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  1. Book: Physiologie des Menschen

    Brandes, Ralf / Lang, Florian / Schmidt, Robert F.

    mit Pathophysiologie

    (Springer-Lehrbuch)

    2019  

    Author's details Ralf Brandes, Florian Lang, Robert F. Schmidt (Hrsg.)
    Series title Springer-Lehrbuch
    Keywords Physiologie ; Pathophysiologie
    Subject Pathologische Physiologie ; Physiologische Pathologie ; Physiopathologie ; Humanphysiologie ; Mensch ; Körperfunktion
    Language German
    Size XXXIII, 1057 Seiten, Illustrationen, Diagramme
    Edition 32. Auflage
    Publisher Springer
    Publishing place Berlin
    Publishing country Germany
    Document type Book
    Old title Vorangegangen ist
    HBZ-ID HT019696743
    ISBN 978-3-662-56467-7 ; 3-662-56467-X ; 9783662564684 ; 3662564688
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 A 444 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: RNA Modification That Breaks the Heart: RNA Acetylase Nat10 Promotes Fibrosis.

    Kurian, Leo / Brandes, Ralf P

    Circulation research

    2023  Volume 133, Issue 12, Page(s) 1003–1005

    MeSH term(s) Humans ; RNA ; Acetylesterase ; Ventricular Remodeling ; Gene Expression Profiling ; Fibrosis ; N-Terminal Acetyltransferases
    Chemical Substances RNA (63231-63-0) ; Acetylesterase (EC 3.1.1.6) ; NAT10 protein, human (EC 2.3.1.88) ; N-Terminal Acetyltransferases (EC 2.3.1.88)
    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.123.323866
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Understanding Arteriosclerosis 2.0: Making Sense of Genetic Variants with scATAC.

    Brandes, Ralf P / Gilsbach, Ralf

    Circulation research

    2021  Volume 129, Issue 2, Page(s) 259–261

    MeSH term(s) Arteriosclerosis ; Humans ; Single-Cell Analysis
    Language English
    Publishing date 2021-07-08
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.121.319585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Is It in the EPIgenome?: Epigenetics Marks at Birth Are Associated With Arterial Stiffness in Children.

    Brandes, Ralf P / Gilsbach, Ralf

    Hypertension (Dallas, Tex. : 1979)

    2021  Volume 78, Issue 3, Page(s) 801–803

    MeSH term(s) Child ; Epigenesis, Genetic ; Epigenome ; Epigenomics ; Humans ; Infant, Newborn ; Vascular Stiffness
    Language English
    Publishing date 2021-08-11
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.121.17777
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Calcium-Controlled Reactive Oxygen Species Afterburner Perpetuates Endothelial Damage After Radiation Therapy.

    Brandes, Ralf P / Wittig, Ilka

    Arteriosclerosis, thrombosis, and vascular biology

    2022  Volume 42, Issue 9, Page(s) 1137–1138

    MeSH term(s) Calcium ; Endothelial Cells ; Endothelium, Vascular ; Reactive Oxygen Species
    Chemical Substances Reactive Oxygen Species ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-07-28
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.122.318058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Europhysiology 2022: bringing together the physiologists of Europe and the World : 16-18 September 2022, Tivoli Congress Center, Copenhagen, Denmark" as subtitle.

    Brandes, Ralf P / Gründer, Stefan

    Pflugers Archiv : European journal of physiology

    2022  Volume 474, Issue 5, Page(s) 481–482

    Language English
    Publishing date 2022-03-02
    Publishing country Germany
    Document type Editorial
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-022-02676-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  7. Article: RNA-DNA triplexes: molecular mechanisms and functional relevance.

    Leisegang, Matthias S / Warwick, Timothy / Stötzel, Julia / Brandes, Ralf P

    Trends in biochemical sciences

    2024  

    Abstract: Interactions of RNA with DNA are principles of gene expression control that have recently gained considerable attention. Among RNA-DNA interactions are R-loops and RNA-DNA hybrid G-quadruplexes, as well as RNA-DNA triplexes. It is proposed that RNA-DNA ... ...

    Abstract Interactions of RNA with DNA are principles of gene expression control that have recently gained considerable attention. Among RNA-DNA interactions are R-loops and RNA-DNA hybrid G-quadruplexes, as well as RNA-DNA triplexes. It is proposed that RNA-DNA triplexes guide RNA-associated regulatory proteins to specific genomic locations, influencing transcription and epigenetic decision making. Although triplex formation initially was considered solely an in vitro event, recent progress in computational, biochemical, and biophysical methods support in vivo functionality with relevance for gene expression control. Here, we review the central methodology and biology of triplexes, outline paradigms required for triplex function, and provide examples of physiologically important triplex-forming long non-coding RNAs.
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 194216-5
    ISSN 1362-4326 ; 0968-0004 ; 0376-5067
    ISSN (online) 1362-4326
    ISSN 0968-0004 ; 0376-5067
    DOI 10.1016/j.tibs.2024.03.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Glycolysis and Inflammation: Partners in Crime!

    Brandes, Ralf P / Rezende, Flávia

    Circulation research

    2021  Volume 129, Issue 1, Page(s) 30–32

    MeSH term(s) Crime ; Glycolysis ; Humans ; Inflammation
    Language English
    Publishing date 2021-06-24
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.121.319447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Experimental uninephrectomy associates with less parasympathetic modulation of heart rate and facilitates sodium-dependent arterial hypertension.

    Pliquett, Rainer U / Brandes, Ralf P

    PloS one

    2022  Volume 17, Issue 3, Page(s) e0265086

    Abstract: Background: Blood pressure is known to be increased in kidney donors following living-donor kidney transplantation. However, the physiological underpinnings of the blood-pressure increase following uninephrectomy remain unclear. We hypothesized that ... ...

    Abstract Background: Blood pressure is known to be increased in kidney donors following living-donor kidney transplantation. However, the physiological underpinnings of the blood-pressure increase following uninephrectomy remain unclear. We hypothesized that changes in sympathetic tone or in parasympathetic modulation of sinus node function are involved in the blood-pressure increase following experimental kidney-mass reduction.
    Methods: C57BL6N mice (6 to 11 per group) subjected to sham surgery (controls) or uninephrectomy with or without a one-week course of sodium chloride-enriched, taurine-deficient diet were studied. Uninephrectomized mice treated with a subcutaneous infusion of angiotensin-II over a period of one week were positive controls. A transfemoral aortic catheter with telemetry unit was implanted, readings of heart-rate and blood-pressure were recorded. Powerspectral analysis of heart rate and systolic blood pressure was performed to gain surrogate parameters of sympathetictone and parasympathetic modulation of sinus node function. Baroreflex sensitivity of heart rate was determined from awake, unrestrained mice using spontaneous baroreflex gain technique.
    Results: Systolic arterial blood pressure, heart rate and baroreflex sensitivity were not different in uninephrectomized mice when compared to controls. Parasympathetic modulation of sinus node function was less in uninephrectomized mice in comparison to controls. Uninephrectomized mice of the high-angiotensin-II model or of the high-salt and taurine-deficiency model had an increased systolic arterial blood pressure.
    Conclusions: Uninephrectomy associated with less parasympathetic modulation of sinus node function. The combination of uninephrectomy, taurine-deficiency and high-salt intake led to arterial hypertension.
    MeSH term(s) Angiotensin II ; Animals ; Baroreflex/physiology ; Blood Pressure/physiology ; Heart Rate/physiology ; Hypertension ; Mice ; Sodium ; Sodium Chloride ; Taurine
    Chemical Substances Angiotensin II (11128-99-7) ; Taurine (1EQV5MLY3D) ; Sodium Chloride (451W47IQ8X) ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2022-03-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0265086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Computational Methods to Study DNA:DNA:RNA Triplex Formation by lncRNAs.

    Warwick, Timothy / Brandes, Ralf P / Leisegang, Matthias S

    Non-coding RNA

    2023  Volume 9, Issue 1

    Abstract: Long non-coding RNAs (lncRNAs) impact cell function via numerous mechanisms. In the nucleus, interactions between lncRNAs and DNA and the consequent formation of non-canonical nucleic acid structures seems to be particularly relevant. Along with ... ...

    Abstract Long non-coding RNAs (lncRNAs) impact cell function via numerous mechanisms. In the nucleus, interactions between lncRNAs and DNA and the consequent formation of non-canonical nucleic acid structures seems to be particularly relevant. Along with interactions between single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA), such as R-loops, ssRNA can also interact with double-stranded DNA (dsDNA) to form DNA:DNA:RNA triplexes. A major challenge in the study of DNA:DNA:RNA triplexes is the identification of the precise RNA component interacting with specific regions of the dsDNA. As this is a crucial step towards understanding lncRNA function, there exist several computational methods designed to predict these sequences. This review summarises the recent progress in the prediction of triplex formation and highlights important DNA:DNA:RNA triplexes. In particular, different prediction tools (
    Language English
    Publishing date 2023-01-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2813993-8
    ISSN 2311-553X ; 2311-553X
    ISSN (online) 2311-553X
    ISSN 2311-553X
    DOI 10.3390/ncrna9010010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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