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Article ; Online: Pachychoroid Spectrum Diseases in Patients with Cushing’s Syndrome

Jeppe K. Holtz / Janni M. E. Larsson / Michael S. Hansen / Elon H. C. van Dijk / Yousif Subhi

Journal of Clinical Medicine, Vol 11, Iss 15, p

A Systematic Review with Meta-Analyses

2022 Volume 4437

Abstract: Cushing’s syndrome is a rare disease with an endogenous cause of excess cortisol secretion. More ... with Cushing’s syndrome. We performed a systematic literature search in 11 databases on 21 May 2022. Studies were ... with Cushing’s syndrome using optical coherence tomography (OCT) scans. We extracted data on subfoveal choroidal thickness ...

Abstract	Cushing’s syndrome is a rare disease with an endogenous cause of excess cortisol secretion. More evidence substantially links cortisol levels to the pachychoroid spectrum diseases. In this systematic review and meta-analysis, we summarize available evidence on pachychoroid spectrum diseases in patients with Cushing’s syndrome. We performed a systematic literature search in 11 databases on 21 May 2022. Studies were considered eligible if they performed retinal examination of a consecutive group of patients with Cushing’s syndrome using optical coherence tomography (OCT) scans. We extracted data on subfoveal choroidal thickness in patients with Cushing’s syndrome compared to matched controls. We also extracted data on the prevalence of pachychoroid pigment epitheliopathy (PPE), central serous chorioretinopathy (CSC), and polypoidal choroidal vasculopathy (PCV). We identified six eligible studies with a total of 159 patients with Cushing’s syndrome. On average, patients with Cushing’s syndrome have 49.5 µm thicker subfoveal choroidal thickness compared to matched healthy individuals. Pachychoroid spectrum diseases were relatively common in these patients: PPE in 20.8%, CSC in 7.7%, and PCV in 2.8%. We conclude that there should be low threshold to recommend ophthalmic examination to patients with Cushing’s syndrome, and that a macular OCT is recommended during this examination.
Keywords	central serous chorioretinopathy ; Cushing’s disease ; meta-analysis ; pachychoroid spectrum ; polypoidal choroidal vasculopathy ; systematic review ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Single-Voxel MR Spectroscopy of Gliomas with s-LASER at 7T.

Prener, Martin / Opheim, Giske / Shams, Zahra / Søndergaard, Christian Baastrup / Lindberg, Ulrich / Larsson, Henrik B W / Ziebell, Morten / Larsen, Vibeke Andrée / Vestergaard, Mark Bitsch / Paulson, Olaf B

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 10

Abstract: Background and purpose: Magnetic resonance spectroscopy (MRS)-a method of analysing metabolites in vivo-has been utilized in several studies of brain glioma biomarkers at lower field strengths. At ultra-high field strengths, MRS provides an improved ... ...

Abstract	Background and purpose: Magnetic resonance spectroscopy (MRS)-a method of analysing metabolites in vivo-has been utilized in several studies of brain glioma biomarkers at lower field strengths. At ultra-high field strengths, MRS provides an improved signal-to-noise-ratio and spectral resolution, but 7T studies on patients with gliomas are sparse. The purpose of this exploratory study was to evaluate the potential clinical implication of the use of single-voxel MRS at 7T to assess metabolic information on lesions in a pilot cohort of patients with grade II and III gliomas. Methods: We scanned seven patients and seven healthy controls using the semi-localization by adiabatic-selective refocusing sequence on a Philips Achieva 7T system with a standard dual-transmit head coil. The metabolic ratios were calculated relative to water and total creatine. Additionally, 2-hydroxyglutarate (2-HG) MRS was carried out in four of the patients, and the 2-HG concentration was calculated relative to water. Results: When comparing the tumour data to control regions in both patients and healthy controls, we found that the choline/creatine and myo-inositol/creatine ratios were significantly increased and that the N-acetylaspartate/creatine and the neurotransmitter glutamate/creatine ratios were significantly decreased. The N-acetylaspartate/water and glutamate/water ratios were also significantly decreased. The lactate/water and lactate/creatine ratios showed increases, although not significant. The GABA/water ratio was significantly decreased, but the GABA/creatine ratio was not. MRS spectra showed the presence of 2-HG in three of the four patients studied. Three of the patients, including the MRS 2-HG-negative patient, were operated on, and all of them had the IDH mutation. Conclusion: Our findings were consistent with the existing literature on 3T and 7T MRS.
Language	English
Publishing date	2023-05-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13101805
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Tumorigenesis promotes Mdm4-S overexpression.

Pant, Vinod / Larsson, Connie A / Aryal, Neeraj / Xiong, Shunbin / You, M James / Quintas-Cardama, Alfonso / Lozano, Guillermina

Oncotarget

2017 Volume 8, Issue 16, Page(s) 25837–25847

Abstract: ... that expression of a splice variant of MDM4, MDM4-S correlates with tumor aggressiveness and can be used ... whether expression of MDM4-S in itself is oncogenic or is simply an outcome of tumorigenesis. Here we have examined ... the role of Mdm4-S in tumor development in a transgenic mouse model. Our results suggest that splicing ...

Abstract	Disruption of the p53 tumor suppressor pathway is a primary cause of tumorigenesis. In addition to mutation of the p53 gene itself, overexpression of major negative regulators of p53, MDM2 and MDM4, also act as drivers for tumor development. Recent studies suggest that expression of splice variants of Mdm2 and Mdm4 may be similarly involved in tumor development. In particular, multiple studies show that expression of a splice variant of MDM4, MDM4-S correlates with tumor aggressiveness and can be used as a prognostic marker in different tumor types. However, in the absence of prospective studies, it is not clear whether expression of MDM4-S in itself is oncogenic or is simply an outcome of tumorigenesis. Here we have examined the role of Mdm4-S in tumor development in a transgenic mouse model. Our results suggest that splicing of Mdm4 does not promote tumor development and does not cooperate with other oncogenic insults to alter tumor latency or aggressiveness. We conclude that Mdm4-S overexpression is a consequence of splicing defects in tumor cells rather than a cause of tumor evolution.
Language	English
Publishing date	2017-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.15552
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Article ; Online: Crowdsourcing digital health measures to predict Parkinson’s disease severity

Solveig K. Sieberts / Jennifer Schaff / Marlena Duda / Bálint Ármin Pataki / Ming Sun / Phil Snyder / Jean-Francois Daneault / Federico Parisi / Gianluca Costante / Udi Rubin / Peter Banda / Yooree Chae / Elias Chaibub Neto / E. Ray Dorsey / Zafer Aydın / Aipeng Chen / Laura L. Elo / Carlos Espino / Enrico Glaab /

Ethan Goan / Fatemeh Noushin Golabchi / Yasin Görmez / Maria K. Jaakkola / Jitendra Jonnagaddala / Riku Klén / Dongmei Li / Christian McDaniel / Dimitri Perrin / Thanneer M. Perumal / Nastaran Mohammadian Rad / Erin Rainaldi / Stefano Sapienza / Patrick Schwab / Nikolai Shokhirev / Mikko S. Venäläinen / Gloria Vergara-Diaz / Yuqian Zhang / the Parkinson’s Disease Digital Biomarker Challenge Consortium / Yuanjia Wang / Yuanfang Guan / Daniela Brunner / Paolo Bonato / Lara M. Mangravite / Larsson Omberg

npj Digital Medicine, Vol 4, Iss 1, Pp 1-

the Parkinson’s Disease Digital Biomarker DREAM Challenge

2021 Volume 12

Abstract: ... symptom burden, particularly in the case of movement disorders like Parkinson’s disease (PD ...

Abstract	Abstract Consumer wearables and sensors are a rich source of data about patients’ daily disease and symptom burden, particularly in the case of movement disorders like Parkinson’s disease (PD). However, interpreting these complex data into so-called digital biomarkers requires complicated analytical approaches, and validating these biomarkers requires sufficient data and unbiased evaluation methods. Here we describe the use of crowdsourcing to specifically evaluate and benchmark features derived from accelerometer and gyroscope data in two different datasets to predict the presence of PD and severity of three PD symptoms: tremor, dyskinesia, and bradykinesia. Forty teams from around the world submitted features, and achieved drastically improved predictive performance for PD status (best AUROC = 0.87), as well as tremor- (best AUPR = 0.75), dyskinesia- (best AUPR = 0.48) and bradykinesia-severity (best AUPR = 0.95).
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	006
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association Between Menstrual Cycle Length and Coronavirus Disease 2019 (COVID-19) Vaccination: A U.S. Cohort.

Hallberg, Ebba / Sundström, Anders / Larsson, Maria / Arthurson, Veronica / Ljung, Rickard

Obstetrics and gynecology

2022 Volume 139, Issue 5, Page(s) 940–941

MeSH term(s)	COVID-19/epidemiology ; COVID-19/prevention & control ; Cohort Studies ; Female ; Humans ; Menstrual Cycle ; SARS-CoV-2 ; Vaccination
Language	English
Publishing date	2022-04-05
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207330-4
ISSN	1873-233X ; 0029-7844
ISSN (online)	1873-233X
ISSN	0029-7844
DOI	10.1097/AOG.0000000000004781
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Article ; Online: The king’s spice cabinet–Plant remains from Gribshunden, a 15th century royal shipwreck in the Baltic Sea

Mikael Larsson / Brendan Foley

PLoS ONE, Vol 18, Iss

2023 Volume 1

Abstract: ... circumstances of the vessel’s last voyage add unique context to the assemblage. Gribshunden and an accompanying ...

Abstract	Maritime archaeological investigations of the wreck of the medieval warship Gribshunden (1495), flagship of King Hans of Denmark and Norway, have revealed diverse artifacts including exotic spices imported from far distant origins: saffron, ginger, clove, peppercorns, and almond. The special circumstances of the vessel’s last voyage add unique context to the assemblage. Gribshunden and an accompanying squadron conveyed the king, courtiers, noblemen, and soldiers from Copenhagen to a political summit in Kalmar, Sweden. At that conference, Hans expected the Swedish Council to elect him king of Sweden, and thereby fulfill his ambition to reunify the Nordic region under a single crown. To achieve this, Hans assembled in his fleet and particularly aboard his flagship the people and elite cultural signifiers that would convince the Swedish delegation to accept his rule. Along the way, the ships anchored near Ronneby, Blekinge. Written sources record that an explosion and fire caused Gribshunden to sink off Stora Ekön (Great Oak Island). Exotic spices were status markers among the aristocracy in Scandinavia and around the Baltic Sea during the Middle Ages (1050–1550 CE). Until the Gribshunden finds, these extravagances have rarely or never been represented archaeologically. Evidence of their use and consumption in medieval Scandinavia has been limited to sparse written references. We present here the botanical remains from the Gribshunden shipwreck and compare them to previous archaeobotanical finds from the medieval Baltic region. These opulent status symbols traveled with a medieval king en route to a major historical event. The combination of textual and archaeological evidence allows a novel analytical view of the social environment in which these luxurious foods were consumed.
Keywords	Medicine ; R ; Science ; Q
Subject code	930
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Didi-Huberman and art history’s amicable incursions

Chari Larsson

Journal of Art Historiography, Iss 22, Pp 22-CL

2020 Volume 1

Abstract: ... s recent text Aperçues (2018). Clearly forsaking art-historical conventions, Aperçues is composed ... of experimental forms of writing in mind, this essay will argue that Didi-Huberman s decision to write ...

Abstract	This paper takes as its departure point French philosopher and art historian Georges Didi-Huberman s recent text Aperçues (2018). Clearly forsaking art-historical conventions, Aperçues is composed completely of fragments. Dated, but not organised chronologically, Didi-Huberman is drawing on a long literary history of essayistic writing that reaches back to Michel de Montaigne. With this history of experimental forms of writing in mind, this essay will argue that Didi-Huberman s decision to write in fragmentary form signals a broader shift in art-historical writing: the turn to the 'I' or loosely demarcated autobiographical practices. This is not, however, a simplistic or uncomplicated return to the humanist subject. Instead, drawing from Roland Barthes 1971 exhumation of the author in Sade, Fourier, Loyola, the author is amicable. This essay discusses the notion of the amical author as a possible trope for experimental art writing practices, where the subject returns, albeit in a fragmented and split condition.
Keywords	didi-huberman ; walter pater ; michael ann holly ; t.j. clark ; roland barthes ; art writing ; autobiography ; Arts in general ; NX1-820 ; Anthropology ; GN1-890
Subject code	700
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Department of Art History, University of Birmingham
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Health Care Personnel’s Perspectives on Quality of Palliative Care During the COVID-19 Pandemic – A Cross-Sectional Study

Granrud MD / Grøndahl VA / Helgesen AK / Bååth C / Olsson C / Tillfors M / Melin-Johansson C / Österlind J / Larsson M / Hov R / Sandsdalen T

Journal of Multidisciplinary Healthcare, Vol Volume 16, Pp 2893-

2023 Volume 2903

Abstract: ... Olsson,3,4 Maria Tillfors,5 Christina Melin-Johansson,6 Jane Österlind,7 Maria Larsson,3 Reidun Hov,8 ...

Abstract	Marie Dahlen Granrud,1 Vigdis Abrahamsen Grøndahl,2 Ann Karin Helgesen,2 Carina Bååth,2,3 Cecilia Olsson,3,4 Maria Tillfors,5 Christina Melin-Johansson,6 Jane Österlind,7 Maria Larsson,3 Reidun Hov,8 Tuva Sandsdalen9 1Department of Social Sciences and Guidance, Faculty of Health and Social Sciences, Inland Norway University of Applied Sciences, Elverum, Norway; 2Department of Nursing, Health and Laboratory Science, Faculty of Health, Welfare and Organization, Østfold University College, Halden, Norway; 3Department of Health Sciences, Faculty of Health Science and Technology, Karlstad University, Karlstad, Sweden; 4Department of Bachelor Education in Nursing, Lovisenberg Diaconal University College, Oslo, Norway; 5Department of Social and Psychological Sciences, Faculty of Arts and Social Sciences, Karlstad University, Karlstad, Sweden; 6Department of Health Sciences, Mid Sweden University, Östersund, Sweden; 7Department of Health Care Sciences, Marie Cederschiöld University, Stockholm, Sweden; 8Centre of Development of Institutional and Home Care Services, Innland (Hedmark), Hamar Municipality, Norway; 9Department of Health and Nursing Sciences, Faculty of Health and Social Sciences, Inland Norway University of Applied Sciences, Elverum, NorwayCorrespondence: Marie Dahlen Granrud, Department of Social Sciences and Guidance, Faculty of Health and Social Sciences, Inland Norway University of Applied Sciences, Elverum, Norway, Tel +47 62 43 02 68, Email marie.granrud@inn.noPurpose: The provision of high-quality palliative care is challenging, especially during a pandemic like COVID-19. The latter entailed major consequences for health care systems and health care personnel (HCP) in both specialist and community health care services, in Norway and worldwide. The aim of this study was to explore how the HCP perceived the quality of palliative care in nursing homes, medical care units, and intensive care units during the COVID-19 pandemic.Methods: This study had a cross-sectional design. A total of 290 HCP from Norway ...
Keywords	covid-19 pandemic ; health care personnel perspective ; palliative care ; quality of care ; Medicine (General) ; R5-920
Subject code	360 ; 300
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Parents’ Perceptions of the Value of Children’s Participation in Pediatric Rehabilitation Services

Lisa Kronsell / Petra Svedberg / Jens Nygren / Ingrid Larsson

International Journal of Environmental Research and Public Health, Vol 18, Iss 10948, p

A Phenomenographic Study

2021 Volume 10948

Abstract: ... to explore parents’ perceptions of the value of children’s participation in pediatric rehabilitation services ... awareness. Parents’ perceptions of the value of children’s participation in pediatric rehabilitation ...

Abstract	Ensuring that children have opportunities to be involved in decision-making regarding their own care is associated with quality improvement in pediatric rehabilitation. The aim of the study was to explore parents’ perceptions of the value of children’s participation in pediatric rehabilitation services. Semi-structured interviews were conducted with 17 parents of children with disabilities who visited pediatric rehabilitation services. A phenomenographic analysis method was used. Three categories developed from the analysis describing how participation generated value in terms of empowerment, self-awareness, and independence. The outcome space describes a hierarchical relationship between the categories and their influence on each other. Independence achieved through participation was a core aspect and is at the highest level in the hierarchy since it includes and depends on the outcomes from both empowerment and self-awareness. Parents’ perceptions of the value of children’s participation in pediatric rehabilitation services include the possibility for the child to use their entire capacity through values created in terms of empowerment, self-awareness, and independence, in order to live the best life possible. Children with disabilities are diverse as a group, and further research to identify barriers and facilitators of participation is needed to adjust interventions within pediatric rehabilitation services to ensure that children with disabilities can be increasingly empowered, self-aware, and independent.
Keywords	child care ; disabled children ; interviews ; parents ; participation ; phenomenography ; Medicine ; R
Subject code	360
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Is ectopic Cushing’s syndrome underdiagnosed in patients with small cell lung cancer?

Marta Piasecka / Martin Larsson / Eleni Papakokkinou / Lena Olsson / Oskar Ragnarsson

Frontiers in Medicine, Vol

2022 Volume 9

Abstract: IntroductionEctopic Cushing’s syndrome (ECS) is an uncommon disorder. Recently, however, a larger ... proportion of patients with endogenous Cushing’s syndrome (CS) had ECS than has previously been reported ...

Abstract	IntroductionEctopic Cushing’s syndrome (ECS) is an uncommon disorder. Recently, however, a larger proportion of patients with endogenous Cushing’s syndrome (CS) had ECS than has previously been reported.ObjectiveThe aim of this study was to determine whether ECS is an underdiagnosed disorder in patients with small-cell lung cancer (SCLC).Materials and methodsMedical records from consecutive patients diagnosed with SCLC at our hospital between 2013 and 2019 were reviewed (N = 213; mean age 69.5 ± 9 years; range, 36–89 years). The probability of having ECS was evaluated by review of biochemical and clinical features, including presence of recent onset diabetes mellitus, therapy resistant hypertension and/or spontaneous hypokalaemia.ResultsOf 213 identified patients with SCLC, one (0.5%) patient had confirmed ECS, two (1%) patients had probable ECS, and twenty-three (11%) patients had possibly ECS. Patients with SCLC and possibly or probable ECS exhibited a significantly shorter survival than patients only with SCLC (8 vs. 14 months, respectively).ConclusionsOur findings indicate that ECS is underdiagnosed in patients with SCLC. Given the serious consequences of untreated ECS, the low detection rate highlights the need to improve endocrine work-up of patients with SCLC who present with biochemical and clinical features associated with ECS. Prospective studies are needed to establish a reliable assessment of the incidence of ECS and to optimise early detection strategies.
Keywords	ectopic ACTH-production ; hypercortisolism ; small-cell lung cancer (SCLC) ; paraneoplastic syndrome ; ectopic Cushing’s syndrome ; Medicine (General) ; R5-920
Subject code	610 ; 616
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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