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Article ; Online: The Realization of Common Prosperity through Relative Poverty Alleviation

Zhao Limei

Contemporary Social Sciences (2022)

Gradient Development and Optimization

2022

Abstract: Relative poverty alleviation is explicitly consistent with common prosperity. Relative poverty alleviation, which is part of the modernization of national governance capacity, is both an objective requirement of effective poverty alleviation and an ... ...

Abstract	Relative poverty alleviation is explicitly consistent with common prosperity. Relative poverty alleviation, which is part of the modernization of national governance capacity, is both an objective requirement of effective poverty alleviation and an inevitable approach to the realization of common prosperity. The alleviation of relative poverty and the realization of common prosperity are intrinsically coupled because they feature overlapping time sequences, monistic values, superimposed fields, similar systems, and homogeneous elements. The relationship between the two is essentially symbiotic, coexistent, and synergistic. Consequently, how to effectively alleviate relative poverty and build a dynamic longterm mechanism for relative poverty alleviation will be one of the major challenges for China to tackle before it can make more obvious and substantial progress toward common prosperity for all by 2035. This paper proposes relevant countermeasures and suggestions, which mainly concern the building of a dynamic, multi-dimensional mechanism for relative poverty alleviation and a coordinated mode for the two missions. The aim is to achieve a balanced integration of the academic logic, social logic, and policy logic
Keywords	relative poverty alleviation ; common prosperity ; coordinated advancement ; Social Sciences ; H
Subject code	360
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	Editorial Department of Contemporary Social Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Regarding the prognostic factors in patients with ALK-positive non-small cell lung cancer treated with crizotinib.

Hu, Limei / Xie, Youjun / Zhao, Hongying

Pulmonology

2024

Language	English
Publishing date	2024-02-23
Publishing country	Spain
Document type	Letter
ZDB-ID	3009651-0
ISSN	2531-0437 ; 2531-0429
ISSN (online)	2531-0437
ISSN	2531-0429
DOI	10.1016/j.pulmoe.2024.02.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Editorial: Application of data mining in pharmaceutical research.

Bu, Qingting / Lyu, Jun / Zhao, Limei / Cao, Shiyi / Jia, Deyong / Pan, Zhenyu

Frontiers in pharmacology

2024 Volume 15, Page(s) 1388738

Language	English
Publishing date	2024-03-01
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1388738
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Article ; Online: Boosting Electrochemical CO

Deng, Jun / Qiu, Limei / Xin, Mudi / He, Wenhui / Zhao, Wenhui / Dong, Juncai / Xu, Guangtong

Small (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e2311060

Abstract: Cu-based metal-organic frameworks (MOFs) have attracted much attention for electrocatalytic ... ...

Abstract	Cu-based metal-organic frameworks (MOFs) have attracted much attention for electrocatalytic CO
Language	English
Publishing date	2024-01-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202311060
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Article ; Online: Collision Energy Analysis within the Vertical Shaft Impact Crusher Based on the Computational Fluid Dynamics-Discrete Element Method.

Wu, Canhui / Zhao, Limei / Cao, Zhen

ACS omega

2024 Volume 9, Issue 7, Page(s) 7967–7975

Abstract: Particles in the vertical shaft impact crusher absorb and dissipate collision energy in the impact breakage. The distribution of the collision energy determines the breakage rate of materials and breakage energy consumption of the entire system. In this ... ...

Abstract	Particles in the vertical shaft impact crusher absorb and dissipate collision energy in the impact breakage. The distribution of the collision energy determines the breakage rate of materials and breakage energy consumption of the entire system. In this paper, the gas-solid coupling method is used to explore the regional distribution of collision energy, collision frequency, and collision energy spectrum of the material particle groups. Hence, a theoretical basis is provided for the efficient and energy-saving design of the crusher. First, a coupling mathematical model of the computational fluid dynamics and discrete element method is established to describe the interaction between material and fluid in the crushing chamber. Moreover, the experiment is carried out using a PL8500 VSI crusher and compared with the simulation results to verify the model's reliability. Finally, the effects of different working conditions on the energy dissipation distribution and energy spectrum are explored. The results show that the collision energy within the crushing chamber can be accurately predicted by using the fluid-solid coupling model. Moreover, increasing the rotational speed can effectively transform low-energy collision events into high-energy collisions and increase the collision frequency with energy dissipation above the threshold energy. Thus, the probability of material breakage is increased. Last, increasing the feed rate minorly affects the material breakage rate, while the specific energy of the entire system is reduced.
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c08017
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: An overview of the regulatory role of annexin A1 in the tumor microenvironment and its prospective clinical application (Review).

Gao, Kuan / Li, Xinyang / Luo, Shuya / Zhao, Limei

International journal of oncology

2024 Volume 64, Issue 5

Abstract: Although annexin A1 (ANXA1), a 37 kDa phospholipid‑binding anti‑inflammatory protein expressed in various tissues and cell types, has been investigated extensively for its regulatory role in cancer biology, studies have mainly focused on its ... ...

Abstract	Although annexin A1 (ANXA1), a 37 kDa phospholipid‑binding anti‑inflammatory protein expressed in various tissues and cell types, has been investigated extensively for its regulatory role in cancer biology, studies have mainly focused on its intracellular role. However, cancer cells and stromal cells expressing ANXA1 have the ability to transmit signals within the tumor microenvironment (TME) through autocrine, juxtacrine, or paracrine signaling. This bidirectional crosstalk between cancer cells and their environment is also crucial for cancer progression, contributing to uncontrolled tumor proliferation, invasion, metastasis and resistance to therapy. The present review explored the important role of ANXA1 in regulating the cell‑specific crosstalk between various compartments of the TME and analyzed the guiding significance of the crosstalk effects in promotion or suppressing cancer progression in the development of cancer treatments. The literature shows that ANXA1 is critical for the regulation of the TME, indicating that ANXA1 signaling between cancer cells and the TME is a potential therapeutic target for the development of novel therapeutic approaches for impeding cancer development.
MeSH term(s)	Humans ; Annexin A1/genetics ; Annexin A1/metabolism ; Neoplasms/drug therapy ; Neoplasms/genetics ; Signal Transduction ; Tumor Microenvironment/genetics
Chemical Substances	Annexin A1
Language	English
Publishing date	2024-03-22
Publishing country	Greece
Document type	Review ; Journal Article
ZDB-ID	1154403-x
ISSN	1791-2423 ; 1019-6439
ISSN (online)	1791-2423
ISSN	1019-6439
DOI	10.3892/ijo.2024.5639
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Article ; Online: Population pharmacokinetic analyses of methotrexate in pediatric patients: a systematic review.

Cheng, Yu / Zhang, Yujia / Zhang, Ying / Liu, Maobai / Zhao, Limei

European journal of clinical pharmacology

2024

Abstract: Background and objectives: Methotrexate is widely utilized in the chemotherapy of malignant tumors and autoimmune diseases in the pediatric population, but dosing can be challenging. Several population pharmacokinetic models were developed to ... ...

Abstract	Background and objectives: Methotrexate is widely utilized in the chemotherapy of malignant tumors and autoimmune diseases in the pediatric population, but dosing can be challenging. Several population pharmacokinetic models were developed to characterize factors influencing variability and improve individualization of dosing regimens. However, significant covariates included varied across studies. The primary objective of this review was to summarize and discuss population pharmacokinetic models of methotrexate and covariates that influence pharmacokinetic variability in pediatric patients. Methods: Systematic searches were conducted in the PubMed and EMBASE databases from inception to 7 July 2023. Reporting Quality was evaluated based on a checklist with 31 items. The characteristics of studies and information for model construction and validation were extracted, summarized, and discussed. Results: Eighteen studies (four prospective studies and fourteen retrospective studies with sample sizes of 14 to 772 patients and 2.7 to 93.1 samples per patient) were included in this study. Two-compartment models were the commonly used structural models for methotrexate, and the clearance range of methotrexate ranged from 2.32 to 19.03 L/h (median: 6.86 L/h). Body size and renal function were found to significantly affect the clearance of methotrexate for pediatric patients. There were limited reports on the role of other covariates, such as gene polymorphisms and co-medications, in the pharmacokinetic parameters of methotrexate pediatric patients. Internal and external evaluations were used to assess the performance of the population pharmacokinetic models. Conclusion: A more rigorous external evaluation needs to be performed before routine clinical use to select the appropriate PopPK model. Further research is necessary to incorporate larger cohorts or pool analyses in specific susceptible pediatric populations to improve the understanding of predicted exposure profiles and covariate identification.
Language	English
Publishing date	2024-03-18
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	121960-1
ISSN	1432-1041 ; 0031-6970
ISSN (online)	1432-1041
ISSN	0031-6970
DOI	10.1007/s00228-024-03665-x
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Article: Development of a UPLC-MS/MS method for simultaneous therapeutic drug monitoring of anti-hepatocellular carcinoma drugs and analgesics in human plasma.

Lu, Shijia / Zhao, Mingming / Zhao, Limei / Li, Guofei

Frontiers in pharmacology

2023 Volume 14, Page(s) 1136735

Abstract: In hepatocellular carcinoma treatment, sorafenib, oxaliplatin, 5-fluorouracil, capecitabine, lenvatinib, and donafenib are first-line drugs; regorafenib, apatinib, and cabozantinib are second-line drugs; and oxycodone, morphine, and fentanyl are commonly ...

Abstract	In hepatocellular carcinoma treatment, sorafenib, oxaliplatin, 5-fluorouracil, capecitabine, lenvatinib, and donafenib are first-line drugs; regorafenib, apatinib, and cabozantinib are second-line drugs; and oxycodone, morphine, and fentanyl are commonly used analgesics. However, the high degree of inter- and intra-individual variability in the efficacy and toxicity of these drugs remains an urgent issue. Therapeutic drug monitoring (TDM) is the most reliable technical means for evaluating drug safety and efficacy. Therefore, we developed an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for simultaneous TDM of three chemotherapy drugs (5-fluorouracil, oxaliplatin, and capecitabin), six targeted drugs (sorafenib, donafenib, apatinib, cabozantinib, regorafenib, and lenvatinib), and three analgesics (morphine, fentanyl, and oxycodone). We extracted 12 analytes and isotope internal standards (ISs) from plasma samples by magnetic solid phase extraction (mSPE) and separated them using a ZORBAX Eclipse Plus C18 column with water containing 0.1% formic acid and methanol containing 0.1% formic acid as the mobile phase. The analytical performance of our method in terms of sensitivity, linearity, specificity, carryover, precision, limit of quantification, matrix effect, accuracy, dilution integrity, extraction recovery, stability, and crosstalk of all the analytes under different conditions met all the criteria stipulated by the guidelines of the Chinese Pharmacopoeia and U.S. Food and Drug Administration. The response function was estimated at 10.0-10 000.0 ng/mL for sorafenib, donafenib, apatinib, cabozantinib, regorafenib, and lenvatinib, and 20.0-20 000.0 ng/mL for 5-fluorouracil, oxaliplatin, capecitabin, morphine, fentanyl, and oxycodone, with a correlation of > 0.9956 for all compounds. The precision and accuracy of all analytes were < 7.21% and 5.62%, respectively. Our study provides empirical support for a simple, reliable, specific, and suitable technique for clinical TDM and pharmacokinetics.
Language	English
Publishing date	2023-05-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1136735
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Article: Analyzing Morphology, Metabolomics, and Transcriptomics Offers Invaluable Insights into the Mechanisms of Pigment Accumulation in the Diverse-Colored Labellum Tissues of

Zhao, Tong / Yu, Qianxia / Lin, Canjia / Liu, Huanfang / Dong, Limei / Feng, Xinxin / Liao, Jingping

Plants (Basel, Switzerland)

2023 Volume 12, Issue 21

Abstract: ... ...

Abstract	Alpinia
Language	English
Publishing date	2023-11-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants12213766
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Article ; Online: Farmers’ adoption intentions of water-saving agriculture under the risks of frequent irrigation-induced landslides

Jue Wang / Limei Liu / Kuanyao Zhao / Qi Wen

Climate Risk Management, Vol 39, Iss , Pp 100484- (2023)

2023

Abstract: Water-saving agriculture (WSA) is often introduced as an effective strategy to reduce water infiltration and mitigate irrigation-induced landslide risks. The effects highly rely on smallholder farmers, who often would rather suffer from landslides than ... ...

Abstract	Water-saving agriculture (WSA) is often introduced as an effective strategy to reduce water infiltration and mitigate irrigation-induced landslide risks. The effects highly rely on smallholder farmers, who often would rather suffer from landslides than adapt. This study focused on farmers’ adoption intention of WSA in general and drip irrigation and drought-tolerant crop in specific, representing changes in technology and farming systems. An integrative theoretical model was developed based on the extended theory of planned behavior (TPB) with elements from the norm activation model and technology acceptance model. Hypotheses were tested using data from a questionnaire survey with 363 farmers in Loess Plateau, Northwest China. The results of structural equation modeling showed that the most crucial factor bolstering farmers’ adoption intention was subjective norm, regardless of different measures. Attitude was more influential than perceived behavior control in drip irrigation and vice versa in drought-tolerant crop adoption, indicating that attitude was more important in technology change and capacity played a crucial role in farming system shift. In addition, awareness of environmental consequences contributed positively to subjective norm and attitude, and perceived ease-of-use improved perceived behavior control. Most notably, the extended TPB model has more explanatory power than the classical one. By considering the moral and technical aspects, the extended model enhanced the comprehensiveness of explaining drivers of farmers’ WSA adoption intention under the irrigation-induced landslide risks. The findings shed light on future disaster risk management for China and other countries under the landslide risk.
Keywords	Irrigation-induced landslide ; Water-saving agriculture ; Smallholder farmer ; Adoption intention ; Extended theory of planned behavior ; Landslide mitigation ; Meteorology. Climatology ; QC851-999
Subject code	650
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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