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Article ; Online: Sex-specific role of the optic gland in octopus maya: A transcriptomic analysis.

Ventura-López, Claudia / López-Galindo, Laura / Rosas, Carlos / Sánchez-Castrejón, Edna / Galindo-Torres, Pavel / Pascual, Cristina / Rodríguez-Fuentes, Gabriela / Juárez, Oscar E / Galindo-Sánchez, Clara E

General and comparative endocrinology

2022 Volume 320, Page(s) 114000

Abstract: The optic glands (OG) of cephalopods are a source of molecules associated with the control of reproductive traits and lifecycle events such as sexual maturation, reproductive behavior, feeding, parental care, and senescence. However, little is known ... ...

Abstract	The optic glands (OG) of cephalopods are a source of molecules associated with the control of reproductive traits and lifecycle events such as sexual maturation, reproductive behavior, feeding, parental care, and senescence. However, little is known about the role of the optic gland in Octopus maya adults during mating and egg laying. RNA sequencing, de novo transcriptome assembly, ubiquity and differential expression analysis were performed. First, we analyzed the expression patterns of transcripts commonly associated with OG regulatory functions to describe their possible role once the maturation of the gonad is complete. The transcriptomic profiles of the optic gland of both sexes were compared with emphasis on the signaling pathways involved in the dimorphism of reproductive traits. Results suggest that in the OG of males, the reproductive condition (mated or non-mated) did not affect the general expression profile. In contrast, more differentially expressed genes were observed in females. In mated females, the mRNA metabolic process and the response to norepinephrine were enriched, suggesting a high cellular activity in preparation for the laying of the embryos. Whereas in egg-laying females, energetic and metabolic processes were the most represented, including the oxidation-reduction process. Finally, the gene expression patterns in senescence females suggest a physiological response to starvation as well as upregulation of genes involved retrotransposon activity. In conclusion, more substantial fluctuations in gene expression were observed in the optic glands of the fertilized females compared to the males. Such differences might be associated with the regulation of the egg-laying and the onset of senescence.
MeSH term(s)	Animals ; Female ; Gene Expression Profiling ; Male ; Octopodiformes/genetics ; Reproduction/genetics ; Sequence Analysis, RNA ; Transcriptome
Language	English
Publishing date	2022-02-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1851-x
ISSN	1095-6840 ; 0016-6480
ISSN (online)	1095-6840
ISSN	0016-6480
DOI	10.1016/j.ygcen.2022.114000
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Article ; Online: A natural antisense transcript of the fem-1 gene was found expressed in female gonads during the characterization, expression profile, and cellular localization of the fem-1 gene in Pacific white shrimp Penaeus vannamei.

Galindo-Torres, Pavel / Ventura-López, Claudia / Llera-Herrera, Raúl / Ibarra, Ana M

Gene

2019 Volume 706, Page(s) 19–31

Abstract: The fem-1 gene in Caenorhabditis elegans is involved in sex differentiation; it is specifically required for all aspects of male development. In this study, the full-length cDNA of the fem-1 (Pvfem-1) gene was isolated from the Pacific whiteleg shrimp ... ...

Abstract	The fem-1 gene in Caenorhabditis elegans is involved in sex differentiation; it is specifically required for all aspects of male development. In this study, the full-length cDNA of the fem-1 (Pvfem-1) gene was isolated from the Pacific whiteleg shrimp Penaeus vannamei. The Pvfem-1 transcript is 3778 nt long and encodes a putative protein (PvFEM-1) of 638 amino acids that presented eight ankyrin repeats. The translated protein showed a significant (P < 0.05) structural similitude by superposition with C. elegans FEM-1 protein. Pvfem-1 expression was evaluated by qPCR and in situ hybridization (ISH) during embryogenesis, larval development, and gonads of both genders in subadult and adult life stages. Pvfem-1 was found expressed in brain, intestine, hepatopancreas, and in the gonads of both genders in subadults and adults when quantified by RT-qPCR. A significant finding was the discovery of a natural antisense transcript (NAT) of Pvfem-1 by ISH. It was present in the oocyte nucleus of subadult female shrimp gonads but was not seen within oocytes from adult females, although it was detected in follicular cells, suggesting a possible post-transcriptional regulation of Pvfem-1 in female gonad. Conversely, in males, no NAT was observed, and Pvfem-1 was found expressed in spermatogonia of both, subadult and adult shrimps indicating a function in male sexual differentiation and gametes generation. This study represents the first step for future functional analysis that is expected to contribute to clarifying the role of Pvfem-1 in sex differentiation and determination.
MeSH term(s)	Amino Acid Sequence ; Animals ; Antisense Elements (Genetics)/genetics ; Antisense Elements (Genetics)/physiology ; Caenorhabditis elegans Proteins/genetics ; Cell Cycle Proteins/genetics ; DNA, Complementary/metabolism ; Female ; Gene Expression Regulation/genetics ; Gonads/metabolism ; In Situ Hybridization ; Male ; Ovary/metabolism ; Penaeidae/genetics ; Phylogeny ; RNA, Messenger/genetics ; Sequence Alignment ; Sequence Analysis, DNA/methods ; Sex Determination Processes/genetics ; Sex Factors
Chemical Substances	Antisense Elements (Genetics) ; Caenorhabditis elegans Proteins ; Cell Cycle Proteins ; DNA, Complementary ; FEM-1 protein, C elegans ; RNA, Messenger
Language	English
Publishing date	2019-04-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2019.04.066
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Article: A natural antisense transcript of the fem-1 gene was found expressed in female gonads during the characterization, expression profile, and cellular localization of the fem-1 gene in Pacific white shrimp Penaeus vannamei

Galindo-Torres, Pavel / Ventura-López, Claudia / Llera-Herrera, Raúl / Ibarra, Ana M

Gene. 2019 July 20, v. 706

2019

Abstract	The fem-1 gene in Caenorhabditis elegans is involved in sex differentiation; it is specifically required for all aspects of male development. In this study, the full-length cDNA of the fem-1 (Pvfem-1) gene was isolated from the Pacific whiteleg shrimp Penaeus vannamei. The Pvfem-1 transcript is 3778 nt long and encodes a putative protein (PvFEM-1) of 638 amino acids that presented eight ankyrin repeats. The translated protein showed a significant (P < 0.05) structural similitude by superposition with C. elegans FEM-1 protein. Pvfem-1 expression was evaluated by qPCR and in situ hybridization (ISH) during embryogenesis, larval development, and gonads of both genders in subadult and adult life stages. Pvfem-1 was found expressed in brain, intestine, hepatopancreas, and in the gonads of both genders in subadults and adults when quantified by RT-qPCR. A significant finding was the discovery of a natural antisense transcript (NAT) of Pvfem-1 by ISH. It was present in the oocyte nucleus of subadult female shrimp gonads but was not seen within oocytes from adult females, although it was detected in follicular cells, suggesting a possible post-transcriptional regulation of Pvfem-1 in female gonad. Conversely, in males, no NAT was observed, and Pvfem-1 was found expressed in spermatogonia of both, subadult and adult shrimps indicating a function in male sexual differentiation and gametes generation. This study represents the first step for future functional analysis that is expected to contribute to clarifying the role of Pvfem-1 in sex differentiation and determination.
Keywords	Caenorhabditis elegans ; Litopenaeus vannamei ; adults ; amino acids ; brain ; complementary DNA ; embryogenesis ; females ; genes ; gonads ; hepatopancreas ; in situ hybridization ; intestines ; larval development ; males ; messenger RNA ; oocytes ; quantitative polymerase chain reaction ; reverse transcriptase polymerase chain reaction ; sexual development ; shrimp ; spermatogonia
Language	English
Dates of publication	2019-0720
Size	p. 19-31.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2019.04.066
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Article ; Online: Treatment with metformin glycinate reduces SARS-CoV-2 viral load: An in vitro model and randomized, double-blind, Phase IIb clinical trial.

Ventura-López, Claudia / Cervantes-Luevano, Karla / Aguirre-Sánchez, Janet S / Flores-Caballero, Juan C / Alvarez-Delgado, Carolina / Bernaldez-Sarabia, Johanna / Sánchez-Campos, Noemí / Lugo-Sánchez, Laura A / Rodríguez-Vázquez, Ileana C / Sander-Padilla, Jose G / Romero-Antonio, Yulia / Arguedas-Núñez, María M / González-Canudas, Jorge / Licea-Navarro, Alexei F

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2022 Volume 152, Page(s) 113223

Abstract: The health crisis caused by the new coronavirus SARS-CoV-2 highlights the need to identify new treatment strategies for this viral infection. During the past year, over 400 coronavirus disease (COVID-19) treatment patents have been registered; ... ...

Abstract	The health crisis caused by the new coronavirus SARS-CoV-2 highlights the need to identify new treatment strategies for this viral infection. During the past year, over 400 coronavirus disease (COVID-19) treatment patents have been registered; nevertheless, the presence of new virus variants has triggered more severe disease presentations and reduced treatment effectiveness, highlighting the need for new treatment options for the COVID-19. This study evaluates the Metformin Glycinate (MG) effect on the SARS-CoV-2 in vitro and in vivo viral load. The in vitro study was conducted in a model of Vero E6 cells, while the in vivo study was an adaptive, two-armed, randomized, prospective, longitudinal, double-blind, multicentric, and phase IIb clinical trial. Our in vitro results revealed that MG effectively inhibits viral replication after 48 h of exposure to the drug, with no cytotoxic effect in doses up to 100 µM. The effect of the MG was also tested against three variants of interest (alpha, delta, and epsilon), showing increased survival rates in cells treated with MG. These results are aligned with our clinical data, which indicates that MG treatment reduces SARS-CoV2-infected patients´ viral load in just 3.3 days and supplementary oxygen requirements compared with the control group. We expect our results can guide efforts to position MG as a therapeutic option for COVID-19 patients.
MeSH term(s)	Humans ; Metformin/pharmacology ; Metformin/therapeutic use ; Prospective Studies ; RNA, Viral ; SARS-CoV-2 ; Viral Load ; COVID-19 Drug Treatment
Chemical Substances	RNA, Viral ; Metformin (9100L32L2N)
Language	English
Publishing date	2022-06-02
Publishing country	France
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2022.113223
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Article: Transcriptomic Analysis Reveals Insights on Male Infertility in

López-Galindo, Laura / Juárez, Oscar E / Larios-Soriano, Ernesto / Del Vecchio, Giulia / Ventura-López, Claudia / Lago-Lestón, Asunción / Galindo-Sánchez, Clara

Frontiers in physiology

2019 Volume 9, Page(s) 1920

Abstract: ... Octopus ... ...

Abstract	Octopus maya
Language	English
Publishing date	2019-01-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2018.01920
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Article ; Online: A novel CHH gene from the Pacific white shrimp Litopenaeus vannamei was characterized and found highly expressed in gut and less in eyestalk and other extra-eyestalk tissues.

Ventura-López, Claudia / Gómez-Anduro, Gracia / Arcos, Fabiola G / Llera-Herrera, Raúl / Racotta, Ilie S / Ibarra, Ana M

Gene

2016 Volume 582, Issue 2, Page(s) 148–160

Abstract: The crustacean hyperglycemic hormone (CHH) family is an important group of neuropeptides involved in controlling growth, reproduction, and stress response in decapod species. In this study, a new gene containing 4 exons-3 introns flanked by canonical 5'- ... ...

Abstract	The crustacean hyperglycemic hormone (CHH) family is an important group of neuropeptides involved in controlling growth, reproduction, and stress response in decapod species. In this study, a new gene containing 4 exons-3 introns flanked by canonical 5'-GT-AG-3' intron splice-site junctions was isolated from Litopenaeus vannamei. Two full length transcripts of this CHH were isolated from eyestalk and pericardial tissue of males and females using rapid amplification of cDNA ends (RACE). Transcripts sequences were 1578bp in length in males pericardial tissues and in males and females eyestalk with 100% identity, but the transcript isolated from females pericardial tissues was shorter (974bp). The differences in transcripts length is a result of two polyadenylation sites present in the 3'UTR resulting in two transcription termination signals. Transcript sequences encoded one unique protein that can be classified as type I CHH subfamily because of the 4 exons and 3 introns structure, although the CPRP region is not-well conserved and there is no amidation in the C-terminal of the deduced amino acid sequence. Furthermore, there is a glycine inserted in the mature peptide not at position 12 as in type II CHHs but after amino acid 31 and the phylogenetic analysis did not group the peptide within type I, but closer to type II CHHs. We demonstrated by endpoint-PCR, qPCR, and in situ hybridization (ISH), that this gene is expressed in neuroendocrine organs known to express CHHs in penaeid shrimp, including X-organ and optic nerve in eyestalk, supraesophageal ganglion (SoG), but it is also expressed in other organs as gill, gut, pericardial cavity, as well as in terminal ampoule or spermatophore and vas deferens of males.
MeSH term(s)	Amino Acid Sequence ; Animals ; Arthropod Proteins/chemistry ; Arthropod Proteins/genetics ; Arthropod Proteins/metabolism ; Base Sequence ; Digestive System/metabolism ; Eye/metabolism ; Gene Expression Profiling ; Gene Expression Regulation ; Invertebrate Hormones/chemistry ; Invertebrate Hormones/genetics ; Invertebrate Hormones/metabolism ; Molecular Sequence Data ; Nerve Tissue Proteins/chemistry ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Organ Specificity/genetics ; Penaeidae/genetics ; Phylogeny ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Sequence Alignment
Chemical Substances	Arthropod Proteins ; Invertebrate Hormones ; Nerve Tissue Proteins ; RNA, Messenger ; hyperglycemic hormone, crustacean
Language	English
Publishing date	2016-05-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2016.02.011
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Article: A novel CHH gene from the Pacific white shrimp Litopenaeus vannamei was characterized and found highly expressed in gut and less in eyestalk and other extra-eyestalk tissues

Ventura-López, Claudia / Ana M. Ibarra / Fabiola G. Arcos / Gracia Gómez-Anduro / Ilie S. Racotta / Raúl Llera-Herrera

Gene. 2016 May 15, v. 582, no. 2

2016

Abstract	The crustacean hyperglycemic hormone (CHH) family is an important group of neuropeptides involved in controlling growth, reproduction, and stress response in decapod species. In this study, a new gene containing 4 exons-3 introns flanked by canonical 5′-GT-AG-3′ intron splice-site junctions was isolated from Litopenaeus vannamei. Two full length transcripts of this CHH were isolated from eyestalk and pericardial tissue of males and females using rapid amplification of cDNA ends (RACE). Transcripts sequences were 1578bp in length in males pericardial tissues and in males and females eyestalk with 100% identity, but the transcript isolated from females pericardial tissues was shorter (974bp). The differences in transcripts length is a result of two polyadenylation sites present in the 3'UTR resulting in two transcription termination signals. Transcript sequences encoded one unique protein that can be classified as type I CHH subfamily because of the 4 exons and 3 introns structure, although the CPRP region is not-well conserved and there is no amidation in the C-terminal of the deduced amino acid sequence. Furthermore, there is a glycine inserted in the mature peptide not at position 12 as in type II CHHs but after amino acid 31 and the phylogenetic analysis did not group the peptide within type I, but closer to type II CHHs. We demonstrated by endpoint-PCR, qPCR, and in situ hybridization (ISH), that this gene is expressed in neuroendocrine organs known to express CHHs in penaeid shrimp, including X-organ and optic nerve in eyestalk, supraesophageal ganglion (SoG), but it is also expressed in other organs as gill, gut, pericardial cavity, as well as in terminal ampoule or spermatophore and vas deferens of males.
Keywords	3' untranslated regions ; amino acid sequences ; complementary DNA ; digestive system ; exons ; females ; ganglia ; gene expression ; genes ; glycine (amino acid) ; in situ hybridization ; introns ; Litopenaeus vannamei ; males ; nerve tissue ; neuropeptides ; pericardium ; phylogeny ; quantitative polymerase chain reaction ; rapid amplification of cDNA ends ; reproduction ; spermatophores ; stress response
Language	English
Dates of publication	2016-0515
Size	p. 148-160.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2016.02.011
Database	NAL-Catalogue (AGRICOLA)

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Article: Population dynamics of the tropical cladoceran Ceriodaphnia rigaudi Richard, 1894 (Crustacea: Anomopoda). Effect of food type and temperature.

Martinez-Jeronimo, Fernando / Ventura-Lopez, Claudia

Journal of environmental biology

2011 Volume 32, Issue 4, Page(s) 513–521

Abstract: The knowledge of population effects of food on tropical, filter-feeding cladocerans is scarce because a reduced number of species has been extensively studied. Ceriodaphnia rigaudi Richard 1894, a small-sized cladoceran distributed mainly in tropical and ...

Abstract	The knowledge of population effects of food on tropical, filter-feeding cladocerans is scarce because a reduced number of species has been extensively studied. Ceriodaphnia rigaudi Richard 1894, a small-sized cladoceran distributed mainly in tropical and subtropical regions of the world, was studied. The aim of this study was to contribute to the knowledge of the reproductive biology of a poor-known Cladoceran; for this we assessed the effect of feeding and temperature on the reproduction and life cycle of this species. Three microalga species (Pseudokirchneriella subcapitata, Ankistrodesmus falcatus, and Chlorella vulgaris) were supplied as food each at a concentration of 12 mg l(-1) (dry weight, equivalent to 1.3 x 10(6), 0.4 x 10(6) and 1.35 x 10(6) cell m1(-1), respectively, and equivalent to 7.8 microg C ml(-1), at two temperatures (20 and 25 degrees C). We evaluated, among other responses, longevity, total progeny, survival, life expectancy at birth and fecundity. Organisms fed with the microalgae A. falcatus and P subcapitata presented both higher longevity (30.7 +/- 5.91, 26.6 +/- 3.59 days, respectively) and total progeny (45 +/- 13.80, 40.7 +/- 0.66 neonates female (-1) values than those organisms fed C. vulgaris (13.5 +/- 4.63 days and 17.6 +/- 6.19 neonates female (-1), respectively). On the other hand, temperature affected significantly the population parameters of C. rigaudi, recording maximal longevity values (56.1 +/- 9.41 days) at 20 degrees C in organisms fed A. falcatus; however, age at first reproduction and total progeny were negatively affected by this temperature: sexual maturation of the females was delayed until the age of 16 days and the number of neonates produced was smaller (9.8 +/- 3.45 with C. vulgaris; 24.7 +/- 6.01 with P subcapitata, and 35.5 +/- 8.59 neonates female(-1) with A. falcatus). The best reproductive responses for C. rigaudi in this study were obtained with A. falcatus at degrees 25 degrees C.
MeSH term(s)	Animals ; Cladocera/physiology ; Ecosystem ; Feeding Behavior ; Female ; Reproduction/physiology ; Temperature ; Time Factors
Language	English
Publishing date	2011-07
Publishing country	India
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	0254-8704
ISSN	0254-8704
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Article ; Online: Transcriptomic information from Pacific white shrimp (Litopenaeus vannamei) ovary and eyestalk, and expression patterns for genes putatively involved in the reproductive process.

Ventura-López, Claudia / Galindo-Torres, Pavel E / Arcos, Fabiola G / Galindo-Sánchez, Clara / Racotta, Ilie S / Escobedo-Fregoso, Cristina / Llera-Herrera, Raúl / Ibarra, Ana M

General and comparative endocrinology

2017 Volume 246, Page(s) 164–182

Abstract: The increased use of massive sequencing technologies has enabled the identification of several genes known to be involved in different mechanisms associated with reproduction that so far have only been studied in vertebrates and other model invertebrate ... ...

Abstract	The increased use of massive sequencing technologies has enabled the identification of several genes known to be involved in different mechanisms associated with reproduction that so far have only been studied in vertebrates and other model invertebrate species. In order to further investigate the genes involved in Litopenaeus vannamei reproduction, cDNA and SSH libraries derived from female eyestalk and gonad were produced, allowing the identification of expressed sequences tags (ESTs) that potentially have a role in the regulation of gonadal maturation. In the present study, different transcripts involved in reproduction were identified and a number of them were characterized as full-length. These transcripts were evaluated in males and females in order to establish their tissue expression profiles during developmental stages (juvenile, subadult and adult), and in the case of females, their possible association with gonad maturation was assessed through expression analysis of vitellogenin. The results indicated that the expression of vitellogenin receptor (vtgr) and minichromosome maintenance (mcm) family members in the female gonad suggest an important role during previtellogenesis. Additionally, the expression profiles of genes such as famet, igfbp and gpcr in brain tissues suggest an interaction between the insulin/insulin-like growth factor signaling pathway (IIS) and methyl farnesoate (MF) biosynthesis for control of reproduction. Furthermore, the specific expression pattern of farnesoic acid O-methyltransferase suggests that final synthesis of MF is carried out in different target tissues, where it is regulated by esterase enzymes under a tissue-specific hormonal control. Finally, the presence of a vertebrate type steroid receptor in hepatopancreas and intestine besides being highly expressed in female gonads, suggest a role of that receptor during sexual maturation.
MeSH term(s)	Animals ; Biomarkers/analysis ; DNA, Complementary/metabolism ; Egg Proteins/genetics ; Egg Proteins/metabolism ; Expressed Sequence Tags ; Eye/metabolism ; Female ; Gene Expression Regulation ; Male ; Ovary/metabolism ; Penaeidae/genetics ; Penaeidae/metabolism ; RNA, Messenger/genetics ; Real-Time Polymerase Chain Reaction ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism ; Reproduction/physiology ; Reverse Transcriptase Polymerase Chain Reaction ; Transcriptome
Chemical Substances	Biomarkers ; DNA, Complementary ; Egg Proteins ; RNA, Messenger ; Receptors, Cell Surface ; vitellogenin receptor
Language	English
Publishing date	2017-05-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1851-x
ISSN	1095-6840 ; 0016-6480
ISSN (online)	1095-6840
ISSN	0016-6480
DOI	10.1016/j.ygcen.2016.12.005
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Article ; Online: Clavulanic Acid and its Potential Therapeutic Effects on the Central Nervous System.

Balcazar-Ochoa, Luis Gerardo / Ventura-Martínez, Rosa / Ángeles-López, Guadalupe Esther / Gómez-Acevedo, Claudia / Carrasco, Omar Francisco / Sampieri-Cabrera, Raúl / Chavarría, Anahí / González-Hernández, Abimael

Archives of medical research

2023 Volume 55, Issue 1, Page(s) 102916

Abstract: Clavulanic acid (CLAV) is a non-antibiotic β-lactam that has been used since the late 1970s as a β-lactamase inhibitor in combination with amoxicillin, another ß-lactam with antibiotic activity. Its long-observed adverse reaction profile allows it to say ...

Abstract	Clavulanic acid (CLAV) is a non-antibiotic β-lactam that has been used since the late 1970s as a β-lactamase inhibitor in combination with amoxicillin, another ß-lactam with antibiotic activity. Its long-observed adverse reaction profile allows it to say that CLAV is a well-tolerated drug with mainly mild adverse reactions. Interestingly, in 2005, it was discovered that β-lactams enhance the astrocytic expression of GLT-1, a glutamate transporter essential for maintaining synaptic glutamate homeostasis involved in several pathologies of the central nervous system (CNS). This finding, along with a favorable pharmacokinetic profile, prompted the appearance of several studies that intended to evaluate the effect of CLAV in preclinical disease models. Studies have revealed that CLAV can increase GLT-1 expression in the nucleus accumbens (NAcc), medial prefrontal cortex (PFC), and spinal cord of rodents, to affect glutamate and dopaminergic neurotransmission, and exert an anti-inflammatory effect by modulating the levels of the cytokines TNF-α and interleukin 10 (IL-10). CLAV has been tested with positive results in preclinical models of epilepsy, addiction, stroke, neuropathic and inflammatory pain, dementia, Parkinson's disease, and sexual and anxiety behavior. These properties make CLAV a potential therapeutic drug if repurposed. Therefore, this review aims to gather information on CLAV's effect on preclinical neurological disease models and to give some perspectives on its potential therapeutic use in some diseases of the CNS.
MeSH term(s)	Clavulanic Acid/therapeutic use ; Clavulanic Acid/metabolism ; Clavulanic Acid/pharmacology ; Anti-Bacterial Agents/therapeutic use ; beta-Lactams/metabolism ; beta-Lactams/pharmacology ; Nucleus Accumbens/metabolism ; Glutamates/metabolism ; Glutamates/pharmacology ; Excitatory Amino Acid Transporter 2/metabolism
Chemical Substances	Clavulanic Acid (23521W1S24) ; Anti-Bacterial Agents ; beta-Lactams ; Glutamates ; Excitatory Amino Acid Transporter 2
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1156844-6
ISSN	1873-5487 ; 0188-4409 ; 0188-0128
ISSN (online)	1873-5487
ISSN	0188-4409 ; 0188-0128
DOI	10.1016/j.arcmed.2023.102916
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In stock of ZB MED Cologne/Königswinter

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