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  1. Book ; Conference proceedings: Calcium signaling

    Morad, Martin

    [proceedings of the NATO Advanced Research Workshop on Calcium Signaling 26 - 30 April 2000 Lucca, Italy]

    (NATO science series : Series 1, Life and behavioural sciences ; 331)

    2001  

    Institution NATO
    Event/congress Advanced Research Workshop on Calcium Signaling (2000, Lucca)
    Author's details ed. by Martin Morad
    Series title NATO science series : Series 1, Life and behavioural sciences ; 331
    NATO science series
    NATO science series ; Series 1, Life and behavioural sciences
    Collection NATO science series
    NATO science series ; Series 1, Life and behavioural sciences
    Keywords Calcium Signaling ; Calcium-Binding Proteins ; Calcium Channels
    Language English
    Size IX, 278 S. : Ill., graph. Darst.
    Publisher IOS Press u.a.
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT013084311
    ISBN 1-58603-157-0 ; 4-274-90422-9 ; 978-1-58603-157-2 ; 978-4-274-90422-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 A 344 order for loan Magazin

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  2. Article ; Online: Calcium Signaling Consequences of RyR2-S4938F Mutation Expressed in Human iPSC-Derived Cardiomyocytes.

    Toth, Noemi / Zhang, Xiao-Hua / Zamaro, Alexandra / Morad, Martin

    International journal of molecular sciences

    2023  Volume 24, Issue 20

    Abstract: Type-2 ryanodine receptor (RyR2) is the major ... ...

    Abstract Type-2 ryanodine receptor (RyR2) is the major Ca
    MeSH term(s) Humans ; Arrhythmias, Cardiac/genetics ; Arrhythmias, Cardiac/metabolism ; Calcium/metabolism ; Calcium Signaling/physiology ; Induced Pluripotent Stem Cells/metabolism ; Mutation ; Myocytes, Cardiac/metabolism ; Ryanodine Receptor Calcium Release Channel/genetics ; Ryanodine Receptor Calcium Release Channel/metabolism ; Sarcoplasmic Reticulum/metabolism
    Chemical Substances Calcium (SY7Q814VUP) ; Ryanodine Receptor Calcium Release Channel ; RyR2 protein, human
    Language English
    Publishing date 2023-10-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242015307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Oxygen sensor of the heart.

    Fernández-Morales, José-Carlos / Morad, Martin

    Canadian journal of physiology and pharmacology

    2022  Volume 100, Issue 9, Page(s) 848–857

    Abstract: How oxygen is sensed by the heart and what mechanisms mediate its sensing remain poorly understood. As recent reports show that low ... ...

    Abstract How oxygen is sensed by the heart and what mechanisms mediate its sensing remain poorly understood. As recent reports show that low PO
    MeSH term(s) Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Heme Oxygenase-1/metabolism ; Humans ; Hypoxia/metabolism ; Mice ; Myocytes, Cardiac/metabolism ; Oxygen/metabolism ; Phosphorylation
    Chemical Substances Heme Oxygenase-1 (EC 1.14.14.18) ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2022-06-09
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 127527-6
    ISSN 1205-7541 ; 0008-4212
    ISSN (online) 1205-7541
    ISSN 0008-4212
    DOI 10.1139/cjpp-2022-0072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Point mutations in RyR2 Ca2+-binding residues of human cardiomyocytes cause cellular remodelling of cardiac excitation contraction-coupling.

    Xia, Yanli / Zhang, Xiao-Hua / Yamaguchi, Naohiro / Morad, Martin

    Cardiovascular research

    2023  Volume 120, Issue 1, Page(s) 44–55

    Abstract: Aims: CRISPR/Cas9 gene edits of cardiac ryanodine receptor (RyR2) in human-induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) provide a novel platform for introducing mutations in RyR2 Ca2+-binding residues and examining the resulting ... ...

    Abstract Aims: CRISPR/Cas9 gene edits of cardiac ryanodine receptor (RyR2) in human-induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) provide a novel platform for introducing mutations in RyR2 Ca2+-binding residues and examining the resulting excitation contraction (EC)-coupling remodelling consequences.
    Methods and results: Ca2+-signalling phenotypes of mutations in RyR2 Ca2+-binding site residues associated with cardiac arrhythmia (RyR2-Q3925E) or not proven to cause cardiac pathology (RyR2-E3848A) were determined using ICa- and caffeine-triggered Ca2+ releases in voltage-clamped and total internal reflection fluorescence-imaged wild type and mutant cardiomyocytes infected with sarcoplasmic reticulum (SR)-targeted ER-GCaMP6 probe. (i) ICa- and caffeine-triggered Fura-2 or ER-GCaMP6 signals were suppressed, even when ICa was significantly enhanced in Q3925E and E3848A mutant cardiomyocytes; (ii) spontaneous beating (Fura-2 Ca2+ transients) persisted in mutant cells without the SR-release signals; (iii) while 5-20 mM caffeine failed to trigger Ca2+-release in voltage-clamped mutant cells, only ∼20% to ∼70% of intact myocytes responded respectively to caffeine; (iv) and 20 mM caffeine transients, however, activated slowly, were delayed, and variably suppressed by 2-APB, FCCP, or ruthenium red.
    Conclusion: Mutating RyR2 Ca2+-binding residues, irrespective of their reported pathogenesis, suppressed both ICa- and caffeine-triggered Ca2+ releases, suggesting interaction between Ca2+- and caffeine-binding sites. Enhanced transmembrane calcium influx and remodelling of EC-coupling pathways may underlie the persistence of spontaneous beating in Ca2+-induced Ca2+ release-suppressed mutant myocytes.
    MeSH term(s) Humans ; Caffeine/pharmacology ; Caffeine/metabolism ; Calcium/metabolism ; Fura-2/metabolism ; Myocytes, Cardiac/metabolism ; Point Mutation ; Ryanodine Receptor Calcium Release Channel/genetics ; Ryanodine Receptor Calcium Release Channel/metabolism ; Sarcoplasmic Reticulum/metabolism
    Chemical Substances Caffeine (3G6A5W338E) ; Calcium (SY7Q814VUP) ; Fura-2 (TSN3DL106G) ; Ryanodine Receptor Calcium Release Channel ; RyR2 protein, human
    Language English
    Publishing date 2023-10-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvad163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 565: Show issues Location:
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  5. Article ; Online: CRISPR/Cas9 Gene Editing of RYR2 in Human iPSC-Derived Cardiomyocytes to Probe Ca

    Yamaguchi, Naohiro / Zhang, Xiao-Hua / Morad, Martin

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2573, Page(s) 41–52

    Abstract: Human-induced pluripotent stem cells (hiPSCs) provide a powerful platform to study biophysical and molecular mechanisms underlying the pathophysiology of genetic mutations associated with cardiac arrhythmia. Human iPSCs can be generated by reprograming ... ...

    Abstract Human-induced pluripotent stem cells (hiPSCs) provide a powerful platform to study biophysical and molecular mechanisms underlying the pathophysiology of genetic mutations associated with cardiac arrhythmia. Human iPSCs can be generated by reprograming of dermal fibroblasts of normal or diseased individuals and be differentiated into cardiac myocytes. Obtaining biopsies from patients afflicted with point mutations causing arrhythmia is often a cumbersome process even when patients are available. Recent development of CRISPR/Cas9 gene editing system makes it, however, possible to introduce arrhythmia-associated point mutations at the desired loci of the wild-type hiPSCs in relatively short times. This platform was used by us to compare the Ca
    MeSH term(s) Arrhythmias, Cardiac/genetics ; Arrhythmias, Cardiac/pathology ; CRISPR-Cas Systems ; Calcium/metabolism ; Gene Editing/methods ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Mutation ; Myocytes, Cardiac/metabolism ; Ryanodine Receptor Calcium Release Channel/genetics ; Ryanodine Receptor Calcium Release Channel/metabolism ; Tachycardia, Ventricular
    Chemical Substances Ryanodine Receptor Calcium Release Channel ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-08-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2707-5_4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Ca

    Zhang, Xiao-Hua / Morad, Martin

    Cell calcium

    2020  Volume 90, Page(s) 102244

    Abstract: Human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CMs) have been extensively used for in vitro modeling of human cardiovascular disease, drug screening and pharmacotherapy, but little rigorous studies have been reported on their ... ...

    Abstract Human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CMs) have been extensively used for in vitro modeling of human cardiovascular disease, drug screening and pharmacotherapy, but little rigorous studies have been reported on their biophysical or Ca
    MeSH term(s) Adult ; Animals ; Calcium Signaling ; Cell Differentiation ; Humans ; Induced Pluripotent Stem Cells/cytology ; Mammals/metabolism ; Models, Biological ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/metabolism
    Language English
    Publishing date 2020-06-13
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2020.102244
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1596: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Book: Molecular physiology and pharmacology of cardiac ion channels and transporters

    Morad, Martin

    (Developments in cardiovascular medicine ; 182)

    1996  

    Author's details ed. by M. Morad
    Series title Developments in cardiovascular medicine ; 182
    Collection
    Keywords Heart / physiology ; Heart / physiopathology ; Myocardium / metabolism ; Ion Channels / physiology ; Ion Transport ; Herzmuskel ; Calcium ; Signaltransduktion ; Ionenkanal
    Subject Signalübertragung ; Signalvermittlung ; Calzium ; Kalzium ; Herzmuskeln ; Herzmuskulatur ; Myokard ; Myocard ; Myocardium ; Herzmuskelgewebe
    Language English
    Size XIV, 593 : Ill., graph. Darst.
    Publisher Kluwer Acad. Publ
    Publishing place Dordrecht u.a.
    Publishing country Netherlands
    Document type Book
    Note Includes index
    HBZ-ID HT007421415
    ISBN 0-7923-3913-4 ; 978-0-7923-3913-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1997 A 1241 order for loan Magazin

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  8. Book ; Conference proceedings: Intracellular regulation of ion channels

    Morad, Martin

    [proceedings of the NATO Advanced Research Workshop on Intracellular Modulation of Cardiac and Neuronal Ion Channels held at Il Ciocco, Lucca (Italy) from April 26 - 30, 1991]

    (NATO ASI series : Series H ; 60)

    1992  

    Institution NATO
    Event/congress Advanced Research Workshop on Intracellular Modulation of Cardiac and Neuronal Ion Channels (1991, Lucca)
    Author's details ed. by Martin Morad
    Series title NATO ASI series : Series H ; 60
    NATO ASI series
    NATO ASI series ; Series H
    Collection NATO ASI series
    NATO ASI series ; Series H
    Keywords Ion Channels / physiology / congresses ; Zelle ; Regulation ; Ionenkanal
    Size X, 251 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Document type Book ; Conference proceedings
    HBZ-ID HT004155218
    ISBN 3-540-54611-1 ; 0-387-54611-1 ; 978-3-540-54611-5 ; 978-0-387-54611-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    1992 A 3278 order for loan Magazin

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  9. Book: The calcium channel

    Morad, Martin

    structure, function and implications

    1988  

    Institution Bayer AG
    Author's details Bayer AG Centenary Symposium, Stresa/Italy, May 11 - 14, 1988. Ed.: Martin Morad
    Keywords Calcium Channels / congresses ; Calciumkanal
    Subject Kalziumkanal
    Language English
    Size XXIV, 643 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT003284250
    ISBN 3-540-50061-8 ; 0-387-50061-8 ; 978-3-540-50061-2 ; 978-0-387-50061-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1989 A 1195 order for loan Magazin

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  10. Article ; Online: Mechanisms of spontaneous pacing: sinoatrial nodal cells, neonatal cardiomyocytes, and human stem cell derived cardiomyocytes.

    Morad, Martin / Zhang, Xiao-Hua

    Canadian journal of physiology and pharmacology

    2017  Volume 95, Issue 10, Page(s) 1100–1107

    Abstract: The sinoatrial (SA) node is the primary site from which the mammalian heart is paced, but the mechanisms underlying the pacemaking still remain clouded. It is generally believed that the hyperpolarization-activated current ... ...

    Abstract The sinoatrial (SA) node is the primary site from which the mammalian heart is paced, but the mechanisms underlying the pacemaking still remain clouded. It is generally believed that the hyperpolarization-activated current I
    Language English
    Publishing date 2017-10
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 127527-6
    ISSN 1205-7541 ; 0008-4212
    ISSN (online) 1205-7541
    ISSN 0008-4212
    DOI 10.1139/cjpp-2016-0743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 589: Show issues Location:
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