmon (Salmo salar L.) fry.

    Macchia, Valeria / Inami, Makoto / Ramstad, Anne / Grammes, Fabian / Reeve, Andrew / Moen, Thomas / Torgersen, Jacob Seilø / Adams, Alexandra / Desbois, Andrew P / Hoare, Rowena

    Journal of fish diseases

    2022  Volume 45, Issue 11, Page(s) 1781–1788

    Abstract: ... psychrophilum isolates collected from each fish species, respectively; fish had been pretreated with 200 mg/L ...

    Abstract Flavobacterium psychrophilum is the causative agent of bacterial cold-water disease (CWBD) and rainbow trout fry syndrome (RTFS), which affect salmonids. To better understand this pathogen and its interaction with the host during infection, including to support the development of resistant breeds and new vaccines and treatments, there is a pressing need for reliable and reproducible immersion challenge models that more closely mimic natural routes of infection. The aim of this present study was to evaluate a challenge model developed previously for rainbow trout for use in Atlantic salmon. First, preliminary challenges were conducted in Atlantic salmon (n = 120) and rainbow trout (n = 80) fry using two F. psychrophilum isolates collected from each fish species, respectively; fish had been pretreated with 200 mg/L hydrogen peroxide for 1 h. Thereafter, the main challenge was performed for just one F. psychrophilum isolate for each species (at 2 × 10
    MeSH term(s) Animals ; Fish Diseases/microbiology ; Flavobacteriaceae Infections/microbiology ; Flavobacterium ; Hydrogen Peroxide ; Immersion ; Oncorhynchus mykiss/microbiology ; Reproducibility of Results ; Salmo salar ; Water
    Chemical Substances Water (059QF0KO0R) ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2022-08-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 432109-1
    ISSN 1365-2761 ; 0140-7775
    ISSN (online) 1365-2761
    ISSN 0140-7775
    DOI 10.1111/jfd.13699
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Efficacy of a polyvalent injectable vaccine against Flavobacterium psychrophilum administered to rainbow trout (Oncorhynchus mykiss L.).

    Hoare, Rowena / Jung, Sung-Ju / Ngo, Thao P H / Bartie, Kerry L / Thompson, Kim D / Adams, Alexandra

    Journal of fish diseases

    2018  Volume 42, Issue 2, Page(s) 229–236

    Abstract: Flavobacterium psychrophilum is one of the most important pathogens affecting cultured rainbow trout (Oncorhynchus mykiss). Recent information from UK salmonid farms showed country-wide distribution of genetically and serologically divergent clones, ... ...

    Abstract Flavobacterium psychrophilum is one of the most important pathogens affecting cultured rainbow trout (Oncorhynchus mykiss). Recent information from UK salmonid farms showed country-wide distribution of genetically and serologically divergent clones, which has hampered the development of a vaccine for rainbow trout fry syndrome. The current study assessed the efficacy of an injectable polyvalent vaccine containing formalin-inactivated F. psychrophilum in rainbow trout. The vaccine was formulated with an oil adjuvant (Montanide ISA 760VG) or formalin-killed cells alone. Duplicate groups of trout (60 ± 13 g) were given phosphate-buffered saline or vaccine formulated with Montanide by intra-peritoneal (i.p.) injection and challenged by intra-muscular (i.m.) injection with a homologous and a heterologous isolate of F. psychrophilum at 525 degree days post-vaccination (dd pv). Significant protection was achieved in vaccinated fish (p = 0.0001, RPS 76% homologous, 88% heterologous). Efficacy of the adjuvanted vaccine was also demonstrated by heterologous challenge at 1155 dd pv resulting in 100% protection, whereas survival in the un-adjuvanted group was not significantly different from control fish. Levels of specific antibody at 1155 dd pv, as measured by ELISA, were significantly higher in the fish vaccinated with adjuvant when compared with unvaccinated fish.
    MeSH term(s) Adjuvants, Immunologic ; Animals ; Aquaculture/methods ; Bacterial Vaccines/administration & dosage ; Bacterial Vaccines/immunology ; Bacterial Vaccines/therapeutic use ; Fish Diseases/immunology ; Fish Diseases/microbiology ; Fish Diseases/prevention & control ; Flavobacteriaceae Infections/immunology ; Flavobacteriaceae Infections/prevention & control ; Flavobacteriaceae Infections/veterinary ; Flavobacterium/immunology ; Mannitol/analogs & derivatives ; Oleic Acids ; Oncorhynchus mykiss ; Vaccination/veterinary
    Chemical Substances Adjuvants, Immunologic ; Bacterial Vaccines ; Oleic Acids ; Mannitol (3OWL53L36A)
    Language English
    Publishing date 2018-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 432109-1
    ISSN 1365-2761 ; 0140-7775
    ISSN (online) 1365-2761
    ISSN 0140-7775
    DOI 10.1111/jfd.12919
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Comparative Molecular Dynamics Simulations Provide Insight Into Antibiotic Interactions: A Case Study Using the Enzyme L,L-Diaminopimelate Aminotransferase (DapL).

    Adams, Lily E / Rynkiewicz, Patrick / Babbitt, Gregory A / Mortensen, Jamie S / North, Rachel A / Dobson, Renwick C J / Hudson, André O

    Frontiers in molecular biosciences

    2020  Volume 7, Page(s) 46

    Abstract: The L,L-diaminopimelate aminotransferase (DapL) pathway, a recently discovered variant ... antibiotic compounds. DapL is a homodimer that catalyzes the conversion of tetrahydrodipicolinate to L,L ...

    Abstract The L,L-diaminopimelate aminotransferase (DapL) pathway, a recently discovered variant of the lysine biosynthetic pathway, is an attractive pipeline to identify targets for the development of novel antibiotic compounds. DapL is a homodimer that catalyzes the conversion of tetrahydrodipicolinate to L,L-diaminopimelate in a single transamination reaction. The penultimate and ultimate products of the lysine biosynthesis pathway,
    Language English
    Publishing date 2020-03-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2020.00046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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