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Article ; Online: Novel compact hard x-ray spectrometer with MCps counting rate capabilities for runaway electron measurements on DIII-D.

Dal Molin, A / Fumagalli, L / Nocente, M / Rigamonti, D / Tardocchi, M / Giacomelli, L / Panontin, E / Lvovskiy, A / Paz-Soldan, C / Edietis, N W / Gorini, G

The Review of scientific instruments

2021 Volume 92, Issue 4, Page(s) 43517

Abstract: ... of the gamma-ray imager diagnostic at the DIII-D tokamak. The spectrometer is based on a 1 × 1 cm ...

Abstract	A novel compact spectrometer optimized for the measurement of hard x rays generated by runaway electrons is presented. The detector is designed to be installed in the fan-shaped collimator of the gamma-ray imager diagnostic at the DIII-D tokamak. The spectrometer is based on a 1 × 1 cm
Language	English
Publishing date	2021-07-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0043762
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Article ; Online: Vitamin D Receptor Polymorphisms Associated with Autism Spectrum Disorder.

Guerini, Franca Rosa / Bolognesi, Elisabetta / Chiappedi, Matteo / Mensi, Maria Martina / Fumagalli, Oscar / Rogantini, Chiara / Zanzottera, Milena / Ghezzo, Alessandro / Zanette, Michela / Agliardi, Cristina / Costa, Andrea Saul / Sotgiu, Stefano / Carta, Alessandra / Al Daghri, Nasser / Clerici, Mario

Autism research : official journal of the International Society for Autism Research

2020 Volume 13, Issue 5, Page(s) 680–690

Abstract: Vitamin D is endowed with a number of biological properties, including down-regulation ... of inflammation, and might contribute to the pathogenesis of autism spectrum disorders (ASD). Vitamin D binds ... to the vitamin D Receptor (VDR); the biological activity of the ensuing complex depends on VDR FokI, BsmI, ApaI ...

Abstract	Vitamin D is endowed with a number of biological properties, including down-regulation of inflammation, and might contribute to the pathogenesis of autism spectrum disorders (ASD). Vitamin D binds to the vitamin D Receptor (VDR); the biological activity of the ensuing complex depends on VDR FokI, BsmI, ApaI, and TaqI gene polymorphisms. We evaluated such Single Nucletoide Polymorphismsm (SNPs) in a cohort of 100 Italian families with ASD children. FokI genotype distribution was skewed in ASD children compared with their healthy sibs (P
MeSH term(s)	Alleles ; Autism Spectrum Disorder/genetics ; Child ; Female ; Genetic Predisposition to Disease/genetics ; Genotype ; Haplotypes ; Humans ; Italy ; Male ; Polymorphism, Genetic/genetics ; Receptors, Calcitriol/genetics
Chemical Substances	Receptors, Calcitriol ; VDR protein, human
Language	English
Publishing date	2020-02-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2481338-2
ISSN	1939-3806 ; 1939-3792
ISSN (online)	1939-3806
ISSN	1939-3792
DOI	10.1002/aur.2279
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Article ; Online: Associations d’hormonothérapie et de radiothérapie pour le cancer de prostate.

Hennequin, C / Fumagalli, I / Martin, V / Quero, L

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

2017 Volume 21, Issue 6-7, Page(s) 462–468

Abstract: Combination of radiotherapy and androgen deprivation is now considered as the standard of care for patients with a localized prostate cancer but poor prognosis factors. Two groups of randomized trials have led to this recommendation: some have compared ... ...

Title translation	Combination of radiotherapy and androgen deprivation therapy for localized prostate cancer.
Abstract	Combination of radiotherapy and androgen deprivation is now considered as the standard of care for patients with a localized prostate cancer but poor prognosis factors. Two groups of randomized trials have led to this recommendation: some have compared radiotherapy alone versus hormonal treatment and radiotherapy: these trials demonstrated, now with a long follow-up, an improvement in 10-year survival for the combined treatment. Three recent trials compared androgen deprivation alone or combined with radiotherapy; a benefit in survival was also demonstrated in favour of the combination. Some questions remained concerning the optimal duration of hormonal treatment, in view of its potential side effects. Patients in the intermediate prognostic groups could receive a short-term androgen deprivation, but those with a high Gleason score must be treated with a long-term hormonal treatment. Modalities of radiotherapy, regarding volumes and dose must also be précised in the next years.
MeSH term(s)	Androgen Antagonists/therapeutic use ; Combined Modality Therapy/methods ; Gonadotropin-Releasing Hormone/agonists ; Humans ; Male ; Orchiectomy ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/therapy
Chemical Substances	Androgen Antagonists ; Gonadotropin-Releasing Hormone (33515-09-2)
Language	French
Publishing date	2017-10
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	1397169-4
ISSN	1769-6658 ; 1278-3218
ISSN (online)	1769-6658
ISSN	1278-3218
DOI	10.1016/j.canrad.2017.07.045
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Article: Synergistic Effect of Static Compliance and D-dimers to Predict Outcome of Patients with COVID-19-ARDS: A Prospective Multicenter Study.

Tonetti, Tommaso / Grasselli, Giacomo / Rucci, Paola / Alessandri, Francesco / Dell'Olio, Alessio / Boscolo, Annalisa / Pasin, Laura / Sella, Nicolò / Mega, Chiara / Melotti, Rita Maria / Girardis, Massimo / Busani, Stefano / Bellani, Giacomo / Foti, Giuseppe / Grieco, Domenico Luca / Scaravilli, Vittorio / Protti, Alessandro / Langer, Thomas / Mascia, Luciana /

Pugliese, Francesco / Cecconi, Maurizio / Fumagalli, Roberto / Nava, Stefano / Antonelli, Massimo / Slutsky, Arthur S / Navalesi, Paolo / Pesenti, Antonio / Ranieri, Vito Marco

Biomedicines

2021 Volume 9, Issue 9

Abstract: The synergic combination of D-dimer (as proxy of thrombotic/vascular injury) and static compliance ... evaluated. The objective is to determine whether the combination of elevated D-dimer and low static ... were collected in nine hospitals. D-dimer and compliance in the first 24 h were recorded. Study outcome ...

Abstract	The synergic combination of D-dimer (as proxy of thrombotic/vascular injury) and static compliance (as proxy of parenchymal injury) in predicting mortality in COVID-19-ARDS has not been systematically evaluated. The objective is to determine whether the combination of elevated D-dimer and low static compliance can predict mortality in patients with COVID-19-ARDS. A "training sample" (March-June 2020) and a "testing sample" (September 2020-January 2021) of adult patients invasively ventilated for COVID-19-ARDS were collected in nine hospitals. D-dimer and compliance in the first 24 h were recorded. Study outcome was all-cause mortality at 28-days. Cut-offs for D-dimer and compliance were identified by receiver operating characteristic curve analysis. Mutually exclusive groups were selected using classification tree analysis with chi-square automatic interaction detection. Time to death in the resulting groups was estimated with Cox regression adjusted for SOFA, sex, age, PaO
Language	English
Publishing date	2021-09-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines9091228
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Article ; Online: Incidence of ventricular arrhythmias after biventricular defibrillator replacement: impact on safety of downgrading from CRT-D to CRT-P.

Nesti, Martina / Ricciardi, Giuseppe / Pieragnoli, Paolo / Fumagalli, Stefano / Padeletti, Margherita / Perini, Alessandro P / Cavarretta, Elena / Sciarra, Luigi

Minerva cardiology and angiology

2020 Volume 70, Issue 4, Page(s) 447–454

Abstract: ... debated whether CRT alone (CRT-P) or CRT plus defibrillator (CRT-D) is preferable, and still guidelines ... are not exhaustive. The aim of the study was to investigate whether to implant CRT-P or CRT-D in CRT-D ... heart failure patients undergoing CRT-D according to guidelines, 103 (67±10 years, 80% men) underwent device ...

Abstract	Background: Cardiac resynchronization therapy (CRT) reduces mortality and hospitalizations. It is debated whether CRT alone (CRT-P) or CRT plus defibrillator (CRT-D) is preferable, and still guidelines are not exhaustive. The aim of the study was to investigate whether to implant CRT-P or CRT-D in CRT-D patients who did not experience malignant arrhythmias at the moment of replacement. Methods: Out of 451 heart failure patients undergoing CRT-D according to guidelines, 103 (67±10 years, 80% men) underwent device replacement with CRT-D. Every 6 months patients underwent to clinical evaluation and device interrogation and episodes of ventricular arrhythmias (VA) stored. At baseline and before replacement echocardiogram was performed. Patients were defined responders if left ventricular (LV) end-systolic volume decreased ≥15% and super-responders if LV ejection fraction increased ≥40% or ≥50%. Results: Mean follow-up was 75±24 months after implantation and 26±10 months after replacement. First VAs incidence per year did not decrease over time (P=0.619). Before replacement, 27 patients (26.2%, 15 responders/12 non-responders) experienced VA. After replacement, 8 patients (7.7%, 4 responders/4 non-responders) experienced VA for the first time. Super-responder condition was not associated with lower VA incidence before (0.499) and after (P=0.339) replacement. At multivariate analysis, age was the only independent predictor of electrical appropriate therapy after substitution (OR<inf>per year</inf>=1.17; 95% CI: 1.03-1.34; P=0.003). Conclusions: Freedom from VA before device replacement does not correlate with freedom from VA after replacement, so downgrade from CRT-D to CRT-P is not feasible at replacement, in particular in the elderlies, independently of responder and super-responder condition.
MeSH term(s)	Arrhythmias, Cardiac ; Cardiac Resynchronization Therapy/adverse effects ; Defibrillators, Implantable/adverse effects ; Female ; Humans ; Incidence ; Male ; Stroke Volume
Language	English
Publishing date	2020-10-15
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3059238-0
ISSN	2724-5772
ISSN (online)	2724-5772
DOI	10.23736/S2724-5683.20.05352-9
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Article ; Online: Synergistic Effect of Static Compliance and D-dimers to Predict Outcome of Patients with COVID-19-ARDS

Tommaso Tonetti / Giacomo Grasselli / Paola Rucci / Francesco Alessandri / Alessio Dell’Olio / Annalisa Boscolo / Laura Pasin / Nicolò Sella / Chiara Mega / Rita Maria Melotti / Massimo Girardis / Stefano Busani / Giacomo Bellani / Giuseppe Foti / Domenico Luca Grieco / Vittorio Scaravilli / Alessandro Protti / Thomas Langer / Luciana Mascia /

Francesco Pugliese / Maurizio Cecconi / Roberto Fumagalli / Stefano Nava / Massimo Antonelli / Arthur S. Slutsky / Paolo Navalesi / Antonio Pesenti / Vito Marco Ranieri

Biomedicines, Vol 9, Iss 1228, p

A Prospective Multicenter Study

2021 Volume 1228

Abstract	The synergic combination of D-dimer (as proxy of thrombotic/vascular injury) and static compliance (as proxy of parenchymal injury) in predicting mortality in COVID-19-ARDS has not been systematically evaluated. The objective is to determine whether the combination of elevated D-dimer and low static compliance can predict mortality in patients with COVID-19-ARDS. A “training sample” (March–June 2020) and a “testing sample” (September 2020–January 2021) of adult patients invasively ventilated for COVID-19-ARDS were collected in nine hospitals. D-dimer and compliance in the first 24 h were recorded. Study outcome was all-cause mortality at 28-days. Cut-offs for D-dimer and compliance were identified by receiver operating characteristic curve analysis. Mutually exclusive groups were selected using classification tree analysis with chi-square automatic interaction detection. Time to death in the resulting groups was estimated with Cox regression adjusted for SOFA, sex, age, PaO 2 /FiO 2 ratio, and sample (training/testing). “Training” and “testing” samples amounted to 347 and 296 patients, respectively. Three groups were identified: D-dimer ≤ 1880 ng/mL (LD); D-dimer > 1880 ng/mL and compliance > 41 mL/cmH 2 O (LD-HC); D-dimer > 1880 ng/mL and compliance ≤ 41 mL/cmH 2 O (HD-LC). 28-days mortality progressively increased in the three groups (from 24% to 35% and 57% (training) and from 27% to 39% and 60% (testing), respectively; p < 0.01). Adjusted mortality was significantly higher in HD-LC group compared with LD (HR = 0.479, p < 0.001) and HD-HC (HR = 0.542, p < 0.01); no difference was found between LD and HD-HC. In conclusion, combination of high D-dimer and low static compliance identifies a clinical phenotype with high mortality in COVID-19-ARDS.
Keywords	acute respiratory distress syndrome ; COVID-19 ; D-dimer ; static compliance ; mechanical ventilation ; Biology (General) ; QH301-705.5
Subject code	310
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Proteomic analysis in clear cell renal cell carcinoma: identification of differentially expressed protein by 2-D DIGE.

Raimondo, Francesca / Salemi, Claudia / Chinello, Clizia / Fumagalli, Daniela / Morosi, Lavinia / Rocco, Francesco / Ferrero, Stefano / Perego, Roberto / Bianchi, Cristina / Sarto, Cecilia / Pitto, Marina / Brambilla, Paolo / Magni, Fulvio

Molecular bioSystems

2012 Volume 8, Issue 4, Page(s) 1040–1051

Abstract: ... difference gel electrophoresis (2-D DIGE) technology in combination with mass spectrometry (MS) was applied ... for these proteins. In conclusion, we suggest that applying 2-D DIGE to RCC may provide the basis for a better ...

Abstract	Renal cell carcinoma (RCC), the most common neoplasm affecting the adult kidney, is characterised by heterogeneity of histological subtypes, drug resistance, and absence of molecular markers. Two-dimensional difference gel electrophoresis (2-D DIGE) technology in combination with mass spectrometry (MS) was applied to detect differentially expressed proteins in 20 pairs of RCC tissues and matched adjacent normal kidney cortex (ANK), in order to search for RCC markers. After gel analysis by DeCyder 6.5 and EDA software, differentially expressed protein spots were excised from Deep Purple stained preparative 2DE gel. A total of 100 proteins were identified by MS out of 2500 spots, 23 and 77 of these were, respectively, over- and down-expressed in RCC. The Principal Component Analysis applied to gels and protein spots exactly separated the two sample classes in two groups: RCC and ANK. Moreover, some spots, including ANXA2, PPIA, FABP7 and LEG1, resulted highly differential. The DIGE data were also confirmed by immunoblotting analysis for these proteins. In conclusion, we suggest that applying 2-D DIGE to RCC may provide the basis for a better molecular characterization and for the discovery of candidate biomarkers.
MeSH term(s)	Aged ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/metabolism ; Computational Biology ; Electrophoresis, Gel, Two-Dimensional/methods ; Female ; Gene Expression Regulation, Developmental ; Humans ; Kidney ; Male ; Mass Spectrometry ; Middle Aged ; Neoplasm Proteins/analysis ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Proteomics/methods ; Reproducibility of Results ; Two-Dimensional Difference Gel Electrophoresis/methods
Chemical Substances	Biomarkers, Tumor ; Neoplasm Proteins
Language	English
Publishing date	2012-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2188635-0
ISSN	1742-2051 ; 1742-206X
ISSN (online)	1742-2051
ISSN	1742-206X
DOI	10.1039/c2mb05390j
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Article ; Online: Increased [³H]D-aspartate release and changes in glutamate receptor expression in the hippocampus of the mnd mouse.

Bigini, Paolo / Milanese, Marco / Gardoni, Fabrizio / Longhi, Annalisa / Bonifacino, Tiziana / Barbera, Sara / Fumagalli, Elena / Di Luca, Monica / Mennini, Tiziana / Bonanno, Giambattista

Journal of neuroscience research

2012 Volume 90, Issue 6, Page(s) 1148–1158

Abstract: ... overflow of [³H]D-aspartate was found in mnd mice compared with controls. This increase was maintained ... mediated release and supporting the involvement of exocytotic [³H]D-aspartate release. Accordingly, Ca²⁺ ...

Abstract	Neuronal ceroid lipofuscinoses (NCLs) are a group of hereditary childhood diseases characterized mainly by lipopigment accumulation and a multisystemic pattern of symptoms including mental retardation, seizures, motor impairment, and blindness. The mnd mouse, carrying a mutation in the Cln8 gene, has been proposed as a model of epilepsy with mental retardation (EPMR, ornorthern epilepsy). We recently showed neuronal hyperexcitability and seizure hypersusceptibility in mnd mice. To elucidate the cellular mechanisms related to hippocampal hyperexcitability, the glutamatergic transmission and the expression of postsynaptic glutamate receptors were investigated in hippocampus. A significant increase in either spontaneous or KCl-stimulated overflow of [³H]D-aspartate was found in mnd mice compared with controls. This increase was maintained after DL-threo-β-benzyloxyaspartic acid (TBOA) treatment, suggesting a nonrelevant role for transporter-mediated release and supporting the involvement of exocytotic [³H]D-aspartate release. Accordingly, Ca²⁺-dependent overflow induced by ionomycin was also increased in mnd mice. Levels of glutamate 1-3 AMPA receptor subunits were increased, and levels of the NR2A NMDA receptor subunit were decreased in the hippocampus of mnd mice, suggesting an adaptive response to glutamate overstimulation.
MeSH term(s)	Analysis of Variance ; Animals ; Aspartic Acid/pharmacology ; Astrocytes/drug effects ; Astrocytes/metabolism ; Calcium Ionophores/pharmacology ; D-Aspartic Acid/metabolism ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/genetics ; Glial Fibrillary Acidic Protein/metabolism ; Hippocampus/cytology ; Hippocampus/drug effects ; Hippocampus/metabolism ; Ionomycin/pharmacology ; Male ; Membrane Proteins/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Potassium Chloride/pharmacology ; Receptors, Glutamate/classification ; Receptors, Glutamate/genetics ; Receptors, Glutamate/metabolism ; Synaptosomes/metabolism ; Tritium/metabolism
Chemical Substances	Calcium Ionophores ; Cln8 protein, mouse ; Glial Fibrillary Acidic Protein ; Membrane Proteins ; Receptors, Glutamate ; benzyloxyaspartate ; Tritium (10028-17-8) ; Aspartic Acid (30KYC7MIAI) ; D-Aspartic Acid (4SR0Q8YD1X) ; Ionomycin (56092-81-0) ; Potassium Chloride (660YQ98I10)
Language	English
Publishing date	2012-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	195324-2
ISSN	1097-4547 ; 0360-4012
ISSN (online)	1097-4547
ISSN	0360-4012
DOI	10.1002/jnr.22831
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Article ; Online: Genetic variability in the ACE gene region surrounding the Alu I/D polymorphism is maintained by balancing selection in human populations.

Cagliani, Rachele / Fumagalli, Matteo / Riva, Stefania / Pozzoli, Uberto / Comi, Giacomo P / Bresolin, Nereo / Sironi, Manuela

Pharmacogenetics and genomics

2010 Volume 20, Issue 2, Page(s) 131–134

Abstract: ... insertion/deletion (Alu I/D) polymorphism or any linked variant has been maintained by natural selection ... in human populations.: Methods: We resequenced a gene region surrounding the Alu I/D polymorphism ... region surrounding the Alu I/D.: Conclusion: Our data imply the presence of a functional polymorphism ...

Abstract	Objective: Angiotensin-converting enzyme plays a critical role in the maintenance of cardiovascular homeostasis. Extensive research has aimed at identifying ACE genetic variants responsible for variation in enzyme plasma concentrations and associated with human diseases. These efforts have been hampered by the extensive linkage disequilibrium across the gene and the identity or location of the functional polymorphism(s) is at presently unknown. The aim of our study was to verify whether the Alu insertion/deletion (Alu I/D) polymorphism or any linked variant has been maintained by natural selection in human populations. Methods: We resequenced a gene region surrounding the Alu I/D polymorphism in four human populations; we applied population neutrality tests and performed haplotype analysis for this region. Results: We observed high levels of nucleotide diversity, an excess of intermediate frequency alleles and, at least in African populations, a higher level of within-species diversity compared with interspecific divergence. Analysis of haplotype genealogy indicated the presence of two major clades separated by deep branches with a coalescence time older than 1.5 million years. All these features strongly suggest the action of balancing selection and we verified that the selection signature is restricted to the gene region surrounding the Alu I/D. Conclusion: Our data imply the presence of a functional polymorphism in the Alu I/D region and illustrate the contribution of evolutionary models to classic single nucleotide polymorphism-phenotype association approaches by providing information about the localization of candidate functional variants.
MeSH term(s)	Alu Elements/genetics ; Genetic Variation ; Genetics, Population ; Haplotypes/genetics ; Humans ; INDEL Mutation/genetics ; Peptidyl-Dipeptidase A/genetics ; Polymorphism, Genetic ; Selection, Genetic ; Time Factors
Chemical Substances	Peptidyl-Dipeptidase A (EC 3.4.15.1)
Language	English
Publishing date	2010-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175826-8
ISSN	1744-6880 ; 0960-314X ; 1744-6872
ISSN (online)	1744-6880
ISSN	0960-314X ; 1744-6872
DOI	10.1097/FPC.0b013e3283333532
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Article ; Online: Release of [3H]D-aspartate induced by K+-stimulation is increased in the cervical spinal cord of the wobbler mouse: a model of motor neuron disease.

Bonanno, Giambattista / Fumagalli, Elena / Milanese, Marco / Zappettini, Simona / Mennini, Tiziana

Neurochemistry international

2009 Volume 55, Issue 5, Page(s) 302–306

Abstract: The Ca2+-dependent exocytotic release of [3H]D-aspartate and [3H]GABA evoked by 15 mM KCl ... release of [3H]D-aspartate was significantly increased in synaptosomes of the cervical region in wobbler ... present both at 4 and 12 weeks. On the contrary, the KCl-induced release of [3H]D-aspartate ...

Abstract	The Ca2+-dependent exocytotic release of [3H]D-aspartate and [3H]GABA evoked by 15 mM KCl depolarization was studied in wobbler mice, an animal model of selective motor neuron degeneration in the cervical tract of the spinal cord. Neurotransmitters release was studied in superfusion using synaptosomes purified from the cervical or lumbar tract of the spinal cord. The early symptomatic stage (4 weeks) and the late symptomatic stage (12 weeks) of the disease were considered. Results showed that the KCl-induced release of [3H]D-aspartate was significantly increased in synaptosomes of the cervical region in wobbler mice with respect to healthy control mice, while the basal outflow was unchanged; this alteration was present both at 4 and 12 weeks. On the contrary, the KCl-induced release of [3H]D-aspartate from the lumbar spinal cord did not differ in wobbler and control mice. The KCl-induced release of [3H]GABA from cervical and lumbar spinal cord synaptosomes was unmodified at 4 weeks of age while it was moderately but significantly reduced in wobbler mice at 12 weeks, selectively in the cervical spinal cord. No changes in K(m) and V(max) for [3H]L-glutamate uptake were found in spinal cord synaptosomes from wobbler mice, compared to controls, both at 4 and 12 weeks of age. Taken together our data indicate the presence of an increased glutamate release in the affected region of spinal cord in wobbler mice, suggesting a possible involvement of altered glutamate homeostasis already in early stages of the wobbler disease, in the absence of appreciable changes in the uptake process.
MeSH term(s)	Animals ; Aspartic Acid/metabolism ; Cervical Vertebrae/drug effects ; Cervical Vertebrae/metabolism ; Disease Models, Animal ; Mice ; Motor Neuron Disease/metabolism ; Potassium/pharmacology ; Spinal Cord/drug effects ; Spinal Cord/metabolism ; Tritium ; gamma-Aminobutyric Acid/metabolism
Chemical Substances	Tritium (10028-17-8) ; Aspartic Acid (30KYC7MIAI) ; gamma-Aminobutyric Acid (56-12-2) ; Potassium (RWP5GA015D)
Language	English
Publishing date	2009-09
Publishing country	England
Document type	Journal Article
ZDB-ID	283190-9
ISSN	1872-9754 ; 0197-0186
ISSN (online)	1872-9754
ISSN	0197-0186
DOI	10.1016/j.neuint.2009.03.013
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