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Article ; Online: A Single Monoclonal Antibody against the Peanut Allergen Ara h 2 Protects against Systemic and Local Peanut Allergy.

Storni, Federico / Cabral-Miranda, Gustavo / Roesti, Elisa / Zha, Lisha / Engeroff, Paul / Zeltins, Andris / Cragg, Mark / Vogel, Monique / Bachmann, Martin F

International archives of allergy and immunology

2020 Volume 181, Issue 5, Page(s) 334–341

Abstract: ... Methods: The monoclonal anti-Ara h 2 antibody (mAb) was produced by hybridoma cells derived from WT BALB ... c mice after immunization with a vaccine based on virus-like particles coupled to Ara h 2. BALB/c ... Results: Here we show in peanut-allergic mice that a single high-affinity mAb specific for Ara h 2 is ...

Abstract	Background: Peanut allergy is the most prevalent and dangerous food allergy. Peanuts consist of a large number of different allergens and peanut-allergic patients are frequently sensitized to multiple allergens. Hence, conventional desensitization approaches aim at targeting as many allergens as possible. Methods: The monoclonal anti-Ara h 2 antibody (mAb) was produced by hybridoma cells derived from WT BALB/c mice after immunization with a vaccine based on virus-like particles coupled to Ara h 2. BALB/c mice were sensitized intraperitoneally with peanut extract absorbed to alum and mAbs were applied i.v. Challenge was performed the next day with the whole peanut extract intravenously and via skin prick test. Results: Here we show in peanut-allergic mice that a single high-affinity mAb specific for Ara h 2 is able to block systemic and local allergic reactions induced by the complex peanut extract. We confirm in vitro binding of the mAb to the inhibitory low-affinity FcγRIIb receptor using a sensitive biosensor and demonstrate in vivo that protection was dependent on FcγRIIb. Conclusion: A single mAb specific for Ara h 2 is able to improve local and systemic allergic symptoms induced by the whole allergen mixture.
MeSH term(s)	2S Albumins, Plant/immunology ; Animals ; Antibodies, Monoclonal/immunology ; Antibody Affinity ; Antigens, Plant/immunology ; Female ; Immunization ; Mice ; Mice, Inbred BALB C ; Peanut Hypersensitivity/immunology
Chemical Substances	2S Albumins, Plant ; Antibodies, Monoclonal ; Antigens, Plant ; Ara h 2 allergen, Arachis hypogaea
Language	English
Publishing date	2020-03-10
Publishing country	Switzerland
Document type	News
ZDB-ID	1108932-5
ISSN	1423-0097 ; 1018-2438
ISSN (online)	1423-0097
ISSN	1018-2438
DOI	10.1159/000505917
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Article ; Online: Special Issue in Honor of Professors John W. Blunt and Murray H. G. Munro.

Copp, Brent R / Cragg, Gordon M / Newman, David J / Pearce, Cedric J

Journal of natural products

2016 Volume 79, Issue 3, Page(s) 453–454

MeSH term(s)	Biological Products ; Humans ; Molecular Structure
Chemical Substances	Biological Products
Language	English
Publishing date	2016-03-25
Publishing country	United States
Document type	Editorial
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.6b00079
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Zs.A 1144: Show issues

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Article ; Online: Agonist Antibodies for Cancer Immunotherapy: History, Hopes, and Challenges.

Lim, Sean H / Beers, Stephen A / Al-Shamkhani, Aymen / Cragg, Mark S

Clinical cancer research : an official journal of the American Association for Cancer Research

2023 Volume 30, Issue 9, Page(s) 1712–1723

Abstract: Immunotherapy is among the most promising new treatment modalities to arise over the last two decades; antibody drugs are delivering immunotherapy to millions of patients with many different types of cancer. Initial success with antibody therapeutics ... ...

Abstract	Immunotherapy is among the most promising new treatment modalities to arise over the last two decades; antibody drugs are delivering immunotherapy to millions of patients with many different types of cancer. Initial success with antibody therapeutics came in the form of direct targeting or cytotoxic antibodies, such as rituximab and trastuzumab, which bind directly to tumor cells to elicit their destruction. These were followed by immunomodulatory antibodies that elicit antitumor responses by either stimulating immune cells or relieving tumor-mediated suppression. By far the most successful approach in the clinic to date has been relieving immune suppression, with immune checkpoint blockade now a standard approach in the treatment of many cancer types. Despite equivalent and sometimes even more impressive effects in preclinical models, agonist antibodies designed to stimulate the immune system have lagged behind in their clinical translation. In this review, we document the main receptors that have been targeted by agonist antibodies, consider the various approaches that have been evaluated to date, detail what we have learned, and consider how their anticancer potential can be unlocked.
MeSH term(s)	Humans ; Neoplasms/immunology ; Neoplasms/drug therapy ; Neoplasms/therapy ; Immunotherapy/methods ; Animals ; Antineoplastic Agents, Immunological/therapeutic use ; Antineoplastic Agents, Immunological/pharmacology
Chemical Substances	Antineoplastic Agents, Immunological
Language	English
Publishing date	2023-12-27
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
DOI	10.1158/1078-0432.CCR-23-1014
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Zs.A 4223: Show issues

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Article: Constitutive histamine H₂ receptor activity regulates serotonin release in the substantia nigra

Threlfell, Sarah / Exley, Richard / Cragg, Stephanie J / Greenfield, Susan A

Journal of neurochemistry. 2008 Nov., v. 107, no. 3

2008

Abstract: ... H₃ receptor. Here we have explored regulation by another HA receptor expressed in SNr, the H₂ ... than or equal to] 20 Hz), and prevailed in the presence of antagonists of GABA, glutamate or H₃-HA ...

Abstract	The substantia nigra pars reticulata (SNr) forms a principal output from the basal ganglia. It also receives significant histamine (HA) input from the tuberomammillary nucleus whose functions in SNr remain poorly understood. One identified role is the regulation of serotonin (5-HT) neurotransmission via the HA-H₃ receptor. Here we have explored regulation by another HA receptor expressed in SNr, the H₂-receptor (H₂R), by monitoring electrically evoked 5-HT release with fast-scan cyclic voltammetry at carbon-fiber microelectrodes in SNr in rat brain slices. Selective H₂R antagonists (inverse agonists) ranitidine and tiotidine enhanced 5-HT release while the agonist amthamine suppressed release. The 'neutral' competitive antagonist burimamide alone was without effect but prevented ranitidine actions indicating that inverse agonist effects result from constitutive H₂R activity independent of HA tone. H₂R control of 5-HT release was most apparent (from inverse agonist effects) at lower frequencies of depolarization ([less-than or equal to] 20 Hz), and prevailed in the presence of antagonists of GABA, glutamate or H₃-HA receptors. These data reveal that H₂Rs in SNr are constitutively active and inhibit 5-HT release through H₂Rs on 5-HT axons. These data may have therapeutic implications for Parkinson's disease, when SNr HA levels increase, and for neuropsychiatric disorders in which 5-HT is pivotal.
Keywords	serotonin ; histamine ; Parkinson disease
Language	English
Dates of publication	2008-11
Size	p. 745-755.
Publisher	Blackwell Publishing Ltd
Publishing place	Oxford, UK
Document type	Article
ZDB-ID	80158-6
ISSN	1471-4159 ; 0022-3042 ; 1474-1644
ISSN (online)	1471-4159
ISSN	0022-3042 ; 1474-1644
DOI	10.1111/j.1471-4159.2008.05646.x
Database	NAL-Catalogue (AGRICOLA)

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Ui II Zs.170: Show issues

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Article ; Online: Lights, fiber, action! A primer on in vivo fiber photometry.

Simpson, Eleanor H / Akam, Thomas / Patriarchi, Tommaso / Blanco-Pozo, Marta / Burgeno, Lauren M / Mohebi, Ali / Cragg, Stephanie J / Walton, Mark E

Neuron

2023 Volume 112, Issue 5, Page(s) 718–739

Abstract: Fiber photometry is a key technique for characterizing brain-behavior relationships in vivo. Initially, it was primarily used to report calcium dynamics as a proxy for neural activity via genetically encoded indicators. This generated new insights into ... ...

Abstract	Fiber photometry is a key technique for characterizing brain-behavior relationships in vivo. Initially, it was primarily used to report calcium dynamics as a proxy for neural activity via genetically encoded indicators. This generated new insights into brain functions including movement, memory, and motivation at the level of defined circuits and cell types. Recently, the opportunity for discovery with fiber photometry has exploded with the development of an extensive range of fluorescent sensors for biomolecules including neuromodulators and peptides that were previously inaccessible in vivo. This critical advance, combined with the new availability of affordable "plug-and-play" recording systems, has made monitoring molecules with high spatiotemporal precision during behavior highly accessible. However, while opening exciting new avenues for research, the rapid expansion in fiber photometry applications has occurred without coordination or consensus on best practices. Here, we provide a comprehensive guide to help end-users execute, analyze, and suitably interpret fiber photometry studies.
MeSH term(s)	Neurons/metabolism ; Brain/metabolism ; Photometry/methods ; Calcium/metabolism
Chemical Substances	Calcium (SY7Q814VUP)
Language	English
Publishing date	2023-12-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2023.11.016
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Zs.A 2496: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 92: Show issues

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Article: Genes for the 'H' subunit of human ferritin are present on a number of human chromosomes.

Cragg, S J / Drysdale, J / Worwood, M

Human genetics

1985 Volume 71, Issue 2, Page(s) 108–112

Abstract: ... and hybridised to a probe for the H subunit of human ferritin, pDBR2. Sequences highly homologous ...

Abstract	DNA has been extracted from hamster-human and mouse-human hybrid cell lines, restricted with EcoRI, and hybridised to a probe for the H subunit of human ferritin, pDBR2. Sequences highly homologous to this probe have been found on at least eight human chromosomes: 1, 2, 3, 6p21----6cen, 11, 14, 20, and Xq23-25----Xqter. Only the gene on chromosome 11 appears to be expressed in these hybrids.
MeSH term(s)	Animals ; Cell Line ; Chromosome Mapping ; Cricetinae ; DNA/genetics ; Electrophoresis, Agar Gel ; Ferritins/genetics ; Genetic Markers ; Humans ; Hybrid Cells ; Macromolecular Substances ; Mice ; Nucleic Acid Hybridization
Chemical Substances	Genetic Markers ; Macromolecular Substances ; DNA (9007-49-2) ; Ferritins (9007-73-2)
Language	English
Publishing date	1985
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	223009-4
ISSN	1432-1203 ; 0340-6717
ISSN (online)	1432-1203
ISSN	0340-6717
DOI	10.1007/bf00283363
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Zs.A 256: Show issues

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Article: Methanogen activity and microbial diversity in Gulf of Cádiz mud volcano sediments.

Webster, Gordon / Cragg, Barry A / Rinna, Joachim / Watkins, Andrew J / Sass, Henrik / Weightman, Andrew J / Parkes, R John

Frontiers in microbiology

2023 Volume 14, Page(s) 1157337

Abstract: The Gulf of Cádiz is a tectonically active continental margin with over sixty mud volcanoes (MV) documented, some associated with active methane ( ... ...

Abstract	The Gulf of Cádiz is a tectonically active continental margin with over sixty mud volcanoes (MV) documented, some associated with active methane (CH
Language	English
Publishing date	2023-05-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1157337
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Article: HLA class I and H ferritin gene polymorphisms in normal subjects and patients with haemochromatosis.

Cragg, S J / Darke, C / Worwood, M

Human genetics

1988 Volume 80, Issue 1, Page(s) 63–68

Abstract: ... of the HLA-A locus. In this region there are many HLA class I genes, and there may also be a gene for the 'H' ... subunit of ferritin. Both HLA class I and H ferritin genes are therefore candidates for the abnormal gene ... from patients and normal subjects with a panel of 12 restriction enzymes and a probe for the H ferritin gene ...

Abstract	The gene for idiopathic haemochromatosis is located on the short arm of chromosome 6 within 1 cM of the HLA-A locus. In this region there are many HLA class I genes, and there may also be a gene for the 'H' subunit of ferritin. Both HLA class I and H ferritin genes are therefore candidates for the abnormal gene in idiopathic haemochromatosis. In 15 unrelated patients the frequency of HLA-A3 was 80% compared with 24% for 600 unrelated individuals from South Wales. The most common haplotype involved is probably HLA-A3, B7. DNA was prepared from leucocytes from 12 of these patients and from 85 normal subjects. After digestion with Taq1, electrophoresis, and Southern blotting, class I sequences were detected by hybridisation to an HLA class I probe (pHLA-A). Of the 34 restriction fragments detected, 22 were polymorphic. Particular fragments correlated with the presence of HLA-A antigens A1, 2, 3, 10, 11, w19, and 28, but there was little correlation with B antigens. Restriction fragment patterns specific for haemochromatosis were not found with TaqI or during less extensive studies with other restriction enzymes. No differences in restriction fragment patterns were found between four patients and four normal subjects apparently homozygous for HLA-A3 and B7. Examination of Southern blotting patterns for genomic DNA from patients and normal subjects with a panel of 12 restriction enzymes and a probe for the H ferritin gene (pDBR-2) revealed no polymorphisms associated with either idiopathic haemochromatosis or particular HLA phenotypes. These studies provide no support for either HLA class I genes or the H ferritin gene as candidates for the haemochromatosis gene.
MeSH term(s)	DNA Restriction Enzymes ; Ferritins/genetics ; Genes ; Genes, MHC Class I ; HLA Antigens/analysis ; Hemochromatosis/genetics ; Hemochromatosis/immunology ; Humans ; Polymorphism, Genetic ; Reference Values
Chemical Substances	HLA Antigens ; Ferritins (9007-73-2) ; DNA Restriction Enzymes (EC 3.1.21.-)
Language	English
Publishing date	1988-09
Publishing country	Germany
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	223009-4
ISSN	1432-1203 ; 0340-6717
ISSN (online)	1432-1203
ISSN	0340-6717
DOI	10.1007/bf00451458
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Article ; Online: Reducing affinity as a strategy to boost immunomodulatory antibody agonism.

Yu, Xiaojie / Orr, Christian M / Chan, H T Claude / James, Sonya / Penfold, Christine A / Kim, Jinny / Inzhelevskaya, Tatyana / Mockridge, C Ian / Cox, Kerry L / Essex, Jonathan W / Tews, Ivo / Glennie, Martin J / Cragg, Mark S

Nature

2023 Volume 614, Issue 7948, Page(s) 539–547

Abstract: Antibody responses during infection and vaccination typically undergo affinity maturation to achieve high-affinity binding for efficient neutralization of ... ...

Abstract	Antibody responses during infection and vaccination typically undergo affinity maturation to achieve high-affinity binding for efficient neutralization of pathogens
MeSH term(s)	Humans ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/pharmacology ; Antibody Affinity ; CD40 Antigens/drug effects ; CD40 Antigens/immunology ; Immunomodulation/drug effects ; Immunomodulation/immunology ; Nivolumab/immunology ; Nivolumab/pharmacology
Chemical Substances	Antibodies, Monoclonal ; CD40 Antigens ; TNFRSF9 protein, human ; PDCD1 protein, human ; Nivolumab (31YO63LBSN)
Language	English
Publishing date	2023-02-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-022-05673-2
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

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Article ; Online: A molecular chemodosimeter to probe "closed shell" ions in kidney cells.

Assel, Amine / Stanley, Meagan M / Mia, Rashid / Boulila, Besma / Cragg, Peter J / Owolabie, Iyanuoluwani / Hetrick, Meredith / Flynt, Alex / Wallace, Karl J / Ben Jannet, Hichem

Organic & biomolecular chemistry

2023 Volume 21, Issue 47, Page(s) 9379–9391

Abstract: Two quinidine-functionalized coumarin molecular probes have been synthesized and have been found to bind metal cations ( ... ...

Abstract	Two quinidine-functionalized coumarin molecular probes have been synthesized and have been found to bind metal cations (Cd
MeSH term(s)	Humans ; HEK293 Cells ; Metals ; Mercury ; Ions ; Cations ; HeLa Cells ; Fluorescent Dyes
Chemical Substances	Metals ; Mercury (FXS1BY2PGL) ; Ions ; Cations ; Fluorescent Dyes
Language	English
Publishing date	2023-12-06
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d3ob01408h
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