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Article ; Online: Effects of Vitamin D Supplementation on Telomere Length: An Analysis of Data from the Randomised Controlled D-Health Trial.

Rahman, S T / Waterhouse, M / Pham, H / Duarte Romero, B / Baxter, C / McLeod, D S A / English, D R / Ebeling, P R / Hartel, G / Armstrong, B K / O'Connell, R L / van der Pols, J C / Venn, A J / Webb, P M / Wells, J K / Whiteman, D C / Pickett, H A / Neale, R E

The journal of nutrition, health & aging

2023 Volume 27, Issue 8, Page(s) 609–616

Abstract: Objectives: Observational studies have suggested that a higher 25-hydroxyvitamin D concentration ... trial of monthly vitamin D (the D-Health Trial) for the prevention of all-cause mortality, conducted ... from 2014 to 2020, to assess the effect of vitamin D supplementation on telomere length (measured ...

Abstract	Objectives: Observational studies have suggested that a higher 25-hydroxyvitamin D concentration may be associated with longer telomere length; however, this has not been investigated in randomised controlled trials. We conducted an ancillary study within a randomised, double-blind, placebo-controlled trial of monthly vitamin D (the D-Health Trial) for the prevention of all-cause mortality, conducted from 2014 to 2020, to assess the effect of vitamin D supplementation on telomere length (measured as the telomere to single copy gene (T/S) ratio). Design, setting, participants, and intervention: Participants were Australians aged 60-84 years and we randomly selected 1,519 D-Health participants (vitamin D: n=744; placebo: n=775) for this analysis. We used quantitative polymerase chain reaction to measure the relative telomere length (T/S ratio) at 4 or 5 years after randomisation. We compared the mean T/S ratio between the vitamin D and placebo groups to assess the effect of vitamin D supplementation on relative telomere length, using a linear regression model with adjustment for age, sex, and state which were used to stratify the randomisation. Results: The mean T/S ratio was 0.70 for both groups (standard deviation 0.18 and 0.16 for the vitamin D and placebo groups respectively). The adjusted mean difference (vitamin D minus placebo) was -0.001 (95% CI -0.02 to 0.02). There was no effect modification by age, sex, body mass index, or predicted baseline 25-hydroxyvitamin D concentration. Conclusion: In conclusion, routinely supplementing older adults, who are largely vitamin D replete, with monthly doses of vitamin D is unlikely to influence telomere length.
MeSH term(s)	Humans ; Aged ; Australia ; Vitamins/pharmacology ; Vitamins/therapeutic use ; Vitamin D ; Calcifediol ; Telomere ; Dietary Supplements ; Randomized Controlled Trials as Topic
Chemical Substances	Vitamins ; Vitamin D (1406-16-2) ; Calcifediol (P6YZ13C99Q)
Language	English
Publishing date	2023-09-12
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2081921-3
ISSN	1760-4788 ; 1279-7707
ISSN (online)	1760-4788
ISSN	1279-7707
DOI	10.1007/s12603-023-1948-3
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Article ; Online: The Effect of Vitamin D Supplementation on Hypothyroidism in the Randomized Controlled D-Health Trial.

Waterhouse, Mary / Pham, Hai / Rahman, Sabbir T / Baxter, Catherine / Duarte Romero, Briony / Armstrong, Bruce K / Ebeling, Peter R / English, Dallas R / Hartel, Gunter / van der Pols, Jolieke C / Venn, Alison J / Webb, Penelope M / Whiteman, David C / McLeod, Donald S A / Neale, Rachel E

Thyroid : official journal of the American Thyroid Association

2023 Volume 33, Issue 11, Page(s) 1302–1310

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Male ; Female ; Humans ; Middle Aged ; Aged ; Thyroxine ; Australia/epidemiology ; Vitamin D/therapeutic use ; Vitamins/therapeutic use ; Pharmaceutical Preparations ; Dietary Supplements/analysis ; Hypothyroidism/drug therapy ; Hypothyroidism/epidemiology ; Hypothyroidism/prevention & control ; Double-Blind Method ; Randomized Controlled Trials as Topic
Chemical Substances	Thyroxine (Q51BO43MG4) ; Vitamin D (1406-16-2) ; Vitamins ; Pharmaceutical Preparations
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1086044-7
ISSN	1557-9077 ; 1050-7256
ISSN (online)	1557-9077
ISSN	1050-7256
DOI	10.1089/thy.2023.0317
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Article ; Online: Vitamin D supplementation and cognition-Results from analyses of the D-Health trial.

Pham, Hai / Waterhouse, Mary / Rahman, Sabbir / Baxter, Catherine / Romero, Briony Duarte / McLeod, Donald S A / Armstrong, Bruce K / Ebeling, Peter R / English, Dallas R / Hartel, Gunter / Kimlin, Michael G / O'Connell, Rachel L / van der Pols, Jolieke C / Venn, Alison J / Webb, Penelope M / Whiteman, David C / Almeida, Osvaldo P / Neale, Rachel E

Journal of the American Geriatrics Society

2023 Volume 71, Issue 6, Page(s) 1773–1784

Abstract: ... hydroxyvitamin D concentration and higher risk of cognitive impairment. Results from randomized controlled trials ... 315 community-dwelling Australians aged between 60 and 84 years to participate in the D-Health Trial ... international units of vitamin D or placebo for 5 years. We assessed cognitive function in a randomly sampled ...

Abstract	Background: Observational studies have consistently found a link between low serum 25-hydroxyvitamin D concentration and higher risk of cognitive impairment. Results from randomized controlled trials have been mixed, and few have been conducted in the general population. Methods: We recruited 21,315 community-dwelling Australians aged between 60 and 84 years to participate in the D-Health Trial, a randomized, double-blind, placebo-controlled trial. The intervention was monthly oral doses of 60,000 international units of vitamin D or placebo for 5 years. We assessed cognitive function in a randomly sampled group of participants aged ≥70 years using the Telephone Interview for Cognitive Status (TICS) at 2 and 5 years after randomization. The primary outcome for this analysis was TICS score; the secondary outcome was the proportion of people who had cognitive impairment (defined as TICS score ≤25). We analyzed data using mixed models (linear and logistic). Results: We interviewed 3887 participants at year 2 and 3614 participants at year 5. The mean TICS score at these time points was 32.3 and 32.2, respectively. Vitamin D supplementation did not affect cognitive function as measured by TICS score (mean difference between vitamin D and placebo groups 0.04; 95% CI -0.14 to 0.23), or alter risk of cognitive impairment (odds ratio 1.00; 95% CI 0.75 to 1.33). Conclusions: Monthly bolus doses of vitamin D supplementation neither enhanced nor hindered cognitive function among older adults. Population-wide vitamin D supplementation of older adults that are largely vitamin D replete is unlikely to substantially benefit cognition.
MeSH term(s)	Humans ; Aged ; Aged, 80 and over ; Dietary Supplements ; Australia/epidemiology ; Vitamins/therapeutic use ; Vitamin D ; Cognition ; Double-Blind Method ; Cholecalciferol ; Randomized Controlled Trials as Topic
Chemical Substances	Vitamins ; Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41)
Language	English
Publishing date	2023-01-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80363-7
ISSN	1532-5415 ; 0002-8614
ISSN (online)	1532-5415
ISSN	0002-8614
DOI	10.1111/jgs.18247
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Article ; Online: The effect of three years of vitamin D supplementation on erectile dysfunction: Results from the randomized placebo-controlled D-Health Trial.

Duarte Romero, Briony / Waterhouse, Mary / Baxter, Catherine / McLeod, Donald S A / English, Dallas R / Armstrong, Bruce K / Chung, Eric / Ebeling, Peter R / Hartel, Gunter / van der Pols, Jolieke C / Roberts, Matthew / Venn, Alison J / Webb, Penelope M / Whiteman, David C / Neale, Rachel E

Clinical nutrition ESPEN

2024 Volume 60, Page(s) 109–115

Abstract: ... serum 25-hydroxy vitamin D concentration. However, this association may be due to uncontrolled ... of vitamin D supplementation on the prevalence of erectile dysfunction, in an exploratory analysis using data ... from a large randomized controlled trial.: Methods: The D-Health Trial recruited Australians aged 60-84 ...

Abstract	Background & aims: Erectile dysfunction is common among older men and has been associated with low serum 25-hydroxy vitamin D concentration. However, this association may be due to uncontrolled confounding, and there is a paucity of evidence from interventional studies. We aimed to examine the effect of vitamin D supplementation on the prevalence of erectile dysfunction, in an exploratory analysis using data from a large randomized controlled trial. Methods: The D-Health Trial recruited Australians aged 60-84 years between January 2014 and May 2015 and randomly assigned them to supplementation with 60,000 IU of vitamin D or placebo per month for up to 5 years. Blood samples were collected annually from randomly selected participants (total N = 3943). We assessed erectile dysfunction at the end of the third year of follow-up. We used log-binomial regression to examine the effect of vitamin D on the prevalence of erectile dysfunction overall, and within sub-groups. Results: Of the 11,530 men enrolled, 8920 (77.4 %) completed the erectile dysfunction question and were included in the analysis. After three years of supplementation, the mean serum 25-hydroxy vitamin D concentration was 76 nmol/L (standard deviation (SD) 24.94) in the placebo group and 106 nmol/L (SD 26.76) in the vitamin D group (p < 0.0001). The prevalence of erectile dysfunction was 58.8 % and 59.0 % in the vitamin D and placebo groups, respectively (prevalence ratio 1.00, 95 % CI 0.97, 1.03); there was no evidence of an effect of vitamin D in any subgroup analyses. Conclusion: Supplementing older men with vitamin D is unlikely to prevent or improve erectile dysfunction. Clinical trials registry: (ACTRN12613000743763).
MeSH term(s)	Male ; Humans ; Aged ; Erectile Dysfunction/drug therapy ; Erectile Dysfunction/epidemiology ; Dietary Supplements ; Australia/epidemiology ; Vitamin D ; Vitamins/therapeutic use ; Calcifediol ; Australasian People
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins ; Calcifediol (P6YZ13C99Q)
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2405-4577
ISSN (online)	2405-4577
DOI	10.1016/j.clnesp.2024.01.011
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Article ; Online: The effect of monthly vitamin D supplementation on fractures: a tertiary outcome from the population-based, double-blind, randomised, placebo-controlled D-Health trial.

Waterhouse, Mary / Ebeling, Peter R / McLeod, Donald S A / English, Dallas / Romero, Briony Duarte / Baxter, Catherine / Armstrong, Bruce K / Hartel, Gunter / Kimlin, Michael / O'Connell, Rachel L / van der Pols, Jolieke C / Venn, Alison J / Webb, Penelope M / Whiteman, David C / Neale, Rachel E

The lancet. Diabetes & endocrinology

2023 Volume 11, Issue 5, Page(s) 324–332

Abstract: Background: Low serum 25-hydroxy vitamin D concentration is associated with increased fracture ... risk. It is uncertain whether vitamin D supplementation reduces fractures, or whether intermittent ... doses of 60 000 international units (IU) vitamin D: Methods: We did a population-based, double-blind ...

Abstract	Background: Low serum 25-hydroxy vitamin D concentration is associated with increased fracture risk. It is uncertain whether vitamin D supplementation reduces fractures, or whether intermittent doses are harmful. We aimed to investigate if supplementing adults living in Australia with monthly doses of 60 000 international units (IU) vitamin D Methods: We did a population-based, double-blind, randomised, placebo-controlled trial of oral vitamin D Findings: Between Feb 14, 2014, and June 17, 2015, we recruited 21 315 participants. For the current analysis, we included 20 326 participants (vitamin D 10 154 [50·0%]; placebo 10 172 [50·0%]). 9295 (45·7%) of 20 326 participants were women and the mean age was 69·3 years (SD 5·5). Over a median follow-up of 5·1 years (IQR 5·1-5·1), 568 (5·6%) participants in the vitamin D group and 603 (5·9%) in the placebo group had one or more fractures. There was no effect on fracture risk overall (HR 0·94 [95% CI 0·84-1·06]), and the interaction between randomisation group and time was not significant (p=0·14). However, the HR for total fractures appeared to decrease with increasing follow-up time. The overall HRs for non-vertebral, major osteoporotic, and hip fractures were 0·96 (95% CI 0·85-1·08), 1·00 (0·85-1·18), and 1·11 (0·86-1·45), respectively. Interpretation: These findings do not support concerns that bolus doses of vitamin D administered monthly increase fracture risk. Long-term supplementation might reduce the incidence of total fractures, but additional research is needed to clarify this effect. Funding: Australian National Health and Medical Research Council.
MeSH term(s)	Adult ; Female ; Humans ; Aged ; Male ; Australia/epidemiology ; Vitamin D ; Vitamins/therapeutic use ; Cholecalciferol/therapeutic use ; Hip Fractures ; Double-Blind Method ; Dietary Supplements
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins ; Cholecalciferol (1C6V77QF41)
Language	English
Publishing date	2023-03-31
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2213-8595
ISSN (online)	2213-8595
DOI	10.1016/S2213-8587(23)00063-3
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Article ; Online: The D-Health Trial: a randomised controlled trial of the effect of vitamin D on mortality.

Neale, Rachel E / Baxter, Catherine / Romero, Briony Duarte / McLeod, Donald S A / English, Dallas R / Armstrong, Bruce K / Ebeling, Peter R / Hartel, Gunter / Kimlin, Michael G / O'Connell, Rachel / van der Pols, Jolieke C / Venn, Alison J / Webb, Penelope M / Whiteman, David C / Waterhouse, Mary

The lancet. Diabetes & endocrinology

2022 Volume 10, Issue 2, Page(s) 120–128

Abstract: Background: The effect of supplementing unscreened adults with vitamin D: Methods: We did ... a randomised, double-blind, placebo-controlled trial of oral vitamin D: Findings: Between Feb 14, 2014, and ... June 17, 2015, we randomly assigned 21 315 participants, including 10 662 to the vitamin D group and 10 ...

Abstract	Background: The effect of supplementing unscreened adults with vitamin D Methods: We did a randomised, double-blind, placebo-controlled trial of oral vitamin D Findings: Between Feb 14, 2014, and June 17, 2015, we randomly assigned 21 315 participants, including 10 662 to the vitamin D group and 10 653 to the placebo group. In 4441 blood samples collected from randomly sampled participants (N=3943) during follow-up, mean serum 25-hydroxy-vitamin D concentrations were 77 (SD 25) in the placebo group and 115 (SD 30) nmol/L in the vitamin D group. Following 5 years of intervention (median follow-up 5·7 years [IQR 5·4-6·7]), 1100 deaths were recorded (placebo 538 [5·1%]; vitamin D 562 [5·3%]). 10 661 participants in the vitamin D group and 10 649 participants in the placebo group were included in the primary analysis. Five participants (one in the vitamin D group and four in the placebo group) were not included as they requested to be withdrawn and their data to be destroyed. The HR of vitamin D Interpretation: Administering vitamin D Funding: The D-Health Trial is funded by National Health and Medical Research Council.
MeSH term(s)	Adult ; Aged ; Australia/epidemiology ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/prevention & control ; Cholecalciferol/therapeutic use ; Dietary Supplements ; Double-Blind Method ; Humans ; Vitamin D ; Vitamins/therapeutic use
Chemical Substances	Vitamins ; Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41)
Language	English
Publishing date	2022-01-10
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ISSN	2213-8595
ISSN (online)	2213-8595
DOI	10.1016/S2213-8587(21)00345-4
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Article ; Online: Vitamin D Supplementation and the Incidence of Cataract Surgery in Older Australian Adults.

Rahman, Sabbir T / Waterhouse, Mary / Romero, Briony Duarte / Baxter, Catherine / English, Dallas / Mackey, David A / Ebeling, Peter R / Armstrong, Bruce K / McLeod, Donald S A / Hartel, Gunter / O'Connell, Rachel L / van der Pols, Jolieke C / Venn, Alison J / Webb, Penelope M / Whiteman, David C / Neale, Rachel E

Ophthalmology

2022 Volume 130, Issue 3, Page(s) 313–323

Abstract: Purpose: Observational studies suggest that higher serum 25-hydroxy vitamin D (25(OH)D ... assessed the effect of vitamin D supplementation on the incidence of cataract. We aimed to assess ... whether vitamin D supplementation reduces the incidence of cataract surgery.: Design: We conducted an ancillary ...

Abstract	Purpose: Observational studies suggest that higher serum 25-hydroxy vitamin D (25(OH)D) concentration may be associated with lower risk of cataract. However, no randomized controlled trials have assessed the effect of vitamin D supplementation on the incidence of cataract. We aimed to assess whether vitamin D supplementation reduces the incidence of cataract surgery. Design: We conducted an ancillary study of the D-Health Trial, a randomized, double-masked, placebo-controlled trial of monthly vitamin D conducted from 2014 through 2020 within the Australian general population. Participants: We invited 421 207 men and women 60 to 84 years of age to participate; including an additional 1896 volunteers, 40 824 expressed interest. Those with hypercalcemia, hyperparathyroidism, kidney stones, osteomalacia, or sarcoidosis or those who were taking more than 500 international units (IU) supplemental vitamin D per day were excluded. A total of 21 315 were randomized, and 1390 participants did not fulfil the eligibility criteria for this analysis (linked data available, no cataract within first 6 months), leaving 19 925 included. The median follow-up was 5 years. Methods: Participants took 60 000 IU of vitamin D Main outcome measures: The primary outcome for this analysis was the first surgical treatment for cataract, ascertained through linkage to universal health insurance records and hospital data. Results: Among 19 925 participants eligible for this analysis (mean age, 69.3 years; 46% women) 3668 participants (18.4%) underwent cataract surgery during follow-up (vitamin D: n = 1841 [18.5%]; placebo: n = 1827 [18.3%] ). The incidence of cataract surgery was similar between the two groups (incidence rate, 41.6 and 41.1 per 1000 person-years in the vitamin D and placebo groups, respectively; hazard ratio, 1.02; 95% confidence interval, 0.95-1.09). In prespecified subgroup analyses, the effect of vitamin D supplementation on the incidence of cataract surgery was not modified by age, sex, body mass index, predicted serum 25(OH)D concentration, or ambient ultraviolet radiation. Conclusions: Routinely supplementing older adults who live in an area with a low prevalence of vitamin D deficiency with high-dose vitamin D is unlikely to reduce the need for cataract surgery. Financial disclosure(s): Proprietary or commercial disclosure may be found after the references.
MeSH term(s)	Male ; Humans ; Female ; Aged ; Incidence ; Ultraviolet Rays ; Australia ; Vitamin D ; Vitamins ; Dietary Supplements ; Double-Blind Method
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins
Language	English
Publishing date	2022-09-27
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	392083-5
ISSN	1549-4713 ; 0161-6420
ISSN (online)	1549-4713
ISSN	0161-6420
DOI	10.1016/j.ophtha.2022.09.015
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Article ; Online: Vitamin D supplementation and major cardiovascular events: D-Health randomised controlled trial.

Thompson, Bridie / Waterhouse, Mary / English, Dallas R / McLeod, Donald S / Armstrong, Bruce K / Baxter, Catherine / Duarte Romero, Briony / Ebeling, Peter R / Hartel, Gunter / Kimlin, Michael G / Rahman, Sabbir T / van der Pols, Jolieke C / Venn, Alison J / Webb, Penelope M / Whiteman, David C / Neale, Rachel E

BMJ (Clinical research ed.)

2023 Volume 381, Page(s) e075230

Abstract: Objective: To investigate whether supplementing older adults with monthly doses of vitamin D ... controlled trial of monthly vitamin D (the D-Health Trial). Computer generated permuted block randomisation ... hyperparathyroidism, kidney stones, osteomalacia, sarcoidosis, taking >500 IU/day supplemental vitamin D, or unable ...

Abstract	Objective: To investigate whether supplementing older adults with monthly doses of vitamin D alters the incidence of major cardiovascular events. Design: Randomised, double blind, placebo controlled trial of monthly vitamin D (the D-Health Trial). Computer generated permuted block randomisation was used to allocate treatments. Setting: Australia from 2014 to 2020. Participants: 21 315 participants aged 60-84 years at enrolment. Exclusion criteria were self-reported hypercalcaemia, hyperparathyroidism, kidney stones, osteomalacia, sarcoidosis, taking >500 IU/day supplemental vitamin D, or unable to give consent because of language or cognitive impairment. Intervention: 60 000 IU/month vitamin D Main outcome measures: The main outcome for this analysis was the occurrence of a major cardiovascular event, including myocardial infarction, stroke, and coronary revascularisation, determined through linkage with administrative datasets. Each event was analysed separately as secondary outcomes. Flexible parametric survival models were used to estimate hazard ratios and 95% confidence intervals. Results: 21 302 people were included in the analysis. The median intervention period was five years. 1336 participants experienced a major cardiovascular event (placebo 699 (6.6%); vitamin D 637 (6.0%)). The rate of major cardiovascular events was lower in the vitamin D group than in the placebo group (hazard ratio 0.91, 95% confidence interval 0.81 to 1.01), especially among those who were taking cardiovascular drugs at baseline (0.84, 0.74 to 0.97; P for interaction=0.12), although the P value for interaction was not significant (<0.05). Overall, the difference in standardised cause specific cumulative incidence at five years was -5.8 events per 1000 participants (95% confidence interval -12.2 to 0.5 per 1000 participants), resulting in a number needed to treat to avoid one major cardiovascular event of 172. The rate of myocardial infarction (hazard ratio 0.81, 95% confidence interval 0.67 to 0.98) and coronary revascularisation (0.89, 0.78 to 1.01) was lower in the vitamin D group, but there was no difference in the rate of stroke (0.99, 0.80 to 1.23). Conclusions: Vitamin D supplementation might reduce the incidence of major cardiovascular events, although the absolute risk difference was small and the confidence interval was consistent with a null finding. These findings could prompt further evaluation of the role of vitamin D supplementation, particularly in people taking drugs for prevention or treatment of cardiovascular disease. Trial registration: ACTRN12613000743763.
MeSH term(s)	Humans ; Aged ; Vitamins/therapeutic use ; Cardiovascular Agents ; Vitamin D/therapeutic use ; Myocardial Infarction ; Dietary Supplements
Chemical Substances	Vitamins ; Cardiovascular Agents ; Vitamin D (1406-16-2)
Language	English
Publishing date	2023-06-28
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj-2023-075230
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Article ; Online: The effect of vitamin D supplementation on the gut microbiome in older Australians - Results from analyses of the D-Health Trial.

Pham, Hai / Waterhouse, Mary / Rahman, Sabbir / Baxter, Catherine / Duarte Romero, Briony / McLeod, Donald S A / Ebeling, Peter R / English, Dallas R / Hartel, Gunter / O'Connell, Rachel L / van der Pols, Jolieke C / Venn, Alison J / Webb, Penelope M / Whiteman, David C / Huygens, Flavia / Neale, Rachel E

Gut microbes

2023 Volume 15, Issue 1, Page(s) 2221429

Abstract: Observational studies suggest a link between vitamin D and the composition of the gut microbiome ... but there is little evidence from randomized controlled trials of vitamin D supplementation ... We analyzed data from the D-Health Trial, a randomized, double-blind, placebo-controlled trial. We recruited 21,315 ...

Abstract	Observational studies suggest a link between vitamin D and the composition of the gut microbiome, but there is little evidence from randomized controlled trials of vitamin D supplementation. We analyzed data from the D-Health Trial, a randomized, double-blind, placebo-controlled trial. We recruited 21,315 Australians aged 60-84 y and randomized them to 60,000 IU of vitamin D
MeSH term(s)	Aged ; Female ; Humans ; Male ; Australia ; Bacteroidetes ; Dietary Supplements ; Double-Blind Method ; Firmicutes ; Gastrointestinal Microbiome ; RNA, Ribosomal, 16S ; Vitamin D ; Aged, 80 and over
Chemical Substances	RNA, Ribosomal, 16S ; Vitamin D (1406-16-2)
Language	English
Publishing date	2023-06-07
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2575755-6
ISSN	1949-0984 ; 1949-0984
ISSN (online)	1949-0984
ISSN	1949-0984
DOI	10.1080/19490976.2023.2221429
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Article ; Online: Vitamin D and Sun Exposure: A Community Survey in Australia.

Tran, Vu / Janda, Monika / Lucas, Robyn M / McLeod, Donald S A / Thompson, Bridie S / Waterhouse, Mary / Whiteman, David C / Neale, Rachel E

Current oncology (Toronto, Ont.)

2023 Volume 30, Issue 2, Page(s) 2465–2481

Abstract: ... established benefit of exposure to ultraviolet (UV) radiation is vitamin D production. Australia has ... one quarter of the population is estimated to be vitamin D deficient. Balancing the risks and benefits ... knowledge and attitudes regarding sun exposure and vitamin D and to examine the associations between ...

Abstract	Sun exposure carries both harms and benefits. Exposing the skin to the sun is the main modifiable cause of skin cancers, which exert a considerable health and economic burden in Australia. The most well-established benefit of exposure to ultraviolet (UV) radiation is vitamin D production. Australia has the highest incidence of skin cancer in the world but, despite the high ambient UV radiation, approximately one quarter of the population is estimated to be vitamin D deficient. Balancing the risks and benefits is challenging and requires effective communication. We sought to provide a snapshot of public knowledge and attitudes regarding sun exposure and vitamin D and to examine the associations between these factors and sun protective behaviors. In 2020 we administered an online survey; 4824 participants with self-reported fair or medium skin color were included in this analysis. Only 25% and 34% of participants were able to identify the amount of time outdoors needed to maintain adequate vitamin D status in summer and winter, respectively and 25% were concerned that sunscreen use inhibits vitamin D synthesis. This lack of knowledge was associated with suboptimal sun protection practices. Public education is warranted to prevent over-exposure, while supporting natural vitamin D production.
MeSH term(s)	Humans ; Vitamin D ; Sunlight ; Vitamin D Deficiency ; Ultraviolet Rays ; Surveys and Questionnaires ; Skin Neoplasms
Chemical Substances	Vitamin D (1406-16-2)
Language	English
Publishing date	2023-02-18
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol30020188
Database	MEDical Literature Analysis and Retrieval System OnLINE

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