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Article: Potential adverse effects of blood pressure lowering--J-curve revisited.

Staessen, J A

1996 Volume 348, Issue 9029, Page(s) 696–697

MeSH term(s)	Aged ; Antihypertensive Agents/adverse effects ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/prevention & control ; Confounding Factors (Epidemiology) ; Coronary Artery Disease/etiology ; Follow-Up Studies ; Humans ; Hypertension/drug therapy ; Male ; Recurrence ; Risk Factors ; Survival Analysis
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	1996-09-14
Publishing country	England
Document type	Journal Article
ZDB-ID	3306-6
ISSN	1474-547X ; 0140-6736 ; 0023-7507
ISSN (online)	1474-547X
ISSN	0140-6736 ; 0023-7507
DOI	10.1016/S0140-6736(05)65599-7
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Ua VI Zs.5: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 94: Show issues

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Article: La technologie comme support à l'observance thérapeutique dans Les pharmacies ouvertes au public--Revue de la littérature.

Staessen, J

Journal de pharmacie de Belgique

2015 , Issue 1, Page(s) 16–23

Abstract: Introduction: Drug-related problems are very common and they need some specific attention. Improper use of medication as well as poor adherence leads to side effects, interaction, increased healthcare costs, ... : Aim: What technologies can be used in ... ...

Title translation	Technology to improve adherence in community pharmacy: a literature review.
Abstract	Introduction: Drug-related problems are very common and they need some specific attention. Improper use of medication as well as poor adherence leads to side effects, interaction, increased healthcare costs,... Aim: What technologies can be used in community pharmacies to improve drug adherence? Method: Articles were found in scientific databases Pubmed, Embase and CINAHL using a fixed search strategy. Results: In this review 21 studies were included. The different technologies were compared with each other. Reminders using sms or smartphone were the most effective. Conclusion: There are already plenty of reminder systems (SMS, Email, internet, smartphone) and practical tools (medication dispensers, MEMS) available in community pharmacies. A major hurdle is the lack of the infrastructure. There needs to be invested in systems were patients are confronted with their own drug use.
MeSH term(s)	Community Pharmacy Services/organization & administration ; Electronic Mail ; Humans ; Medication Adherence ; Patient Education as Topic ; Telephone
Language	French
Publishing date	2015-03
Publishing country	Belgium
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	840991-2
ISSN	0047-2166
ISSN	0047-2166
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Article ; Online: Body Position and Orthostatic Hypotension in Hypertensive Adults: Results from the Syst-Eur Trial.

Grobman, Ben / Turkson-Ocran, Ruth-Alma N / Staessen, Jan A / Yu, Yu-Ling / Lipsitz, Lewis A / Mukamal, Kenneth J / Juraschek, Stephen P

Hypertension (Dallas, Tex. : 1979)

2023 Volume 80, Issue 4, Page(s) 820–827

Abstract: Background: We recently demonstrated that more intensive blood pressure (BP) treatment lowered risk of orthostatic hypotension (OH) measured with a seated-to-standing protocol. However, seated-to-standing OH assessments are less sensitive than supine-to- ...

Abstract	Background: We recently demonstrated that more intensive blood pressure (BP) treatment lowered risk of orthostatic hypotension (OH) measured with a seated-to-standing protocol. However, seated-to-standing OH assessments are less sensitive than supine-to-standing and could miss clinically relevant OH. Objectives: Using data from the Syst-Eur trial (Systolic Hypertension in Europe), we examined the effect of hypertension treatment on incidence of OH based on the difference in BP from 3 body positions. Methods: Syst-Eur was a multi-center, randomized trial that enrolled adults with isolated systolic hypertension to investigate whether active hypertension treatment could reduce cardiovascular events. Participants underwent BP measurement in supine, seated, and standing positions. Using differences in BP between the 3 body positions (seated minus supine, standing minus seated, and standing minus supine), we defined OH as a drop in systolic BP ≥20 mm Hg or diastolic BP ≥10 mm Hg. We included measurements from baseline and follow-up visits. Results: Among 4695 participants (mean age, 70.2±6.7 years; 66.9% female) with 42 636 BP measurements, OH was present in 4.9% of measures with supine-to-seated, 7.9% with seated-to-standing, and 11.4% with supine-to-standing protocols, respectively. Compared with placebo, BP treatment did not increase OH with any set of maneuvers, OR, 0.79 (95% CI, 0.65-0.95) with seated-to standing, 1.03 (95% CI, 0.86-1.24) with supine-to-seated, and 0.99 (95% CI, 0.86-1.15) with supine-to-standing. Conclusions: Regardless of protocol, active hypertension treatment did not increase the risk of OH, reinforcing evidence that OH should not be viewed as a complication of hypertension treatment. Registration: URL: https://www. Clinicaltrials: gov; Unique identifier: NCT02088450.
MeSH term(s)	Humans ; Adult ; Female ; Middle Aged ; Aged ; Male ; Hypotension, Orthostatic/diagnosis ; Hypertension/diagnosis ; Hypertension/drug therapy ; Blood Pressure ; Posture ; Blood Pressure Determination/methods
Language	English
Publishing date	2023-02-06
Publishing country	United States
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	423736-5
ISSN	1524-4563 ; 0194-911X ; 0362-4323
ISSN (online)	1524-4563
ISSN	0194-911X ; 0362-4323
DOI	10.1161/HYPERTENSIONAHA.122.20602
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Zs.A 1488: Show issues

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Article: Effect of dietary NSP level and bile acid supplementation on nutrient digestibility and the bile acid metabolism in rainbow trout (Oncorhynchus mykiss)

Staessen, T.W.O. / Verdegem, M.C.J. / Schrama, J.W.

Aquaculture. 2022 Dec. 15, v. 561

2022

Abstract: The effects of dietary bile acid supplementation (BAS) on apparent digestibility coefficients (ADC) and the bile acid metabolism in rainbow trout (Oncorhynchus mykiss) were investigated for diets differing in non-starch polysaccharide (NSP) level. Four ... ...

Abstract	The effects of dietary bile acid supplementation (BAS) on apparent digestibility coefficients (ADC) and the bile acid metabolism in rainbow trout (Oncorhynchus mykiss) were investigated for diets differing in non-starch polysaccharide (NSP) level. Four experimental diets were formulated according to an 2 by 2 factorial design. A low-NSP and High-NSP diet (0 vs. 160 g kg⁻¹ inclusion of an NSP-rich ingredient mixture) were first formulated. The aim of this was to create differences in the amount of faecal waste produced, and consequently as previously shown in rainbow, the amount of faecal bile acid loss (FBAL). Both NSP-level diets were tested with 0% and 0.3% BAS (0 vs. 3 g kg⁻¹ inclusion of a bile acid mixture). The bile acid mixture contained taurocholic acid (T-CA) and glycocholic acid (G-CA) in a 2:1 ratio. Glycocholic acid does not naturally occur in trout and was used as marker to see if supplemented bile acids are efficiently absorbed and enter enterohepatic circulation (EHC). Fish were fed to apparent satiation for 42 days. Dietary NSP level did not enhance FBAL. BAS was beneficial for fat ADC, but not for the ADC of protein and carbohydrates. BAS improved fat ADC regardless of NSP level, which suggests that bile acids are a limiting factor for fat digestion in rainbow trout. Total bile acid synthesis was a 4-fold lower in fish fed the 0.3% BAS diets compared to the 0% BAS diets. Lower bile acid synthesis with BAS occurred alongside enlarged body and liver + gallbladder bile acid pools and a higher content of bile acids in the chyme. These higher bile acid levels most likely caused a negative feedback inhibition of bile acid synthesis. Negative synthesis rates of G-CA were found when feeding the 0.3% BAS diets, which suggests that this bile acid is catabolised or converted into other bile acid types in rainbow trout. The enlarged pool of T-CA, but especially of the body foreign G-CA, with BAS in both the body and liver + gallbladder shows that dietary bile acids are effectively taking part in EHC. The relative absorption of T-CA and G-CA over the different intestinal compartments was comparable, which shows that EHC does not differentiate between T-CA and G-CA. While relative absorption of bile acids was highest between the distal intestine and the faeces, the absolute decrease in chyme bile acid content was highest between the pyloric region and the mid intestine. The latter shows that significant bile acid absorption occurs more proximal in the intestine of rainbow trout than previously thought.
Keywords	Oncorhynchus mykiss ; absorption ; aquaculture ; bile ; digestibility ; feces ; gall bladder ; glycocholic acid ; ingredients ; intestines ; lipid metabolism ; liver ; polysaccharides ; satiety ; taurocholic acid ; trout
Language	English
Dates of publication	2022-1215
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	185380-6
ISSN	0044-8486 ; 0044-8516
ISSN	0044-8486 ; 0044-8516
DOI	10.1016/j.aquaculture.2022.738724
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: What did we learn from the International Databases on Ambulatory and Home Blood Pressure in Relation to Cardiovascular Outcome?

Asayama, Kei / Stolarz-Skrzypek, Katarzyna / Yang, Wen-Yi / Hansen, Tine W / Brguljan-Hitij, Jana / Odili, Augustine N / Li, Yan / Staessen, Jan A

Hypertension research : official journal of the Japanese Society of Hypertension

2023 Volume 46, Issue 4, Page(s) 934–949

Abstract: To assess in individual-person meta-analyses how out-of-office blood pressure (BP) contributes to risk stratification and the management of hypertension, an international consortium set up the International Databases on Ambulatory (IDACO) and Home ( ... ...

Abstract	To assess in individual-person meta-analyses how out-of-office blood pressure (BP) contributes to risk stratification and the management of hypertension, an international consortium set up the International Databases on Ambulatory (IDACO) and Home (IDHOCO) Blood Pressure in Relation to Cardiovascular Outcome. This review summarizes key findings of recent IDACO/IDHOCO articles. Among various BP indexes derived from office and ambulatory BP recordings, the 24-h and nighttime BP level were the best predictors of adverse health outcomes. Second, using the 10-year cardiovascular risk associated with guideline-endorsed office BP thresholds as reference, corresponding thresholds were derived for home and ambulatory BP. Stratified by the underlying cardiovascular risk, the rate of cardiovascular events in white-coat hypertensive patients and matched normotensive controls were not substantially different. The observation that masked hypertension carries a high cardiovascular risk was replicated in Nigerian Blacks, using home BP monitoring. The thresholds for 24-h mean arterial pressure, i.e., the BP component measured by oscillometric devices, delineating normotension, elevated BP and hypertension were <90, 90 to 92 and ≥92 mmHg. At young age, the absolute risk associated with out-of-office BP was low, but the relative risk was high, whereas with advancing age, the relative risk decreased and the absolute risk increased. Using pulse pressure as an exemplary case, the relative risks of death, cardiovascular endpoints and stroke decreased over 3-fold from 55 to 75 years of age, whereas in contrast absolute risk rose 3-fold. In conclusion, IDACO/IDHOCO forcefully support the notion that the pressing need to curb the hypertension pandemic cannot be met without out-of-the-office BP monitoring.
MeSH term(s)	Humans ; Blood Pressure/physiology ; Cardiovascular Diseases ; Risk Factors ; Hypertension ; Blood Pressure Determination ; Blood Pressure Monitoring, Ambulatory ; Masked Hypertension/diagnosis
Language	English
Publishing date	2023-02-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1175297-x
ISSN	1348-4214 ; 0916-9636
ISSN (online)	1348-4214
ISSN	0916-9636
DOI	10.1038/s41440-023-01191-4
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Zs.A 3898: Show issues

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Article: Treatment of Peripheral Circulatory Disturbances with Cinnarizine: A Multi-centre Double-blind, Placebo-controlled Evaluation.

Staessen, A J

Proceedings of the Royal Society of Medicine

2010 Volume 70, Issue Suppl 8, Page(s) 17–20

Language	English
Publishing date	2010-10-04
Publishing country	England
Document type	Journal Article
ZDB-ID	209243-8
ISSN	0035-9157
ISSN	0035-9157
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Article: Effect of type of dietary non‐protein energy source (starch vs. fat) on the body bile acid pool size and composition, faecal bile acid loss and bile acid synthesis in rainbow trout (Oncorhynchus mykiss)

Staessen, Thomas W. O / Verdegem, Marc C. J / Nederlof, Marit A. J / Eding, Ep H / Schrama, Johan W

Aquaculture nutrition. 2021 June, v. 27, no. 3

2021

Abstract: Effects of the type of dietary non‐protein energy source on the size and composition of the total body bile acid pool, on faecal bile acid loss and on bile acid synthesis were investigated in rainbow trout. Two diets were formulated (similar DP:DE ratio) ...

Abstract	Effects of the type of dietary non‐protein energy source on the size and composition of the total body bile acid pool, on faecal bile acid loss and on bile acid synthesis were investigated in rainbow trout. Two diets were formulated (similar DP:DE ratio) that differed in the inclusion of either maize starch (Starch) or rapeseed oil (Fat) as main non‐protein source. Fish were fed to satiation for 44 days. Type of non‐protein energy source did not substantially affect the body bile acid pool composition. However, feeding the Starch diet resulted in a larger total body bile acid pool size compared with the Fat diet, and this despite enhanced faecal bile acid loss when feeding the Starch diet that was related to more faeces being produced. Bile acid synthesis in fish fed the Starch diet was more than two times higher compared with fish fed the Fat diet. The difference in body bile acid pool size between diets suggests upregulation of bile acid synthesis in fish fed the Starch diet beyond the level needed to compensate for the higher faecal bile acid loss and/or downregulation of bile acid synthesis in fish fed the Fat diet. The underlying mechanisms for this difference in synthesis need further investigation.
Keywords	Oncorhynchus mykiss ; aquaculture ; bile acids ; corn starch ; diet ; energy ; feces ; fish ; rapeseed oil ; satiety ; starch
Language	English
Dates of publication	2021-06
Size	p. 865-879.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	NAL-AP-2-clean ; JOURNAL ARTICLE
ZDB-ID	1235332-2
ISSN	1365-2095 ; 1353-5773
ISSN (online)	1365-2095
ISSN	1353-5773
DOI	10.1111/anu.13231
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Proteomic Biomarkers in the Cardiorenal Syndrome: Toward Deciphering Molecular Pathophysiology.

He, Tianlin / Zhang, Zhenyu / Staessen, Jan A / Mischak, Harald / Latosinska, Agnieszka / Beige, Joachim

American journal of hypertension

2021 Volume 34, Issue 7, Page(s) 669–679

Abstract: Cardiorenal syndrome (CRS) is defined by coexisting heart and renal dysfunctions. Malfunction of 1 organ may cause dysfunction of the other with variable causative disease that defines the type of CRS (1-5). Numerous studies showed that the prevalence of ...

Abstract	Cardiorenal syndrome (CRS) is defined by coexisting heart and renal dysfunctions. Malfunction of 1 organ may cause dysfunction of the other with variable causative disease that defines the type of CRS (1-5). Numerous studies showed that the prevalence of cardiovascular disease is increased in patients with chronic kidney disease (CKD). Similarly, CKD affects a large proportion of patients with heart failure. This overlap between primary heart or primary kidney disease blurs cause-effect inferences of the initiator/target organ. The classical subdivision of CRS in 5 categories does not provide pathophysiological suggestions for targeted intervention. It seems timely to revisit the value of CRS biomarkers in a pathophysiology-centered approach. We systematically reviewed the literature in CRS, which revealed 53 clinical studies describing the use of 44 biomarkers and 4 proteomic panels. All biomarkers are involved in at least one of the CRS comorbidities. Among the pathways affected, inflammation, aberrant glucose metabolism, neurohormonal activation, and oxidative stress are well described. There is growing evidence that fibrosis may be the "cornerstone" that unifies most of the pathways leading to CRS. Formation of excess fibrous connective tissue antedates CRS in many cases. This review highlights that biomarkers reflecting fibrosis may be of substantial clinical value in the early detection, prognostication, and guiding treatment of CRS. Biomarkers detecting changes in collagen turnover in the extracellular matrix of heart and kidney appear able to depict subclinical changes in the fibrotic remodeling of tissues and constitute a promising approach toward personalized intervention in CRS.
MeSH term(s)	Biomarkers ; Cardio-Renal Syndrome/diagnosis ; Cardio-Renal Syndrome/physiopathology ; Fibrosis ; Humans ; Proteomics
Chemical Substances	Biomarkers
Language	English
Publishing date	2021-04-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	639383-4
ISSN	1941-7225 ; 1879-1905 ; 0895-7061
ISSN (online)	1941-7225 ; 1879-1905
ISSN	0895-7061
DOI	10.1093/ajh/hpaa201
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Article ; Online: Effect of Spironolactone on QRS Duration in Patients at Risk for Heart Failure (from the HOMAGE Trial).

Ferreira, João Pedro / Cleland, John G F / Girerd, Nicolas / Pellicori, Pierpaolo / Hazebroek, Mark R / Verdonschot, Job / Collier, Timothy J / Petutschnigg, Johannes / Clark, Andrew L / Staessen, Jan A / Heymans, Stephane / Rossignol, Patrick / Zannad, Faiez

The American journal of cardiology

2023 Volume 191, Page(s) 39–42

Abstract: The QRS duration can be easily obtained from a 12-lead electrocardiogram. Increased QRS duration reflects greater ventricular activation times and often ventricular dyssynchrony. Dyssynchrony causes an impairment of the global cardiac function and ... ...

Abstract	The QRS duration can be easily obtained from a 12-lead electrocardiogram. Increased QRS duration reflects greater ventricular activation times and often ventricular dyssynchrony. Dyssynchrony causes an impairment of the global cardiac function and adversely affects the prognosis of patients with heart failure (HF). Little is known about the impact of pharmacologic therapies on the QRS duration, particularly for patients with presymptomatic HF with a preserved left ventricular (LV) ejection fraction (i.e., stage B HF with preserved ejection fraction [HFpEF]). The HOMAGE (Heart OMics in AGEing) trial enrolled patients at risk factors for developing HF and assigned them to receive either spironolactone or the usual care for approximately 9 months in a randomized manner. This analysis reports the effect of spironolactone on the QRS duration. A total of 525 patients was included in the analysis. The median (percentile
MeSH term(s)	Humans ; Heart Failure ; Spironolactone/therapeutic use ; Stroke Volume/physiology ; Ventricular Function, Left/physiology
Chemical Substances	Procollagen Type I ; Spironolactone (27O7W4T232)
Language	English
Publishing date	2023-01-10
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2022.12.016
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Article ; Online: Effect of dietary NSP level and bile acid supplementation on nutrient digestibility and the bile acid metabolism in rainbow trout (Oncorhynchus mykiss)

Staessen, T.W.O. / Verdegem, M.C.J. / Schrama, J.W.

Aquaculture

2022 Volume 561

Abstract	The effects of dietary bile acid supplementation (BAS) on apparent digestibility coefficients (ADC) and the bile acid metabolism in rainbow trout (Oncorhynchus mykiss) were investigated for diets differing in non-starch polysaccharide (NSP) level. Four experimental diets were formulated according to an 2 by 2 factorial design. A low-NSP and High-NSP diet (0 vs. 160 g kg−1 inclusion of an NSP-rich ingredient mixture) were first formulated. The aim of this was to create differences in the amount of faecal waste produced, and consequently as previously shown in rainbow, the amount of faecal bile acid loss (FBAL). Both NSP-level diets were tested with 0% and 0.3% BAS (0 vs. 3 g kg−1 inclusion of a bile acid mixture). The bile acid mixture contained taurocholic acid (T-CA) and glycocholic acid (G-CA) in a 2:1 ratio. Glycocholic acid does not naturally occur in trout and was used as marker to see if supplemented bile acids are efficiently absorbed and enter enterohepatic circulation (EHC). Fish were fed to apparent satiation for 42 days. Dietary NSP level did not enhance FBAL. BAS was beneficial for fat ADC, but not for the ADC of protein and carbohydrates. BAS improved fat ADC regardless of NSP level, which suggests that bile acids are a limiting factor for fat digestion in rainbow trout. Total bile acid synthesis was a 4-fold lower in fish fed the 0.3% BAS diets compared to the 0% BAS diets. Lower bile acid synthesis with BAS occurred alongside enlarged body and liver + gallbladder bile acid pools and a higher content of bile acids in the chyme. These higher bile acid levels most likely caused a negative feedback inhibition of bile acid synthesis. Negative synthesis rates of G-CA were found when feeding the 0.3% BAS diets, which suggests that this bile acid is catabolised or converted into other bile acid types in rainbow trout. The enlarged pool of T-CA, but especially of the body foreign G-CA, with BAS in both the body and liver + gallbladder shows that dietary bile acids are effectively taking part in EHC. The ...
Keywords	Apparent nutrient digestibility ; Bile acid synthesis ; Cholic acid ; Faecal bile acid loss ; Non-starch polysaccharide
Subject code	540
Language	English
Publishing country	nl
Document type	Article ; Online
ZDB-ID	185380-6
ISSN	0044-8486 ; 0044-8516
ISSN	0044-8486 ; 0044-8516
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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