LIVIVO - Search results -

Search results

Result 1 - 10 of total 103

Search options

Article ; Online: An Efficient Microwave Assisted Copper Catalyzed C-3 Amination of 3-Bromopyrazolo[1,5–a]pyrimidine

Iorkula, Terungwa / Tolman, Bryce / Singleton, Justin D. / Peterson, Matt A.

Tetrahedron Letters. 2023 Feb. 04, p.154393-

2023 , Page(s) 154393–

Abstract: Treatment of 3-bromopyrazolo[1,5–a]pyrimidine with a variety of 1° or 2° alkylamines with 20 mol% CuI, 40 mol% L-proline, and Et₃N (2 equiv) in DMSO under microwave heating at 130 °C (4 hours) gave the corresponding C-3 aminated products in good to ... ...

Abstract	Treatment of 3-bromopyrazolo[1,5–a]pyrimidine with a variety of 1° or 2° alkylamines with 20 mol% CuI, 40 mol% L-proline, and Et₃N (2 equiv) in DMSO under microwave heating at 130 °C (4 hours) gave the corresponding C-3 aminated products in good to excellent isolated yields (54–90%; ave. yield = 77%). The reaction worked well for simple 1° alkylamines (e.g. butylamine, benzylamine, cyclohexylamine, and isopropylamine), and 1° amines with CH₂- or CH₂CH₂-linked heterocycles (e.g. furan, thiophene, pyridine, and/or indole) were also well tolerated. 2° Alkylamines were also good substrates for this reaction (e.g. piperidine, pyrrolidine, and morpholine). The reaction worked well under conventional heating conditions on both the mg or gram-scales, with representative gram-scale reactions giving products in 72-76% yield under conventional heating. Coupling to a pegylated azide (11-azido-3,6,9-trioxaundecan-1-amine, 65% yield microwave) demonstrated compatibility of this coupling methodology for potential click-type conjugation of the pyrazolo[1,5–a]pyrimidine to biologically relevant target ligands.
Keywords	amination ; azides ; benzylamines ; butylamine ; furans ; heat ; indoles ; ligands ; morpholine ; piperidines ; proline ; pyridines ; thiophene ; Pyrazolo[1,5–a]pyrimidine ; 3-Bromopyrazolo[1,5–a]pyrimidine ; Copper catalyzed amination
Language	English
Dates of publication	2023-0204
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	204287-3
ISSN	1873-3581 ; 0040-4039
ISSN (online)	1873-3581
ISSN	0040-4039
DOI	10.1016/j.tetlet.2023.154393
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 2837: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Machine Learning Models for Predicting Zirconocene Properties and Barriers.

Kirkland, Justin K / Kumawat, Jugal / Shaban Tameh, Maliheh / Tolman, Tyson / Lambert, Allison C / Lief, Graham R / Yang, Qing / Ess, Daniel H

Journal of chemical information and modeling

2024 Volume 64, Issue 3, Page(s) 775–784

Abstract: Zr metallocenes have significant potential to be highly tunable polyethylene catalysts through modification of the aromatic ligand framework. Here we report the development of multiple machine learning models using a large library (>700 systems) of DFT- ... ...

Abstract	Zr metallocenes have significant potential to be highly tunable polyethylene catalysts through modification of the aromatic ligand framework. Here we report the development of multiple machine learning models using a large library (>700 systems) of DFT-calculated zirconocene properties and barriers for ethylene polymerization. We show that very accurate machine learning models are possible for HOMO-LUMO gaps of precatalysts but the performance significantly depends on the machine learning algorithm and type of featurization, such as fingerprints, Coulomb matrices, smooth overlap of atomic positions, or persistence images. Surprisingly, the description of the bonding hapticity, the number of direct connections between Zr and the ligand aromatic carbons, only has a moderate influence on the performance of most models. Despite robust models for HOMO-LUMO gaps, these types of machine learning models based on structure connectivity type features perform poorly in predicting ethylene migratory insertion barrier heights. Therefore, we developed several relatively robust and accurate machine learning models for barrier heights that are based on quantum-chemical descriptors (QCDs). The quantitative accuracy of these models depends on which potential energy surface structure QCDs were harvested from. This revealed a Hammett-type principle to naturally emerge showing that QCDs from the π-coordination complexes provide much better descriptions of the transition states than other potential-energy structures. Feature importance analysis of the QCDs provides several fundamental principles that influence zirconocene catalyst reactivity.
MeSH term(s)	Ligands ; Organometallic Compounds/chemistry ; Ethylenes/chemistry ; Machine Learning ; Zirconium
Chemical Substances	Zirconocene dichloride (1291-32-3) ; Ligands ; Organometallic Compounds ; ethylene (91GW059KN7) ; Ethylenes ; Zirconium (C6V6S92N3C)
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	190019-5
ISSN	1549-960X ; 0095-2338
ISSN (online)	1549-960X
ISSN	0095-2338
DOI	10.1021/acs.jcim.3c01575
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1230: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Treatment options for refractory and difficult to treat seizures: focus on vigabatrin.

Tolman, Justin A / Faulkner, Michele A

Therapeutics and clinical risk management

2011 Volume 7, Page(s) 367–375

Abstract: Complex partial seizures are often refractory to current pharmacological therapies. These difficult to treat seizures are typically managed using multiple antiepileptic drugs (AEDs). AEDs as a group are frequently associated with significant adverse drug ...

Abstract	Complex partial seizures are often refractory to current pharmacological therapies. These difficult to treat seizures are typically managed using multiple antiepileptic drugs (AEDs). AEDs as a group are frequently associated with significant adverse drug effects, multiple drug interactions, and numerous potential clinical complications due to their individual pharmacokinetic profiles and unique drug properties. Recently, the approval of vigabatrin by the US Food and Drug Administration has necessitated that clinicians re-evaluate these risk-benefit relationships and determine where the drug fits within the treatment scheme for the management of complex partial seizures. This review will facilitate that re-evaluation through a brief review of AEDs used in the treatment of complex partial seizures, followed by a focused discussion on vigabatrin.
Language	English
Publishing date	2011-09-01
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2186560-7
ISSN	1178-203X ; 1176-6336
ISSN (online)	1178-203X
ISSN	1176-6336
DOI	10.2147/TCRM.S8519
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6067: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Safety and efficacy of vigabatrin for the treatment of infantile spasms.

Faulkner, Michele A / Tolman, Justin A

Journal of central nervous system disease

2011 Volume 3, Page(s) 199–207

Abstract: In 2009, vigabatrin became the first FDA approved medication for the treatment of infantile spasms in the United States. There are few well-designed prospective studies comparing the drug to placebo or other modalities used in the treatment of infantile ... ...

Abstract	In 2009, vigabatrin became the first FDA approved medication for the treatment of infantile spasms in the United States. There are few well-designed prospective studies comparing the drug to placebo or other modalities used in the treatment of infantile spasms. The available data have demonstrated that vigabatrin is efficacious in the treatment of infantile spasms regardless of underlying etiology, but that it is particularly beneficial in patients with a diagnosis of tuberous sclerosis. Adrenocorticotropic hormone (ACTH), the only other medication with robust efficacy data, has been used as first line therapy for infantile spasms associated with other etiologies, and in general controls spasms sooner than vigabatrin, though relapse is common with both therapies. Vigabatrin is generally well tolerated. However, use has been associated with permanent loss of peripheral vision in some patients. In children with tuberous sclerosis, vigabatrin should be considered as initial therapy for infantile spasms. It is a viable alternative for patients with suboptimal response, contraindications or intolerance to ACTH.
Language	English
Publishing date	2011-09-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2586873-1
ISSN	1179-5735
ISSN	1179-5735
DOI	10.4137/JCNSD.S6371
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Characterization and Systemic Delivery of Dibenzoylmethane via the Intranasal Route.

Vora, Deepal / Kincaid, Anthony E / Tolman, Justin / Chauhan, Harsh

AAPS PharmSciTech

2021 Volume 22, Issue 1, Page(s) 30

Abstract: Intranasal (IN) administration is known to be noninvasive with the potential to carry a drug or vaccine directly to the blood, bypassing first-pass metabolism in the liver and the harsh environment of the gastrointestinal system. Orally administered ... ...

Abstract	Intranasal (IN) administration is known to be noninvasive with the potential to carry a drug or vaccine directly to the blood, bypassing first-pass metabolism in the liver and the harsh environment of the gastrointestinal system. Orally administered dibenzoylmethane (DBM) has been shown experimentally to be neuroprotective in animal models of tauopathy and prion disease and effective in the treatment of certain forms of cancers. The purpose of this study was to prepare, characterize, and test formulations of DBM designed for IN administration. DBM was formulated in brain homogenate (BH) and hypromellose and as nanoparticles (NPs). These formulations were detected using UPLC and characterized in solid and suspension states; NPs were also characterized by in vitro cell culture-based studies. Particle size for DBM NP was 163.8 ± 3.2 nm, and in vitro release studies showed 95.80% of DBM was released from the NPs within 8 days. In vitro cell, culture studies suggested no drug uptake until 6 h. A histological analysis of nasal cavity (NC) sections and blood detection studies were carried out 30 min after inhalation. DBM amounting to 40.77 ± 4.93 and 44.45 ± 5.36 ng/mL was detected in the blood of animals administered DBM in polymeric and NP formulation, respectively. Histological studies on NCs confirmed the presence of BH within lymphatic vessels in the lamina propria of each animal; BH was identified traversing the mucosa in 2 animals. Thus, formulations for DBM administered via IN route were successfully designed and characterized and able to cross the nasal mucosa following inhalation.
MeSH term(s)	Administration, Intranasal ; Animals ; Brain/metabolism ; Chalcones/administration & dosage ; Drug Carriers/administration & dosage ; Drug Delivery Systems ; Nanoparticles/administration & dosage ; Nasal Mucosa/drug effects ; Nasal Mucosa/metabolism ; Particle Size
Chemical Substances	Chalcones ; Drug Carriers ; dibenzoylmethane (ANS7ME8OKC)
Language	English
Publishing date	2021-01-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2052070-0
ISSN	1530-9932 ; 1530-9932
ISSN (online)	1530-9932
ISSN	1530-9932
DOI	10.1208/s12249-020-01904-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Advances in the pulmonary delivery of poorly water-soluble drugs: influence of solubilization on pharmacokinetic properties.

Tolman, Justin A / Williams, Robert O

Drug development and industrial pharmacy

2010 Volume 36, Issue 1, Page(s) 1–30

Abstract: Background: Pulmonary drug delivery is an accepted route of drug administration for the management of lung conditions and diseases as well as an evolving route of administration for the systemic delivery of agents. Many inhaled drugs pose formulation ... ...

Abstract	Background: Pulmonary drug delivery is an accepted route of drug administration for the management of lung conditions and diseases as well as an evolving route of administration for the systemic delivery of agents. Many inhaled drugs pose formulation and delivery challenges in part because of poor aqueous solubility. The influence of poor aqueous solubility and formulation-based solubility enhancements on the pharmacokinetic profile of inhaled agents was reviewed. Method: A systematic review was performed to identify literature that reported pharmacokinetic findings following the pulmonary delivery of a poorly water-soluble agent. Results: The influence of solubility and formulation-based solubility enhancements on pharmacokinetic parameters following inhalation of corticosteroids, antifungals, oligopeptides, and opioids, was compiled. Conclusion: Poor aqueous solubility did not uniformly affect the pharmacokinetic profile for inhaled agents. Physicochemical and formulation-based solubility enhancement did affect drug absorption from the lungs. Numerous drug- and formulation-dependant pharmacokinetic effects were identified.
MeSH term(s)	Administration, Inhalation ; Animals ; Drug Delivery Systems ; Humans ; Lung/metabolism ; Lung Diseases/drug therapy ; Pharmaceutical Preparations/administration & dosage ; Pharmaceutical Preparations/chemistry ; Pharmacokinetics ; Solubility
Chemical Substances	Pharmaceutical Preparations
Language	English
Publishing date	2010-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	751874-2
ISSN	1520-5762 ; 0363-9045
ISSN (online)	1520-5762
ISSN	0363-9045
DOI	10.3109/03639040903092319
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1335: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Vigabatrin: a comprehensive review of drug properties including clinical updates following recent FDA approval.

Tolman, Justin A / Faulkner, Michele A

Expert opinion on pharmacotherapy

2009 Volume 10, Issue 18, Page(s) 3077–3089

Abstract: Background: Vigabatrin (Sabril) was approved in the USA in mid-2009 for the adjunctive treatment of refractory complex partial seizures and as treatment of infantile spasms. Vigabatrin's more than 30-year history of research and development is condensed ...

Abstract	Background: Vigabatrin (Sabril) was approved in the USA in mid-2009 for the adjunctive treatment of refractory complex partial seizures and as treatment of infantile spasms. Vigabatrin's more than 30-year history of research and development is condensed into a clinically relevant review pertaining to this 2009 approval. Methods/discussion: A review of the scientific literature was conducted with special focus given to the drug molecule, its mechanism of action, its effects on living systems (e.g., pharmacokinetic, pharmacologic and toxicologic), and its anticipated role among antiepileptic drugs in the USA. Conclusions: The recent approval of vigabatrin makes a significant addition to antiepileptic drug options. The FDA implemented a Risk Evaluation and Mitigation Strategy to control for the possibility of severe adverse drug events.
MeSH term(s)	Adult ; Animals ; Anticonvulsants/adverse effects ; Anticonvulsants/chemistry ; Anticonvulsants/pharmacology ; Anticonvulsants/therapeutic use ; Drug Approval ; Epilepsy, Complex Partial/drug therapy ; Humans ; Infant ; Middle Aged ; Registries ; Spasms, Infantile/drug therapy ; United States ; Vigabatrin/adverse effects ; Vigabatrin/chemistry ; Vigabatrin/pharmacology ; Vigabatrin/therapeutic use ; Vision Disorders/chemically induced ; Young Adult
Chemical Substances	Anticonvulsants ; Vigabatrin (GR120KRT6K)
Language	English
Publishing date	2009-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2001535-5
ISSN	1744-7666 ; 1465-6566
ISSN (online)	1744-7666
ISSN	1465-6566
DOI	10.1517/14656560903451690
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5130: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Evaluation of triazole-chelated lanthanides as chemically stabile bioimaging agents.

Indapurkar, Amruta / Henriksen, Brian / Tolman, Justin / Fletcher, James

Journal of pharmaceutical sciences

2013 Volume 102, Issue 8, Page(s) 2589–2598

Abstract: Europium (Eu), dysprosium (Dy), samarium (Sm), and terbium (Tb) complexes were prepared using the neutral tridentate chelator 2,6-bis(1-benzyl-1,2,3-triazol-4-yl)pyridine and one equivalent of each lanthanide salt. The physicochemical, aerodynamic, and ... ...

Abstract	Europium (Eu), dysprosium (Dy), samarium (Sm), and terbium (Tb) complexes were prepared using the neutral tridentate chelator 2,6-bis(1-benzyl-1,2,3-triazol-4-yl)pyridine and one equivalent of each lanthanide salt. The physicochemical, aerodynamic, and in vitro cellular properties of each lanthanide metal complex were studied to determine their viability as cell surface fluorescent probes. Each compound was characterized by electrospray ionization mass spectroscopy (ESI-MS), ultraperformance liquid chromatography (UPLC), differential scanning calorimetry (DSC), and thermogravimetic analysis (TGA). Upon excitation at 320 nm each complex displayed characteristic lanthanide-based fluorescence emission in the visible wavelength range with stokes shifts greater than 200 nm. Each complex was found to be chemically stable when exposed to pH range of 1-11 for 72 h and resistant to photobleaching. To simulate pulmonary administration of these fluorophores, the aerodynamic properties of the Eu and Tb complexes were determined using a next generation impactor (NGI). This measurement confirmed that the complexes retain their fluorescence emission properties after nebulization. Cellular cytotoxicity was determined on A-549 lung cancer cell line using methylthiazol tetrazolium (MTT) cytotoxicity assay at 24, 48, and 72 h postexposure to the complexes. The complexes showed a dose and time-dependent effect on the percent viability of the cells.
MeSH term(s)	Cell Line, Tumor ; Cell Survival/drug effects ; Chelating Agents/chemistry ; Chelating Agents/toxicity ; Coordination Complexes/chemistry ; Coordination Complexes/toxicity ; Fluorescent Dyes/chemistry ; Fluorescent Dyes/toxicity ; Humans ; Lanthanoid Series Elements/chemistry ; Lanthanoid Series Elements/toxicity ; Solubility ; Triazoles/chemistry ; Triazoles/toxicity
Chemical Substances	Chelating Agents ; Coordination Complexes ; Fluorescent Dyes ; Lanthanoid Series Elements ; Triazoles
Language	English
Publishing date	2013-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3151-3
ISSN	1520-6017 ; 0022-3549
ISSN (online)	1520-6017
ISSN	0022-3549
DOI	10.1002/jps.23616
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uf I Zs.50: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Safety and Efficacy of Vigabatrin for the Treatment of Infantile Spasms

Michele A. Faulkner / Justin A. Tolman

Journal of Central Nervous System Disease, Vol 2011, Iss 3, Pp 199-

2011 Volume 207

Keywords	Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Neurology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2011-09-01T00:00:00Z
Publisher	Libertas Academica
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book: Pharmaceutics

Dash, Alekha K / Singh, Somnath / Tolman, Justin

basic principles and application to pharmacy practice

2014

Author's details	edited by Alekha K. Dash, Somnath Singh, Justin Tolman
MeSH term(s)	Pharmacy/methods ; Pharmaceutical Preparations ; Chemistry, Pharmaceutical ; Drug Therapy
Language	English
Size	xiii, 378 pages :, illustrations
Document type	Book
ISBN	9780123868909 ; 0123868904
Database	Catalogue of the US National Library of Medicine (NLM)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED