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  1. Article ; Online: TGF-β Regulation of T Cells.

    Chen, WanJun

    Annual review of immunology

    2023  Volume 41, Page(s) 483–512

    Abstract: Transforming growth factor β (TGF-β) is a key cytokine regulating the development, activation, proliferation, differentiation, and death of T cells. In ... ...

    Abstract Transforming growth factor β (TGF-β) is a key cytokine regulating the development, activation, proliferation, differentiation, and death of T cells. In CD4
    MeSH term(s) Animals ; Humans ; CD8-Positive T-Lymphocytes ; Cell Differentiation ; Immunity, Innate ; Lymphocytes/metabolism ; T-Lymphocytes, Regulatory/metabolism ; Transforming Growth Factor beta1/metabolism
    Chemical Substances Transforming Growth Factor beta1
    Language English
    Publishing date 2023-02-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 604953-9
    ISSN 1545-3278 ; 0732-0582
    ISSN (online) 1545-3278
    ISSN 0732-0582
    DOI 10.1146/annurev-immunol-101921-045939
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 849: Show issues Location:
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  2. Article ; Online: The Protection of Enzyme Activity for the Preparation of Humanized Polymerized Hemoglobin-Superoxide Dismutase-Catalase-Carbonic Anhydrase.

    Wang, Yaoxi / Wang, Wanjun / Zhang, Lili / Chen, Gang

    Doklady. Biochemistry and biophysics

    2024  

    Abstract: This work finds suitable enzyme activity protectants to improve the recovery rate of enzyme activity in the preparation of human polymerized hemoglobin-superoxide dismutase-catalase-carbonic anhydrase (PolyHb-SOD-CAT-CA), including trehalose, sucrose, ... ...

    Abstract This work finds suitable enzyme activity protectants to improve the recovery rate of enzyme activity in the preparation of human polymerized hemoglobin-superoxide dismutase-catalase-carbonic anhydrase (PolyHb-SOD-CAT-CA), including trehalose, sucrose, glucose, hydroxypropyl-β-cyclodextrin, and mannitol.Different types and concentrations of enzyme activity protective agents were added during polymerization to compare their protective ability to enzyme activity and the effect on the properties of hemoglobin. The study found that compared with trehalose, the protective effect of sucrose on CA enzyme activity is non-significant to that on hemoglobin, the recovery rate of SOD, and CAT enzyme activity has significant increased. Glucose, hydroxypropyl-β-cyclodextrin, and mannitol are unsuitable for the added enzyme activity protective agent of PolyHb-SOD-CAT-CA.The protective effect of sucrose on CA was non-significant with trehalose. The protective effect of sucrose on SOD and CAT enzyme activity was higher than trehalose, and the protective effect reached the maximum when the concentration reached 1.5%.
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2062390-2
    ISSN 1608-3091 ; 1607-6729
    ISSN (online) 1608-3091
    ISSN 1607-6729
    DOI 10.1134/S1607672923600483
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A potential treatment of COVID-19 with TGF-β blockade.

    Chen, WanJun

    International journal of biological sciences

    2020  Volume 16, Issue 11, Page(s) 1954–1955

    MeSH term(s) COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/immunology ; Coronavirus Infections/pathology ; Fibrosis/drug therapy ; Humans ; Immunotherapy ; Inflammation/drug therapy ; Lung/immunology ; Lung/pathology ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/immunology ; Pneumonia, Viral/pathology ; Transforming Growth Factor beta/antagonists & inhibitors
    Chemical Substances Transforming Growth Factor beta
    Keywords covid19
    Language English
    Publishing date 2020-04-21
    Publishing country Australia
    Document type Editorial ; Research Support, N.I.H., Intramural
    ZDB-ID 2179208-2
    ISSN 1449-2288 ; 1449-2288
    ISSN (online) 1449-2288
    ISSN 1449-2288
    DOI 10.7150/ijbs.46891
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Quantification of Hybrid Topological Spin Textures and Their Nanoscale Fluctuations in Ferrimagnets.

    Zhang, Yuxuan / Xu, Teng / Jiang, Wanjun / Yu, Rong / Chen, Zhen

    Nano letters

    2024  Volume 24, Issue 9, Page(s) 2727–2734

    Abstract: Noncolinear spin textures, including chiral stripes and skyrmions, have shown great potential in spintronics. Basic configurations of spin textures are either Bloch or Néel types, and the intermediate hybrid type has rarely been reported. A major ... ...

    Abstract Noncolinear spin textures, including chiral stripes and skyrmions, have shown great potential in spintronics. Basic configurations of spin textures are either Bloch or Néel types, and the intermediate hybrid type has rarely been reported. A major challenge in identifying hybrid spin textures is to quantitatively determine the hybrid angle, especially in ferrimagnets with weak net magnetization. Here, we develop an approach to quantify magnetic parameters, including chirality, saturation magnetization, domain wall width, and hybrid angle with sub-5 nm spatial resolution, based on Lorentz four-dimensional scanning transmission electron microscopy (Lorentz 4D-STEM). We find strong nanometer-scale variations in the hybrid angle and domain wall width within structurally and chemically homogeneous FeGd ferrimagnetic films. These variations fluctuate during different magnetization circles, revealing intrinsic local magnetization inhomogeneities. Furthermore, hybrid skyrmions can also be nucleated in FeGd films. These analyses demonstrate that the Lorentz 4D-STEM is a quantitative tool for exploring complex spin textures.
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.3c04409
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  6. Article: Disseminated Talaromyces Marneffei in a Patient with Newly Diagnosed HIV Co-Infection with Syphilis.

    Chen, Wanjun / Zhong, Meifeng / Song, Jinlong

    Clinical laboratory

    2023  Volume 69, Issue 11

    Abstract: Background: This article reports on a young male with respiratory symptoms as the first presentation.: Methods: We identified the suspected pathogen by microscopic examination of blood smears, which was subsequently confirmed by blood culture.: ... ...

    Abstract Background: This article reports on a young male with respiratory symptoms as the first presentation.
    Methods: We identified the suspected pathogen by microscopic examination of blood smears, which was subsequently confirmed by blood culture.
    Results: The patient was confirmed to be infected with Talaromyces marneffei, and further testing revealed that he was a patient with HIV co-infected with syphilis.
    Conclusions: With heavy fungemia the organisms may be seen on the peripheral blood smear, which can facilitate prompt diagnosis and treatment.
    MeSH term(s) Humans ; Male ; Syphilis ; Coinfection ; HIV Infections/complications ; HIV Infections/diagnosis ; HIV Infections/drug therapy ; Talaromyces ; Antifungal Agents/therapeutic use
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2023-11-10
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 1307629-2
    ISSN 1433-6510 ; 0941-2131
    ISSN 1433-6510 ; 0941-2131
    DOI 10.7754/Clin.Lab.2023.230523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Zs.MO 25: Show issues

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  7. Article ; Online: Modulation of Macrophage Immunometabolism: A New Approach to Fight Infections.

    Gauthier, Thierry / Chen, Wanjun

    Frontiers in immunology

    2022  Volume 13, Page(s) 780839

    Abstract: Macrophages are essential innate immune cells that contribute to host defense during infection. An important feature of macrophages is their ability to respond to extracellular cues and to adopt different phenotypes and functions in response to these ... ...

    Abstract Macrophages are essential innate immune cells that contribute to host defense during infection. An important feature of macrophages is their ability to respond to extracellular cues and to adopt different phenotypes and functions in response to these stimuli. The evidence accumulated in the last decade has highlighted the crucial role of metabolic reprogramming during macrophage activation in infectious context. Thus, understanding and manipulation of macrophage immunometabolism during infection could be of interest to develop therapeutic strategies. In this review, we focus on 5 major metabolic pathways including glycolysis, pentose phosphate pathway, fatty acid oxidation and synthesis, tricarboxylic acid cycle and amino acid metabolism and discuss how they sustain and regulate macrophage immune function in response to parasitic, bacterial and viral infections as well as trained immunity. At the end, we assess whether some drugs including those used in clinic and in development can target macrophage immunometabolism for potential therapy during infection with an emphasis on SARS-CoV2 infection.
    MeSH term(s) Animals ; COVID-19/immunology ; Humans ; Immunity, Innate/immunology ; Infections/immunology ; Infections/metabolism ; Macrophage Activation/immunology ; Macrophages/immunology ; Macrophages/metabolism ; SARS-CoV-2
    Language English
    Publishing date 2022-01-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.780839
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: IFN-γ and TGF-β, Crucial Players in Immune Responses: A Tribute to Howard Young.

    Gauthier, Thierry / Chen, WanJun

    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

    2022  Volume 42, Issue 12, Page(s) 643–654

    Abstract: Interferon gamma (IFN-γ) and transforming growth factor beta (TGF-β), both pleiotropic cytokines, have been long studied and described as critical mediators of the immune response, notably in T cells. One of the investigators who made seminal and ... ...

    Abstract Interferon gamma (IFN-γ) and transforming growth factor beta (TGF-β), both pleiotropic cytokines, have been long studied and described as critical mediators of the immune response, notably in T cells. One of the investigators who made seminal and critical discoveries in the field of IFN-γ biology is Dr. Howard Young. In this review, we provide an overview of the biology of IFN-γ as well as its role in cancer and autoimmunity with an emphasis on Dr. Young's critical work in the field. We also describe how Dr. Young's work influenced our own research studying the role of TGF-β in the modulation of immune responses.
    MeSH term(s) Interferon-gamma ; Transforming Growth Factor beta ; Cytokines ; Tumor Cells, Cultured ; Immunity
    Chemical Substances Interferon-gamma (82115-62-6) ; Transforming Growth Factor beta ; Cytokines
    Language English
    Publishing date 2022-11-04
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Intramural
    ZDB-ID 1226675-9
    ISSN 1557-7465 ; 1079-9907
    ISSN (online) 1557-7465
    ISSN 1079-9907
    DOI 10.1089/jir.2022.0132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1748: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: Comparison of preparation methods of rat kidney single-cell suspensions.

    Wang, Tiantian / Shen, Wanjun / Li, Lin / Wang, Haoran / Zhang, Min / Chen, Xiangmei

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 2785

    Abstract: Preparation of kidney tissue single-cell suspensions is the basis of single-cell sequencing, flow cytometry and primary cell culture, but it is difficult to prepare high quality whole kidney single-cell suspensions because of the complex structure of the ...

    Abstract Preparation of kidney tissue single-cell suspensions is the basis of single-cell sequencing, flow cytometry and primary cell culture, but it is difficult to prepare high quality whole kidney single-cell suspensions because of the complex structure of the kidney. We explored a technique called stepwise enzymatic digestion (StE) method for preparing a single-cell suspension of rat whole kidney tissue which contained three main steps. The first step is to cut the kidney into a homogenate. The second step is the digestion of renal tubules using Multi Tissue Dissociation Kit 2 and the last step is the digestion of glomeruli using type IV collagenase. We also compared it with two previous techniques, mechanical grinding method and simple enzymatic digestion method. The StE method had the advantages of high intrinsic glomerular cells and immune cells harvest rate, high singlets rate and high cell viability compared with the other two techniques. In conclusion, the StE method is feasible, highly efficient, and worthy of further research and development.
    MeSH term(s) Rats ; Animals ; Flow Cytometry/methods ; Kidney ; Kidney Glomerulus ; Epithelial Cells ; Kidney Tubules
    Language English
    Publishing date 2024-02-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-53270-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Editorial: Hexose Uptake and Metabolism in Immune Homeostasis and Inflammation.

    Zhang, Dunfang / Liu, Chaohong / Nakatsukasa, Hiroko / Chen, WanJun

    Frontiers in immunology

    2022  Volume 12, Page(s) 832293

    MeSH term(s) Animals ; Biomarkers ; Carbohydrate Metabolism ; Disease Susceptibility ; Hexoses/metabolism ; Homeostasis/immunology ; Humans ; Immune System ; Inflammation/etiology ; Inflammation/metabolism
    Chemical Substances Biomarkers ; Hexoses
    Language English
    Publishing date 2022-01-10
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.832293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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