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  1. Article ; Online: In Vitro Generation of Human Tolerogenic Monocyte-Derived Dendritic Cells.

    Hilkens, Catharien M U / Diboll, Julie / Cooke, Fiona / Anderson, Amy E

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2654, Page(s) 477–492

    Abstract: Human monocyte-derived dendritic cells (moDC) are commonly used as a research tool to investigate interactions between antigen-presenting cells and T cells. Generation of these cells involves the isolation of CD14 positive monocytes from peripheral blood ...

    Abstract Human monocyte-derived dendritic cells (moDC) are commonly used as a research tool to investigate interactions between antigen-presenting cells and T cells. Generation of these cells involves the isolation of CD14 positive monocytes from peripheral blood and their in vitro differentiation into immature moDC by the cytokines GM-CSF and IL-4. Their functional characteristics can then be manipulated by maturing these cells with a cocktail of agents, which can be tailored to induce either immune activating or tolerogenic properties. Here, we describe a protocol for the generation of moDC with stable tolerogenic function, referred to as tolerogenic dendritic cells. These cells have been developed as an immunotherapeutic tool for the treatment of autoimmune disease but have also proven useful to dissect mechanisms of T cell tolerance induction in vitro.
    MeSH term(s) Humans ; Monocytes ; Dendritic Cells ; Cytokines ; T-Lymphocytes ; Cell Differentiation ; Cells, Cultured
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3135-5_31
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reply: Contrasting effect of iron supplementation in protoporphyria.

    Levy, Cynthia / Dickey, Amy K / Anderson, Karl E / Keel, Sioban B / Balwani, Manisha

    Hepatology (Baltimore, Md.)

    2023  Volume 79, Issue 3, Page(s) E89–E90

    MeSH term(s) Humans ; Iron/therapeutic use ; Protoporphyria, Erythropoietic/drug therapy ; Dietary Supplements
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000640
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  3. Article: Comparing the gender wage gap in PA education and clinical practice.

    Bradford, Paul D / Anderson, Jennifer L / Baker, Amy E

    JAAPA : official journal of the American Academy of Physician Assistants

    2021  Volume 34, Issue 12, Page(s) 1

    MeSH term(s) Educational Status ; Humans ; Salaries and Fringe Benefits
    Language English
    Publishing date 2021-11-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2415226-2
    ISSN 0893-7400 ; 1547-1896
    ISSN (online) 0893-7400
    ISSN 1547-1896
    DOI 10.1097/01.JAA.0000800600.25483.2c
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  4. Article: Colostrum and Preterm Babies: A Systematic Review.

    Slouha, Ethan / Anderson, Zoe S / Ankrah, Nana Mansa N / Kalloo, Amy E / Gorantla, Vasavi Rakesh

    Cureus

    2023  Volume 15, Issue 7, Page(s) e42021

    Abstract: Colostrum from mothers is rich in immunomodulating bio-factors such as immunoglobulins (IgA), lactoferrin, and oligosaccharides and supports gut microbial and inflammatory processes. The support in these processes may provide some relief for infants who ... ...

    Abstract Colostrum from mothers is rich in immunomodulating bio-factors such as immunoglobulins (IgA), lactoferrin, and oligosaccharides and supports gut microbial and inflammatory processes. The support in these processes may provide some relief for infants who are born pre-term. Pre-term infants are more likely to develop necrotizing enterocolitis (NEC), late-onset sepsis (LOS), and ventilator-acquired/associated pneumonia (VAP). Due to the components of colostrum, there may be incentives towards early administration for preterm infants. An extensive literature review was done using ProQuest, ScienceDirect, and PubMed. Only meta-analyses and experimental studies were used. The search included the keywords 'colostrum and preterm' and 'colostrum and necrotizing enterocolitis'. The initial search generated 13,543 articles and was narrowed to 25 articles through comprehensive inclusion and exclusion criteria. There were significantly higher levels of
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.42021
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  5. Article ; Online: "ContraceptED": A Multidisciplinary Framework for Emergency Department-Initiated Contraception.

    Liang, Amy C / Sanders, Noah S / Anderson, Erik S / Heeney, Megan E / Hirschmann, Claire M / Kane, Amy R / Wills, Charlotte P

    Annals of emergency medicine

    2023  Volume 81, Issue 5, Page(s) 630–636

    Abstract: Emergency departments (EDs) are common access points for patients who are at high risk for unintended pregnancy. Low-barrier access to effective contraception represents a crucial and low-cost intervention to address this public health need. Same-day ... ...

    Abstract Emergency departments (EDs) are common access points for patients who are at high risk for unintended pregnancy. Low-barrier access to effective contraception represents a crucial and low-cost intervention to address this public health need. Same-day initiation of contraception during an ED visit is a unique opportunity to provide reproductive health care for high-risk patients with otherwise limited health care access. We collaborated with our obstetrics and gynecology (OB/GYN) department, pharmacists, and a team of community health advocates to support emergency clinicians (namely, emergency physicians and advanced practice providers) in assessing pregnancy and contraceptive readiness, increasing proficiency in contraception counseling, prescribing hormonal contraception, counseling on barrier and emergency contraception, and inserting (and removing) the Nexplanon implant, a form of long-acting reversible contraception. With this novel approach, we found that emergency clinicians voluntarily participated in trainings on contraception, including low-threshold long-acting reversible contraception initiation; and, after completing these trainings, clinicians integrated these skills into their workflow in the ED. We report our results after screening 38 patients during our current Pilot Phase of implementing this program.
    MeSH term(s) Pregnancy ; Female ; Humans ; Contraception, Postcoital ; Contraceptive Agents ; Health Services Accessibility ; Counseling ; Emergency Service, Hospital
    Chemical Substances Contraceptive Agents
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603080-4
    ISSN 1097-6760 ; 0196-0644
    ISSN (online) 1097-6760
    ISSN 0196-0644
    DOI 10.1016/j.annemergmed.2023.01.002
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  6. Article ; Online: Adenosine metabolic signature in circulating CD4+ T cells predicts remission in rheumatoid arthritis.

    Brown, Philip M / Anderson, Amy E / Naamane, Najib / Lendrem, Dennis W / Morgan, Ann W / Isaacs, John D / Pratt, Arthur G

    RMD open

    2024  Volume 10, Issue 1

    Abstract: Objectives: Long-term outcomes in rheumatoid arthritis (RA) depend on early and effective disease control. Methotrexate (MTX) remains the first-line disease modifying therapy, however there are no biomarkers with which to identify those most likely to ... ...

    Abstract Objectives: Long-term outcomes in rheumatoid arthritis (RA) depend on early and effective disease control. Methotrexate (MTX) remains the first-line disease modifying therapy, however there are no biomarkers with which to identify those most likely to achieve remission. To address this unmet need we explored metabolic pathways involved in MTX mechanism of action within circulating CD4+T cells in a cohort of treatment naive patients with early RA.
    Methods: Purified CD4+T cells were isolated from peripheral blood of 68 patients with early RA commencing MTX. The expression of a range of putative MTX metabolism and mechanism of action targets were explored by flow-cytometry and transcriptional analysis. From these data significant predictors of Disease Activity Score 28-C reactive protein (DAS28-CRP) remission (<2.4 at 6 months) were determined by logistic regression (clinical; flow-cytometry data) and linear modelling (gene expression data).
    Results: Low baseline DAS28-CRP was associated with remission at 6 months (p=0.02). Expression of the ectonucleotidase CD39, involved in ATP-ADP conversion during adenosine synthesis, was higher on CD4+CD25 High regulatory T cells at baseline in those achieving remission (molecules of equivalent fluorescence 1264 vs 847; p=0.007). Expression of other adenosine signalling elements in CD4+T cells were also upregulated at baseline in patients achieving remission:
    MeSH term(s) Humans ; Antirheumatic Agents/therapeutic use ; CD4-Positive T-Lymphocytes/metabolism ; Adenosine/therapeutic use ; Treatment Outcome ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Methotrexate/therapeutic use ; Biomarkers ; C-Reactive Protein/metabolism
    Chemical Substances Antirheumatic Agents ; Adenosine (K72T3FS567) ; Methotrexate (YL5FZ2Y5U1) ; Biomarkers ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2024-02-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2812592-7
    ISSN 2056-5933 ; 2056-5933
    ISSN (online) 2056-5933
    ISSN 2056-5933
    DOI 10.1136/rmdopen-2023-003858
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  7. Article ; Online: Skeletal manifestations of disease experience: Length of illness and porous cranial lesion formation in a contemporary juvenile mortality sample.

    O'Donnell, Lexi / Buikstra, Jane E / Hill, Ethan C / Anderson, Amy S / O'Donnell, Michael J

    American journal of human biology : the official journal of the Human Biology Council

    2023  Volume 35, Issue 8, Page(s) e23896

    Abstract: Objectives: Porous lesions of the orbit (cribra orbitalia [CO]) and cranial vault (porotic hyperostosis [PH]) are used as skeletal indicators of childhood stress. Because they are understudied in contemporary populations, their relationship to disease ... ...

    Abstract Objectives: Porous lesions of the orbit (cribra orbitalia [CO]) and cranial vault (porotic hyperostosis [PH]) are used as skeletal indicators of childhood stress. Because they are understudied in contemporary populations, their relationship to disease experience is poorly understood. This paper examines the relationship between length of childhood illness and CO/PH formation in a clinically documented sample. "Turning points," which identify the window for lesion formation for CO/PH, are defined, implications for hidden heterogeneity in frailty are considered.
    Methods: Data are from 333 (199 males; 134 females) pediatric postmortem computed tomography scans. Individuals died in New Mexico (2011-2019) and are 0.5 to 15.99 years (mean = 7.1). Length of illness was estimated using information from autopsy and field reports. Logistic regression was used to estimate predicted probabilities, odds ratios, and the temporal window for lesion formation.
    Results: Illness, single bouts, or cumulative episodes lasting over 1 month is associated with higher odds of CO; individuals who were never sick have lower odds of having PH. This relationship was consistent for fatal and incidental illnesses that did not cause death. The developmental window for CO formation appears to close at 8 years.
    Conclusions: Those ill for over 1 month are more likely to have CO/PH than those with acute illnesses. Some individuals lived sufficiently long to form CO/PH but died of illness. Others with lesions died of circumstances unrelated to disease. This indicates hidden variation in robusticity even among ill individuals with CO/PH, which is vital in interpreting lesion frequencies in the archeological record.
    MeSH term(s) Male ; Female ; Humans ; Child ; Porosity ; Skull/pathology ; Orbit/pathology ; Hyperostosis/complications ; Hyperostosis/pathology ; New Mexico
    Language English
    Publishing date 2023-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1025339-7
    ISSN 1520-6300 ; 1042-0533
    ISSN (online) 1520-6300
    ISSN 1042-0533
    DOI 10.1002/ajhb.23896
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    Zs.A 2567: Show issues Location:
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  8. Article ; Online: Identifying predictors of psychological well-being among volunteer mentors in Big Brothers Big Sisters.

    Anderson, Amy J / Jones, Kristian V / Melton, Theresa N / Keller, Thomas E / DuBois, David L

    Journal of community psychology

    2023  Volume 51, Issue 7, Page(s) 2802–2827

    Abstract: Big Brothers Big Sisters (BBBS) facilitates mentoring relationships between youth and volunteer mentors. Although research has examined outcomes for youth in BBBS, relatively less investigation has been undertaken for volunteer outcomes. This study ... ...

    Abstract Big Brothers Big Sisters (BBBS) facilitates mentoring relationships between youth and volunteer mentors. Although research has examined outcomes for youth in BBBS, relatively less investigation has been undertaken for volunteer outcomes. This study explored factors associated with changes in psychological well-being among BBBS volunteer mentors. Participants included 593 mentors (Mage = 31) surveyed at study baseline and 15-month follow-up. A classification and regression decision tree approach was used to predict residualized change in psychological well-being from study baseline with match length included as the first split variable, and demographic, individual, and relationship variables included as candidate predictors. Analyses indicated that mentors with longer relationships (>4.5 months) reported more positive change in psychological well-being compared with mentors with shorter relationships. Perceived quality of program supervision was a further predictor within both groups of volunteers. Findings suggest that longer relationships and greater program support may contribute to mentor well-being.
    MeSH term(s) Adolescent ; Humans ; Female ; Mentors/psychology ; Interpersonal Relations ; Psychological Well-Being ; Mentoring ; Volunteers
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 1491194-2
    ISSN 1520-6629 ; 0090-4392
    ISSN (online) 1520-6629
    ISSN 0090-4392
    DOI 10.1002/jcop.23073
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  9. Article: Novel hair snare and genetic methods for non-invasive bobcat detection.

    Rounsville, Thomas F / Rogers, Richard E / Welsh, Amy B / Ryan, Christopher W / Anderson, James T

    Ecology and evolution

    2022  Volume 12, Issue 1, Page(s) e8435

    Abstract: Over the past 20 years, the use of non-invasive hair snare surveys in wildlife research and management has become more prevalent. While these tools have been used to answer important research questions, these techniques often fail to gather information ... ...

    Abstract Over the past 20 years, the use of non-invasive hair snare surveys in wildlife research and management has become more prevalent. While these tools have been used to answer important research questions, these techniques often fail to gather information on elusive carnivores, such as bobcats (
    Language English
    Publishing date 2022-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2635675-2
    ISSN 2045-7758
    ISSN 2045-7758
    DOI 10.1002/ece3.8435
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  10. Article ; Online: Pruritic dermatitis caused by bird mite infestation.

    Leib, Amy E / Anderson, Bryan E

    Cutis

    2016  Volume 97, Issue 1, Page(s) E6–8

    MeSH term(s) Animals ; Birds ; Dermatitis/diagnosis ; Humans ; Mite Infestations/diagnosis ; Pruritus ; Zoonoses/diagnosis
    Language English
    Publishing date 2016-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 391840-3
    ISSN 2326-6929 ; 0011-4162 ; 0151-9522
    ISSN (online) 2326-6929
    ISSN 0011-4162 ; 0151-9522
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