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Article: Waiting to be seen: social perspectives on trans health.

Newman, Christy E / Smith, Anthony K J / Duck-Chong, Elizabeth / Vivienne, Son / Davies, Cristyn / Robinson, Kerry H / Aggleton, Peter

Health sociology review : the journal of the Health Section of the Australian Sociological Association

2020 Volume 30, Issue 1, Page(s) 1–8

MeSH term(s)	Health Equity/statistics & numerical data ; Humans ; Transgender Persons/statistics & numerical data
Language	English
Publishing date	2020-11-22
Publishing country	United States
Document type	Editorial ; Introductory Journal Article
ZDB-ID	2146435-2
ISSN	1839-3551 ; 1446-1242
ISSN (online)	1839-3551
ISSN	1446-1242
DOI	10.1080/14461242.2020.1868900
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Article ; Online: Xist nucleates local protein gradients to propagate silencing across the X chromosome.

Markaki, Yolanda / Chong, Johnny Gan / Wang, Yuying / Jacobson, Elsie C / Luong, Christy / Tan, Shawn Y X / Jachowicz, Joanna W / Strehle, Mackenzie / Maestrini, Davide / Banerjee, Abhik K / Mistry, Bhaven A / Dror, Iris / Dossin, Francois / Schӧneberg, Johannes / Heard, Edith / Guttman, Mitchell / Chou, Tom / Plath, Kathrin

Cell

2021 Volume 184, Issue 25, Page(s) 6212

Language	English
Publishing date	2021-12-10
Publishing country	United States
Document type	Published Erratum
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2021.11.028
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Zs.A 1167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Determining the Association Between Continuity of Primary Care and Acute Care Use in Chronic Kidney Disease: A Retrospective Cohort Study.

Chong, Christy / Campbell, David / Elliott, Meghan / Aghajafari, Fariba / Ronksley, Paul

Annals of family medicine

2022 Volume 20, Issue 3, Page(s) 237–245

Abstract: Purpose: Acute care use is high among individuals with chronic kidney disease (CKD). It is unclear how relational continuity of primary care influences downstream acute care use. We aimed to determine if poor continuity of care is associated with ... ...

Abstract	Purpose: Acute care use is high among individuals with chronic kidney disease (CKD). It is unclear how relational continuity of primary care influences downstream acute care use. We aimed to determine if poor continuity of care is associated with greater rates of acute care use and decreased prescriptions for guideline-recommended drugs. Methods: We conducted a population-based retrospective cohort study of adults with stage 3-4 CKD and ≥3 visits to a primary care clinician during the period April 1, 2011 to March 31, 2014 in Alberta, Canada. Continuity was calculated using the Usual Provider Continuity index. Descriptive statistics were used to summarize patient and acute care encounter characteristics. Adjusted rates and incidence rate ratios for all-cause and CKD-related ambulatory care-sensitive condition (ACSC) hospitalizations and emergency department (ED) visits were estimated using negative binomial regression. Adjusted odds ratios for prescription use were estimated by multivariable logistic regression. Results: Among 86,475 patients with CKD, 51.3%, 30.0%, and 18.7% had high, moderate, and poor continuity of care, respectively. There were 77,988 all-cause hospitalizations, 6,489 ACSC-related hospitalizations, 204,615 all-cause ED visits, and 8,461 ACSC-related ED visits during a median follow-up of 2.3 years. Rates of all-cause and ACSC hospitalization and ED use increased with poorer continuity of care in a stepwise fashion across CKD stages. Patients with poor continuity were less likely to be prescribed a statin. Conclusions: Poor continuity of care is associated with increased acute care use among patients with CKD. Targeted strategies that strengthen patient-physician relationships and guide physicians regarding guideline-recommended prescribing are needed.
MeSH term(s)	Adult ; Ambulatory Care ; Cohort Studies ; Continuity of Patient Care ; Emergency Service, Hospital ; Hospitalization ; Humans ; Primary Health Care ; Renal Insufficiency, Chronic/therapy ; Retrospective Studies
Language	English
Publishing date	2022-05-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2171425-3
ISSN	1544-1717 ; 1544-1709
ISSN (online)	1544-1717
ISSN	1544-1709
DOI	10.1370/afm.2813
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Zs.A 6065: Show issues

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Article ; Online: "False positive" urine pregnancy test results after successful medication abortion.

Raymond, Elizabeth G / Anger, Holly A / Chong, Erica / Haskell, Sue / Grant, Melissa / Boraas, Christy / Tocce, Kristina / Banks, Joey / Kaneshiro, Bliss / Baldwin, Maureen K / Coplon, Leah / Bednarek, Paula / Shochet, Tara / Platais, Ingrida

Contraception

2021 Volume 103, Issue 6, Page(s) 400–403

Abstract: Objective: To examine the proportion of high-sensitivity urine pregnancy test (HSPT) results that were positive by time after successful medication abortion.: Study design: We used data from an ongoing study that provides mifepristone and misoprostol ...

Abstract	Objective: To examine the proportion of high-sensitivity urine pregnancy test (HSPT) results that were positive by time after successful medication abortion. Study design: We used data from an ongoing study that provides mifepristone and misoprostol for medication abortion by direct-to-patient telemedicine and mail. Providers evaluated abortion outcomes by patient interview and clinical tests per clinical judgment and participant preference. We identified all participants enrolled July 2016 to September, 2020 who had an HSPT result and no indication of viable pregnancy after treatment. We used logistic regression to examine the association between the timing of the initial post-treatment HSPT, gestational age, and the proportion of HSPTs that gave a positive result. Results: Of the 472 participants in our analysis, 88 (19%) had positive initial HSPTs. The proportions that were positive at ≤20 days, 21 to 27 days, 28 to 34 days, and ≥35 days after mifepristone ingestion was 14 of 29 (48%), 15 of 58 (26%), 49 of 258 (19%), and 10 of 127 (8%), respectively (p < 0.001). Gestational age at mifepristone ingestion was not significantly related to positive HSPT results (p = 0.28). Multivariable logistic regression confirmed both findings and did not identify a statistically significant interaction between these variables. In the 67 participants who relied solely on further HSPTs to confirm abortion outcome, the median interval between the initial positive test and first negative test was 14 days. Conclusions: The proportion of participants with positive HSPTs declined with time after successful medication abortion. However, nearly one-fifth of participants with complete abortion had positive tests 4 weeks after treatment. Implications: HSPTs provide an inexpensive, convenient option for confirming success of medication abortion at home. However, a substantial minority of patients without ongoing pregnancy have positive HSPT results. Development of a symptom-based strategy for medication abortion outcome assessment without any confirmatory tests should be a priority.
MeSH term(s)	Abortion, Induced ; Abortion, Spontaneous ; Female ; Humans ; Mifepristone ; Misoprostol ; Pregnancy ; Pregnancy Tests
Chemical Substances	Misoprostol (0E43V0BB57) ; Mifepristone (320T6RNW1F)
Language	English
Publishing date	2021-02-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80106-9
ISSN	1879-0518 ; 0010-7824
ISSN (online)	1879-0518
ISSN	0010-7824
DOI	10.1016/j.contraception.2021.02.004
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Zs.A 629: Show issues

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Article ; Online: Xist nucleates local protein gradients to propagate silencing across the X chromosome.

Markaki, Yolanda / Gan Chong, Johnny / Wang, Yuying / Jacobson, Elsie C / Luong, Christy / Tan, Shawn Y X / Jachowicz, Joanna W / Strehle, Mackenzie / Maestrini, Davide / Banerjee, Abhik K / Mistry, Bhaven A / Dror, Iris / Dossin, Francois / Schöneberg, Johannes / Heard, Edith / Guttman, Mitchell / Chou, Tom / Plath, Kathrin

Cell

2021 Volume 184, Issue 25, Page(s) 6174–6192.e32

Abstract: The lncRNA Xist forms ∼50 diffraction-limited foci to transcriptionally silence one X chromosome. How this small number of RNA foci and interacting proteins regulate a much larger number of X-linked genes is unknown. We show that Xist foci are locally ... ...

Abstract	The lncRNA Xist forms ∼50 diffraction-limited foci to transcriptionally silence one X chromosome. How this small number of RNA foci and interacting proteins regulate a much larger number of X-linked genes is unknown. We show that Xist foci are locally confined, contain ∼2 RNA molecules, and nucleate supramolecular complexes (SMACs) that include many copies of the critical silencing protein SPEN. Aggregation and exchange of SMAC proteins generate local protein gradients that regulate broad, proximal chromatin regions. Partitioning of numerous SPEN molecules into SMACs is mediated by their intrinsically disordered regions and essential for transcriptional repression. Polycomb deposition via SMACs induces chromatin compaction and the increase in SMACs density around genes, which propagates silencing across the X chromosome. Our findings introduce a mechanism for functional nuclear compartmentalization whereby crowding of transcriptional and architectural regulators enables the silencing of many target genes by few RNA molecules.
MeSH term(s)	Animals ; Apoptosis Regulatory Proteins/metabolism ; Cell Line ; Embryonic Stem Cells ; Fibroblasts ; Gene Silencing ; Humans ; Mice ; Mitochondrial Proteins/metabolism ; Protein Binding ; RNA, Long Noncoding/metabolism ; X Chromosome/metabolism ; X Chromosome Inactivation
Chemical Substances	Apoptosis Regulatory Proteins ; DIABLO protein, human ; Mitochondrial Proteins ; RNA, Long Noncoding ; XIST non-coding RNA
Language	English
Publishing date	2021-11-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2021.10.022
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Article: Cost of Potentially Preventable Hospitalizations Among Adults With Chronic Kidney Disease: A Population-Based Cohort Study.

Chong, Christy / Wick, James / Klarenbach, Scott / Manns, Braden / Hemmelgarn, Brenda / Ronksley, Paul

Canadian journal of kidney health and disease

2021 Volume 8, Page(s) 20543581211018528

Abstract: Background: Prior studies report high hospitalization rates among patients with chronic kidney disease (CKD) and approximately 10% to 20.9% of hospitalizations are potentially preventable.: Objective: To determine the rate, proportion, and cost of ... ...

Abstract	Background: Prior studies report high hospitalization rates among patients with chronic kidney disease (CKD) and approximately 10% to 20.9% of hospitalizations are potentially preventable. Objective: To determine the rate, proportion, and cost of potentially preventable hospitalizations and whether this varied by CKD category. Design: Retrospective cohort study using population-based data. Setting: Alberta, Canada. Patients: All adults with an outpatient serum creatinine measurement between January 1 and December 31, 2017 in the Alberta Kidney Disease Network data repository. Measurements: CKD risk categories were based on measures of proteinuria (where available), eGFR, and use of dialysis. Patients were linked to administrative data to capture frequency and cost of hospital encounters and followed until death or end of study (December 31, 2018). The outcomes of interest were the rate and cost of potentially preventable hospitalizations, as identified using the Canadian Institute for Health Information (CIHI)-defined ambulatory care sensitive condition (ACSC) algorithm and a CKD-related ACSC algorithm. Methods: Unadjusted and adjusted rates per 1000-patient years, proportions, and cost attributable to preventable hospitalizations were identified for the cohort as a whole and for patients within each CKD risk category. Results: Of the 1,110,895 adults with eGFR and proteinuria measurements, 181,422 had CKD. During a median follow-up of 1 year, there were 62,023 hospitalizations among patients with CKD resulting in a total cost of $946 million CAD; 6907 (11.1%) of these hospitalizations were for CIHI-defined ACSCs while 4323 (7.0%) were for CKD-related ACSCs. Adjusted rates of hospitalization for ACSCs increased with CKD risk category and were highest among patients treated with dialysis. Among CKD patients, the total cost of potentially preventable hospitalizations was $79 million and $58 million CAD for CIHI-defined and CKD-related ACSCs (8.4% and 6.2% of total hospitalization cost, respectively). Limitations: Based on the ACSC construct, we were unable to determine if these hospitalizations were truly preventable. Conclusions: Potentially preventable hospitalizations have a substantial cost and burden on the health care system among people with CKD. Effective strategies that reduce preventable admissions among CKD patients may lead to significant cost savings. Trial registration: Not applicable-observational study design.
Language	English
Publishing date	2021-06-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2765462-X
ISSN	2054-3581
ISSN	2054-3581
DOI	10.1177/20543581211018528
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Article ; Online: Gender diversity and social change: transgressions, translations, transformations.

Newman, Christy E / Smith, Anthony K J / Harvey, Shannon / Duck-Chong, Elizabeth

Culture, health & sexuality

2023 Volume 25, Issue 12, Page(s) 1758–1761

MeSH term(s)	Humans ; Social Change ; Social Behavior ; Gender Identity ; Morals
Language	English
Publishing date	2023-12-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2023577-X
ISSN	1464-5351 ; 1369-1058
ISSN (online)	1464-5351
ISSN	1369-1058
DOI	10.1080/13691058.2023.2277606
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Article ; Online: A Qualitative Content Analysis of Comments on Press Articles on Deemed Consent for Organ Donation in Canada.

Fox, Danielle E / Donald, Maoliosa / Chong, Christy / Quinn, Robert R / Ronksley, Paul E / Elliott, Meghan J / Lam, Ngan N

Clinical journal of the American Society of Nephrology : CJASN

2022 Volume 17, Issue 11, Page(s) 1656–1664

Abstract: Background and objectives: In 2019, two Canadian provinces became the first jurisdictions in North America to pass deemed consent legislation to increase deceased organ donation and transplantation rates. We sought to explore the perspectives of the ... ...

Abstract	Background and objectives: In 2019, two Canadian provinces became the first jurisdictions in North America to pass deemed consent legislation to increase deceased organ donation and transplantation rates. We sought to explore the perspectives of the deemed consent legislation for organ donation in Canada from the viewpoint of individuals commenting on press articles. Design, setting, participants, & measurements: In this qualitative descriptive study, we extracted public comments regarding deemed consent from online articles published by four major Canadian news outlets between January 2019 and July 2020. A total of 4357 comments were extracted from 35 eligible news articles. Comments were independently analyzed by two research team members using a conventional content analysis approach. Results: Commenters' perceptions of the deemed consent legislation for organ donation in Canada predominantly fit within three organizational groups: perceived positive implications of the bills, perceived negative implications of the bills, and key considerations. Three themes emerged within each group that summarized perspectives of the proposed legislation. Themes regarding the perceived positive implications of the bills included majority rules, societal effect, and prioritizing donation. Themes regarding the perceived negative implications of the bills were a right to choose, the potential for abuse and errors, and a possible slippery slope. Improving government transparency and communication, clarifying questions and addressing concerns, and providing evidence for the bills were identified as key considerations. Conclusions: If deemed consent legislation is meant to increase organ donation and transplantation, addressing public concerns will be important to ensure successful implementation.
MeSH term(s)	Humans ; Canada ; Tissue and Organ Procurement ; Organ Transplantation ; Qualitative Research ; Informed Consent ; Tissue Donors
Language	English
Publishing date	2022-10-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2226665-3
ISSN	1555-905X ; 1555-9041
ISSN (online)	1555-905X
ISSN	1555-9041
DOI	10.2215/CJN.04340422
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Article ; Online: Differential cortical thinning of auditory cortex in first episode schizophrenia: Association with auditory verbal hallucinations.

Lee, Edwin H M / Camchong, Jazmin / Skouras, Stavros / Hui, Christy L M / Chan, P Y / Law, Eunice Y L / Chong, Catherine S Y / Chang, W C / Chan, Sherry K W / Lo, William T L / Chen, Eric Y H / Lim, Kelvin O

Schizophrenia research

2018 Volume 206, Page(s) 464–465

MeSH term(s)	Auditory Cortex/diagnostic imaging ; Auditory Cortex/pathology ; Hallucinations/diagnostic imaging ; Hallucinations/etiology ; Hallucinations/pathology ; Humans ; Magnetic Resonance Imaging ; Schizophrenia/complications ; Schizophrenia/diagnostic imaging ; Schizophrenia/pathology ; Schizophrenia/physiopathology
Language	English
Publishing date	2018-12-01
Publishing country	Netherlands
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	639422-x
ISSN	1573-2509 ; 0920-9964
ISSN (online)	1573-2509
ISSN	0920-9964
DOI	10.1016/j.schres.2018.11.014
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Article: Identifying Mobile Applications Aimed at Self-Management in People With Chronic Kidney Disease.

Lewis, Rachel A / Lunney, Meaghan / Chong, Christy / Tonelli, Marcello

Canadian journal of kidney health and disease

2019 Volume 6, Page(s) 2054358119834283

Abstract: Background: A growing number of mobile applications (apps) target people with chronic illness as the primary user. There is increasing evidence that digital technology can improve health outcomes for users but the sheer number of apps available is ... ...

Abstract	Background: A growing number of mobile applications (apps) target people with chronic illness as the primary user. There is increasing evidence that digital technology can improve health outcomes for users but the sheer number of apps available is likely to overwhelm many potential users. Objective: The purpose of this study was to systematically search for apps aimed at people with chronic kidney disease. An important secondary objective was to develop a search strategy that could be used to identify similar apps in the future. Design: A systematic review of the scientific and gray literature including app stores, clearinghouses, and Google. Setting/patients: The focus of this research was the identification of apps that may be of use to people interested in self-management of chronic kidney disease. Methods: Three reviewers independently searched app stores, websites, and databases to identify apps of potential interest and any information related to the function and efficacy of these. Apps that met the inclusion criteria were short-listed, reviewed in more detail, and cross-referenced with other sources such as clearinghouses, Google, and kidney care organizations. A population, intervention, comparison, outcome, and design framework was used to search selected databases. Results: Of the 1464 apps purporting to be for chronic kidney disease, only 15 were eligible for inclusion. Searching the 2 major app stores (iOS and Android) appeared to be the most productive way of identifying apps of potential interest. An increasing number of public and private clearinghouses have been established to assist users with finding apps. Privacy and security of user information is a particular and valid concern of health care professionals and organizations. Limitations: The breadth and depth of information relating to each app varied and made it difficult to systematize the evaluation of apps. Due to the large number of health care apps and the challenges to searching app stores and websites, it is possible that some apps were missed during our searches. Similarly, while there are many kidney care-related websites that contain useful information, these were not captured by our study. Conclusion: There are very few available apps aimed specifically at people with chronic kidney disease; those that are available are best identified by manually searching the 2 major app stores. Privacy and confidentiality of user information when using the apps is a concern among health care providers in particular.
Language	English
Publishing date	2019-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2765462-X
ISSN	2054-3581
ISSN	2054-3581
DOI	10.1177/2054358119834283
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