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  1. Article: Long Non-Coding RNAs in Hypoxia and Oxidative Stress: Novel Insights Investigating a Piglet Model of Perinatal Asphyxia.

    Grebstad Tune, Benedicte / Melheim, Maria / Åsegg-Atneosen, Monica / Dotinga, Baukje / Saugstad, Ola Didrik / Solberg, Rønnaug / Baumbusch, Lars Oliver

    Biology

    2023  Volume 12, Issue 4

    Abstract: Birth asphyxia is the leading cause of death and disability in young children worldwide. Long non-coding RNAs (lncRNAs) may provide novel targets and intervention strategies due to their regulatory potential, as demonstrated in various diseases and ... ...

    Abstract Birth asphyxia is the leading cause of death and disability in young children worldwide. Long non-coding RNAs (lncRNAs) may provide novel targets and intervention strategies due to their regulatory potential, as demonstrated in various diseases and conditions. We investigated cardinal lncRNAs involved in oxidative stress, hypoxia, apoptosis, and DNA damage using a piglet model of perinatal asphyxia. A total of 42 newborn piglets were randomized into 4 study arms: (1) hypoxia-normoxic reoxygenation, (2) hypoxia-3 min of hyperoxic reoxygenation, (3) hypoxia-30 min of hyperoxic reoxygenation, and (4) sham-operated controls. The expression of lncRNAs
    Language English
    Publishing date 2023-04-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12040549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Withanone as an Emerging Anticancer Agent and Understanding Its Molecular Mechanisms: Experimental and Computational Evidence.

    Stephen, Annatasha / Tune, Bernadette Xin Jie / Wu, Yuan Seng / Batumalaie, Kalaivani / Sekar, Mahendran / Sarker, Md Moklesur Rahman / Subramaniyan, Vetriselvan / Fuloria, Neeraj Kumar / Fuloria, Shivkanya / Gopinath, Subash C B

    Current cancer drug targets

    2024  

    Abstract: Despite decades of research and effort, treating cancer is still a challenging task. Current conventional treatments are still unsatisfactory to fully eliminate and prevent re-emergence or relapses, and targeted or personalised therapy, which are more ... ...

    Abstract Despite decades of research and effort, treating cancer is still a challenging task. Current conventional treatments are still unsatisfactory to fully eliminate and prevent re-emergence or relapses, and targeted or personalised therapy, which are more effective in managing cancer, may be unattainable or inaccessible for some. In the past, research in natural products have yielded some of the most commonly used cancer treatment drugs known today. Hence it is possible more are awaiting to be discovered. Withanone, a common withanolide found in the Ayurvedic herb Withania somnifera, has been claimed to possess multiple benefits capable of treating cancer. This review focuses on the potential of withanone as a safe cancer treatment drug based on the pharmacokinetic profile and molecular mechanisms of actions of withanone. Through these in silico and in vitro studies discussed in this review, withanone showspotent anticancer activities and interactions with molecular targets involved in cancer progression. Furthermore, some evidences also show the selective killing property of withanone, which highlights the safety and specificity of withanone in targeting cancer cell. By compiling these evidences, this review hopes to spark interest for future research to be conducted in more extensive studies involving withanone to generate more data, especially involving in vivo experiments and toxicity evaluation of withanone.
    Language English
    Publishing date 2024-03-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2064824-8
    ISSN 1873-5576 ; 1568-0096
    ISSN (online) 1873-5576
    ISSN 1568-0096
    DOI 10.2174/0115680096290673240223043650
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5589: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: The hemolytic-uremic syndrome.

    Tune, B M

    The Western journal of medicine

    2008  Volume 120, Issue 5, Page(s) 404

    Language English
    Publishing date 2008-08-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189235-6
    ISSN 1476-2978 ; 0093-0415 ; 0008-1264
    ISSN (online) 1476-2978
    ISSN 0093-0415 ; 0008-1264
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 168: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Assessing nuclear versus mitochondrial cell-free DNA (cfDNA) by qRT-PCR and droplet digital PCR using a piglet model of perinatal asphyxia.

    Bitenc, Marie / Grebstad Tune, Benedicte / Melheim, Maria / Atneosen-Åsegg, Monica / Lai, Xiaoran / Rajar, Polona / Solberg, Rønnaug / Baumbusch, Lars Oliver

    Molecular biology reports

    2022  Volume 50, Issue 2, Page(s) 1533–1544

    Abstract: Background: Since the discovery more than half a century ago, cell-free DNA (cfDNA) has become an attractive objective in multiple diagnostic, prognostic, and monitoring settings. However, despite the increasing number of cfDNA applications in liquid ... ...

    Abstract Background: Since the discovery more than half a century ago, cell-free DNA (cfDNA) has become an attractive objective in multiple diagnostic, prognostic, and monitoring settings. However, despite the increasing number of cfDNA applications in liquid biopsies, we still lack a comprehensive understanding of the nature of cfDNA including optimal assessment. In the presented study, we continued testing and validation of common techniques for cfDNA extraction and quantification (qRT-PCR or droplet digital PCR) of nuclear- and mitochondrial cfDNA (ncfDNA and mtcfDNA) in blood, using a piglet model of perinatal asphyxia to determine potential temporal and quantitative changes at the levels of cfDNA.
    Methods and results: Newborn piglets (n = 19) were either exposed to hypoxia (n = 11) or were part of the sham-operated control group (n = 8). Blood samples were collected at baseline (= start) and at the end of hypoxia or at 40-45 min for the sham-operated control group. Applying the qRT-PCR method, ncfDNA concentrations in piglets exposed to hypoxia revealed an increasing trend from 7.1 ng/ml to 9.5 ng/ml for HK2 (hexokinase 2) and from 4.6 ng/ml to 7.9 ng/ml for β-globulin, respectively, whereas the control animals showed a more balanced profile. Furthermore, median levels of mtcfDNA were much higher in comparison to ncfDNA, but without significant differences between intervention versus the control group.
    Conclusions: Both, qRT-PCR and the droplet digital PCR technique identified overall similar patterns for the concentration changes of cfDNA; but, the more sensitive digital PCR methodology might be required to identify minimal responses.
    MeSH term(s) Animals ; Swine ; Cell-Free Nucleic Acids/genetics ; Asphyxia ; Polymerase Chain Reaction/methods ; Liquid Biopsy ; Hypoxia
    Chemical Substances Cell-Free Nucleic Acids
    Language English
    Publishing date 2022-12-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-022-08135-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Dry shear aligning: a simple and versatile method to smooth and align the surfaces of carbon nanotube thin films.

    Tune, D D / Stolz, B W / Pfohl, M / Flavel, B S

    Nanoscale

    2016  Volume 8, Issue 6, Page(s) 3232–3236

    Abstract: We show that the application of lateral shear force on a randomly oriented thin film of carbon nanotubes, in the dry state, causes significant reordering of the nanotubes at the film surface. This new technique of dry shear aligning is applicable to ... ...

    Abstract We show that the application of lateral shear force on a randomly oriented thin film of carbon nanotubes, in the dry state, causes significant reordering of the nanotubes at the film surface. This new technique of dry shear aligning is applicable to carbon nanotube thin films produced by many of the established methods.
    Language English
    Publishing date 2016-02-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/c5nr08784h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Correction: Dry shear aligning: a simple and versatile method to smooth and align the surfaces of carbon nanotube thin films.

    Tune, D D / Stolz, B W / Pfohl, M / Flavel, B S

    Nanoscale

    2016  Volume 8, Issue 9, Page(s) 5387

    Abstract: ... of carbon nanotube thin films' by D. D. Tune et al., Nanoscale, 2016, DOI: 10.1039/c5nr08784h. ...

    Abstract Correction for 'Dry shear aligning: a simple and versatile method to smooth and align the surfaces of carbon nanotube thin films' by D. D. Tune et al., Nanoscale, 2016, DOI: 10.1039/c5nr08784h.
    Language English
    Publishing date 2016-03-07
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/c6nr90039a
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  7. Article ; Online: Chronic high-rate pacing induces heart failure with preserved ejection fraction-like phenotype in Ossabaw swine.

    Tune, Johnathan D / Goodwill, Adam G / Baker, Hana E / Dick, Gregory M / Warne, Cooper M / Tucker, Selina M / Essajee, Salman I / Bailey, Chastidy A / Klasing, Jessica A / Russell, Jacob J / McCallinhart, Patricia E / Trask, Aaron J / Bender, Shawn B

    Basic research in cardiology

    2022  Volume 117, Issue 1, Page(s) 50

    Abstract: The lack of pre-clinical large animal models of heart failure with preserved ejection fraction (HFpEF) remains a growing, yet unmet obstacle to improving understanding of this complex condition. We examined whether chronic cardiometabolic stress in ... ...

    Abstract The lack of pre-clinical large animal models of heart failure with preserved ejection fraction (HFpEF) remains a growing, yet unmet obstacle to improving understanding of this complex condition. We examined whether chronic cardiometabolic stress in Ossabaw swine, which possess a genetic propensity for obesity and cardiovascular complications, produces an HFpEF-like phenotype. Swine were fed standard chow (lean; n = 13) or an excess calorie, high-fat, high-fructose diet (obese; n = 16) for ~ 18 weeks with lean (n = 5) and obese (n = 8) swine subjected to right ventricular pacing (180 beats/min for ~ 4 weeks) to induce heart failure (HF). Baseline blood pressure, heart rate, LV end-diastolic volume, and ejection fraction were similar between groups. High-rate pacing increased LV end-diastolic pressure from ~ 11 ± 1 mmHg in lean and obese swine to ~ 26 ± 2 mmHg in lean HF and obese HF swine. Regression analyses revealed an upward shift in LV diastolic pressure vs. diastolic volume in paced swine that was associated with an ~ twofold increase in myocardial fibrosis and an ~ 50% reduction in myocardial capillary density. Hemodynamic responses to graded hemorrhage revealed an ~ 40% decrease in the chronotropic response to reductions in blood pressure in lean HF and obese HF swine without appreciable changes in myocardial oxygen delivery or transmural perfusion. These findings support that high-rate ventricular pacing of lean and obese Ossabaw swine initiates underlying cardiac remodeling accompanied by elevated LV filling pressures with normal ejection fraction. This distinct pre-clinical tool provides a unique platform for further mechanistic and therapeutic studies of this highly complex syndrome.
    MeSH term(s) Animals ; Fructose ; Heart Failure ; Obesity/complications ; Oxygen ; Phenotype ; Stroke Volume/physiology ; Swine ; Ventricular Function, Left
    Chemical Substances Fructose (30237-26-4) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2022-10-12
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 189755-x
    ISSN 1435-1803 ; 0300-8428 ; 0175-9418
    ISSN (online) 1435-1803
    ISSN 0300-8428 ; 0175-9418
    DOI 10.1007/s00395-022-00958-z
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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.30: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Disentangling the Gordian knot of local metabolic control of coronary blood flow.

    Tune, Johnathan D / Goodwill, Adam G / Kiel, Alexander M / Baker, Hana E / Bender, Shawn B / Merkus, Daphne / Duncker, Dirk J

    American journal of physiology. Heart and circulatory physiology

    2019  Volume 318, Issue 1, Page(s) H11–H24

    Abstract: Recognition that coronary blood flow is tightly coupled with myocardial metabolism has been appreciated for well over half a century. However, exactly how coronary microvascular resistance is tightly coupled with myocardial oxygen consumption ( ... ...

    Abstract Recognition that coronary blood flow is tightly coupled with myocardial metabolism has been appreciated for well over half a century. However, exactly how coronary microvascular resistance is tightly coupled with myocardial oxygen consumption (MV̇o
    MeSH term(s) Animals ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/physiopathology ; Coronary Circulation ; Coronary Vessels/physiology ; Disease Models, Animal ; Energy Metabolism ; Hemodynamics ; Humans ; Models, Cardiovascular ; Myocardium/metabolism ; Oxygen Consumption ; Species Specificity
    Language English
    Publishing date 2019-11-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00325.2019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
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  9. Article ; Online: Impact of Regulatory T Cells on Type 2 Alveolar Epithelial Cell Transcriptomes during Resolution of Acute Lung Injury and Contributions of IFN-γ.

    Mock, Jason R / Dial, Catherine F / Tune, Miriya K / Gilmore, Rodney C / O'Neal, Wanda K / Dang, Hong / Doerschuk, Claire M

    American journal of respiratory cell and molecular biology

    2020  Volume 63, Issue 4, Page(s) 464–477

    Abstract: By enhancing tissue repair and modulating immune responses, ... ...

    Abstract By enhancing tissue repair and modulating immune responses, Foxp3
    MeSH term(s) Acute Lung Injury/immunology ; Alveolar Epithelial Cells/immunology ; Animals ; B-Lymphocytes/immunology ; Female ; Forkhead Transcription Factors/immunology ; Inflammation/immunology ; Interferon-gamma/immunology ; Lung/immunology ; Macrophages/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Signal Transduction/immunology ; T-Lymphocytes, Regulatory/immunology ; Transcriptome/immunology
    Chemical Substances Forkhead Transcription Factors ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2020-06-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2019-0399OC
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2851: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  10. Article: From Pediatric to Adult Brain Cancer: Exploring Histone H3 Mutations in Australian Brain Cancer Patients.

    Grebstad Tune, Benedicte / Sareen, Heena / Powter, Branka / Kahana-Edwin, Smadar / Cooper, Adam / Koh, Eng-Siew / Lee, Cheok S / Po, Joseph W / McCowage, Geoff / Dexter, Mark / Cain, Lucy / O'Neill, Geraldine / Prior, Victoria / Karpelowsky, Jonathan / Tsoli, Maria / Baumbusch, Lars O / Ziegler, David / Roberts, Tara L / DeSouza, Paul /
    Becker, Therese M / Ma, Yafeng

    Biomedicines

    2023  Volume 11, Issue 11

    Abstract: Genetic histone variants have been implicated in cancer development and progression. Mutations affecting the histone 3 (H3) family, H3.1 (encoded ... ...

    Abstract Genetic histone variants have been implicated in cancer development and progression. Mutations affecting the histone 3 (H3) family, H3.1 (encoded by
    Language English
    Publishing date 2023-10-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11112907
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