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Article ; Online: [Inibitori della calcineurina e trapianto renale].

Ponticelli, Claudio

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

2021 Volume 38, Issue Suppl 77

Language	Italian
Publishing date	2021-09-07
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1237110-5
ISSN	1724-5990 ; 0393-5590
ISSN (online)	1724-5990
ISSN	0393-5590
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Article: Storia naturale dell'infezione da virus dell'epatite C in dialisi.

Fabrizi, F / Martin, P / Lunghi, G / Ponticelli, C

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

2003 Volume 20, Issue 5, Page(s) 470–477

Abstract: Dialysis patients remain at risk for acquiring hepatitis C virus (HCV) infection. The issue ... advocated to this purpose. However, the rate of persistence of HCV after acute hepatitis C is probably ...

Title translation	Natural history of hepatitis C virus infection in dialysis.
Abstract	Dialysis patients remain at risk for acquiring hepatitis C virus (HCV) infection. The issue of the natural history of HCV infection among patients undergoing long-term dialysis is surrounded by great controversy. An accurate assessment of the clinical outcomes of HCV in end-stage renal disease (ESRD) is hampered by numerous items, namely the primary features of the disease: its onset is rarely recognized and its course is prolonged exceedingly. Viral, host, and/or environmental factors may influence the outcome of chronic HCV infection but their precise role in promoting disease progression are yet to be defined in dialysis patients. It is well known that HCV-related liver disease usually runs an asymptomatic course and the liver-related mortality in the dialysis population is very low. In addition, it has been suggested that the HD procedure may exert a protective effect on the course of HCV and several mechanisms have been advocated to this purpose. However, the rate of persistence of HCV after acute hepatitis C is probably extremely high among dialysis patients. Recently a strong and independent relationship between HCV status and survival in the dialysis population has been observed. The frequency of liver cancer in dialysis patients appears higher than that seen in the general population. These findings have been obtained by several prospective studies with adequate size and long follow-ups. The natural history of HCV in patients on long-term dialysis will be better defined as more data are generated from ongoing studies. Dialysis patients desperately need effective and safe antiviral agents for the treatment of HCV-related liver disease.
MeSH term(s)	Acute Disease ; Hepatitis C/epidemiology ; Hepatitis C/etiology ; Hepatitis C, Chronic/epidemiology ; Hepatitis C, Chronic/etiology ; Humans ; Renal Dialysis ; Risk Factors
Language	Italian
Publishing date	2003-09
Publishing country	Italy
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1237110-5
ISSN	0393-5590
ISSN	0393-5590
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Zs.A 4313: Show issues

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Book: Medical complications of kidney transplantation

Ponticelli, Claudio

2007

Author's details	Claudio Ponticelli
Language	English
Size	V, 425 S. : Ill.
Publisher	Informa Healthcare
Publishing place	Abingdon
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT014983973
ISBN	0-415-41715-5 ; 978-0-415-41715-0
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Hepatitis C virus infection and renal transplantation.

Fabrizi, F / Martin, P / Ponticelli, C

American journal of kidney diseases : the official journal of the National Kidney Foundation

2001 Volume 38, Issue 5, Page(s) 919–934

Abstract: ... have shown that hepatitis C virus (HCV) infection is the leading cause of chronic liver disease ... studies do not support interferon (IFN) treatment for RT recipients with chronic hepatitis C ...

Abstract	With the success of organ transplantation, liver disease has emerged as an important cause of morbidity and mortality of renal transplant (RT) recipients. Numerous studies performed during the 1990s have shown that hepatitis C virus (HCV) infection is the leading cause of chronic liver disease among RT recipients. The transmission of HCV by renal transplantation of a kidney from an HCV-infected organ donor has been shown unequivocally. Liver biopsy is essential in the evaluation of liver disease of RT recipients, and histological studies have shown that HCV-related liver disease after renal transplantation is progressive. The outcome of HCV-related liver disease is probably more aggressive in RT recipients than immunocompetent individuals. Various factors can affect the progression of HCV in the RT population: coinfection with hepatitis B virus, time of HCV acquisition, type of immunosuppressive treatment, and concomitant alcohol abuse. The role of virological features of HCV remains unclear. The natural history of HCV infection after renal transplantation is under evaluation; however, recent surveys with long follow-ups have documented adverse effects of HCV infection on patient and graft survival in RT recipients. Use of renal grafts from HCV-infected donors in recipients with HCV infection does not appear to result in a greater burden of liver disease, at least for a short period. The association between HCV and de novo or recurrent glomerulonephritis after RT has been hypothesized and is an area of avid research. Reported studies do not support interferon (IFN) treatment for RT recipients with chronic hepatitis C because of the frequent occurrence of graft failure, and information on the use of other types of IFN or combined therapy (IFN plus ribavirin or amantadine) is not yet available in the RT population.
MeSH term(s)	Genome, Viral ; Hepacivirus/genetics ; Hepatitis C/complications ; Hepatitis C/virology ; Humans ; Kidney Diseases/complications ; Kidney Diseases/therapy ; Kidney Transplantation ; Liver Diseases/etiology ; Renal Dialysis
Language	English
Publishing date	2001-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	604539-x
ISSN	1523-6838 ; 0272-6386
ISSN (online)	1523-6838
ISSN	0272-6386
DOI	10.1053/ajkd.2001.28576
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Zs.A 1669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 468: Show issues

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Article: Hepatitis C virus infection and rituximab therapy after renal transplantation.

Fabrizi, F / Martin, P / Elli, A / Montagnino, G / Banfi, G / Passerini, P / Campise, M R / Tarantino, A / Ponticelli, C

The International journal of artificial organs

2006 Volume 30, Issue 5, Page(s) 445–449

Abstract: ... with chronic hepatitis C who received rituximab therapy for gastric cancer. Four rituximab infusions of 375 mg ... m(2) were given.: Results: Rituximab therapy was complicated by cholestatic hepatitis C with very ... therapy was implicated in the pathogenesis of cholestatic hepatitis C in our patient.: Conclusions ...

Abstract	Background: Rituximab, a chimeric monoclonal antibody, has been successfully given in various diseases including HCV-associated mixed cryoglobulinemia. However, only preliminary data exists on its efficacy and safety after renal transplantation. Methods: We report on a renal transplant recipient with chronic hepatitis C who received rituximab therapy for gastric cancer. Four rituximab infusions of 375 mg/m(2) were given. Results: Rituximab therapy was complicated by cholestatic hepatitis C with very high HCV RNA levels; liver insufficiency occurred. The patient developed bacterial pneumoniae and respiratory insufficiency was the cause of death. Although other mechanisms cannot be excluded, we found that rituximab therapy was implicated in the pathogenesis of cholestatic hepatitis C in our patient. Conclusions: We suggest that rituximab therapy may be associated with significant side effects. More experience has to be accumulated before any conclusions on efficacy and safety of rituximab therapy after RT can be drawn.
MeSH term(s)	Adult ; Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Murine-Derived ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Female ; Hepacivirus/isolation & purification ; Hepatitis C, Chronic/pathology ; Hepatitis C, Chronic/virology ; Humans ; Immunosuppression/adverse effects ; Immunosuppressive Agents/therapeutic use ; Kidney Transplantation/adverse effects ; Lymphoproliferative Disorders/drug therapy ; RNA, Viral ; Rituximab ; Stomach Neoplasms/drug therapy
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Murine-Derived ; Antineoplastic Agents ; Immunosuppressive Agents ; RNA, Viral ; Rituximab (4F4X42SYQ6)
Language	English
Publishing date	2006-12-15
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80456-3
ISSN	1724-6040 ; 0391-3988
ISSN (online)	1724-6040
ISSN	0391-3988
DOI	10.1177/039139880703000513
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Zs.A 1439: Show issues

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Article: Natural history of hepatitis C virus infection in adult renal graft recipients.

Aroldi, A / Lampertico, P / Montagnino, G / Lunghi, G / Passerini, P / Villa, M / Campise, M / Cesana, B M / Ponticelli, C

Transplantation proceedings

2005 Volume 37, Issue 2, Page(s) 940–941

Abstract: Aim: To study the natural history of hepatitis C virus infection in renal transplantation, 464 ... C+). HCVRNA was confirmed in 89% of C+ patients. Compared with the 255 anti-HCV negative (C-), C+ had ... patients. The causes of death in 84 patients (51 C+ vs 33 C-) were cardiovascular disease in 49%, sepsis ...

Abstract	Aim: To study the natural history of hepatitis C virus infection in renal transplantation, 464 HbsAg negative patients were prospectively studied from 1989. Methods: AntiHCV was tested by ELISA II and HCVRNA by Amplicor HCV RNA tests. Results: Two hundred nine patients were antiHCV positive (C+). HCVRNA was confirmed in 89% of C+ patients. Compared with the 255 anti-HCV negative (C-), C+ had undergone longer periods of dialysis (P = .0001), were more transfused (P = .01), and included more retransplants (P = .002). Immunosuppression was azathioprine (AZA) plus steroids in 133 and cyclosporine (CsA) in 331 patients. Liver biopsy showed chronic active hepatitis in 50, cirrhosis in 8, and fibrosing cholestatic hepatitis in 2 patients. Histologic progression of liver disease was confirmed in 18 of 26 patients. The causes of death in 84 patients (51 C+ vs 33 C-) were cardiovascular disease in 49%, sepsis in 13%, liver failure in 14%, neoplasia in 21%, and hepatocarcinoma in 2%. The 14-year patient survival was 75% in C+ and 86% in C- (P = .002). By multivariate analysis, age (>40) (P = .001) and C+ (P = .019) correlated with a worse patient survival. If patients were stratified according to age (<40 vs > or =40), younger C+ patients had a lower survival probability (P = .03). The 14-year graft survival was 44% in C+ vs 60% in C- patients (P = .001) but pure graft survival was similar (68% in C+ vs 72% in C-) (P = .13). Conclusion: The presence of C+ significantly reduced both patient and graft survival in the long-term with liver failure being the second most frequent cause of death.
MeSH term(s)	Adult ; Cause of Death ; Chi-Square Distribution ; Drug Therapy, Combination ; Enzyme-Linked Immunosorbent Assay ; Graft Survival ; Hepatitis C/physiopathology ; Hepatitis C Antibodies/blood ; Humans ; Immunosuppressive Agents/therapeutic use ; Kidney Transplantation/mortality ; Kidney Transplantation/physiology ; Liver Failure/etiology ; Liver Failure/mortality ; RNA, Viral/isolation & purification ; Recurrence ; Survival Analysis
Chemical Substances	Hepatitis C Antibodies ; Immunosuppressive Agents ; RNA, Viral
Language	English
Publishing date	2005-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2004.11.068
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Zs.A 835: Show issues

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Article: Natural history of hepatitis B and C in renal allograft recipients.

Aroldi, Adriana / Lampertico, Pietro / Montagnino, Giuseppe / Passerini, Patrizia / Villa, Margherita / Campise, Maria R / Lunghi, Giovanna / Tarantino, Antonio / Cesana, Bruno M / Messa, PierGiorgio / Ponticelli, Claudio

Transplantation

2005 Volume 79, Issue 9, Page(s) 1132–1136

Abstract: ... B virus and hepatitis C virus (HCV). The natural history of hepatitis C and B was studied in 286 ... At enrollment in 1989 (5.5+/-4 years after transplantation), 209 patients were anti-HCV positive (C+), 42 ... patients were HBsAg-positive (B+), and 35 patients were both B+ and C+ (C+B+). One hundred four patients ...

Abstract	Background: In renal allograft recipients, most cases of liver dysfunction are caused by hepatitis B virus and hepatitis C virus (HCV). The natural history of hepatitis C and B was studied in 286 renal allograft recipients who received a kidney allograft between 1972 and 1989 when tests for anti-HCV became available. Methods: In all patients, hepatitis B (HB) surface (s) antigen (Ag) was tested before and anti-HCV (by enzyme-linked immunosorbent assay II) after transplantation. Results: At enrollment in 1989 (5.5+/-4 years after transplantation), 209 patients were anti-HCV positive (C+), 42 patients were HBsAg-positive (B+), and 35 patients were both B+ and C+ (C+B+). One hundred four patients were receiving azathioprine (AZA) and 182 were on cyclosporine A (CsA). Since transplantation, the median follow-up was 18 years in AZA-treated and 13 years in CsA-treated patients. Liver biopsy showed chronic hepatitis in 73 patients, cirrhosis in 20 patients, and fibrosing cholestatic hepatitis in 2 patients. In 34 patients, liver biopsy was repeated, and progression of fibrosis was observed in 24 patients. The 12-year patient survival rate was similar in B+, C+, and B+C+ patients (67%, 78%, and 71%, respectively; P=not significant). Liver-related death was the first cause of death in B+ and B+C+ infected patients (58% and 72%, respectively), whereas cardiovascular disease was the leading cause of death in C+ patients (40%). Multivariate analysis showed that older age (>40 years) (relative risk [RR], 2.8), B+ status (RR, 2.36), and C+ status (RR, 1.65) were independently associated with a worse patient survival. Conclusions: In the long term, B+ patients had a higher risk of death related to liver disease than C+ patients, and co-infection did not worsen patient survival.
MeSH term(s)	Follow-Up Studies ; Graft Survival ; Hepatitis B/epidemiology ; Hepatitis B/mortality ; Hepatitis B/physiopathology ; Hepatitis C/epidemiology ; Hepatitis C/mortality ; Hepatitis C/physiopathology ; Humans ; Immunosuppressive Agents/therapeutic use ; Kidney Transplantation/adverse effects ; Kidney Transplantation/mortality ; Liver/pathology ; Liver/virology ; Retrospective Studies ; Survival Analysis ; Time Factors ; Transplantation, Homologous
Chemical Substances	Immunosuppressive Agents
Language	English
Publishing date	2005-05-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/01.tp.0000161250.83392.73
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 509: Show issues

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Article ; Online: Synthesis of functionalized quinolines and benzo[c][2,7]naphthyridines based on a photo-Fries rearrangement.

Guerrini, Giacomo / Taddei, Maurizio / Ponticelli, Fabio

The Journal of organic chemistry

2011 Volume 76, Issue 18, Page(s) 7597–7601

Abstract: An efficient one-pot method for the synthesis of functionalized quinolines and tetrahydronaphthyridines has been developed. The photo-Fries rearrangement of p-substituted anilides afforded differently substituted o-amino ketones that reacted in situ with ...

Abstract	An efficient one-pot method for the synthesis of functionalized quinolines and tetrahydronaphthyridines has been developed. The photo-Fries rearrangement of p-substituted anilides afforded differently substituted o-amino ketones that reacted in situ with acetylenic Michael acceptors such as dimethyl acetylenedicarboxylate (DMAD) to give 6,4-disubstituted quinoline 2,3-dicarboxylates. Starting from anilides derived from β-alanine, a naphthyridine nucleus can also be assembled.
Language	English
Publishing date	2011-09-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/jo201316k
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Zs.A 4473: Show issues

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Article: COVID-19 Vaccination in Kidney Transplant Candidates and Recipients.

Ponticelli, Claudio / Campise, Mariarosaria

Vaccines

2022 Volume 10, Issue 11

Abstract: Kidney transplant candidates and kidney transplant recipients (KTRs) are at particular risk of severe complications of COVID-19 disease. In Western countries, mortality in affected hospitalized KTRs ranges between 19% and 50%. COVID-19 vaccination ... ...

Abstract	Kidney transplant candidates and kidney transplant recipients (KTRs) are at particular risk of severe complications of COVID-19 disease. In Western countries, mortality in affected hospitalized KTRs ranges between 19% and 50%. COVID-19 vaccination remains the most important measure to prevent the severity of infection in candidates and recipients of kidney transplant. However, the uraemic condition may affect the vaccine-induced immunity in patients with advanced chronic kidney disease (CKD) and in KTRs. Retention of uraemic toxins, dysbiosis, dysmetabolism, and dialysis can diminish the normal response to vaccination, leading to dysfunction of inflammatory and immune cells. In KTRs the efficacy of vaccines may be reduced by the immunosuppressive medications, and more than half of kidney transplant recipients are unable to build an immune response even after four administrations of anti-COVID-19 vaccines. The lack of antibody response leaves these patients at high risk for SARS-CoV-2 infection and severe COVID-19 disease. The aim of the present review is to focus on the main reasons for the impaired immunological response among candidates and kidney transplant recipients and to highlight some of the present options available to solve the problem.
Language	English
Publishing date	2022-10-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10111808
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Article: Non-Immunologic Causes of Late Death-Censored Kidney Graft Failure: A Personalized Approach.

Ponticelli, Claudio / Citterio, Franco

Journal of personalized medicine

2022 Volume 12, Issue 8

Abstract: Despite continuous advances in surgical and immunosuppressive protocols, the long-term survival of transplanted kidneys is still far from being satisfactory. Antibody-mediated rejection, recurrent autoimmune diseases, and death with functioning graft are ...

Abstract	Despite continuous advances in surgical and immunosuppressive protocols, the long-term survival of transplanted kidneys is still far from being satisfactory. Antibody-mediated rejection, recurrent autoimmune diseases, and death with functioning graft are the most frequent causes of late-kidney allograft failure. However, in addition to these complications, a number of other non-immunologic events may impair the function of transplanted kidneys and directly or indirectly lead to their failure. In this narrative review, we will list and discuss the most important nonimmune causes of late death-censored kidney graft failure, including quality of the donated kidney, adherence to prescriptions, drug toxicities, arterial hypertension, dyslipidemia, new onset diabetes mellitus, hyperuricemia, and lifestyle of the renal transplant recipient. For each of these risk factors, we will report the etiopathogenesis and the potential consequences on graft function, keeping in mind that in many cases, two or more risk factors may negatively interact together.
Language	English
Publishing date	2022-08-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm12081271
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