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Article ; Online: Macular Edema of Choroidal Origin.

Soubrane, Gisèle

2017 Volume 58, Page(s) 202–219

Abstract: Macular edema is most often clinically defined as an accumulation of serous fluid within the neurosensory retina with increased thickness of the central retina. In exudative age-related macular degeneration the leakage of fluid from the choroidal new ... ...

Abstract	Macular edema is most often clinically defined as an accumulation of serous fluid within the neurosensory retina with increased thickness of the central retina. In exudative age-related macular degeneration the leakage of fluid from the choroidal new vessels may be the origin of macular edema. Their abnormal permeability and the inflammatory reaction are mechanisms involved in this accumulation of fluid, which occurs in all layers. Cystoid macular edema is more often associated with subepithelial occult choroidal neovascularization (CNV) than it is with pre-epithelial classic CNV. The simultaneous presence of choroidal new vessels and ME implies a number of cellular dysfunctions especially of Müller cells and subsequently metabolic alterations. The leakage from the choroidal new vessels, predominantly vascular endothelial growth factor (VEGF)-induced, may produce a large accumulation of fluid under the neurosensory retina. It is also likely that the key signaling steps occur prior to the upregulation of VEGF either initiated by, or facilitated by, cytokines, which act under normal basic conditions to counterbalance the integral VEGF effects and, in pathologic circumstances, may either counteract or serve to amplify the process.
MeSH term(s)	Choroid/pathology ; Choroidal Neovascularization/complications ; Choroidal Neovascularization/diagnosis ; Fluorescein Angiography ; Fundus Oculi ; Humans ; Macular Edema/diagnosis ; Macular Edema/etiology ; Retina/pathology
Language	English
Publishing date	2017
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	1662-2790 ; 0250-3751
ISSN (online)	1662-2790
ISSN	0250-3751
DOI	10.1159/000455282
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Article ; Online: Un ophtalmologiste s'en est allé, emportant son rire. . .

Soubrane, G

Journal francais d'ophtalmologie

2013 Volume 36, Issue 5, Page(s) 391–392

Title translation	An ophthalmologist is gone with his laughter.
MeSH term(s)	Baltimore ; Chorioretinitis/diagnosis ; Chorioretinitis/history ; Hawaii ; History, 20th Century ; History, 21st Century ; Humans ; Laughter ; Los Angeles ; Ophthalmology/history ; Workforce
Language	French
Publishing date	2013-07-08
Publishing country	France
Document type	Biography ; Historical Article ; Journal Article ; Portrait
ZDB-ID	426662-6
ISSN	1773-0597 ; 0181-5512
ISSN (online)	1773-0597
ISSN	0181-5512
DOI	10.1016/j.jfo.2013.05.001
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Book: Macular edema

Coscas, Gabriel / Bandello, Francesco / Loewenstein, Anat / Vaz, J. G. da Cunha / Soubrane, Gisèle

(Developments in ophthalmology ; vol. 58)

2017

Author's details	volume editor Gabriel Coscas ; co-editors Anat Loewenstein, José Cunha-Vaz, Gisèle Soubrane
Series title	Developments in ophthalmology ; vol. 58
Collection
Keywords	Ophthalmology ; Makulaödem
Subject	Maculaödem
Language	English
Size	XI, 244 Seiten, 127 Illustrationen, Diagramme
Edition	2nd, Revised and extended edition
Publisher	Karger
Publishing place	Basel
Publishing country	Switzerland
Document type	Book
HBZ-ID	HT019336998
ISBN	978-3-318-06032-4 ; 3-318-06032-1 ; 9783318060331 ; 331806033X
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2017 A 842	available for loan (reading room)	Lesesaal EG

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Article ; Online: Macular edema of choroidal origin.

Soubrane, Gisèle

Developments in ophthalmology

2010 Volume 47, Page(s) 168–182

Abstract: Macular edema (ME) is most often clinically defined as an accumulation of serous fluid within the neurosensory retina with increased thickness of the central retina. In exudative age-related macular degeneration the leakage of fluid from the choroidal ... ...

Abstract	Macular edema (ME) is most often clinically defined as an accumulation of serous fluid within the neurosensory retina with increased thickness of the central retina. In exudative age-related macular degeneration the leakage of fluid from the choroidal new vessels may be the origin of ME. Their abnormal permeability and the inflammatory reaction are mechanisms involved in this accumulation of fluid, which occurs in all layers. Cystoid ME is more often associated with subepithelial occult choroidal neovascularization (CNV) than it is with pre-epithelial classic CNV. The simultaneous presence of choroidal new vessels and ME implies a number of cellular dysfunctions and metabolic alternations. The leakage from the choroidal new vessels, predominantly VEGF-induced, may produce a large accumulation of fluid under the neurosensory retina. It is also likely that the key signalling steps occur prior to the upregulation of VEGF either initiated by, or facilitated by, cytokines, which act under normal basic conditions to counterbalance the integral VEGF effects and, in pathologic circumstances, may either counteract or serve to amplify the process.
MeSH term(s)	Choroid/pathology ; Choroidal Neovascularization/complications ; Choroidal Neovascularization/diagnosis ; Diagnosis, Differential ; Fluorescein Angiography ; Fundus Oculi ; Humans ; Macula Lutea/pathology ; Macular Edema/diagnosis ; Macular Edema/etiology
Language	English
Publishing date	2010-08-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	1662-2790 ; 0250-3751
ISSN (online)	1662-2790
ISSN	0250-3751
DOI	10.1159/000320080
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Article ; Online: Perceptions of surgical difficulty in liver transplantation: A European survey and development of the Pitié-Salpêtrière classification.

Lim, Chetana / Turco, Célia / Goumard, Claire / Jeune, Florence / Perdigao, Fabiano / Savier, Eric / Rousseau, Géraldine / Soubrane, Olivier / Scatton, Olivier

Surgery

2023 Volume 174, Issue 4, Page(s) 979–993

Abstract: Background: Significant variations exist regarding the definition of difficult liver transplantation. The study goals were to investigate how liver transplant surgeons evaluate the surgical difficulty of liver transplantation and to use the identified ... ...

Abstract	Background: Significant variations exist regarding the definition of difficult liver transplantation. The study goals were to investigate how liver transplant surgeons evaluate the surgical difficulty of liver transplantation and to use the identified factors to classify liver transplantation difficulty. Methods: A Web-based online European survey was presented to liver transplant surgeons. The survey was divided into 3 parts: (1) participant demographics and practices; (2) various situations based on recipient, liver disease, tumor treatment, and technical factors; and (3) 8 real-life clinical vignettes with different levels of complexity. In part 3 of the survey, respondents were asked whether they would perform liver transplantation but were not aware that these patients eventually underwent liver transplantation. Results: A total of 143 invites were sent out, and 97 (67.8%) participants completed the survey. Most participants considered previous spontaneous bacterial peritonitis, previous supra-mesocolic surgery, hypertrophy of segment I, and obesity to be recipient factors for high-difficulty liver transplantation. Most participants considered liver transplantation to be challenging in patients with Budd-Chiari syndrome, Kasai surgery, polycystic liver disease, diffuse portal vein thrombosis, and a history of open hepatectomy. The proportion of participants indicating that liver transplantation was warranted varied across the 8 cases, from 69% to 100%. Our classification of the surgical difficulty of liver transplantation employed these recipient-related, surgical history-related, and liver disease-related variables and 3 difficulty groups were identified: low, intermediate, and high difficulty groups. Conclusion: This survey provides an overview of the surgical difficulty of various situations in liver transplantation that could be useful for further benchmark and textbook outcome studies.
MeSH term(s)	Humans ; Liver Transplantation ; Budd-Chiari Syndrome/surgery ; Venous Thrombosis/surgery ; Hypertrophy ; Surveys and Questionnaires
Language	English
Publishing date	2023-08-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	202467-6
ISSN	1532-7361 ; 0039-6060
ISSN (online)	1532-7361
ISSN	0039-6060
DOI	10.1016/j.surg.2023.06.041
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Article ; Online: Staged Double Hepatectomy, Double Total Vascular Exclusion, and Double Venous Reconstruction by Peritoneal Patches in One Patient with Colorectal Liver Metastases.

Dokmak, Safi / Aussilhou, Béatrice / Levenson, Guillaume / Guarneri, Giovanni / Soubrane, Olivier

Annals of surgical oncology

2020 Volume 28, Issue 4, Page(s) 2028–2029

Abstract: Background: Surgical resection is the best treatment for colorectal liver metastases with good response to chemotherapy and in the absence of extrahepatic disease.1 With the amelioration of surgical technique, primary and recurrent colorectal liver ... ...

Abstract	Background: Surgical resection is the best treatment for colorectal liver metastases with good response to chemotherapy and in the absence of extrahepatic disease.1 With the amelioration of surgical technique, primary and recurrent colorectal liver metastases with venous invasion can be resected safely under short total vascular exclusion (TVE), and associated right thoracotomy can have a major benefit if resection at the hepato-caval junction is planned.2 The availability of the peritoneum as an autologous graft for venous reconstruction considerably facilitates the task of the surgeon.3 In this video, we present a patient who had staged double liver resection, double TVE, and double venous reconstruction by a peritoneal graft on the vena cava and the hepatic vein. Methods: In March 2017, a 47-year-old female was diagnosed with rectal cancer and synchronous liver metastases, microsatellite stability, and Kras mutation. The patient received folinic acid, fluorouracil, and oxaliplatin (FOLFOX) chemotherapy, with good response and a decrease in tumor markers. After chemotherapy, a computed tomography (CT) scan showed one lesion located on the right liver with lateral invasion of the vena cava, and another lesion located in segment I. A liver-first strategy was decided and, in October 2017, the patient had a right hepatectomy extended to segment I and partially on the diaphragm, with lateral resection of the vena cava under isolated clampage of the vena cava and reconstruction with a peritoneal graft (60 mm). The patient received FOLFOX adjuvant chemotherapy for 3 months, and, while under radiotherapy for the rectal cancer, recurrence was diagnosed on the left liver lobe (two lesions), with lateral invasion of the left hepatic vein. Chemotherapy was shifted to folinic acid, fluorouracil, and irinotecan (FOLFIRI)-Avastin, with good response, allowing resection of the primary (T3N0M1), followed by adjuvant chemotherapy. In May 2019, the patient underwent two large resections on the left liver, including one under TVE, with opening of the diaphragm and intrathoracic control of the vena cava. The left hepatic vein was reconstructed laterally with a peritoneal graft (30 mm). Results: Postoperative outcome was uneventful and the two hospital stays were 12 and 15 days, respectively. For the first hepatectomy, pathological examination showed two lesions (80 and 50 mm) with a residual tumor at 10% and R0 resection, and, for the second resection, pathological examination showed two lesions (18 and 20 mm) with residual tumor at 40-60% and R0 resection. In both cases, the tumor was in contact with the resected vein without wall infiltration. The reconstructed vena cava and hepatic vein were patent without stenosis. The patient is disease-free 3 years after the diagnosis. Conclusion: Improvements in surgical technique combined with short TVE and associated thoracotomy allow some complicated liver resections to be performed safely. The use of the peritoneum for venous reconstruction is of great benefit in relation to safety and availability, especially in 'redo' liver surgery where intense adhesions can be encountered.
MeSH term(s)	Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/surgery ; Female ; Hepatectomy ; Hepatic Veins/diagnostic imaging ; Hepatic Veins/surgery ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/surgery ; Middle Aged ; Peritoneum ; Vena Cava, Inferior
Language	English
Publishing date	2020-09-23
Publishing country	United States
Document type	Case Reports ; Journal Article ; Video-Audio Media
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-020-09155-5
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Article ; Online: Micro-implant d'acétonide de fluocinolone (ILUVIEN(®)) pour l'œdème maculaire diabétique chronique.

Soubrane, G / Behar-Cohen, F

Journal francais d'ophtalmologie

2015 Volume 38, Issue 2, Page(s) 159–167

Abstract: Diabetic macular edema (DME) is a frequent complication of diabetic retinopathy and may cause severe visual loss. In this article, we examine the pathophysiology of DME and review various treatment options, such as laser photocoagulation, anti-vascular ... ...

Title translation	Fluocinolone acetonide (ILUVIEN®) micro-implant for chronic diabetic macular edema.
Abstract	Diabetic macular edema (DME) is a frequent complication of diabetic retinopathy and may cause severe visual loss. In this article, we examine the pathophysiology of DME and review various treatment options, such as laser photocoagulation, anti-vascular endothelial growth factor (VEGF) receptor antibodies, and steroids including ILUVIEN(®), which is a new sustained-release, non biodegradable, injectable, intravitreal micro-implant containing fluocinolone acetonide. The results of the FAME (Fluocinolone Acetonide in Diabetic Macular Edema) studies, conducted to evaluate the efficacy and safety of ILUVIEN(®) in DME, are discussed.
MeSH term(s)	Chronic Disease ; Diabetic Retinopathy/complications ; Diabetic Retinopathy/drug therapy ; Drug Implants ; Fluocinolone Acetonide/administration & dosage ; Humans ; Intravitreal Injections ; Macular Edema/drug therapy ; Macular Edema/etiology
Chemical Substances	Drug Implants ; Fluocinolone Acetonide (0CD5FD6S2M)
Language	French
Publishing date	2015-02
Publishing country	France
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	426662-6
ISSN	1773-0597 ; 0181-5512
ISSN (online)	1773-0597
ISSN	0181-5512
DOI	10.1016/j.jfo.2014.09.007
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Article: Choroidal neovascularization in pathologic myopia: recent developments in diagnosis and treatment.

Soubrane, Gisèle

Survey of ophthalmology

2008 Volume 53, Issue 2, Page(s) 121–138

Abstract: Choroidal neovascularization is a common cause of vision loss in patients with pathologic myopia, often resulting in irreversible central vision loss. This is particularly important because choroidal neovascularization secondary to pathologic myopia ... ...

Abstract	Choroidal neovascularization is a common cause of vision loss in patients with pathologic myopia, often resulting in irreversible central vision loss. This is particularly important because choroidal neovascularization secondary to pathologic myopia affects many people of working age. Patients may be limited in the types of tasks they can perform effectively or may even have to give up work; thus, in addition to the emotional strain, the vision loss caused by choroidal neovascularization can have a severe impact on career expectations and financial status. This is an important issue for younger patients who may be supporting themselves and their families. In this article, the epidemiology and risk factors of pathologic myopia are reviewed, as well as the pathologic mechanisms, clinical features, and diagnostic tests for choroidal neovascularization secondary to pathologic myopia. The focus of the article is on treatment options, which until recently were limited. The evidence for the beneficial effects of laser photocoagulation, photodynamic therapy with verteporfin, surgery, and other techniques in the treatment of choroidal neovascularization secondary to pathologic myopia will be evaluated.
MeSH term(s)	Choroidal Neovascularization/diagnosis ; Choroidal Neovascularization/etiology ; Choroidal Neovascularization/therapy ; Diagnostic Techniques, Ophthalmological/trends ; Humans ; Myopia, Degenerative/complications ; Myopia, Degenerative/diagnosis ; Myopia, Degenerative/therapy ; Risk Factors
Language	English
Publishing date	2008-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	391346-6
ISSN	1879-3304 ; 0039-6257
ISSN (online)	1879-3304
ISSN	0039-6257
DOI	10.1016/j.survophthal.2007.12.004
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Article ; Online: Oncological Outcome After Laparoscopic 'No-touch' RAMPS

Mazzotta, Alessandro D / VAN Bodegraven, Eduard A / Petrucciani, Niccolo / Usai, Sofia / Carneiro, Adriano Costa / Tribillon, Ecoline / Ferraz, Jean Marc / Busch, Olivier R / Gayet, Brice / Besselink, Marc G / Soubrane, Olivier

Anticancer research

2023 Volume 43, Issue 11, Page(s) 4983–4991

Abstract: Background/aim: The validity of laparoscopic distal pancreatectomy in left-sided pancreatic adenocarcinoma (PDAC) is still unclear. However, a meticulous surgical dissection through a "no-touch" technique might allow a radical oncological resection with ...

Abstract	Background/aim: The validity of laparoscopic distal pancreatectomy in left-sided pancreatic adenocarcinoma (PDAC) is still unclear. However, a meticulous surgical dissection through a "no-touch" technique might allow a radical oncological resection with minimal risk of tumor dissemination and seeding. This study aimed to evaluate the oncological outcomes of the laparoscopic "no touch" technique versus the "touch" technique. Patients and methods: From 2001 to 2020, we retrospectively analyzed 45 patients undergoing laparoscopic distal pancreatectomy (LDP) for PDAC in two centers. Factors associated with overall (OS), disease-free survival (DFS) and time to recurrence (TTR) were identified. Results: The OS rates in the 'no-touch' and 'touch' groups were 95% vs. 78% (1-year OS); 50% vs. 50% (3-year OS), respectively (p=0.60). The DFS rates in the 'no-touch' and 'touch' groups were 72 % vs. 57% (1-year DFS); 32% vs. 28% (3-year DFS), respectively (p=0.11). The TTR rates in the 'no-touch' and 'touch' groups were 77% vs. 61% (1-year TTR); 54% vs. 30% (3-year TTR); 46% vs. 11% (5-year TTR); respectively (p=0.02) In multivariate analysis the only factors were Touch technique [odds ratio (OR)=2.62, p=0.02] and lymphovascular emboli (OR=4.8; p=0.002). Conclusion: We advise the 'no-touch' technique in patients with resectable PDAC in the pancreatic body and tail. Although this study does not provide definitive proof of superiority, no apparent downsides are present for the 'no-touch' technique in this setting although there could be oncological benefits.
MeSH term(s)	Humans ; Pancreatectomy ; Adenocarcinoma/surgery ; Pancreatic Neoplasms/surgery ; Retrospective Studies ; Laparoscopy ; Pancreatic Neoplasms
Language	English
Publishing date	2023-12-13
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.16697
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Article ; Online: Upfront multi-bipolar radiofrequency ablation for HCC in transplant-eligible cirrhotic patients with salvage transplantation in case of recurrence.

Boros, Carina / Sutter, Olivier / Cauchy, François / Ganne-Carrié, Nathalie / Nahon, Pierre / N'kontchou, Gisele / Ziol, Marianne / Grando, Véronique / Demory, Alix / Blaise, Lorraine / Dondero, Fédérica / Durand, François / Soubrane, Olivier / Lesurtel, Mickael / Laurent, Alexis / Seror, Oliver / Nault, Jean Charles

Liver international : official journal of the International Association for the Study of the Liver

2024

Abstract: Introduction: We aim to assess the long-term outcomes of percutaneous multi-bipolar radiofrequency (mbpRFA) as the first treatment for hepatocellular carcinoma (HCC) in transplant-eligible cirrhotic patients, followed by salvage transplantation for ... ...

Abstract	Introduction: We aim to assess the long-term outcomes of percutaneous multi-bipolar radiofrequency (mbpRFA) as the first treatment for hepatocellular carcinoma (HCC) in transplant-eligible cirrhotic patients, followed by salvage transplantation for intrahepatic distant tumour recurrence or liver failure. Materials and methods: We included transplant-eligible patients with cirrhosis and a first diagnosis of HCC within Milan criteria treated by upfront mbp RFA. Transplantability was defined by age <70 years, social support, absence of significant comorbidities, no active alcohol use and no recent extrahepatic cancer. Baseline variables were correlated with outcomes using the Kaplan-Meier and Cox models. Results: Among 435 patients with HCC, 172 were considered as transplantable with HCCs >2 cm (53%), uninodular (87%) and AFP >100 ng/mL (13%). Median overall survival was 87 months, with 75% of patients alive at 3 years, 61% at 5 years and 43% at 10 years. Age (p = .003) and MELD>10 (p = .01) were associated with the risk of death. Recurrence occurred in 118 patients within Milan criteria in 81% of cases. Local recurrence was observed in 24.5% of cases at 10 years and distant recurrence rates were observed in 69% at 10 years. After local recurrence, 69% of patients were still alive at 10 years. At the first tumour recurrence, 75 patients (65%) were considered transplantable. Forty-one patients underwent transplantation, mainly for distant intrahepatic tumour recurrence. The overall 5-year survival post-transplantation was 72%, with a tumour recurrence of 2.4%. Conclusion: Upfront multi-bipolar RFA for a first diagnosis of early HCC on cirrhosis coupled with salvage liver transplantation had a favourable intention-to-treat long-term prognosis, allowing for spare grafts.
Language	English
Publishing date	2024-04-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2102783-3
ISSN	1478-3231 ; 1478-3223
ISSN (online)	1478-3231
ISSN	1478-3223
DOI	10.1111/liv.15900
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