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  1. Article ; Online: Universal Cardiology Electronic Consultations.

    Phadke, Neelam A

    Circulation. Cardiovascular quality and outcomes

    2022  Volume 15, Issue 1, Page(s) e008709

    MeSH term(s) Cardiology ; Humans ; Referral and Consultation ; Remote Consultation
    Language English
    Publishing date 2022-01-18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2483197-9
    ISSN 1941-7705 ; 1941-7713
    ISSN (online) 1941-7705
    ISSN 1941-7713
    DOI 10.1161/CIRCOUTCOMES.121.008709
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  2. Article ; Online: Improving care using outpatient electronic consults in patients with chemotherapy hypersensitivity reactions.

    Banerji, Aleena / Phadke, Neelam / McMahon, Aubree E / Cogan, Amelia S / Blumenthal, Kimberly G

    The journal of allergy and clinical immunology. In practice

    2023  

    Language English
    Publishing date 2023-11-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.10.052
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  3. Article ; Online: Home Hospital Heart Failure Admissions are an Opportunity to Optimize Guideline-Directed Medical Therapy.

    Achanta, Aditya / Phadke, Neelam / Wasfy, Jason H / Levine, David / Weiner, Rory B

    Journal of cardiac failure

    2023  Volume 30, Issue 1, Page(s) 115–116

    MeSH term(s) Humans ; Heart Failure/drug therapy ; Hospitalization ; Patient Readmission ; Hospitals ; Stroke Volume
    Language English
    Publishing date 2023-10-26
    Publishing country United States
    Document type Letter
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2023.09.012
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    Zs.A 4340: Show issues Location:
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  4. Article ; Online: Safety Surveillance of COVID-19 mRNA Vaccines Through the Vaccine Safety Datalink.

    Blumenthal, Kimberly G / Phadke, Neelam A / Bates, David W

    JAMA

    2021  Volume 326, Issue 14, Page(s) 1375–1377

    MeSH term(s) Adverse Drug Reaction Reporting Systems ; COVID-19 ; COVID-19 Vaccines ; Humans ; RNA, Messenger ; SARS-CoV-2 ; Vaccines/adverse effects
    Chemical Substances COVID-19 Vaccines ; RNA, Messenger ; Vaccines
    Language English
    Publishing date 2021-09-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2021.14808
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  5. Article ; Online: Understanding the Patient Experience of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): A Qualitative Study.

    Samarakoon, Upeka / Wolfson, Anna R / Zhou, Li / Bassir, Fatima / Phillips, Elizabeth / Kroshinsky, Daniela / Cucka, Bethany / Biglione, Bianca / Phadke, Neelam A / Jaggers, Jordon / Byrne, Emily C / Judd, Allen D / Blumenthal, Kimberly G

    Journal of the American Academy of Dermatology

    2024  

    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2024.04.036
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  6. Article ; Online: Case 8-2022: A 54-Year-Old Woman with Episodes of Swelling.

    Banerji, Aleena / Phadke, Neelam A / Gottumukkala, Ravi / Sharma, Rohit / Murali, Mandakolathur R

    The New England journal of medicine

    2022  Volume 386, Issue 11, Page(s) 1071–1079

    MeSH term(s) Antibodies, Monoclonal, Humanized/therapeutic use ; Complement C1 Inhibitor Protein/analysis ; Complement System Proteins/analysis ; Diagnosis, Differential ; Edema/etiology ; Female ; Gene Deletion ; Hereditary Angioedema Types I and II/diagnosis ; Hereditary Angioedema Types I and II/drug therapy ; Hereditary Angioedema Types I and II/genetics ; Humans ; Middle Aged ; Radiography, Abdominal ; Tomography, X-Ray Computed ; Urticaria/etiology
    Chemical Substances Antibodies, Monoclonal, Humanized ; Complement C1 Inhibitor Protein ; lanadelumab (2372V1TKXK) ; Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2022-03-01
    Publishing country United States
    Document type Case Reports ; Clinical Conference ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcpc2027087
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  7. Article ; Online: Immediate reaction to ibrutinib amenable to oral desensitization.

    Phadke, Neelam A / Luk, Samantha O / Hochberg, Ephraim P / Banerji, Aleena

    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

    2021  Volume 27, Issue 7, Page(s) 1802–1805

    Abstract: Introduction: Although up to half of patients receiving chemotherapeutic agents develop hypersensitivity reactions to the same, desensitization protocols can induce temporary tolerance to allow patients to continue to receive first-line treatment. ... ...

    Abstract Introduction: Although up to half of patients receiving chemotherapeutic agents develop hypersensitivity reactions to the same, desensitization protocols can induce temporary tolerance to allow patients to continue to receive first-line treatment. Approximately 25% of patients develop cutaneous hypersensitivity reactions to ibrutinib, but there are no published management guidelines.
    Case report: We describe the case of a 71-year-old woman with chronic lymphocytic leukemia who developed a delayed maculopapular rash with lip tingling and swelling following ibrutinib therapy.
    Management and outcome: We performed a novel 11-step desensitization procedure to ibrutinib allowing us to successfully induce tolerance against IgE-mediated symptoms in this patient.
    Discussion: As indications for ibrutinib use expand and more patients present with IgE-mediated symptoms, we expect that this protocol will provide benefit for many such patients.
    MeSH term(s) Adenine/analogs & derivatives ; Aged ; Desensitization, Immunologic ; Drug Hypersensitivity/therapy ; Female ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Piperidines ; Pyrimidines/adverse effects
    Chemical Substances Piperidines ; Pyrimidines ; ibrutinib (1X70OSD4VX) ; Adenine (JAC85A2161)
    Language English
    Publishing date 2021-04-01
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1330764-2
    ISSN 1477-092X ; 1078-1552
    ISSN (online) 1477-092X
    ISSN 1078-1552
    DOI 10.1177/10781552211004689
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    Zs.A 4488: Show issues Location:
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  8. Article ; Online: Gender Differences in the Amount and Type of Student Participation During In-Person and Virtual Classes in Academic Medicine Learning Environments.

    Cromer, Sara J / D'Silva, Kristin M / Phadke, Neelam A / Lord, Emma / Rigotti, Nancy A / Baer, Heather J

    JAMA network open

    2022  Volume 5, Issue 1, Page(s) e2143139

    MeSH term(s) Academic Medical Centers ; Adult ; Education, Distance/statistics & numerical data ; Education, Medical, Graduate/methods ; Education, Medical, Graduate/statistics & numerical data ; Female ; Humans ; Male ; Problem-Based Learning/statistics & numerical data ; Sex Factors ; Students, Medical/statistics & numerical data
    Language English
    Publishing date 2022-01-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2021.43139
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  9. Article ; Online: Allergy Safety Events in Health Care: Development and Application of a Classification Schema Based on Retrospective Review.

    Phadke, Neelam A / Wickner, Paige / Wang, Liqin / Zhou, Li / Mort, Elizabeth / Bates, David W / Seguin, Claire / Fu, Xiaoqing / Blumenthal, Kimberly G

    The journal of allergy and clinical immunology. In practice

    2022  Volume 10, Issue 7, Page(s) 1844–1855.e3

    Abstract: Background: Allergy safety requires understanding the operational processes that expose patients to their known allergens, including how and when such processes fail.: Objective: To improve health care safety for patients with allergies, we developed ...

    Abstract Background: Allergy safety requires understanding the operational processes that expose patients to their known allergens, including how and when such processes fail.
    Objective: To improve health care safety for patients with allergies, we developed and assessed an allergy safety event classification schema to describe failures resulting in allergy-related safety events.
    Methods: Using keyword searches followed by expert manual review of 299,031 voluntarily-filed safety event reports at 2 large academic medical centers, we identified and classified allergy-related safety events from 5 years of safety reports. We used driver diagrams to elucidate root causes for commonly observed allergy safety events in health care settings.
    Results: From 299,031 safety reports, 1922 (0.6%) were extracted with keywords and 744 (0.2%) were manually confirmed as allergy-related safety events. Safety failures were due to incomplete/inaccurate electronic health record documentation (n = 375, 50.4%), human factors (n = 175, 23.5%), allergy alert limitation and/or malfunction (n = 127, 17.1%), data exchange and interoperability failures (n = 92, 12.4%), and electronic health record system default options (n = 30, 4.0%). Safety failures resulted in known allergen exposures to drugs (n = 537), including heparin (n = 27) and topical anesthetics such as lidocaine (n = 8); latex (n = 114); food allergens (n = 73); and adhesive (n = 23).
    Conclusions: We identified 744 allergy-related safety events to inform a novel safety failure classification schema as an important step toward a safer health care environment for patients with allergies. Improved systems are required to address safety issues with certain food and drug allergens.
    MeSH term(s) Allergens ; Delivery of Health Care ; Documentation ; Drug Hypersensitivity/epidemiology ; Food Hypersensitivity ; Humans ; Retrospective Studies
    Chemical Substances Allergens
    Language English
    Publishing date 2022-04-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.03.026
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  10. Article ; Online: Home Hospital Outcomes for Acute Decompensated Heart Failure and Factors Associated With Escalation of Care.

    Achanta, Aditya / Wasfy, Jason H / Moss, Carson Tyler / Cherukara, Abraham / Ho, David / Boxer, Robert / Schmieding, Malte / Phadke, Neelam Ameya / Thompson, Ryan / Levine, David Michael / Weiner, Rory B

    Circulation. Cardiovascular quality and outcomes

    2023  Volume 17, Issue 1, Page(s) e010031

    Abstract: Background: Overall outcomes and the escalation rate for home hospital admissions for heart failure (HF) are not known. We report overall outcomes, predict escalation, and describe care provided after escalation among patients admitted to home hospital ... ...

    Abstract Background: Overall outcomes and the escalation rate for home hospital admissions for heart failure (HF) are not known. We report overall outcomes, predict escalation, and describe care provided after escalation among patients admitted to home hospital for HF.
    Methods: Our retrospective analysis included all patients admitted for HF to 2 home hospital programs in Massachusetts between February 2020 and October 2022. Escalation of care was defined as transfer to an inpatient hospital setting (emergency department, inpatient medical unit) for at least 1 overnight stay. Unexpected mortality was defined as mortality excluding those who desired to pass away at home on admission or transitioned to hospice. We performed the least absolute shrinkage and selection operator logistic regression to predict escalation.
    Results: We included 437 hospitalizations; patients had a median age of 80 (interquartile range, 69-89) years, 58.1% were women, and 64.8% were White. Of the cohort, 29.2% had reduced ejection fraction, 50.9% had chronic kidney disease, and 60.6% had atrial fibrillation. Median admission Get With The Guidelines HF score was 39 (interquartile range, 35-45; 1%-5% predicted inpatient mortality). Escalation occurred in 10.3% of hospitalizations. Thirty-day readmission occurred in 15.1%, 90-day readmission occurred in 33.8%, and 6-month mortality occurred in 11.5%. There was no unexpected mortality during home hospitalization. Patients who experienced escalation had significantly longer median length of stays (19 versus 7.5 days,
    Conclusions: About 1 in 10 home hospital patients with HF required escalation; none had unexpected mortality. Patients requiring escalation had longer length of stays. A low mean arterial pressure at the time of admission to home hospital was the most important predictor of escalation of care in the least absolute shrinkage and selection operator logistic regression model.
    MeSH term(s) Humans ; Female ; Aged ; Aged, 80 and over ; Male ; Retrospective Studies ; Hospitalization ; Patient Readmission ; Heart Failure/diagnosis ; Heart Failure/therapy ; Heart Failure/complications ; Hospitals
    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2483197-9
    ISSN 1941-7705 ; 1941-7713
    ISSN (online) 1941-7705
    ISSN 1941-7713
    DOI 10.1161/CIRCOUTCOMES.123.010031
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