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  1. Article ; Online: Cefiderocol: A Siderophore Cephalosporin.

    El-Lababidi, Rania M / Rizk, John George

    The Annals of pharmacotherapy

    2020  Volume 54, Issue 12, Page(s) 1215–1231

    Abstract: Objective: This article reviews the available data on the chemistry, spectrum of activity, pharmacokinetic and pharmacodynamic properties, clinical efficacy, and potential place in therapy of cefiderocol.: Data sources: A literature search through ... ...

    Abstract Objective: This article reviews the available data on the chemistry, spectrum of activity, pharmacokinetic and pharmacodynamic properties, clinical efficacy, and potential place in therapy of cefiderocol.
    Data sources: A literature search through PubMed, Google Scholar, and ClinicalTrials.gov was conducted (2009 to March 2020) using the search terms
    Study selection and data extraction: All relevant published articles, package inserts, and unpublished meeting abstracts on cefiderocol were reviewed.
    Data synthesis: Cefiderocol is the first siderophore antibiotic to be approved by the FDA. It was shown to be active against a wide range of resistant Gram-negative pathogens, including multidrug-resistant (MDR)
    Relevance to patient care and clinical practice: The approval of cefiderocol provides a new option in the treatment of cUTIs and potentially treatment of nosocomial pneumonia caused by resistant Gram-negative pathogens. Given the higher mortality observed with cefiderocol, its use in the treatment of CR Gram-negative infections should be carefully considered.
    Conclusion: Cefiderocol shows promising activity against MDR Gram-negative pathogens. Its use in the treatment of serious infections caused by CR Gram-negative bacteria needs further evaluation in phase III clinical studies.
    MeSH term(s) Adult ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Cephalosporins/chemistry ; Cephalosporins/pharmacology ; Cephalosporins/therapeutic use ; Drug Resistance, Multiple, Bacterial/drug effects ; Gram-Negative Bacteria/drug effects ; Gram-Negative Bacterial Infections/drug therapy ; Gram-Negative Bacterial Infections/microbiology ; Humans ; Microbial Sensitivity Tests ; Molecular Structure ; Siderophores/chemistry ; Siderophores/pharmacology ; Siderophores/therapeutic use ; Urinary Tract Infections/drug therapy ; Urinary Tract Infections/microbiology ; Cefiderocol
    Chemical Substances Anti-Bacterial Agents ; Cephalosporins ; Siderophores
    Language English
    Publishing date 2020-06-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1101370-9
    ISSN 1542-6270 ; 1060-0280
    ISSN (online) 1542-6270
    ISSN 1060-0280
    DOI 10.1177/1060028020929988
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 900: Show issues Location:
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  2. Article: Treatment of severe pneumonia due to COVID-19 with peginterferon alfa 2a.

    El-Lababidi, Rania M / Mooty, Mohamad / Bonilla, Maria-Fernanda / Salem, Nouran M

    IDCases

    2020  Volume 21, Page(s) e00837

    Abstract: The outbreak of the new coronavirus disease 2019 (COVID-19) has spread rapidly worldwide. Until now, no definite effective treatment has been identified. We reported 3 patients with severe COVID-19 treated with pegylated interferon alfa 2a with ... ...

    Abstract The outbreak of the new coronavirus disease 2019 (COVID-19) has spread rapidly worldwide. Until now, no definite effective treatment has been identified. We reported 3 patients with severe COVID-19 treated with pegylated interferon alfa 2a with satisfactory recovery. Based on these observations, randomized studies with interferons should be considered in deteriorating patients infected with COVID-19.
    Keywords covid19
    Language English
    Publishing date 2020-05-22
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2020.e00837
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  3. Article: A case of acute disseminated encephalomyelitis following

    Laila, Alla / El-Lababidi, Rania M / Hisham, Mohamed / Mooty, Mohammad

    IDCases

    2018  Volume 12, Page(s) 41–43

    Abstract: We report a case of acute disseminated encephalomyelitis (ADEM) secondary ... ...

    Abstract We report a case of acute disseminated encephalomyelitis (ADEM) secondary to
    Keywords covid19
    Language English
    Publishing date 2018-03-12
    Publishing country Netherlands
    Document type Journal Article ; Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2018.03.003
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  4. Article: Clinical Outcomes of Trimethoprim/Sulfamethoxazole in Critically Ill Patients with

    El Nekidy, Wasim S / Al Zaman, Khaled / Abidi, Emna / Alrahmany, Diaa / Ghazi, Islam M / El Lababidi, Rania / Mooty, Mohamad / Hijazi, Fadi / Ghosn, Muriel / Askalany, Mohamed / Helal, Mohamed / Taha, Ahmed / Ismail, Khaled / Mallat, Jihad

    Journal of clinical medicine

    2024  Volume 13, Issue 8

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-04-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13082275
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  5. Article ; Online: Treatment of severe pneumonia due to COVID-19 with peginterferon alfa 2a

    Rania M. El-Lababidi / Mohamad Mooty / Maria-Fernanda Bonilla / Nouran M. Salem

    IDCases, Vol 21, Iss , Pp e00837- (2020)

    2020  

    Abstract: The outbreak of the new coronavirus disease 2019 (COVID-19) has spread rapidly worldwide. Until now, no definite effective treatment has been identified. We reported 3 patients with severe COVID-19 treated with pegylated interferon alfa 2a with ... ...

    Abstract The outbreak of the new coronavirus disease 2019 (COVID-19) has spread rapidly worldwide. Until now, no definite effective treatment has been identified. We reported 3 patients with severe COVID-19 treated with pegylated interferon alfa 2a with satisfactory recovery. Based on these observations, randomized studies with interferons should be considered in deteriorating patients infected with COVID-19.
    Keywords Coronavirus disease 2019 ; Pegylated interferon alfa 2a ; Interferons ; SARS-CoV-2 ; Infectious and parasitic diseases ; RC109-216 ; covid19
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Treatment of severe pneumonia due to COVID-19 with peginterferon alfa 2a

    El-Lababidi, Rania M. / Mooty, Mohamad / Bonilla, Maria-Fernanda / Salem, Nouran M.

    IDCases

    2020  Volume 21, Page(s) e00837

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2020.e00837
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Engaging Pharmacy Students, Residents, and Fellows in Antimicrobial Stewardship.

    Chahine, Elias B / El-Lababidi, Rania M / Sourial, Mariette

    Journal of pharmacy practice

    2015  Volume 28, Issue 6, Page(s) 585–591

    Abstract: Antimicrobial stewardship programs are mainly established by infectious diseases physicians and infectious diseases-trained clinical pharmacists with the goal of optimizing patients' outcomes while halting antimicrobial resistance, decreasing adverse ... ...

    Abstract Antimicrobial stewardship programs are mainly established by infectious diseases physicians and infectious diseases-trained clinical pharmacists with the goal of optimizing patients' outcomes while halting antimicrobial resistance, decreasing adverse events, and controlling health care cost. The role of the infectious diseases-trained clinical pharmacist in antimicrobial stewardship is well established; however, there are not enough formally trained pharmacists to assume the challenging responsibilities of the steward coordinator. The purpose of this article was to review the available literature and resources and propose a model to engage introductory pharmacy practice experience students, advanced pharmacy practice experience students, postgraduate year (PGY) 1 pharmacy residents, PGY2 infectious diseases pharmacy residents, and PGY2 or PGY3 infectious diseases pharmacy fellows in antimicrobial stewardship. Further studies are needed to assess and document the impact of pharmacy students and postgraduate trainees on antimicrobial stewardship programs.
    MeSH term(s) Anti-Infective Agents/therapeutic use ; Communicable Diseases/drug therapy ; Education, Pharmacy/methods ; Humans ; Pharmacy Residencies ; Pharmacy Service, Hospital ; Students, Pharmacy
    Chemical Substances Anti-Infective Agents
    Language English
    Publishing date 2015-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1027474-1
    ISSN 1531-1937 ; 0897-1900
    ISSN (online) 1531-1937
    ISSN 0897-1900
    DOI 10.1177/0897190013516506
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2893: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Clinical outcomes of ceftolozane-tazobactam dosing in patients with sepsis undergoing renal replacement therapies.

    El Nekidy, Wasim S / Al Ali, Mooza / Abidi, Emna / Ghazi, Islam M / Attallah, Nizar / El Lababidi, Rania / Hijazi, Fadi / Mallat, Jihad

    Clinical nephrology

    2023  Volume 100, Issue 3, Page(s) 126–131

    Abstract: Ceftolozane-tazobactam (C/T) recommended dosing in patients undergoing renal replacement therapies (RRT) is lacking evidence. The objective of this study was to evaluate the clinical outcomes of C/T dosing in patients on RRT.: Materials and methods: A ...

    Abstract Ceftolozane-tazobactam (C/T) recommended dosing in patients undergoing renal replacement therapies (RRT) is lacking evidence. The objective of this study was to evaluate the clinical outcomes of C/T dosing in patients on RRT.
    Materials and methods: A retrospective descriptive study conducted at our institution between May 1, 2017, and March 15, 2022. The primary endpoint was to determine the clinical cure for patients who received C/T for documented infection while on RRT. The secondary endpoints were the microbiologic cure, 30-day infection recurrence, and 30-day crude mortality.
    Results: Of the 27 patients who met the inclusion criteria, 17 (63%) were males, median age was 69 (62 - 82) years, and weight 67 (57 - 79) kg. The majority of patients had pneumonia 19 (70.4%) followed by bacteremia 5 (18.5%). Multidrug resistant
    Conclusion: The used doses of C/T in this study were higher than those approved by the U.S. FDA, while clinical success is uncertain. Larger outcomes and pharmacokinetics studies are needed to establish effective dosing and therapy duration.
    MeSH term(s) Male ; Humans ; Aged ; Female ; Anti-Bacterial Agents/therapeutic use ; Retrospective Studies ; Tazobactam/pharmacokinetics ; Tazobactam/therapeutic use ; Bacteremia/drug therapy ; Continuous Renal Replacement Therapy
    Chemical Substances ceftolozane (37A4IES95Q) ; Anti-Bacterial Agents ; ceftolozane, tazobactam drug combination ; Tazobactam (SE10G96M8W)
    Language English
    Publishing date 2023-07-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185101-9
    ISSN 0301-0430
    ISSN 0301-0430
    DOI 10.5414/CN111166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 873: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Treatment of severe pneumonia due to COVID-19 with peginterferon alfa 2a

    El-Lababidi, Rania M. / Mooty, Mohamad / Bonilla, Maria-Fernanda / Salem, Nouran M.

    IDCases

    Abstract: The outbreak of the new coronavirus disease 2019 (COVID-19) has spread rapidly worldwide. Until now, no definite effective treatment has been identified. We reported 3 patients with severe COVID-19 treated with pegylated interferon alfa 2a with ... ...

    Abstract The outbreak of the new coronavirus disease 2019 (COVID-19) has spread rapidly worldwide. Until now, no definite effective treatment has been identified. We reported 3 patients with severe COVID-19 treated with pegylated interferon alfa 2a with satisfactory recovery. Based on these observations, randomized studies with interferons should be considered in deteriorating patients infected with COVID-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #327230
    Database COVID19

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  10. Article ; Online: Pulmonary cavitation: an under-recognized late complication of severe COVID-19 lung disease.

    Zoumot, Zaid / Bonilla, Maria-Fernanda / Wahla, Ali S / Shafiq, Irfan / Uzbeck, Mateen / El-Lababidi, Rania M / Hamed, Fadi / Abuzakouk, Mohamed / ElKaissi, Mahmoud

    BMC pulmonary medicine

    2021  Volume 21, Issue 1, Page(s) 24

    Abstract: Background: Pulmonary radiological findings of the novel coronavirus disease 2019 (COVID-19) have been well documented and range from scattered ground-glass infiltrates in milder cases to confluent ground-glass change, dense consolidation, and crazy ... ...

    Abstract Background: Pulmonary radiological findings of the novel coronavirus disease 2019 (COVID-19) have been well documented and range from scattered ground-glass infiltrates in milder cases to confluent ground-glass change, dense consolidation, and crazy paving in the critically ill. However, lung cavitation has not been commonly described in these patients. The objective of this study was to assess the incidence of pulmonary cavitation in patients with COVID-19 and describe its characteristics and evolution.
    Methods: We conducted a retrospective review of all patients admitted to our institution with COVID-19 and reviewed electronic medical records and imaging to identify patients who developed pulmonary cavitation.
    Results: Twelve out of 689 (1.7%) patients admitted to our institution with COVID-19 developed pulmonary cavitation, comprising 3.3% (n = 12/359) of patients who developed COVID-19 pneumonia, and 11% (n = 12/110) of those admitted to the intensive care unit. We describe the imaging characteristics of the cavitation and present the clinical, pharmacological, laboratory, and microbiological parameters for these patients. In this cohort six patients have died, and six discharged home.
    Conclusion: Cavitary lung disease in patients with severe COVID-19 disease is not uncommon, and is associated with a high level of morbidity and mortality.
    MeSH term(s) Adult ; Aged ; COVID-19/complications ; Humans ; Incidence ; Lung Diseases/diagnostic imaging ; Lung Diseases/pathology ; Lung Diseases/virology ; Male ; Middle Aged ; Retrospective Studies ; Severity of Illness Index ; Time Factors ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-020-01379-1
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