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  1. Article ; Online: Mitochondrial Targeted Therapies to Prevent Maternal Diabetes-Induced Congenital Heart Defects.

    Reddy, Sushma

    JACC. Basic to translational science

    2024  Volume 9, Issue 3, Page(s) 319–321

    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Editorial
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2024.01.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Investigations on anticancer activity of Eu

    Sai Manogna, K / Deva Prasad Raju, B / Rajasekhara Reddy, G / Kallem, Parashuram / Shaik, Mannur Ismail / John Sushma, N

    Heliyon

    2024  Volume 10, Issue 3, Page(s) e25064

    Abstract: Breast cancer remains a significant global health concern, necessitating the development of novel therapeutic approaches. In this study, we investigate the role of ... ...

    Abstract Breast cancer remains a significant global health concern, necessitating the development of novel therapeutic approaches. In this study, we investigate the role of Eu
    Language English
    Publishing date 2024-01-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e25064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: iPSC model of congenital heart disease predicts disease outcome.

    Tripathi, Dipti / Reddy, Sushma

    Cell stem cell

    2022  Volume 29, Issue 5, Page(s) 659–660

    Abstract: In this issue of Cell Stem Cell, Xu et al. demonstrate that induced pluripotent stem cell-derived cardiomyocytes from patients with hypoplastic left heart syndrome exhibit mitochondrial dysfunction and can be used for disease modeling. In addition, they ... ...

    Abstract In this issue of Cell Stem Cell, Xu et al. demonstrate that induced pluripotent stem cell-derived cardiomyocytes from patients with hypoplastic left heart syndrome exhibit mitochondrial dysfunction and can be used for disease modeling. In addition, they show the potential to predict future heart failure and develop therapies.
    MeSH term(s) Cell Differentiation ; Heart Defects, Congenital ; Heart Failure ; Humans ; Induced Pluripotent Stem Cells ; Myocytes, Cardiac
    Language English
    Publishing date 2022-05-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2022.04.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6589: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 75: Show issues

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  4. Article ; Online: Bill shape imposes biomechanical tradeoffs in cavity-excavating birds.

    Chhaya, Vaibhav / Reddy, Sushma / Krishnan, Anand

    Proceedings. Biological sciences

    2023  Volume 290, Issue 1995, Page(s) 20222395

    Abstract: Organisms are subject to physical forces that influence morphological evolution. Birds use their bills as implements to perform various functions, each exerting unique physical demands. When excavating cavities, bird bills must resist a range of ... ...

    Abstract Organisms are subject to physical forces that influence morphological evolution. Birds use their bills as implements to perform various functions, each exerting unique physical demands. When excavating cavities, bird bills must resist a range of mechanical stresses to prevent fracture. However, the contribution of bill geometry and material composition to excavation stress resistance remains poorly understood. Here, we study the biomechanical consequences of bill diversification in the cavity-excavating palaeotropical barbets. Using finite-element models and beam theory, we compare excavation performance for two loading regimes experienced by barbet bills during cavity excavation: impact and torsion. We find that deeper and wider maxillae perform better for impact loads than for torsional loads, with the converse for narrower maxillae. This results in tradeoffs between impact and torsion resistance imposed by bill geometry. Analytical beam models validate this prediction, showing that this relationship holds even when maxillae are simplified to solid elliptical beams. Finally, we find that composite bill structures broadly exhibit lower stresses than homogeneous structures of the same geometry, indicating a functional synergy between the keratinous rhamphotheca and bony layers of the bill. Overall, our findings demonstrate the strong link between morphological evolution, behaviour and functional performance in organisms.
    MeSH term(s) Animals ; Finite Element Analysis ; Biomechanical Phenomena ; Birds/anatomy & histology ; Stress, Mechanical
    Language English
    Publishing date 2023-03-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 209242-6
    ISSN 1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
    ISSN (online) 1471-2954
    ISSN 0080-4649 ; 0962-8452 ; 0950-1193
    DOI 10.1098/rspb.2022.2395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1364: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Personalized Virtual Care Using Continuous Glucose Monitoring in Adults With Type 2 Diabetes Treated With Less Intensive Therapies.

    Reddy, Sushma / Wu, Calvin C / José, Aimée / Hsieh, Jennifer L / Rautela, Shetal Desai

    Diabetes care

    2023  

    Language English
    Publishing date 2023-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/cd22-0128
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    Zs.A 1434: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 365: Show issues

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  6. Article ; Online: Drug Interactions Between Psychotropic Medications and Treatment of Mpox (tecovirimat and cidofovir).

    Mansuri, Zeeshan / Shah, Bhumika / Yadav, Garima / Kainth, Tejasvi / Kochhar, Hansini / Srinivas, Sushma / Kamil, Sahar Hooda / Bachu, Anil / Reddy, Abhishek

    The primary care companion for CNS disorders

    2024  Volume 26, Issue 1

    MeSH term(s) Humans ; Cidofovir ; Mpox (monkeypox) ; Benzamides ; Drug Interactions ; Isoindoles ; Psychotropic Drugs
    Chemical Substances Cidofovir (JIL713Q00N) ; Benzamides ; Isoindoles ; Psychotropic Drugs
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2675414-9
    ISSN 2155-7780 ; 2155-7780
    ISSN (online) 2155-7780
    ISSN 2155-7780
    DOI 10.4088/PCC.23lr03608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Is Intravenous Ketamine Better Than Intranasal Esketamine for Treating Treatment-Resistant Depression?

    Mansuri, Zeeshan / Shah, Bhumika / Yadav, Garima / Kamil, Sahar Hooda / Kainth, Tejasvi / Srinivas, Sushma / Patel, Hiren / Reddy, Abhishek / Bachu, Anil

    The primary care companion for CNS disorders

    2024  Volume 26, Issue 1

    MeSH term(s) Humans ; Ketamine/pharmacology ; Ketamine/therapeutic use ; Depression ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Depressive Disorder, Major/drug therapy ; Depressive Disorder, Treatment-Resistant/drug therapy
    Chemical Substances Esketamine (50LFG02TXD) ; Ketamine (690G0D6V8H) ; Antidepressive Agents
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2675414-9
    ISSN 2155-7780 ; 2155-7780
    ISSN (online) 2155-7780
    ISSN 2155-7780
    DOI 10.4088/PCC.23lr03607
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Evolution: Brainier Birds.

    Makovicky, Peter J / Reddy, Sushma

    Current biology : CB

    2020  Volume 30, Issue 13, Page(s) R778–R780

    Abstract: A groundbreaking study of brain evolution across birds and dinosaurs reveals potential drivers of increased brain size including biogeography and ecology. The most dramatic change occurred in the Neoaves after the Cretaceous-Paleogene extinction rather ... ...

    Abstract A groundbreaking study of brain evolution across birds and dinosaurs reveals potential drivers of increased brain size including biogeography and ecology. The most dramatic change occurred in the Neoaves after the Cretaceous-Paleogene extinction rather than earlier in bird evolution.
    MeSH term(s) Animals ; Biological Evolution ; Birds ; Brain ; Dinosaurs/anatomy & histology ; Fossils ; Organ Size ; Phylogeny
    Language English
    Publishing date 2020-07-06
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2020.05.025
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    Zs.A 3208: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Development, Characterization, and Antibacterial Analysis of the Selenium-Doped Bio-Glass-Collagen-Gelatin Composite Scaffold for Guided Bone Regeneration.

    Reddy, Sushma B / Arumugam, Parkavi / Kishore, Obuli G / K, Saranya

    Cureus

    2023  Volume 15, Issue 11, Page(s) e48838

    Abstract: Background Guided bone regeneration (GBR) is an often-used technique to aid the successful placement of dental implants in sites with deficient bone. The search for the ideal GBR membrane with bioactive components improving the regenerative outcomes is ... ...

    Abstract Background Guided bone regeneration (GBR) is an often-used technique to aid the successful placement of dental implants in sites with deficient bone. The search for the ideal GBR membrane with bioactive components improving the regenerative outcomes is still on. In this study, a novel composite GBR membrane was developed using selenium-doped bio-glass, collagen, and gelatin. It was further characterized for surface, chemical, biocompatibility, and antibacterial properties. Methodology Selenium-doped bio-glass was prepared using the sol-gel method. The membrane was fabricated using an equal ratio of collagen and gelatin mixed with 1% selenium-doped bio-glass. The solution was poured to obtain a thin layer of the material which was lyophilized to obtain the final GBR membrane. The membrane was analyzed with scanning electron microscopy, energy dispersive X-ray (EDX) analysis, attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), zebrafish cytotoxicity test, and antibacterial assay. Results The membrane revealed good surface roughness with lamellar and fibrillar arrangement with a minute granular surface ideal for cell attachment and proliferation. The EDX analysis revealed the presence of carbon, oxygen, and nitrogen as predominant components with trace amounts of calcium, phosphorus, silica, and selenium. Fourier transform infrared spectroscopy analysis also proved the presence of collagen, gelatin, and bio-glass. The membrane revealed excellent biocompatibility with zebrafish growth at a normal rate with 90% viability maintained at 48, 72, and 96 hours and 95% viability at 120 hours. It also exhibited excellent antibacterial activity against
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.48838
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Influence of Probiotics in Reducing Cisplatin-Induced Toxicity in Zebrafish (Danio rerio).

    Kandati, Kusuma / Reddy, Ankireddy Seshadri / Nannepaga, John Sushma / Viswanath, Buddolla

    Current microbiology

    2023  Volume 80, Issue 4, Page(s) 109

    Abstract: In this work, the effects of probiotic supplementation on cisplatin toxicity in zebrafish (Danio rerio) were examined. For this study, adult female zebrafish were given cisplatin (G2), the probiotic, Bacillus megaterium (G3), and cisplatin+B. megaterium ( ...

    Abstract In this work, the effects of probiotic supplementation on cisplatin toxicity in zebrafish (Danio rerio) were examined. For this study, adult female zebrafish were given cisplatin (G2), the probiotic, Bacillus megaterium (G3), and cisplatin+B. megaterium (G4) for 30 days, in addition to the control (G1). In order to investigate changes in antioxidative enzymes, ROS production, and histological changes after treatment, the intestines and ovaries were excised. The levels of lipid peroxidation, glutathione peroxidase, glutathione reductase, catalase, and superoxide dismutase were found to be significantly higher in the cisplatin group than in the control group in both the intestine and the ovaries. Administration of the probiotic and cisplatin effectively reversed this damage. Histopathological analyses showed that the cisplatin group had much more damage than the control group and that probiotic+cisplatin treatment significantly cured these damages. It opens the door to probiotics being combined with cancer-related drugs, which may be a more efficient approach for minimizing side effects. The underlying molecular mechanisms of probiotics must be further investigated.
    MeSH term(s) Animals ; Female ; Zebrafish/metabolism ; Oxidative Stress ; Cisplatin/pharmacology ; Antioxidants/pharmacology ; Catalase/metabolism ; Catalase/pharmacology ; Superoxide Dismutase/metabolism ; Probiotics ; Lipid Peroxidation
    Chemical Substances Cisplatin (Q20Q21Q62J) ; Antioxidants ; Catalase (EC 1.11.1.6) ; Superoxide Dismutase (EC 1.15.1.1)
    Language English
    Publishing date 2023-02-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 134238-1
    ISSN 1432-0991 ; 0343-8651
    ISSN (online) 1432-0991
    ISSN 0343-8651
    DOI 10.1007/s00284-023-03203-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1446: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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