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Article: A Machine Learning Approach for Modelling Cold-Rolling Curves for Various Stainless Steels.

Contreras-Fortes, Julia / Rodríguez-García, M Inmaculada / Sales, David L / Sánchez-Miranda, Rocío / Almagro, Juan F / Turias, Ignacio

Materials (Basel, Switzerland)

2023 Volume 17, Issue 1

Abstract: Stainless steel is a cold-work-hardened material. The degree and mechanism of hardening depend on the grade and family of the steel. This characteristic has a direct effect on the mechanical behaviour of stainless steel when it is cold-formed. Since cold ...

Abstract	Stainless steel is a cold-work-hardened material. The degree and mechanism of hardening depend on the grade and family of the steel. This characteristic has a direct effect on the mechanical behaviour of stainless steel when it is cold-formed. Since cold rolling is one of the most widespread processes for manufacturing flat stainless steel products, the prediction of their strain-hardening mechanical properties is of great importance to materials engineering. This work uses artificial neural networks (ANNs) to forecast the mechanical properties of the stainless steel as a function of the chemical composition and the applied cold thickness reduction. Multiple linear regression (MLR) is also used as a benchmark model. To achieve this, both traditional and new-generation austenitic, ferritic, and duplex stainless steel sheets are cold-rolled at a laboratory scale with different thickness reductions after the industrial intermediate annealing stage. Subsequently, the mechanical properties of the cold-rolled sheets are determined by tensile tests, and the experimental cold-rolling curves are drawn based on those results. A database is created from these curves to generate a model applying machine learning techniques to predict the values of the tensile strength (
Language	English
Publishing date	2023-12-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma17010147
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Article: PHARMACOKINETICS AND EFFICACY OF A SINGLE TOPICAL DOSE OF EPRINOMECTIN IN GIRAFFE (

Richardson, Ashley / Dadone, Liza / Johnston, Matthew / Bapodra-Villaverde, Priya / Schilz, Amy / Contreras, Eunice / Rivas, Anne / Schwenzer, Sarah / Zec, Stephanie / Cordova, Brenda / Ferguson, Sara / Banks, Krista E / Gustafson, Daniel L / Sadar, Miranda J

Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians

2024 Volume 55, Issue 1, Page(s) 67–72

Abstract: Growing resistance to current antiparasitic medications, both in livestock and in zoological species under human care, makes it imperative to evaluate available drugs on the market, such as eprinomectin. In this prospective study, five males and one ... ...

Abstract	Growing resistance to current antiparasitic medications, both in livestock and in zoological species under human care, makes it imperative to evaluate available drugs on the market, such as eprinomectin. In this prospective study, five males and one female of reticulated (
MeSH term(s)	Male ; Humans ; Female ; Animals ; Cattle ; Anthelmintics/therapeutic use ; Giraffes ; Prospective Studies ; Administration, Topical ; Ivermectin/therapeutic use ; Ivermectin/analogs & derivatives
Chemical Substances	eprinomectin (75KP30FD8O) ; Anthelmintics ; Ivermectin (70288-86-7)
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2174930-9
ISSN	1937-2825 ; 1042-7260
ISSN (online)	1937-2825
ISSN	1042-7260
DOI	10.1638/2023-0054
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Article ; Online: Coastal pollution from the industrial park Quintero bay of central Chile: Effects on abundance, morphology, and development of the kelp Lessonia spicata (Phaeophyceae).

Oyarzo-Miranda, Carolina / Latorre, Nicolás / Meynard, Andrés / Rivas, Jorge / Bulboa, Cristian / Contreras-Porcia, Loretto

PloS one

2020 Volume 15, Issue 10, Page(s) e0240581

Abstract: ... population studies of L. spicata (or other seaweed species) nor studies about the effects of pollution ... the abundance and morphological features of L. spicata populations from Ventanas, Horcón and Cachagua (sites ... in seawater Cu 20-859 μg L-1; sediments Cu > 50,000 μg kg-1). Unexpectedly in Cachagua, a site often ...

Abstract	The industrial park of Quintero Bay (QB) in the central coast of Chile was established in the 1960s, presents high levels of pollution due to the industrial activity, and it is known as one of the five Chilean "sacrifice zones". Lessonia spicata is the most important habitat-forming kelp species in the intertidal along the central and south shores of Chile, and currently there are no morphometric and population studies of L. spicata (or other seaweed species) nor studies about the effects of pollution on its development in QB and neighbouring sites. In this context, the aims of this study were (i) to register the abundance and morphological features of L. spicata populations from Ventanas, Horcón and Cachagua (sites with different pollution histories and located only up to 40 km from the QB); ii) to determine the heavy metals (HMs) concentration in seawater and marine sediments; and (iii) to evaluate in vitro the effects of exposure to seawater from the three sampling sites on spore release and early developmental stages, up to the juvenile sporophyte. Results showed that the chronically exposed Ventanas kelp population had the smallest adult individuals in comparison with the other sites. Ventanas and Horcón registered high HMs concentration in the seawater and marine sediments exceeding the international permissible limits (e.g in seawater Cu 20-859 μg L-1; sediments Cu > 50,000 μg kg-1). Unexpectedly in Cachagua, a site often considered unpolluted, high concentrations of Cu and As were also registered in the seawater (859 and 1,484 μg L-1, respectively) and of As in marine sediments (20,895 μg kg-1). Exposure of gametophytes to the seawater from Ventanas resulted in a developmental delay compared to the other treatments; however, low sporophyte production was determined in all treatments. Our results indicate that QB, more notably Ventanas, induce highly negative effects on individual development, and consequently on seaweed populations, which suggest a long-term negative impact on the community structure of these marine zones. Furthermore, the high concentrations of HMs reported here at Cachagua suggest a recent expansion of pollution along the central coast of Chile, evidencing effects on the marine ecosystem health even on sites far from the pollution source.
MeSH term(s)	Bays ; Chile ; Environmental Monitoring/statistics & numerical data ; Kelp/drug effects ; Kelp/growth & development ; Manufacturing and Industrial Facilities ; Plant Dispersal/drug effects ; Seawater/chemistry ; Water Pollutants, Chemical/adverse effects
Chemical Substances	Water Pollutants, Chemical
Language	English
Publishing date	2020-10-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0240581
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Article ; Online: Efficacy of the combination of milbemycin oxime and afoxolaner for the control of myiasis by Musca domestica in desert tortoises (Gopherus berlandieri).

Fuantos Gámez, Braulio Alejandro / Sánchez Cisneros, Jocelín Selene / Miranda Contreras, Laura / Romero Núñez, Camilo

Veterinary dermatology

2023 Volume 34, Issue 6, Page(s) 618–620

Abstract: The efficacy of the combination of milbemycin oxime and afoxolaner was evaluated in desert tortoises infested with fly larvae. Oral administration of the combination of milbemycin oxime and afoxolaner eliminated the infestation without generating any ... ...

Abstract	The efficacy of the combination of milbemycin oxime and afoxolaner was evaluated in desert tortoises infested with fly larvae. Oral administration of the combination of milbemycin oxime and afoxolaner eliminated the infestation without generating any evident adverse effects on the tortoises.
MeSH term(s)	Animals ; Dogs ; Houseflies ; Turtles ; Macrolides/therapeutic use ; Myiasis/veterinary ; Administration, Oral ; Dog Diseases/drug therapy
Chemical Substances	milbemycin oxime (0502PUN0GT) ; afoxolaner (02L07H6D0U) ; Macrolides
Language	English
Publishing date	2023-08-25
Publishing country	England
Document type	Case Reports
ZDB-ID	2011122-8
ISSN	1365-3164 ; 0959-4493
ISSN (online)	1365-3164
ISSN	0959-4493
DOI	10.1111/vde.13199
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Article ; Online: Efficacy of different 8 h time-restricted eating schedules on visceral adipose tissue and cardiometabolic health: A study protocol.

Dote-Montero, Manuel / Merchan-Ramirez, Elisa / Oses, Maddi / Echarte, Jon / Clavero-Jimeno, Antonio / Alcantara, Jma / Camacho-Cardenosa, Alba / Cupeiro, Rocío / Rodríguez-Miranda, María de Las Nieves / López-Vázquez, Alejandro / Amaro-Gahete, Francisco J / González Cejudo, María Trinidad / Martin-Olmedo, Juan J / Molina-Fernandez, Marcos / García Pérez, Patricia Virginia / Contreras-Bolívar, Victoria / Muñoz-Garach, Araceli / Andreo-López, María C / Carneiro-Barrera, Almudena /

Miranda-Ferrúa, Emiliano / Zugasti, Ana / Petrina, Estrella / Álvarez de Eulate, Natalia / Goñi, Elena / Ribelles, María Jesús / Brugos, Cristina Armendáriz / Izquierdo, Claudia / Fernández-Puggioni, Victoria / Galbete, Arkaitz / Villanueva, Arantxa / Medrano, María / Alfaro-Magallanes, Víctor Manuel / Muñoz-Torres, Manuel / Martín-Rodríguez, José L / Idoate, Fernando / Cabeza, Rafael / Ruiz, Jonatan R / Labayen, Idoia

Nutrition, metabolism, and cardiovascular diseases : NMCD

2023 Volume 34, Issue 1, Page(s) 177–187

Abstract: Background and aims: To investigate the efficacy and feasibility of three different 8 h time-restricted eating (TRE) schedules (i.e., early, late, and self-selected) compared to each other and to a usual-care (UC) intervention on visceral adipose tissue ...

Abstract	Background and aims: To investigate the efficacy and feasibility of three different 8 h time-restricted eating (TRE) schedules (i.e., early, late, and self-selected) compared to each other and to a usual-care (UC) intervention on visceral adipose tissue (VAT) and cardiometabolic health in men and women. Methods and results: Anticipated 208 adults (50% women) aged 30-60 years, with overweight/obesity (25 ≤ BMI<40 kg/m Conclusion: This study will determine whether the timing of the eating window during TRE impacts its efficacy on VAT, body composition and cardiometabolic risk factors and provide insights about its feasibility.
MeSH term(s)	Adult ; Male ; Humans ; Female ; Intra-Abdominal Fat ; Body Composition ; Cardiometabolic Risk Factors ; Educational Status ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Fasting ; Randomized Controlled Trials as Topic ; Multicenter Studies as Topic
Language	English
Publishing date	2023-09-21
Publishing country	Netherlands
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	1067704-5
ISSN	1590-3729 ; 0939-4753
ISSN (online)	1590-3729
ISSN	0939-4753
DOI	10.1016/j.numecd.2023.09.014
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Article ; Online: Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance.

Contreras-Rodriguez, O / Arnoriaga-Rodríguez, M / Miranda-Olivos, R / Blasco, G / Biarnés, C / Puig, J / Rivera-Pinto, J / Calle, M L / Pérez-Brocal, V / Moya, A / Coll, C / Ramió-Torrentà, L / Soriano-Mas, C / Fernandez-Real, J M

International journal of obesity (2005)

2021 Volume 46, Issue 1, Page(s) 30–38

Abstract: Background: Functional connectivity alterations in the lateral and medial hypothalamic networks have been associated with the development and maintenance of obesity, but the possible impact on the structural properties of these networks remains largely ... ...

Abstract	Background: Functional connectivity alterations in the lateral and medial hypothalamic networks have been associated with the development and maintenance of obesity, but the possible impact on the structural properties of these networks remains largely unexplored. Also, obesity-related gut dysbiosis may delineate specific hypothalamic alterations within obese conditions. We aim to assess the effects of obesity, and obesity and gut-dysbiosis on the structural covariance differences in hypothalamic networks, executive functioning, and depressive symptoms. Methods: Medial (MH) and lateral (LH) hypothalamic structural covariance alterations were identified in 57 subjects with obesity compared to 47 subjects without obesity. Gut dysbiosis in the subjects with obesity was defined by the presence of high (n = 28) and low (n = 29) values in a BMI-associated microbial signature, and posthoc comparisons between these groups were used as a proxy to explore the role of obesity-related gut dysbiosis on the hypothalamic measurements, executive function, and depressive symptoms. Results: Structural covariance alterations between the MH and the striatum, lateral prefrontal, cingulate, insula, and temporal cortices are congruent with previously functional connectivity disruptions in obesity conditions. MH structural covariance decreases encompassed postcentral parietal cortices in the subjects with obesity and gut-dysbiosis, but increases with subcortical nuclei involved in the coding food-related hedonic information in the subjects with obesity without gut-dysbiosis. Alterations for the structural covariance of the LH in the subjects with obesity and gut-dysbiosis encompassed increases with frontolimbic networks, but decreases with the lateral orbitofrontal cortex in the subjects with obesity without gut-dysbiosis. Subjects with obesity and gut dysbiosis showed higher executive dysfunction and depressive symptoms. Conclusions: Obesity-related gut dysbiosis is linked to specific structural covariance alterations in hypothalamic networks relevant to the integration of somatic-visceral information, and emotion regulation.
MeSH term(s)	Adult ; Body Mass Index ; Cross-Sectional Studies ; Dysbiosis/complications ; Dysbiosis/physiopathology ; Female ; Humans ; Hypothalamic Diseases/etiology ; Hypothalamus/physiopathology ; Male ; Middle Aged ; Neural Pathways/abnormalities ; Neural Pathways/physiology ; Obesity/complications ; Obesity/physiopathology
Language	English
Publishing date	2021-09-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752409-2
ISSN	1476-5497 ; 0307-0565
ISSN (online)	1476-5497
ISSN	0307-0565
DOI	10.1038/s41366-021-00953-9
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Article: Immune response of human cultured cells towards macrocyclic Fe

Salazar-Medina, Alex J / Velazquez-Contreras, Enrique F / Sugich-Miranda, Rocio / Santacruz, Hisila / Navarro, Rosa E / Rocha-Alonzo, Fernando / Islas-Osuna, Maria A / Chen, Patricia L / Christian, Sarah G B / Romoser, Amelia A / Dindot, Scott V / Sayes, Christie M / Sotelo-Mundo, Rogerio R / Criscitiello, Michael F

PeerJ

2020 Volume 8, Page(s) e8956

Abstract: Synthetic molecules that mimic the function of natural enzymes or molecules have untapped potential for use in the next generation of drugs. Cyclic compounds that contain aromatic rings are macrocyclic cyclophanes, and when they coordinate iron ions are ... ...

Abstract	Synthetic molecules that mimic the function of natural enzymes or molecules have untapped potential for use in the next generation of drugs. Cyclic compounds that contain aromatic rings are macrocyclic cyclophanes, and when they coordinate iron ions are of particular interest due to their antioxidant and biomimetic properties. However, little is known about the molecular responses at the cellular level. This study aims to evaluate the changes in immune gene expression in human cells exposed to the cyclophanes Fe
Language	English
Publishing date	2020-04-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.8956
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Article ; Online: Valores de referencia del hemograma completo en escolares de 8 a 12 años de edad residentes a 2.760m sobre el nivel del mar.

Armando García-Miranda, L / Contreras, I / Estrada, J A

Anales de pediatria (Barcelona, Spain : 2003)

2014 Volume 80, Issue 4, Page(s) 221–228

Abstract: Objective: To determine reference values for full blood count parameters in a population of children 8 to 12 years old, living at an altitude of 2760 m above sea level.: Material and methods: Our sample consisted of 102 individuals on whom a full ... ...

Title translation	Full blood count reference values in children of 8 to 12 years old residing at 2,760 m above sea level.
Abstract	Objective: To determine reference values for full blood count parameters in a population of children 8 to 12 years old, living at an altitude of 2760 m above sea level. Material and methods: Our sample consisted of 102 individuals on whom a full blood count was performed. The parameters included: total number of red blood cells, platelets, white cells, and a differential count (millions/μl and %) of neutrophils, lymphocytes, monocytes, eosinophils and basophils. Additionally, we obtained values for hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, concentration of corpuscular hemoglobin and red blood cell distribution width. The results were statistically analyzed with a non-parametric test, to divide the sample in quartiles and obtain the lower and upper limits for our intervals. Moreover, the values for the intervals obtained from this analysis were compared to intervals obtained estimating+- 2 standard deviations above and below from our mean values. Results: Our results showed significant differences compared to normal interval values reported for the adult Mexican population in most of the parameters studied. Conclusions: The full blood count is an important laboratory test used routinely for the initial assessment of a patient. Values of full blood counts in healthy individuals vary according to gender, age and geographic location; therefore, each population should have its own reference values.
MeSH term(s)	Altitude ; Blood Cell Count ; Child ; Female ; Humans ; Male ; Mexico ; Reference Values
Language	Spanish
Publishing date	2014-04
Publishing country	Spain
Document type	English Abstract ; Journal Article
ISSN	1695-9531
ISSN (online)	1695-9531
DOI	10.1016/j.anpedi.2013.06.035
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Article ; Online: Post-vaccination seropositivity against SARS-CoV-2 in peruvian health workers vaccinated with BBIBP-CorV (Sinopharm).

Cvetkovic-Vega, Aleksandar / Urrunaga-Pastor, Diego / Soto-Becerra, Percy / Figueroa-Montes, Luis E / Fernandez-Bolivar, Lizette / Alvizuri-Pastor, Sergio / Oyanguren-Miranda, Martin / Neyra-Vera, Ibeth / Carrillo-Ramos, Elizabeth / Sagástegui, Arturo / Contreras-Macazana, Roxana / Lecca-Rengifo, Diana / Grande-Castro, Nikolai / Apolaya-Segura, Moises / Maguina, Jorge L

Travel medicine and infectious disease

2022 Volume 52, Page(s) 102514

Abstract: Objective: To estimate the prevalence of post-vaccination seropositivity against SARS-CoV-2 and identify its predictors in Peruvian Social Health Insurance (EsSalud) personnel in 2021.: Methods: We conducted a cross-sectional study in a ... ...

Abstract	Objective: To estimate the prevalence of post-vaccination seropositivity against SARS-CoV-2 and identify its predictors in Peruvian Social Health Insurance (EsSalud) personnel in 2021. Methods: We conducted a cross-sectional study in a representative simple stratified sample of EsSalud workers. We evaluated IgG anti-SARS-CoV-2 antibodies response (seropositivity) by passive (previous infection) and active immunization (vaccination), and epidemiological and occupational variables obtained by direct interview and a data collection form. Descriptive and inferential statistics were used with correction of sample weights adjusted for non-response rate, and crude and adjusted odds ratio (OR) and geometric mean ratio (GMR) with their respective 95% confidence intervals (95%CI) were estimated. Results: We enrolled 1077 subjects. Seropositivity was 67.4% (95%CI: 63.4-71.1). Predictors of seropositivity were age (negative relation; p < 0.001), previous infection (aOR = 11.7; 95%CI: 7.81-17.5), working in COVID-19 area (aOR = 1.47; 95%CI: 1.02-2.11) and time since the second dose. In relation to antibody levels measured by geometric means, there was an association between male sex (aGMR = 0.77; 95%CI: 0.74-0.80), age (negative relation; p < 0.001), previous infection (aGMR = 13.1; 95%CI:4.99-34.40), non-face-to-face/licensed work modality (aGMR = 0.78; 95%CI: 0.73-0.84), being a nursing technician (aGMR = 1.30; 95%CI: 1.20-1.41), working in administrative areas (aGMR = 1.17; 95%CI: 1.10-1.25), diagnostic support (aGMR = 1.07; 95%CI: 1.01-1.15), critical care (aGMR = 0.85; 95%CI: 0.79-0.93), and in a COVID-19 area (aGMR = 1.30; 95%CI: 1.24-1.36) and time since receiving the second dose (negative relation; p < 0.001). Conclusions: Seropositivity and antibody levels decrease as the time since receiving the second dose increases. Older age and no history of previous infection were associated with lower seropositivity and antibody values. These findings may be useful for sentinel antibody surveillance and the design of booster dose strategies.
MeSH term(s)	Humans ; Male ; SARS-CoV-2 ; COVID-19/epidemiology ; COVID-19/prevention & control ; Cross-Sectional Studies ; Peru/epidemiology ; Antibodies, Viral
Chemical Substances	BIBP COVID-19 vaccine ; Antibodies, Viral
Language	English
Publishing date	2022-11-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2170891-5
ISSN	1873-0442 ; 1477-8939
ISSN (online)	1873-0442
ISSN	1477-8939
DOI	10.1016/j.tmaid.2022.102514
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Article ; Online: Baseline and post-stress seasonal changes in immunocompetence and redox state maintenance in the fishing bat Myotis vivesi.

Hernández-Arciga, Ulalume / Herrera M, L Gerardo / Ibáñez-Contreras, Alejandra / Miranda-Labra, Roxana U / Flores-Martínez, José Juan / Königsberg, Mina

PloS one

2018 Volume 13, Issue 1, Page(s) e0190047

Abstract: Little is known of how the stress response varies when animals confront seasonal life-history processes. Antioxidant defenses and damage caused by oxidative stress and their link with immunocompetence are powerful biomarkers to assess animal´s ... ...

Abstract	Little is known of how the stress response varies when animals confront seasonal life-history processes. Antioxidant defenses and damage caused by oxidative stress and their link with immunocompetence are powerful biomarkers to assess animal´s physiological stress response. The aim of this study was A) to determine redox state and variation in basal (pre-acute stress) immune function during summer, autumn and winter (spring was not assessed due to restrictions in collecting permit) in the fish-eating Myotis (Myotis vivesi; Chiroptera), and B) to determine the effect of acute stress on immunocompetence and redox state during each season. Acute stress was stimulated by restricting animal movement for 6 and 12 h. The magnitude of the cellular immune response was higher during winter whilst that of the humoral response was at its highest during summer. Humoral response increased after 6 h of movement restriction stress and returned to baseline levels after 12 h. Basal redox state was maintained throughout the year, with no significant changes in protein damage, and antioxidant activity was modulated mainly in relation to variation to environment cues, increasing during high temperatures and decreasing during windy nights. Antioxidant activity increased after the 6 h of stressful stimuli especially during summer and autumn, and to a lesser extent in early winter, but redox state did not vary. However, protein damage increased after 12 h of stress during summer. Prolonged stress when the bat is engaged in activities of high energy demand overcame its capacity to maintain homeostasis resulting in oxidative damage.
MeSH term(s)	Animals ; Antibody Formation ; Chiroptera/immunology ; Chiroptera/physiology ; Immunocompetence ; Oxidation-Reduction ; Oxidative Stress ; Principal Component Analysis ; Seasons ; Stress, Physiological ; Weather
Language	English
Publishing date	2018-01-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0190047
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