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  1. Book ; Online ; E-Book: Cerebrovascular and endovascular neurosurgery

    Gandhi, Chirag D. / Prestigiacomo, Charles J.

    complication avoidance and management

    2018  

    Author's details Chirag D. Gandhi, Charles J. Prestigiacomo editors
    Keywords Neurosurgery ; Radiology, Medical ; Vascular Surgery
    Subject code 617.48
    Language English
    Size 1 Online-Ressource (xxi, 483 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019806415
    ISBN 978-3-319-65206-1 ; 9783319652047 ; 3-319-65206-0 ; 3319652044
    DOI 10.1007/978-3-319-65206-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Surgical endovascular neuroradiology

    Prestigiacomo, Charles / Duffis, E. Jesus / Gandhi, Chirag D.

    theory and clinical practice

    2015  

    Abstract: Few medical fields have enjoyed the explosive growth and continued maturation as the subspecialty of endovascular surgical neuroradiology. In pouring through the literature on all things associated with neurointerventional, I recognized the need to ... ...

    Title variant Endovascular surgical neuroradiology
    Author's details Charles J. Prestigiacomo ; E. Jesus Duffis ; Chirag D. Gandhi
    Abstract "Few medical fields have enjoyed the explosive growth and continued maturation as the subspecialty of endovascular surgical neuroradiology. In pouring through the literature on all things associated with neurointerventional, I recognized the need to develop a resource that brought focus to the many devices and the techniques and procedures we do. This book does just that: It brings to sharp focus the most current, and up-to-date methods of an ever-changing specialty. It brings this information to you, through the lens of experts in their respective fields by focusing all their research into the textbook that sits before you. The "Clinical Practice" portion of this textbook integrates and translates this theory into a working paradigm that brings benefit to our patients. By focusing on technique and emphasizing complication avoidance and in those unfortunate times when the complication occurs, complication management, your patient benefits"--Provided by publisher
    Keywords Cerebrovascular Disorders / surgery ; Endovascular Procedures / methods ; Radiography, Interventional / methods
    Language English
    Size XXIV, 722 S. : Ill., graph. Darst.
    Publisher Thieme
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT018528402
    ISBN 978-1-60406-057-7 ; 9781604067781 ; 1-60406-057-3 ; 1604067780
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2015 A 468 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Cerebrospinal fluid drainage in non-traumatic subarachnoid hemorrhage: which way out?

    Vazquez, Sima / Subah, Galadu / Dorilio, Jessica / Nolan, Bridget / Dominguez, Jose / Gandhi, Chirag D / Al-Mufti, Fawaz

    Journal of neurointerventional surgery

    2024  

    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Letter
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/jnis-2023-021319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Letter: Early Experience Using Omniscient Neurotechnology Fiber Tracking Software for Resection of Intra-Axial Brain Tumors.

    Dicpinigaitis, Alis J / Feldstein, Eric / Gandhi, Chirag D / Hanft, Simon

    Operative neurosurgery (Hagerstown, Md.)

    2022  Volume 22, Issue 6, Page(s) e306–e308

    MeSH term(s) Brain Neoplasms/pathology ; Brain Neoplasms/surgery ; Diffusion Tensor Imaging ; Humans ; Software
    Language English
    Publishing date 2022-04-14
    Publishing country United States
    Document type Letter
    ZDB-ID 2767575-0
    ISSN 2332-4260 ; 2332-4252
    ISSN (online) 2332-4260
    ISSN 2332-4252
    DOI 10.1227/ons.0000000000000239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Use of femoral compression device for neck compression in carotid blowout as a temporizing measure to achieve coil sacrifice.

    Kaur, Gurmeen / Stein, Alan / Gandhi, Chirag D

    Journal of neurointerventional surgery

    2020  Volume 12, Issue 9, Page(s) 921–922

    Language English
    Publishing date 2020-06-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/neurintsurg-2020-016119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Discrete Mechanistic Target of Rapamycin Signaling Pathways, Stem Cells, and Therapeutic Targets.

    Jhanwar-Uniyal, Meena / Zeller, Sabrina L / Spirollari, Eris / Das, Mohan / Hanft, Simon J / Gandhi, Chirag D

    Cells

    2024  Volume 13, Issue 5

    Abstract: The mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that functions via its discrete binding partners to form two multiprotein complexes, mTOR complex 1 and 2 (mTORC1 and mTORC2). Rapamycin-sensitive mTORC1, which regulates protein ... ...

    Abstract The mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that functions via its discrete binding partners to form two multiprotein complexes, mTOR complex 1 and 2 (mTORC1 and mTORC2). Rapamycin-sensitive mTORC1, which regulates protein synthesis and cell growth, is tightly controlled by PI3K/Akt and is nutrient-/growth factor-sensitive. In the brain, mTORC1 is also sensitive to neurotransmitter signaling. mTORC2, which is modulated by growth factor signaling, is associated with ribosomes and is insensitive to rapamycin. mTOR regulates stem cell and cancer stem cell characteristics. Aberrant Akt/mTOR activation is involved in multistep tumorigenesis in a variety of cancers, thereby suggesting that the inhibition of mTOR may have therapeutic potential. Rapamycin and its analogues, known as rapalogues, suppress mTOR activity through an allosteric mechanism that only suppresses mTORC1, albeit incompletely. ATP-catalytic binding site inhibitors are designed to inhibit both complexes. This review describes the regulation of mTOR and the targeting of its complexes in the treatment of cancers, such as glioblastoma, and their stem cells.
    MeSH term(s) Humans ; Glioblastoma/metabolism ; Intercellular Signaling Peptides and Proteins/therapeutic use ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Sirolimus/pharmacology ; TOR Serine-Threonine Kinases/metabolism ; Neoplastic Stem Cells/metabolism
    Chemical Substances Intercellular Signaling Peptides and Proteins ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; Mechanistic Target of Rapamycin Complex 2 (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Sirolimus (W36ZG6FT64) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2024-02-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13050409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Treatment trends and clinical outcomes of endovascular embolization for unruptured intracranial aneurysms in the pediatric population.

    Dicpinigaitis, Alis J / Syed, Shoaib A / Sillari, Catherine / Fifi, Johanna T / Pisapia, Jared / Nuoman, Rolla / Gandhi, Chirag D / Al-Mufti, Fawaz

    Journal of neurointerventional surgery

    2024  

    Abstract: Background: Owing to the relative rarity of unruptured intracranial aneurysms (UIAs) in the pediatric population, evidence regarding treatment modalities and clinical outcomes remains limited.: Objective: To characterize the use and clinical outcomes ...

    Abstract Background: Owing to the relative rarity of unruptured intracranial aneurysms (UIAs) in the pediatric population, evidence regarding treatment modalities and clinical outcomes remains limited.
    Objective: To characterize the use and clinical outcomes of endovascular therapy (EVT) and microsurgical clipping (MSC) for pediatric UIAs over a two-decade interval using a large national registry.
    Methods: Pediatric (<18 years of age) UIA hospitalizations were identified in the National Inpatient Sample from 2002 to 2019. Temporal use and clinical outcomes were compared for treatment with EVT and MSC.
    Results: Among 734 UIAs identified, 64.9% (n=476) were treated with EVT. Use of EVT significantly increased during the study period from 54.3% (2002-2004) to 78.6% (2017-2019) (P=0.002 by Cochrane-Armitage test). In comparison with those treated with MSC, pediatric patients treated with EVT demonstrated higher rates of favorable outcomes (discharge to home without services) (96.0% vs 91.1%, P=0.006), shorter durations of hospital stay (4.6 vs 10.0 days, P<0.001), and lower rates of ischemic or hemorrhagic procedural-related complications (1% vs 4%, P=0.010). Conservative management also increased significantly over the study period (P<0.001 by Cochrane-Armitage test).
    Conclusion: A retrospective evaluation of nearly 20 years of population-level data from the United States demonstrates increasing use of EVT for the treatment of pediatric UIAs, with high rates of favorable outcomes and shorter hospital stays in comparison with those treated with microsurgery.
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/jnis-2024-021648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6845: Show issues Location:
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  8. Article ; Online: Endovascular thrombectomy for treatment of isolated posterior cerebral artery occlusion: a real-world analysis of hospitalizations in the United States.

    Dicpinigaitis, Alis J / Syed, Shoaib A / Al-Mufti, Jude / Medicherla, Chaitanya / Kaur, Gurmeen / Gandhi, Chirag D / Al-Mufti, Fawaz

    Acta neurochirurgica

    2024  Volume 166, Issue 1, Page(s) 191

    Abstract: ... adjustment, EVT was associated with favorable outcome in IPCA patients presenting with mild deficits (M-D ... in those presenting with moderate-to-severe deficits (M-S-D) (NIHSS 6-42) (aOR 2.00, 95% CI 1.86, 2.15; p < 0.001 ... Mortality rates did not differ among those with M-S-D [EVT 4.8% vs. MM 4.7%, p = 0.742], while ICH rates ...

    Abstract Background: Despite renewed interest and recently demonstrated efficacy for endovascular thrombectomy (EVT) for treatment of acute ischemic stroke (AIS) of the posterior circulation, to date, no randomized clinical trials have been conducted to evaluate EVT for isolated occlusions of the posterior cerebral artery (IPCA).
    Methods: Hospitalizations for adult patients with primary admission diagnoses of IPCA occlusion were identified in the National Inpatient Sample registry during the period of 2016-2020. The study exposure was treatment with EVT, and primary clinical endpoints included favorable functional outcome (defined as discharge disposition to home without services, previously shown to have high concordance with modified Rankin scale scores 0-2), in-hospital mortality, and any intracranial hemorrhage (ICH). Inverse probability of treatment weighting (IPTW) was performed to balance baseline clinical characteristics between those receiving EVT or medical management (MM).
    Results: This analysis identified 34,880 IPCA occlusion hospitalizations, 730 (2.1%) of which documented treatment with EVT. Following IPTW adjustment, EVT was associated with favorable outcome in IPCA patients presenting with mild deficits (M-D) (NIHSS < 6) [adjusted odds ratio (aOR) 2.36, 95% confidence interval (CI) 2.27, 2.45; p < 0.001] and in those presenting with moderate-to-severe deficits (M-S-D) (NIHSS 6-42) (aOR 2.00, 95% CI 1.86, 2.15; p < 0.001). Mortality rates did not differ among those with M-S-D [EVT 4.8% vs. MM 4.7%, p = 0.742], while ICH rates were lower.
    Conclusion: Retrospective analysis of a large administrative registry in the Unites States demonstrates an association of EVT with favorable outcomes following IPCA occlusion, without concomitant risk of hemorrhagic transformation or mortality.
    MeSH term(s) Humans ; Male ; Female ; Aged ; United States ; Endovascular Procedures/methods ; Middle Aged ; Thrombectomy/methods ; Hospitalization/statistics & numerical data ; Treatment Outcome ; Hospital Mortality ; Ischemic Stroke/surgery ; Aged, 80 and over ; Retrospective Studies ; Registries/statistics & numerical data
    Language English
    Publishing date 2024-04-24
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-024-06050-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Evolving Advance Care Planning in a Health Ecosystem: The Kaiser Permanente Experience.

    Ngo, Jason / Le, John / Gandhi, Chirag H / Mariano, Jeffrey D / Viveros, Lori A / Wang, Susan E

    Journal of pain and symptom management

    2023  Volume 66, Issue 2, Page(s) e245–e253

    Abstract: Background: Advance care planning is an integral part of supporting patients through serious illness and end-of-life care.: Problem: Several components of advance care planning may be too inflexible to account for patients' changing disease and ... ...

    Abstract Background: Advance care planning is an integral part of supporting patients through serious illness and end-of-life care.
    Problem: Several components of advance care planning may be too inflexible to account for patients' changing disease and evolving goals as serious illness progresses. Health systems are starting to implement processes to address these barriers, though implementation has varied.
    Proposed solution: In 2017, Kaiser Permanente introduced Life Care Planning (LCP), incorporating advance care planning dynamically into concurrent disease management. LCP provides a framework for identifying surrogates, documenting goals, and eliciting patient values across disease progression. LCP provides standardized training to facilitate communication and utilizes a centralized section within the electronic health record for longitudinal documentation of goals.
    Outcomes: More than 6000 physicians, nurses, and social workers have been trained in LCP. Over one million patients have engaged in LCP since its inception, with over 52% of patients age 55+ having a surrogate designated. There is evidence of high treatment concordance with patients' desired wishes (88.9%), with high rates of advance directive completion as well (84.1%).
    MeSH term(s) Humans ; Middle Aged ; Ecosystem ; Advance Care Planning ; Terminal Care ; Advance Directives ; Electronic Health Records
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639142-4
    ISSN 1873-6513 ; 0885-3924
    ISSN (online) 1873-6513
    ISSN 0885-3924
    DOI 10.1016/j.jpainsymman.2023.03.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Time-to-treatment with endovascular thrombectomy in patients with large core ischemic stroke: the 'late window paradox'.

    Al-Mufti, Fawaz / Elfil, Mohamed / Ghaith, Hazem S / Ghozy, Sherief / Elmashad, Ahmed / Jadhav, Ashutosh P / Gandhi, Chirag D / Mayer, Stephan

    Journal of neurointerventional surgery

    2023  Volume 15, Issue 8, Page(s) 733–734

    MeSH term(s) Humans ; Ischemic Stroke/diagnostic imaging ; Ischemic Stroke/surgery ; Time-to-Treatment ; Thrombectomy ; Stroke/surgery ; Endovascular Procedures ; Brain Ischemia/diagnostic imaging ; Brain Ischemia/surgery ; Treatment Outcome
    Language English
    Publishing date 2023-05-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/jnis-2023-020493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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