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  1. Article ; Online: Commentary 4: OPPERA-2 Conundrums and Challenges: Lumping Versus Splitting?

    Benoliel, Rafael

    Journal of oral & facial pain and headache

    2020  Volume 34, Issue Suppl, Page(s) s11

    Keywords covid19
    Language English
    Publishing date 2020-09-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2762048-7
    ISSN 2333-0376 ; 2333-0384
    ISSN (online) 2333-0376
    ISSN 2333-0384
    DOI 10.11607/ofph.2020.suppl.c4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2302: Show issues Location:
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  2. Article ; Online: Clinical Handbook for Oral, Facial, and Head Pain.

    Huff, Kevin D / Benoliel, Rafael

    Journal of oral & facial pain and headache

    2023  Volume 37, Issue 4, Page(s) 219–268

    MeSH term(s) Humans ; Headache ; Facial Pain ; Face
    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2762048-7
    ISSN 2333-0376 ; 2333-0384
    ISSN (online) 2333-0376
    ISSN 2333-0384
    DOI 10.11607/ofph.3488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2302: Show issues Location:
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  3. Article: Pharmacological Topical Therapy for Intra-Oral Post Traumatic Trigeminal Neuropathic Pain: A Comprehensive Review.

    Sharav, Yair / Heiliczer, Shimrit / Benoliel, Rafael / Haviv, Yaron

    Pharmaceuticals (Basel, Switzerland)

    2024  Volume 17, Issue 2

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-02-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17020264
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  4. Article: Post-Traumatic Trigeminal Neuropathy: Neurobiology and Pathophysiology.

    Eliav, Tal / Benoliel, Rafael / Korczeniewska, Olga A

    Biology

    2024  Volume 13, Issue 3

    Abstract: Painful traumatic trigeminal neuropathy (PTTN) is a chronic neuropathic pain that may develop following injury to the trigeminal nerve. Etiologies include cranio-orofacial trauma that may result from dental, surgical, or anesthetic procedures or physical ...

    Abstract Painful traumatic trigeminal neuropathy (PTTN) is a chronic neuropathic pain that may develop following injury to the trigeminal nerve. Etiologies include cranio-orofacial trauma that may result from dental, surgical, or anesthetic procedures or physical trauma, such as a motor vehicle accident. Following nerve injury, there are various mechanisms, including peripheral and central, as well as phenotypic changes and genetic predispositions that may contribute to the development of neuropathic pain. In this article, we review current literature pertaining to the cellular processes that occur following traumatic damage to the trigeminal nerve, also called cranial nerve V, that results in chronic neuropathic pain. We examine the neurobiology and pathophysiology based mostly on pre-clinical animal models of neuropathic/trigeminal pain.
    Language English
    Publishing date 2024-03-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology13030167
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  6. Article ; Online: Classifying head, face and oral pain.

    Benoliel, Rafael

    Cephalalgia : an international journal of headache

    2017  Volume 37, Issue 14, Page(s) 1315–1316

    MeSH term(s) Facial Pain/classification ; Headache/classification ; Humans ; Mouth ; Mouth Diseases/classification
    Language English
    Publishing date 2017-10-16
    Publishing country England
    Document type Editorial
    ZDB-ID 604567-4
    ISSN 1468-2982 ; 0333-1024
    ISSN (online) 1468-2982
    ISSN 0333-1024
    DOI 10.1177/0333102417739311
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1645: Show issues Location:
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  7. Article ; Online: Orofacial Migraine or Neurovascular Orofacial Pain from Pathogenesis to Treatment.

    Sharav, Yair / Haviv, Yaron / Benoliel, Rafael

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: The purpose of the present study is to examine possible differences between orofacial migraine (OFM) and neurovascular orofacial pain (NVOP). Facial presentations of primary headache are comparable to primary headache disorders; but occurring in the V2 ... ...

    Abstract The purpose of the present study is to examine possible differences between orofacial migraine (OFM) and neurovascular orofacial pain (NVOP). Facial presentations of primary headache are comparable to primary headache disorders; but occurring in the V2 or V3 dermatomes of the trigeminal nerve. These were classified and recently published in the International Classification of Orofacial Pain, 1st edition (ICOP). A category in this classification is "orofacial pains resembling presentations of primary headaches," which encompasses OFM and NVOP. The differences between NVOP and OFM are subtle, and their response to therapy may be similar. While classified under two separate entities, they contain many features in common, suggesting a possible overlap between the two. Consequently, their separation into two entities warrants further investigations. We describe OFM and NVOP, and their pathophysiology is discussed. The similarities and segregating clinical signs and symptoms are analyzed, and the possibility of unifying the two entities is debated.
    MeSH term(s) Humans ; Facial Pain/diagnosis ; Facial Pain/etiology ; Facial Pain/therapy ; Migraine Disorders/diagnosis ; Migraine Disorders/etiology ; Migraine Disorders/therapy ; Headache
    Language English
    Publishing date 2023-01-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032456
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  8. Article ; Online: The changing face of trigeminal neuralgia-A narrative review.

    Maarbjerg, Stine / Benoliel, Rafael

    Headache

    2021  Volume 61, Issue 6, Page(s) 817–837

    Abstract: Objective: This narrative review aims to update the reader on the new classification of trigeminal neuralgia (TN), clinical signs, pathophysiologic evidence, and their implications on management. This review is based on the authors' collective ... ...

    Abstract Objective: This narrative review aims to update the reader on the new classification of trigeminal neuralgia (TN), clinical signs, pathophysiologic evidence, and their implications on management. This review is based on the authors' collective experience and knowledge of the literature in addition to a literature search.
    Background: In recent years, the phenotype of TN has been intensively studied leading to discrete groups of patients. These include patients with TN with additional continuous pain, and patients with and without neurovascular compression of the trigeminal dorsal root entry zone. A number of associated clinical signs such as tearing and sensory changes need further research.
    Methods: The literature on TN was searched in PubMed with the aims of providing evidence for the recently published third edition of the International Classification of Headache Disorders (ICHD) and update the clinical phenotype and management of the TN subcategories.
    Results: The ICHD's new classification for TN is based on reliable clinical data, imaging, and neurophysiologic studies. The TN classification reflects current knowledge and has improved the possibility for clinicians to choose adequate management options. However, there is a lack of effective, safe drugs for the management of TN and sparse, robust data on neurosurgical options.
    Conclusion: Research into all aspects of TN-diagnosis, pharmacotherapy, surgery, long-term management prognosis, and natural history-is needed. Research should adhere to the ICHD's schema for TN. Improved drugs are needed along with rigorous research into surgical options and their efficacy for different subtypes of TN.
    MeSH term(s) Humans ; Trigeminal Neuralgia/classification ; Trigeminal Neuralgia/diagnosis ; Trigeminal Neuralgia/physiopathology ; Trigeminal Neuralgia/therapy
    Language English
    Publishing date 2021-07-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 410130-3
    ISSN 1526-4610 ; 0017-8748
    ISSN (online) 1526-4610
    ISSN 0017-8748
    DOI 10.1111/head.14144
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 539: Show issues Location:
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  9. Article ; Online: Orofacial Migraine or Neurovascular Orofacial Pain from Pathogenesis to Treatment

    Yair Sharav / Yaron Haviv / Rafael Benoliel

    International Journal of Molecular Sciences, Vol 24, Iss 2456, p

    2023  Volume 2456

    Abstract: The purpose of the present study is to examine possible differences between orofacial migraine (OFM) and neurovascular orofacial pain (NVOP). Facial presentations of primary headache are comparable to primary headache disorders; but occurring in the V2 ... ...

    Abstract The purpose of the present study is to examine possible differences between orofacial migraine (OFM) and neurovascular orofacial pain (NVOP). Facial presentations of primary headache are comparable to primary headache disorders; but occurring in the V2 or V3 dermatomes of the trigeminal nerve. These were classified and recently published in the International Classification of Orofacial Pain, 1st edition (ICOP). A category in this classification is “orofacial pains resembling presentations of primary headaches,” which encompasses OFM and NVOP. The differences between NVOP and OFM are subtle, and their response to therapy may be similar. While classified under two separate entities, they contain many features in common, suggesting a possible overlap between the two. Consequently, their separation into two entities warrants further investigations. We describe OFM and NVOP, and their pathophysiology is discussed. The similarities and segregating clinical signs and symptoms are analyzed, and the possibility of unifying the two entities is debated.
    Keywords orofacial migraine ; neurovascular orofacial pain ; orofacial pain classification ; orofacial pain pathophysiology ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: A Review of Current Perspectives on Facial Presentations of Primary Headaches.

    Peng, Kuan-Po / Benoliel, Rafael / May, Arne

    Journal of pain research

    2022  Volume 15, Page(s) 1613–1621

    Abstract: Orofacial pain (OFP) has recently been classified and subdivided into a number of groups, similar to headache disorders in the International Classification of Headache Disorders (ICHD). A novel group of OFP has been established whose major feature is ... ...

    Abstract Orofacial pain (OFP) has recently been classified and subdivided into a number of groups, similar to headache disorders in the International Classification of Headache Disorders (ICHD). A novel group of OFP has been established whose major feature is that they resemble primary headache disorders occurring in the V2 or V3 dermatomes. These follow the clinical criteria and associated symptoms of the eponymous headache syndromes. Following the recent International Classification of Orofacial Pain (ICOP), three types are differentiated: Headache which spread into the face (type 1), facial pain which replaced headache but maintained the same characteristics and associated symptoms of the former headache (type 2), and de-novo orofacial pain that resembles primary headache types without any involvement of the ophthalmic trigeminal branch (type 3). The epidemiology is unclear: type 1 and 2 are not exactly common, they certainly exist in a notable proportion of headache patients, whereas type 3 may be rather rare. Since effective treatment options are available, it is important for clinicians to recognize such syndromes early to avoid misdiagnosis and unnecessary treatment, which most of these patients still experience. This review gives an up-to-date summary of diagnosis, pathophysiology and treatment of attack-like non-dental facial pain disorders.
    Language English
    Publishing date 2022-06-03
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2495284-9
    ISSN 1178-7090
    ISSN 1178-7090
    DOI 10.2147/JPR.S294404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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