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Article ; Online: In the clinic. Insomnia.

Masters, Philip A

2014 Volume 161, Issue 7, Page(s) ITC1–15; quiz ITC16

Abstract: This issue provides a clinical overview of Insomnia focusing on prevention, diagnosis, treatment, practice improvement, and patient information. The content of In the Clinic is drawn from the clinical information and education resources of the American ... ...

Abstract	This issue provides a clinical overview of Insomnia focusing on prevention, diagnosis, treatment, practice improvement, and patient information. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including ACP Smart Medicine and MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic from these primary sources in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of science writers and physician writers. Editorial consultants from ACP Smart Medicine and MKSAP provide expert review of the content. Readers who are interested in these primary resources for more detail can consult http://smartmedicine.acponline.org, http://mksap.acponline.org, and other resources referenced in each issue of In the Clinic.
MeSH term(s)	Cognitive Therapy ; Comorbidity ; Diagnosis, Differential ; Humans ; Hypnotics and Sedatives/therapeutic use ; Physical Examination ; Polysomnography ; Sleep Initiation and Maintenance Disorders/diagnosis ; Sleep Initiation and Maintenance Disorders/etiology ; Sleep Initiation and Maintenance Disorders/therapy
Chemical Substances	Hypnotics and Sedatives
Language	English
Publishing date	2014-10-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	336-0
ISSN	1539-3704 ; 0003-4819
ISSN (online)	1539-3704
ISSN	0003-4819
DOI	10.7326/0003-4819-161-7-201410070-01004
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Article ; Online: Persistent symptoms up to four months after community and hospital-managed SARS-CoV-2 infection.

Darley, David R / Dore, Gregory J / Cysique, Lucette / Wilhelm, Kay A / Andresen, David / Tonga, Katrina / Stone, Emily / Byrne, Anthony / Plit, Marshall / Masters, Jeffrey / Tang, Helen / Brew, Bruce / Cunningham, Philip / Kelleher, Anthony / Matthews, Gail V

The Medical journal of Australia

2021 Volume 214, Issue 6, Page(s) 279–280

MeSH term(s)	Australia ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/physiopathology ; COVID-19/therapy ; Female ; Follow-Up Studies ; Hospitalization ; Humans ; Lung/physiopathology ; Male ; Middle Aged ; Prognosis ; Prospective Studies ; Quality of Life ; SARS-CoV-2 ; Symptom Assessment
Language	English
Publishing date	2021-03-03
Publishing country	Australia
Document type	Letter
ZDB-ID	186082-3
ISSN	1326-5377 ; 0025-729X
ISSN (online)	1326-5377
ISSN	0025-729X
DOI	10.5694/mja2.50963
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Article: Inter-scanner Aβ-PET harmonization using barrel phantom spatial resolution matching.

Ruwanpathirana, Gihan P / Williams, Robert C / Masters, Colin L / Rowe, Christopher C / Johnston, Leigh A / Davey, Catherine E

Alzheimer's & dementia (Amsterdam, Netherlands)

2024 Volume 16, Issue 1, Page(s) e12561

Abstract: ... Philips Gemini TF64. A total of five, eight, and five subjects were each scanned twice with [: Results ...

Abstract	Introduction: The standardized uptake value ratio (SUVR) is used to measure amyloid beta-positron emission tomography (Aβ-PET) uptake in the brainDifferences in PET scanner technologies and image reconstruction techniques can lead to variability in PET images across scanners. This poses a challenge for Aβ-PET studies conducted in multiple centers. The aim of harmonization is to achieve consistent Aβ-PET measurements across different scanners. In this study, we propose an Aβ-PET harmonization method of matching spatial resolution, as measured via a barrel phantom, across PET scanners. Our approach was validated using paired subject data, for which patients were imaged on multiple scanners. Methods: In this study, three different PET scanners were evaluated: the Siemens Biograph Vision 600, Siemens Biograph molecular computed tomography (mCT), and Philips Gemini TF64. A total of five, eight, and five subjects were each scanned twice with [ Results: Vision-mCT harmonization Conclusion: Based on data obtained from three sets of participants, each scanned on a pair of PET scanners, it has been verified that using reconstruction configurations that produce matched-barrel, phantom spatial resolutions results in maximally harmonized Aβ-PET quantitation between scanner pairs. This finding is encouraging for the use of PET scanners in multi-center trials or updates during longitudinal studies. Highlights: Question
Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2832898-X
ISSN	2352-8729
ISSN	2352-8729
DOI	10.1002/dad2.12561
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Article ; Online: Insulin resistance, cognition and Alzheimer's disease biomarkers: Evidence that CSF Aβ42 moderates the association between insulin resistance and increased CSF tau levels.

Woodfield, Amy / Porter, Tenielle / Gilani, Israa / Noordin, Siti / Li, Qiao-Xin / Collins, Steven / Martins, Ralph N / Maruff, Paul / Masters, Colin L / Rowe, Christopher C / Villemagne, Victor L / Dore, Vincent / Newsholme, Philip / Laws, Simon M / Verdile, Giuseppe

Neurobiology of aging

2022 Volume 114, Page(s) 38–48

Abstract: Mounting evidence implicates insulin resistance (IR) with reduced cognition, increased dementia risk and changes in Alzheimer's disease biomarkers. It's unclear how, and at what stage IR has the greatest impact on Alzheimer's disease biomarker ... ...

Abstract	Mounting evidence implicates insulin resistance (IR) with reduced cognition, increased dementia risk and changes in Alzheimer's disease biomarkers. It's unclear how, and at what stage IR has the greatest impact on Alzheimer's disease biomarker progression indicative of cognitive decline. Exploration of potential factors influencing this relationship continue. We have previously reported IR to be associated with cognitive function, and increased CSF tau in a cognitively unimpaired cohort. Now, we aimed to determine if CSF total (t-tau) or phosphorylated tau (p-tau) mediated the relationship between HOMA-IR and cognition, and explore sex or amyloid-β (Aβ) biomarkers as moderators of this relationship. Mediation analysis demonstrated that CSF tau does not directly influence the association between HOMA-IR and cognition. Moderation analysis revealed CSF Aβ42 moderates the relationships between HOMA-IR and CSF tau. The combination of lower CSF Aβ42 and higher HOMA-IR was associated with increases in CSF tau. The CSF Aβ42 moderation finding has potential to be considered when assessing type 2 diabetic risk for tau pathology and cognitive decline.
MeSH term(s)	Alzheimer Disease/pathology ; Amyloid beta-Peptides ; Biomarkers ; Cognition ; Cognitive Dysfunction ; Humans ; Insulin Resistance ; Peptide Fragments ; tau Proteins
Chemical Substances	Amyloid beta-Peptides ; Biomarkers ; Peptide Fragments ; amyloid beta-protein (1-42) ; tau Proteins
Language	English
Publishing date	2022-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	604505-4
ISSN	1558-1497 ; 0197-4580
ISSN (online)	1558-1497
ISSN	0197-4580
DOI	10.1016/j.neurobiolaging.2022.03.004
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Zs.A 1685: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Correction to: The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease.

Acta neuropathologica communications

2021 Volume 9, Issue 1, Page(s) 161

Language	English
Publishing date	2021-09-29
Publishing country	England
Document type	Published Erratum
ZDB-ID	2715589-4
ISSN	2051-5960 ; 2051-5960
ISSN (online)	2051-5960
ISSN	2051-5960
DOI	10.1186/s40478-021-01258-8
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Article ; Online: Airborne hyperspectral imaging of nitrogen deficiency on crop traits and yield of maize by machine learning and radiative transfer modeling

Sheng Wang / Kaiyu Guan / Zhihui Wang / Elizabeth A. Ainsworth / Ting Zheng / Philip A. Townsend / Nanfeng Liu / Emerson Nafziger / Michael D. Masters / Kaiyuan Li / Genghong Wu / Chongya Jiang

International Journal of Applied Earth Observations and Geoinformation, Vol 105, Iss , Pp 102617- (2021)

2021

Abstract: Nitrogen is an essential nutrient that directly affects plant photosynthesis, crop yield, and biomass production for bioenergy crops, but excessive application of nitrogen fertilizers can cause environmental degradation. To achieve sustainable nitrogen ... ...

Abstract	Nitrogen is an essential nutrient that directly affects plant photosynthesis, crop yield, and biomass production for bioenergy crops, but excessive application of nitrogen fertilizers can cause environmental degradation. To achieve sustainable nitrogen fertilizer management for precision agriculture, there is an urgent need for nondestructive and high spatial resolution monitoring of crop nitrogen and its allocation to photosynthetic proteins as that changes over time. Here, we used visible to shortwave infrared (400–2400 nm) airborne hyperspectral imaging with high spatial (0.5 m) and spectral (3–5 nm) resolutions to accurately estimate critical crop traits, i.e., nitrogen, chlorophyll, and photosynthetic capacity (CO2-saturated photosynthesis rate, Vmax,27), at leaf and canopy scales, and to assess nitrogen deficiency on crop yield. We conducted three airborne campaigns over a maize (Zea mays L.) field during the growing season of 2019. Physically based soil-canopy Radiative Transfer Modeling (RTM) and data-driven approaches i.e. Partial-Least Squares Regression (PLSR) were used to retrieve crop traits from hyperspectral reflectance, with ground truth of leaf nitrogen, chlorophyll, Vmax,27, Leaf Area Index (LAI), and harvested grain yield. To improve computational efficiency of RTMs, Random Forest (RF) was used to mimic RTM simulations to generate machine learning surrogate models RTM-RF. The results show that prior knowledge of soil background and leaf angle distribution can significantly reduce the ill-posed RTM retrieval. RTM-RF achieved a high accuracy to predict leaf chlorophyll content (R2 = 0.73) and LAI (R2 = 0.75). Meanwhile, PLSR exhibited better accuracy to predict leaf chlorophyll content (R2 = 0.79), nitrogen concentration (R2 = 0.83), nitrogen content (R2 = 0.77), and Vmax,27 (R2 = 0.69) but required measured traits for model training. We also found that canopy structure signals can enhance the use of spectral data to predict nitrogen related photosynthetic traits, as combining RTM-RF LAI and ...
Keywords	Nitrogen ; Photosynthetic capacity ; Chlorophyll ; Yield ; Hyperspectral ; Airborne ; Physical geography ; GB3-5030 ; Environmental sciences ; GE1-350
Subject code	580 ; 333
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Reply to: "Current Challenges in Defining Futile Liver Resection and Predicting Early Recurrence After Curative-Intent Treatment for Colorectal Liver Metastases", by Wong, Geoffrey Yuet Mun et al.

Fromer, Marc W / Scoggins, Charles R / Egger, Michael E / Philips, Prejesh / McMasters, Kelly M / Martin, Robert C G

Annals of surgical oncology

2023 Volume 30, Issue 9, Page(s) 5461–5462

MeSH term(s)	Humans ; Neoplasm Recurrence, Local/surgery ; Medical Futility ; Liver Neoplasms/surgery ; Hepatectomy ; Colorectal Neoplasms/surgery ; Retrospective Studies ; Prognosis
Language	English
Publishing date	2023-06-12
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-022-13046-2
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Book ; Online: 8-bit Numerical Formats for Deep Neural Networks

Noune, Badreddine / Jones, Philip / Justus, Daniel / Masters, Dominic / Luschi, Carlo

2022

Abstract: Given the current trend of increasing size and complexity of machine learning architectures, it has become of critical importance to identify new approaches to improve the computational efficiency of model training. In this context, we address the ... ...

Abstract	Given the current trend of increasing size and complexity of machine learning architectures, it has become of critical importance to identify new approaches to improve the computational efficiency of model training. In this context, we address the advantages of floating-point over fixed-point representation, and present an in-depth study on the use of 8-bit floating-point number formats for activations, weights, and gradients for both training and inference. We explore the effect of different bit-widths for exponents and significands and different exponent biases. The experimental results demonstrate that a suitable choice of these low-precision formats enables faster training and reduced power consumption without any degradation in accuracy for a range of deep learning models for image classification and language processing.
Keywords	Computer Science - Machine Learning
Publishing date	2022-06-06
Publishing country	us
Document type	Book ; Online
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Article: Patient Selection and Outcomes of Laparoscopic Microwave Ablation of Hepatocellular Carcinoma.

Martin, Robert C G / Woeste, Matthew / Egger, Michael E / Scoggins, Charles R / McMasters, Kelly M / Philips, Prejesh

Cancers

2023 Volume 15, Issue 7

Abstract: Background: Laparoscopic microwave ablation (MWA) of hepatocellular carcinoma is underutilized and predictors of survival in this setting are not well characterized.: Methods: The prognostic value of clinicopathologic variables was evaluated on ... ...

Abstract	Background: Laparoscopic microwave ablation (MWA) of hepatocellular carcinoma is underutilized and predictors of survival in this setting are not well characterized. Methods: The prognostic value of clinicopathologic variables was evaluated on progression-free survival (PFS) and overall survival (OS) by univariate and multivariate analyses. The aim of this study was to evaluate a preferred laparoscopic MWA approach in HCC patients that are not candidates for percutaneous ablation and further classify clinicopathologic factors that may predict survival outcomes following operative MWA in the setting of primary HCC. Results: 184 patients with HCC (median age 66, (33-86), 70% male) underwent laparoscopic MWA (N = 162, 88% laparoscopic) compared to 12% undergoing open MWA (N = 22). Median PFS was 29.3 months (0.2-170) and OS was 44.2 months (2.8-170). Ablation success was confirmed in 100% of patients. Ablation recurrence occurred in 3% (6/184), and local/hepatic recurrence occurred in 34%, at a median time of 19 months (9-18). Distant progression was noted in 8%. Median follow up was 34.1 months (6.4-170). Procedure-related complications were recorded in six (9%) patients with one 90-day mortality. Further, >1 lesion, AFP levels ≥ 80 ng/mL, and an "invader" on pre-operative radiology were associated with increased risk of progression (>1 lesion HR 2.92, 95% CI 1.06 -7.99, Conclusions: Preoperative lesion number, AFP ≥ 80 ng/mL, and an aggressive imaging characteristic (Invader) independently predict PFS and OS following laparoscopic operative MWA.
Language	English
Publishing date	2023-03-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15071965
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Article ; Online: Multi-institutional review of adverse events associated with irreversible electroporation in the treatment of locally advanced pancreatic cancer.

Stephens, Kyle / Philips, Prejesh P / Egger, Michael E / Scoggins, Charles R / McMasters, Kelly M / Martin, Robert C G

Surgery

2023 Volume 175, Issue 3, Page(s) 704–711

Abstract: Background: Irreversible electroporation is a novel approach for treating locally advanced pancreatic adenocarcinoma. However, this ablative technique is not without risk and has the potential to precipitate adverse events. The aim of this study was to ... ...

Abstract	Background: Irreversible electroporation is a novel approach for treating locally advanced pancreatic adenocarcinoma. However, this ablative technique is not without risk and has the potential to precipitate adverse events. The aim of this study was to delineate risk factors that increase this risk, as well as to elucidate the risk profile associated with irreversible electroporation in the setting of locally advanced pancreatic adenocarcinoma. Methods: A review of our prospective multi-institutional database from December 2015 to March 2022 of patients with locally advanced pancreatic adenocarcinoma who underwent irreversible electroporation was analyzed for adverse events. These were then compared with a control population of patients undergoing pancreatectomy for adenocarcinoma. Results: Adverse events occurred in 51 patients of the 201 patients treated with irreversible electroporation compared with 78 of the 200 patients treated with pancreatectomy. The irreversible electroporation group had a significantly greater incidence of postoperative ascites in stage 3C patients. The most common complications in the irreversible electroporation group were infectious (n = 13), gastrointestinal bleed (n = 11), and ascites (n = 7). Multivariate analysis demonstrated increased risk of severe (grade ≥3) adverse events in the irreversible electroporation cohort who received high dose, neoadjuvant radiation (hazard ratio, 2.4; 95% confidence interval, 1.4-5.4), irreversible electroporation electrodes bracketing the superior mesenteric artery, superior mesenteric vein, and portal venous vein (hazard ratio, 1.9; 95% confidence interval, 1.3-3.4), and who had a bile duct stent in place for >6 months (hazard ratio, 1.7; 95% confidence interval, 1.2-5.6). There were similar rates of 90-day mortality in both groups, irreversible electroporation 2.4% vs pancreatectomy 2.8%. Conclusion: This study revealed a 25% rate of adverse events associated with irreversible electroporation in locally advanced pancreatic adenocarcinoma, which was significantly less (P = .004) than the 39% rate of adverse events associated with pancreatectomy in early-stage disease. Certain unique adverse events in the irreversible electroporation group have been established and should be understood in the care of these patients.
MeSH term(s)	Humans ; Pancreatic Neoplasms/surgery ; Prospective Studies ; Adenocarcinoma/surgery ; Ascites ; Electroporation/methods ; Treatment Outcome ; Multicenter Studies as Topic
Language	English
Publishing date	2023-10-16
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	202467-6
ISSN	1532-7361 ; 0039-6060
ISSN (online)	1532-7361
ISSN	0039-6060
DOI	10.1016/j.surg.2023.08.042
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