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Article ; Online: A Novel Preoperative Patient Survey Predicts Adverse Patient Outcomes-Implementation and Preliminary Results of the Tennessee Preoperative Assessment Tool.

Schmocker, Ryan K / Gray, Keith D / Eric Heidel, R / Vanterpool, Stephanie G / McLoughlin, James M

2023 Volume 89, Issue 7, Page(s) 3192–3199

Abstract: Background: Accurate preoperative risk stratification remains elusive. Existing tools are often missing important patient-reported and functional factors. We sought to implement a novel tool, with dynamic functional data and comorbidity variables, to ... ...

Abstract	Background: Accurate preoperative risk stratification remains elusive. Existing tools are often missing important patient-reported and functional factors. We sought to implement a novel tool, with dynamic functional data and comorbidity variables, to define factors which predict postoperative outcomes. Materials and methods: We expanded a previously validated functional questionnaire to create the Tennessee Preoperative Assessment Tool (TPAT). Unique elements included change in functional status, usual and best activity tolerance, and development of new conditions. The survey was administered to all new patients seen in several surgery clinics from July 2021 to June 2022. Results: A total of 1950 patients completed the survey. Of the completed surveys, 197 patients underwent an elective, inpatient, abdominal surgery and were included in the study. Several patient-reported factors were associated with poor postoperative outcomes. For example, decrease in functional activity in the previous 60 days (n = 50; 25.4%) was a strong predictor of poor postoperative outcomes including readmission (30-day: 8.8% vs .0%; Discussion: In this preliminary implementation study, patients undergoing elective, inpatient, abdominal surgery, utilization of a novel, patient-reported survey tool proactively identifies patients at risk of clinically relevant postoperative outcomes. Patient-reported decreased activity in the 60 days prior to surgeon evaluation was associated with several adverse postoperative outcomes. Additionally, this study demonstrates that the TPAT can be seamlessly integrated into the usual clinical workflow and is hypothesis generating for future interventional studies.
MeSH term(s)	Humans ; Tennessee/epidemiology ; Postoperative Complications/epidemiology ; Comorbidity ; Surveys and Questionnaires ; Risk Factors ; Retrospective Studies
Language	English
Publishing date	2023-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/00031348231157848
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Article ; Online: Impact of the COVID-19 pandemic on patients with pre-existing mood disorders.

McLoughlin, James / O'Grady, Margaret M / Hallahan, Brian

Irish journal of psychological medicine

2021 Volume 39, Issue 4, Page(s) 363–372

Abstract: Objectives: To examine the psychological and social impact of the COVID-19 pandemic on patients with established mood disorders during a period of stringent mandated social restrictions.: Methods: Semi-structured interviews were conducted with 36 ... ...

Abstract	Objectives: To examine the psychological and social impact of the COVID-19 pandemic on patients with established mood disorders during a period of stringent mandated social restrictions. Methods: Semi-structured interviews were conducted with 36 individuals attending the Galway-Roscommon Mental Health Services with an International Statistical Classification of Diseases and Related Health Problems, tenth revision (ICD-10) diagnosis of either Bipolar Affective Disorder (BPAD) ( Results: The COVID-19 pandemic deleteriously impacted mental health (56.3% Conclusions: Individuals with EUPD are experiencing significant mental health difficulties related to the COVID-19 pandemic. The provision and recommencement of therapeutic interventions to this cohort, in particular, are warranted given the significant distress and symptoms being experienced.
MeSH term(s)	Humans ; Mood Disorders/epidemiology ; Mood Disorders/psychology ; Cross-Sectional Studies ; Pandemics ; Quality of Life ; COVID-19
Language	English
Publishing date	2021-04-29
Publishing country	England
Document type	Journal Article
ZDB-ID	227751-7
ISSN	2051-6967 ; 0790-9667
ISSN (online)	2051-6967
ISSN	0790-9667
DOI	10.1017/ipm.2021.38
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Article ; Online: Merkel Cell Polyomavirus Antibody Titer Predicts Recurrence-Free Survival.

Arroyave, Aaron J / Lewis, James M / Landry, Miles / McLoughlin, James M / Enomoto, Laura M

Annals of surgical oncology

2021 Volume 29, Issue 3, Page(s) 1620–1626

Abstract: Background: Merkel cell polyomavirus (MCPyV) is associated with the development of Merkel cell carcinoma (MCC). Antibody (MCPyV-Ab) titers may have prognostic implications. This study evaluated the impact of the presence or absence of MCPyV-Ab on the 2- ... ...

Abstract	Background: Merkel cell polyomavirus (MCPyV) is associated with the development of Merkel cell carcinoma (MCC). Antibody (MCPyV-Ab) titers may have prognostic implications. This study evaluated the impact of the presence or absence of MCPyV-Ab on the 2-year overall survival (OS) and disease-free survival (DFS) of MCC patients. Methods: This single-center, IRB-approved, retrospective cohort study evaluated 51 adult patients with MCC from 2014 to 2021 using a prospectively maintained database. Patients were compared by MCPyV-Ab status, and Kaplan-Meier analysis was used to evaluate 2-year OS and DFS. Results: Of the 51 patients, 13 (25.4%) were seropositive, 41 (80.4%) underwent wide excision, 40 (80.0%) received radiotherapy, and 43 (84.3%) received multimodal therapy. The median follow-up period was 15.5 months (range 1-69.5 months). The median 2-year OS of the entire cohort was not reached. The median 2-year OS was not reached for either the seronegative or the seropositive patients. The difference in 2-year OS between the groups was not statistically significant (p = 0.37). Eight patients, all seronegative, were never rendered disease-free and were removed from recurrence analysis. The seropositive patients experienced no recurrences. Of the 30 seronegative patients, 9 (30.0%) experienced recurrence. The median 2-year DFS of the entire cohort was not reached. The median 2-year DFS of the seronegative group was 22.2 months. The 2-year DFS was not reached for the seropositive cohort. Seropositivity conferred a significantly better 2-year DFS than seronegativity (p = 0.04). Conclusion: The MCPyV-Ab seropositive patients demonstrated improved 2-year DFS. The seropositive patients showed a strong trend toward improved 2-year OS, although the difference not statistically significant. This study substantiated the value of MCPyV-Ab assessment for MCC.
MeSH term(s)	Carcinoma, Merkel Cell/therapy ; Humans ; Merkel cell polyomavirus ; Prognosis ; Retrospective Studies ; Skin Neoplasms/therapy
Language	English
Publishing date	2021-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-021-11008-8
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Article ; Online: Mn(II), Fe(II), and Co(II) Aryloxides: Steric and Dispersion Effects and the Thermal Rearrangement of a Cobalt Aryloxide to a Co(II) Semiquinone Complex.

McLoughlin, Connor P / Fettinger, James C / Power, Philip P

Inorganic chemistry

2023 Volume 62, Issue 26, Page(s) 10131–10140

Abstract: A series of Mn(II), Fe(II), and Co(II) bisaryloxide dimers ([M(OC ...

Abstract	A series of Mn(II), Fe(II), and Co(II) bisaryloxide dimers ([M(OC
Language	English
Publishing date	2023-06-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.3c00610
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Article ; Online: Further Distance From Treating Facility is Associated With Advanced Colon Cancer at Presentation and Increased Mortality.

Schmocker, Ryan K / Enomoto, Laura M / Low, Gregory K / McLoughlin, James M / Casillas, Mark A / Antill, Andrew C / Heidel, Robert E / Russ, Andrew J

The American surgeon

2024 , Page(s) 31348241241613

Abstract: Background: Colon cancer outcomes in the United States have improved over the last thirty years. However, there remain significant outcome disparities, especially in rural regions. It is unclear if distance to the treating facility has an independent ... ...

Abstract	Background: Colon cancer outcomes in the United States have improved over the last thirty years. However, there remain significant outcome disparities, especially in rural regions. It is unclear if distance to the treating facility has an independent effect on colon cancer mortality and outcomes. We sought to evaluate whether distance from a treating facility impacts stage at diagnosis and mortality. Methods: The National Cancer Database (NCDB) was utilized to identify a cohort of adult patients with colon cancer between the years 2013 and 2017 in all regions of the United States. Outcomes measured included colon cancer TNM stage, time to surgery, time to chemotherapy, and overall survival. Results: A total of n = 356,189 patients met inclusion criteria. When controlling for race, education status, insurance status, comorbidities, and income, distance from the treating facility was a significant predictor of stage at presentation with more advanced clinical TNM stage as distance increased (AORs 1.12-1.62, Conclusions: Increased distance from the treating facility resulted in a significantly higher stage at presentation, increased time to surgery, and increased mortality. These results suggest that there are significant disparities in access to cancer care for patients who live in rural areas. Targeted interventions by treating facilities are needed to improve screening and timely treatment for rural colon cancer patients.
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/00031348241241613
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Article ; Online: Overcoming a Radical Polarity Mismatch in Strain-Release Pentafluorosulfanylation of [1.1.0]Bicyclobutanes: An Entryway to Sulfone- and Carbonyl-Containing SF

Kraemer, Yannick / Buldt, Jón Atiba / Kong, Wang-Yeuk / Stephens, Alexander M / Ragan, Abbey N / Park, Soojun / Haidar, Zane C / Patel, Ansh Hiten / Shey, Rachel / Dagan, Roee / McLoughlin, Connor P / Fettinger, James C / Tantillo, Dean J / Pitts, Cody Ross

Angewandte Chemie (International ed. in English)

2024 Volume 63, Issue 19, Page(s) e202319930

Abstract: The first assortment of achiral pentafluorosulfanylated cyclobutanes ( ... ...

Abstract	The first assortment of achiral pentafluorosulfanylated cyclobutanes (SF
Language	English
Publishing date	2024-03-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202319930
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Article ; Online: When to Consider Lynch Syndrome in Non-Colon and Non-Endometrial Malignancies.

Arroyave, Aaron J / Good, Alan W / Ward, Andrew J / Orucevic, Amila L / McLoughlin, James M

The American surgeon

2021 Volume 89, Issue 5, Page(s) 1912–1922

Abstract: Lynch syndrome (LS) is a common genetic syndrome characterized by pathogenic mutations of DNA mismatch repair genes resulting in a hereditary predisposition to cancer. While typically associated with colonic and endometrial cancer, LS additionally ... ...

Abstract	Lynch syndrome (LS) is a common genetic syndrome characterized by pathogenic mutations of DNA mismatch repair genes resulting in a hereditary predisposition to cancer. While typically associated with colonic and endometrial cancer, LS additionally influences the development of many other malignancies. The Amsterdam II and Revised Bethesda Guidelines are the established clinical criteria for diagnosing LS. These guidelines are based on the most general characteristics of LS and do not address specific characteristics of the less commonly LS-associated malignancies. For individuals that present initially with a non-colon and non-endometrial malignancy, recommendations and guidelines on when to consider screening for LS are limited. Therefore, it is essential that clinicians are familiar with distinct LS-associated patient- and tumor-specific characteristics, especially of the less common LS-associated cancers, so that LS's diagnosis is not missed. In this review article, we focus on extra-colonic and extra-endometrial LS-associated cancers, paying particular attention to any established or currently investigated cancer features that help raise suspicion for LS and potentially lead to its earlier diagnosis. This review will also discuss current guidelines specific to each LS-associated malignancy.
MeSH term(s)	Female ; Humans ; Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis/pathology ; Mutation ; Genetic Testing ; Genetic Predisposition to Disease ; Endometrial Neoplasms/diagnosis ; Endometrial Neoplasms/genetics ; Endometrial Neoplasms/pathology
Language	English
Publishing date	2021-07-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/00031348211031835
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Article ; Online: Osteochondroma-induced pseudoaneurysms of the extremities mimicking sarcoma: a report of seven contemporary and one historical case.

Iqbal, A / McLoughlin, E / Patel, A / James, S L / Botchu, R / Davies, A M

Clinical radiology

2020 Volume 75, Issue 8, Page(s) 642.e9–642.e13

Abstract: Aim: To provide a diagnostic approach to distinguish osteochondroma-induced pseudoaneurysm from sarcoma on imaging and prevent biopsy which may be fatal.: Materials and methods: A retrospective study of the orthopaedic oncology database was performed ...

Abstract	Aim: To provide a diagnostic approach to distinguish osteochondroma-induced pseudoaneurysm from sarcoma on imaging and prevent biopsy which may be fatal. Materials and methods: A retrospective study of the orthopaedic oncology database was performed to identify all patients referred to specialist orthopaedic oncology service with a final diagnosis of osteochondroma-induced pseudoaneurysm. The demographics of the cohort, the anatomical location of the osteochondromas and pseudoaneurysms, and the imaging appearances were assessed. Results: Seven contemporary and one historical case of osteochondroma-induced-pseudoaneurysm were identified. There were five patients with solitary osteochondroma and three cases of hereditary multiple exostosis. Five cases underwent magnetic resonance imaging (MRI) of which pulsation artefact was present in 40%. On MRI, all the present cases demonstrated a small central pseudoaneurysm surrounded by multiple eccentric layers of thrombus and haemorrhage, which was termed the "eccentric-whorl sign". Conclusion: Osteochondroma-induced pseudoaneurysms are often misdiagnosed as malignant transformation of an osteochondroma or a soft-tissue sarcoma and referred for urgent biopsy. This study presents the largest case series, which includes the first documented case diagnosed in 1934. Differentiating and characterising pseudoaneurysms from sarcomas is imperative in order to prevent a biopsy, which could be fatal.
MeSH term(s)	Adolescent ; Adult ; Aneurysm, False/diagnosis ; Aneurysm, False/etiology ; Bone Neoplasms/complications ; Bone Neoplasms/diagnosis ; Child ; Diagnosis, Differential ; Female ; Follow-Up Studies ; Humans ; Lower Extremity ; Magnetic Resonance Imaging/methods ; Male ; Osteochondroma/complications ; Osteochondroma/diagnosis ; Popliteal Artery ; Retrospective Studies ; Sarcoma/diagnosis ; Soft Tissue Neoplasms/diagnosis ; Young Adult
Language	English
Publishing date	2020-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	391227-9
ISSN	1365-229X ; 0009-9260
ISSN (online)	1365-229X
ISSN	0009-9260
DOI	10.1016/j.crad.2020.02.017
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Article ; Online: Lifetime Stressor Exposure and Psychophysiological Reactivity and Habituation to Repeated Acute Social Stressors.

McLoughlin, Ella / Arnold, Rachel / Freeman, Paul / Turner, James E / Roberts, Gareth A / Fletcher, David / Slavich, George M / Moore, Lee J

Journal of sport & exercise psychology

2022 Volume 44, Issue 6, Page(s) 427–438

Abstract: This study addressed whether lifetime stressor exposure was associated with psychophysiological reactivity and habituation to a novel laboratory-based stressor. Eighty-six participants (Mage = 23.31 years, SD = 4.94) reported their exposure to lifetime ... ...

Abstract	This study addressed whether lifetime stressor exposure was associated with psychophysiological reactivity and habituation to a novel laboratory-based stressor. Eighty-six participants (Mage = 23.31 years, SD = 4.94) reported their exposure to lifetime non-sport and sport-specific stressors before completing two consecutive trials of the Trier Social Stress Test, while cardiovascular (i.e., heart rate) and endocrine (i.e., salivary cortisol) data were recorded. Exposure to a moderate number of lifetime non-sport and sport-specific stressors was associated with adaptive cardiovascular reactivity, whereas very low or very high stressor exposure was related to maladaptive reactivity. Moreover, experiencing a very low number of lifetime non-sport (but not sport-specific) stressors was associated with poorer habituation. In contrast, lifetime stressor severity was unrelated to cardiovascular reactivity. Finally, greater lifetime non-sport and sport-specific stressor counts were associated with blunted cortisol reactivity and poorer habituation. These results suggest that lifetime stressor exposure may influence sport performers' acute stress responses.
MeSH term(s)	Humans ; Habituation, Psychophysiologic ; Hydrocortisone ; Sports ; Heart Rate
Chemical Substances	Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2022-11-30
Publishing country	United States
Document type	Journal Article
ISSN	1543-2904
ISSN (online)	1543-2904
DOI	10.1123/jsep.2022-0196
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Article ; Online: Calcific tendinopathy of the direct head of rectus femoris: a rare cause of groin pain treated with ultrasound guided percutaneous irrigation.

McLoughlin, E / Iqbal, A / Tillman, R M / James, S L / Botchu, R

Journal of ultrasound

2019 Volume 23, Issue 3, Page(s) 425–430

Abstract: Groin pain can be caused by a myriad of pathologies. Abnormalities of the rectus femoris are a very rare cause of groin pain; calcific tendinopathy of the direct head is particularly so, with only two case reports in the literature. We report the first ... ...

Abstract	Groin pain can be caused by a myriad of pathologies. Abnormalities of the rectus femoris are a very rare cause of groin pain; calcific tendinopathy of the direct head is particularly so, with only two case reports in the literature. We report the first case of calcific tendinopathy of the direct head of the rectus femoris that was treated effectively with ultrasound-guided percutaneous irrigation of calcific tendinopathy (USPICT). The anatomy of the rectus femoris and the technique for US-PICT of the rectus femoris are also described.
MeSH term(s)	Adult ; Calcinosis/complications ; Calcinosis/therapy ; Female ; Groin/physiopathology ; Humans ; Pain/etiology ; Pain/physiopathology ; Quadriceps Muscle/diagnostic imaging ; Tendinopathy/etiology ; Tendinopathy/therapy ; Therapeutic Irrigation/methods ; Ultrasonography, Interventional/methods
Language	English
Publishing date	2019-08-01
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	2365426-0
ISSN	1876-7931 ; 1971-3495
ISSN (online)	1876-7931
ISSN	1971-3495
DOI	10.1007/s40477-019-00402-4
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