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  1. Article: Cold agglutinin-mediated autoimmune haemolytic anaemia associated with COVID-19 infection: a case report.

    Chang, C Y / Chin, H H / Chin, P W / Zaid, M

    Hong Kong medical journal = Xianggang yi xue za zhi

    2022  Volume 28, Issue 3, Page(s) 257–259

    MeSH term(s) Agglutinins ; Anemia, Hemolytic, Autoimmune/diagnosis ; Anemia, Hemolytic, Autoimmune/etiology ; COVID-19/complications ; Cryoglobulins ; Humans
    Chemical Substances Agglutinins ; Cryoglobulins ; cold agglutinins
    Language English
    Publishing date 2022-04-27
    Publishing country China
    Document type Case Reports
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
    DOI 10.12809/hkmj219828
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4347: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Establishing a synthetic orthogonal replication system enables accelerated evolution in

    Tian, Rongzhen / Rehm, Fabian B H / Czernecki, Dariusz / Gu, Yangqi / Zürcher, Jérôme F / Liu, Kim C / Chin, Jason W

    Science (New York, N.Y.)

    2024  Volume 383, Issue 6681, Page(s) 421–426

    Abstract: The evolution of new function in living organisms is slow and fundamentally limited by their critical mutation rate. Here, we established a stable orthogonal replication system ... ...

    Abstract The evolution of new function in living organisms is slow and fundamentally limited by their critical mutation rate. Here, we established a stable orthogonal replication system in
    MeSH term(s) DNA Replication ; DNA-Directed DNA Polymerase/genetics ; DNA-Directed DNA Polymerase/metabolism ; Escherichia coli/drug effects ; Escherichia coli/genetics ; Escherichia coli Proteins/genetics ; Replicon ; Directed Molecular Evolution/methods ; Green Fluorescent Proteins/genetics ; Evolution, Molecular ; Tigecycline/pharmacology ; Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial/genetics ; Fluorescence
    Chemical Substances DNA-Directed DNA Polymerase (EC 2.7.7.7) ; Escherichia coli Proteins ; Green Fluorescent Proteins (147336-22-9) ; Tigecycline (70JE2N95KR) ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adk1281
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    Zs.A 27: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 77: Show issues

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  3. Article ; Online: Computational discoveries of reaction mechanisms: recent highlights and emerging challenges.

    Chin, Yuk Ping / See, Nicholas W / Jenkins, Ian D / Krenske, Elizabeth H

    Organic & biomolecular chemistry

    2022  Volume 20, Issue 10, Page(s) 2028–2042

    Abstract: This review examines some of the notable advances and trends that have shaped the field of computational elucidation of organic reaction mechanisms over the last 10-15 years. It highlights the types of mechanistic problems that have recently become ... ...

    Abstract This review examines some of the notable advances and trends that have shaped the field of computational elucidation of organic reaction mechanisms over the last 10-15 years. It highlights the types of mechanistic problems that have recently become possible to study and summarizes the methodological developments that have permitted these new advances. Case studies are taken from three representative areas of organic chemistry-asymmetric catalysis, glycosylation reactions, and single electron transfer reactions-which illustrate themes common to the broader field. These include the trend towards modelling systems that are increasingly complex (both structurally and mechanistically), the growing appreciation of the mechanistic roles of non-covalent interactions, and the increasing ability to explore dynamical features of reaction mechanisms. Some interesting new challenges that have emerged in the field are identified.
    Language English
    Publishing date 2022-03-09
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d1ob02139g
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  4. Article ; Online: Hot Instantaneous Temperature and Affect: Meaningful Activities as a Buffer for Older Adults With Low Socioeconomic Status.

    Lin, Zhixuan / Chin, David C W / Fung, Helene H / Lay, Jennifer C / Tse, Dwight C K

    Innovation in aging

    2023  Volume 7, Issue 6, Page(s) igad057

    Abstract: Background and objectives: Extremely hot temperature affects psychological well-being negatively, especially for older adults with lower socioeconomic status (SES). The objectives of this study are to examine: (a) the impact of hot instantaneous ... ...

    Abstract Background and objectives: Extremely hot temperature affects psychological well-being negatively, especially for older adults with lower socioeconomic status (SES). The objectives of this study are to examine: (a) the impact of hot instantaneous temperature on older adults' emotional well-being and (b) whether meaningful engagement could reduce the above impact, particularly for those of lower SES.
    Research design and methods: We conducted a quantitative time-sampling study during hot-weather months (May-September) in 2021 and 2022. The sample comprises 344 participants aged 60 years or older (
    Results: Hotter instantaneous temperature predicted greater momentary negative affect and less positive affect immediately afterwards. Meaningful engagement significantly buffered against the affective impacts of hotter temperature, and this buffering effect was more salient among older adults of lower SES.
    Discussion and implications: This study highlights the role of meaningful engagement in reducing the impact of hotter instantaneous temperature on older adults' emotional well-being, particularly for those of lower SES. Meaningful activity engagement may be capitalized on, as a strategy, to reduce climate-related social inequality.
    Language English
    Publishing date 2023-06-19
    Publishing country England
    Document type Journal Article
    ISSN 2399-5300
    ISSN (online) 2399-5300
    DOI 10.1093/geroni/igad057
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  5. Article ; Online: Bioinspired 3D microprinted cell scaffolds: Integration of graph theory to recapitulate complex network wiring in lymph nodes.

    Chin, Matthew H W / Reid, Barry / Lachina, Veronika / Acton, Sophie E / Coppens, Marc-Olivier

    Biotechnology journal

    2023  Volume 19, Issue 1, Page(s) e2300359

    Abstract: Physical networks are ubiquitous in nature, but many of them possess a complex organizational structure that is difficult to recapitulate in artificial systems. This is especially the case in biomedical and tissue engineering, where the microstructural ... ...

    Abstract Physical networks are ubiquitous in nature, but many of them possess a complex organizational structure that is difficult to recapitulate in artificial systems. This is especially the case in biomedical and tissue engineering, where the microstructural details of 3D cell scaffolds are important. Studies of biological networks-such as fibroblastic reticular cell (FRC) networks-have revealed the crucial role of network topology in a range of biological functions. However, cell scaffolds are rarely analyzed, or designed, using graph theory. To understand how networks affect adhered cells, 3D culture platforms capturing the complex topological properties of biologically relevant networks would be needed. In this work, we took inspiration from the small-world organization (high clustering and low path length) of FRC networks to design cell scaffolds. An algorithmic toolset was created to generate the networks and process them to improve their 3D printability. We employed tools from graph theory to show that the networks were small-world (omega factor, ω = -0.10 ± 0.02; small-world propensity, SWP = 0.74 ± 0.01). 3D microprinting was employed to physicalize networks as scaffolds, which supported the survival of FRCs. This work, therefore, represents a bioinspired, graph theory-driven approach to control the networks of microscale cell niches.
    MeSH term(s) Lymph Nodes ; Tissue Scaffolds
    Language English
    Publishing date 2023-11-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2221885-3
    ISSN 1860-7314 ; 1860-6768
    ISSN (online) 1860-7314
    ISSN 1860-6768
    DOI 10.1002/biot.202300359
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    Zs.A 6349: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  6. Article: A retrospective cross-sectional study on the risk factors and survival outcome of End Stage Kidney Disease patients receiving regular maintenance haemodialysis with COVID-19 infection in Hospital Enche' Besar Hajjah Khalsom, Kluang.

    Chin, H H / Chin, Y H / Yap, Y L / Tan, P S / Tiong, X T / Noor Hidayah, Y / Chin, P W

    The Medical journal of Malaysia

    2021  Volume 76, Issue 6, Page(s) 845–852

    Abstract: Introduction: COVID-19 pandemic has affected healthcare services around the globe as hospitals were turned into designated hospitals to accommodate high risk groups of patients with COVID-19 infection including end stage kidney disease (ESKD) patients. ... ...

    Abstract Introduction: COVID-19 pandemic has affected healthcare services around the globe as hospitals were turned into designated hospitals to accommodate high risk groups of patients with COVID-19 infection including end stage kidney disease (ESKD) patients. In Malaysia, there was insufficient data on COVID-19 infection among ESKD patients. This study aims to determine factors and survival outcomes associated with COVID-19 infection among ESKD patients in a designated COVID-19 hospital in Malaysia.
    Methods and materials: A retrospective cross-sectional study involving 80 haemodialysis (HD) patients recruited from March 2020 till March 2021. Patients' information and results was retrieved and evaluated. Risk factors affecting the COVID-19 mortality were analysed using a one-way analysis of variance (ANOVA) and binary logistic regression.
    Results: The mean age of the patients was 54 years who were predominantly Malays (87.5%) and living in rural areas. Majority of them had comorbidities such as diabetes mellitus (71%) and hypertension (90%). The most common presentations were fever (46%) and cough (54%) with chest radiographs showing bilateral lower zone ground glass opacities (45%). A quarter of the study population were admitted to the intensive care unit, necessitating mechanical ventilation. This study found that 51% of the patients were given steroids and 45% required oxygen supplementation. The COVID-19 infection mortality among the study population was 12.5%. Simple logistic regression analysis showed that albumin, Odd Ratio, OR=0.85 (95% Confidence Interval, 95%CI: 0.73, 0.98)) and absolute lymphocyte count OR=0.08 (95%CI: 0.11, 0.56) have inverse association with COVID-19 mortality. C-reactive protein OR=1.02 (95%CI: 1.01, 1.04), lactate dehydrogenase OR=1.01 (95%CI: 1.00, 1.01), mechanical ventilation OR=17.21 (95%CI: 3.03, 97.67) and high dose steroids OR=15.71 (95%CI: 1.80, 137.42) were directly associated with COVID-19 mortality.
    Conclusion: The high mortality rate among ESKD patients receiving HD was alarming. This warrants additional infection control measures to prevent the spread of COVID- 19 infection among this vulnerable group of patients. Expediting vaccination efforts in this group of patients should be advocated to reduce the incidence of complications from COVID-19 infection.
    MeSH term(s) COVID-19 ; Cross-Sectional Studies ; Hospitals ; Humans ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/therapy ; Middle Aged ; Pandemics ; Renal Dialysis ; Retrospective Studies ; Risk Factors ; SARS-CoV-2
    Language English
    Publishing date 2021-11-26
    Publishing country Malaysia
    Document type Journal Article
    ZDB-ID 604286-7
    ISSN 0300-5283
    ISSN 0300-5283
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1206: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Acute pericarditis as a clinical manifestation in COVID-19 infection in a district hospital setting.

    Tai, S S / Siek, S S / Siti Hajar, M F / Azri, A M / Chin, H H / Chin, P W

    The Medical journal of Malaysia

    2022  Volume 77, Issue 3, Page(s) 393–395

    Abstract: The global outbreak of coronavirus disease 2019(COVID-19) pandemic has heavily impacted the health service, leading to increased mortality and morbidity. Although known to manifest primarily as a respiratory illness, there are reports of cardiac ... ...

    Abstract The global outbreak of coronavirus disease 2019(COVID-19) pandemic has heavily impacted the health service, leading to increased mortality and morbidity. Although known to manifest primarily as a respiratory illness, there are reports of cardiac involvement as extrapulmonary manifestation. We are reporting a case of pericarditis in a young patient who presented with only cardiac symptoms in COVID-19. He was admitted to the hospital for observation and treated with oral colchicine and oral ibuprofen. His conditions improved and subsequently discharged well. Acute pericarditis can present as part of the COVID-19 extrapulmonary spectrum. Therefore, it is important and challenging for clinicians to recognise the atypical presentations of COVID-19 to reduce morbidity and mortality.
    MeSH term(s) COVID-19/complications ; Disease Outbreaks ; Hospitalization ; Hospitals, District ; Humans ; Male ; Pericarditis/diagnosis ; Pericarditis/drug therapy ; Pericarditis/etiology
    Language English
    Publishing date 2022-05-31
    Publishing country Malaysia
    Document type Case Reports ; Journal Article
    ZDB-ID 604286-7
    ISSN 0300-5283
    ISSN 0300-5283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1206: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Stability of SARS-CoV-2 in different environmental conditions - Authors' reply.

    Chin, Alex W H / Poon, Leo L M

    The Lancet. Microbe

    2020  Volume 1, Issue 4, Page(s) e146

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2020-08-06
    Publishing country England
    Document type Letter ; Comment
    ISSN 2666-5247
    ISSN (online) 2666-5247
    DOI 10.1016/S2666-5247(20)30095-1
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  9. Article ; Online: Deleting IP6K1 stabilizes neuronal sodium-potassium pumps and suppresses excitability.

    Jin, Hongfu / Liu, Aili / Chin, Alfred C / Fu, Chenglai / Shen, Hui / Cheng, Weiwei

    Molecular brain

    2024  Volume 17, Issue 1, Page(s) 8

    Abstract: Inositol pyrophosphates are key signaling molecules that regulate diverse neurobiological processes. We previously reported that the inositol pyrophosphate 5- ... ...

    Abstract Inositol pyrophosphates are key signaling molecules that regulate diverse neurobiological processes. We previously reported that the inositol pyrophosphate 5-InsP
    MeSH term(s) Sodium-Potassium-Exchanging ATPase ; Inositol ; Signal Transduction ; Protein Transport ; Neurons/physiology
    Chemical Substances Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13) ; Inositol (4L6452S749)
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2436057-0
    ISSN 1756-6606 ; 1756-6606
    ISSN (online) 1756-6606
    ISSN 1756-6606
    DOI 10.1186/s13041-024-01080-y
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  10. Article ; Online: Unilateral Diaphragmatic Paralysis After Stereotactic Ablative Radiation Therapy to a Lung Tumor Abutting the Course of the Phrenic Nerve.

    Eke, Iris / Guo, H Henry / Loo, Billy W / Sung, Arthur W / Diehn, Maximilian / Vitzthum, Lucas / Chin, Alexander L / Gensheimer, Michael F

    Practical radiation oncology

    2023  Volume 13, Issue 5, Page(s) e383–e388

    Abstract: We present the case of a woman with metastatic adenoid cystic carcinoma who received stereotactic ablative radiation therapy with a total dose of 50 Gy in 4 fractions to 2 lung metastases and developed symptomatic left phrenic nerve injury 2 years after ... ...

    Abstract We present the case of a woman with metastatic adenoid cystic carcinoma who received stereotactic ablative radiation therapy with a total dose of 50 Gy in 4 fractions to 2 lung metastases and developed symptomatic left phrenic nerve injury 2 years after radiation. The maximum dose to the approximate location of the phrenic nerve was 57.7 Gy, which corresponds to a biologically effective dose for late effects (using α/β ratio = 3) of 335.14 Gy. Here, we discuss the case, planning considerations by radiation oncologists and medical physicists, and the multidisciplinary medical management of this patient.
    MeSH term(s) Female ; Humans ; Phrenic Nerve/pathology ; Respiratory Paralysis/etiology ; Lung Neoplasms/pathology ; Radiosurgery/adverse effects ; Disease Progression
    Language English
    Publishing date 2023-05-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2655748-4
    ISSN 1879-8519 ; 1879-8500
    ISSN (online) 1879-8519
    ISSN 1879-8500
    DOI 10.1016/j.prro.2023.04.010
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