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  1. Article ; Online: COVID-19.

    Marks, Kristen M / Gulick, Roy M

    Annals of internal medicine

    2023  Volume 176, Issue 10, Page(s) ITC145–ITC160

    Abstract: COVID-19, the illness caused by SARS-CoV-2, became a worldwide pandemic in 2020. Initial clinical manifestations range from asymptomatic infection to mild upper respiratory illness but may progress to pulmonary involvement with hypoxemia and, in some ... ...

    Abstract COVID-19, the illness caused by SARS-CoV-2, became a worldwide pandemic in 2020. Initial clinical manifestations range from asymptomatic infection to mild upper respiratory illness but may progress to pulmonary involvement with hypoxemia and, in some cases, multiorgan involvement, shock, and death. Older adults, pregnant persons, those with common comorbidities, and those with immunosuppression are at greatest risk for progression. Vaccination is effective in preventing symptomatic infection and reducing risk for severe disease, hospitalization, and death. Antiviral treatment and immunomodulators have been shown to benefit certain patients. This article summarizes current recommendations on prevention, diagnosis, management, and treatment of COVID-19.
    MeSH term(s) Pregnancy ; Female ; Humans ; Aged ; COVID-19 ; SARS-CoV-2 ; Pandemics/prevention & control ; COVID-19 Drug Treatment ; Hospitalization
    Language English
    Publishing date 2023-10-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/AITC202310170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Managing HIV Treatment Failure: Time to REVAMP?

    Gulick, Roy M / Glesby, Marshall J

    Annals of internal medicine

    2021  Volume 174, Issue 12, Page(s) 1753–1754

    Language English
    Publishing date 2021-10-26
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M21-3903
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: HIV: Closing the Mortality Gap.

    Glesby, Marshall J / Gulick, Roy M

    Annals of internal medicine

    2021  Volume 174, Issue 9, Page(s) 1311–1312

    MeSH term(s) HIV Infections/drug therapy ; Humans
    Language English
    Publishing date 2021-07-06
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M21-2586
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: New HIV drugs: 2018 and beyond.

    Gulick, Roy M

    Current opinion in HIV and AIDS

    2018  Volume 13, Issue 4, Page(s) 291–293

    MeSH term(s) Anti-HIV Agents/administration & dosage ; Drug Discovery ; HIV Infections/drug therapy ; HIV Infections/virology ; HIV-1/drug effects ; HIV-1/physiology ; Humans
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2018-04-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 2502511-9
    ISSN 1746-6318 ; 1746-630X
    ISSN (online) 1746-6318
    ISSN 1746-630X
    DOI 10.1097/COH.0000000000000478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Selecting Treatments During an Infectious Disease Pandemic: Chasing the Evidence.

    Glesby, Marshall J / Gulick, Roy M

    Annals of internal medicine

    2021  Volume 174, Issue 10, Page(s) 1464–1465

    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Antiviral Agents/therapeutic use ; Communicable Diseases/drug therapy ; Evidence-Based Medicine ; Humans ; Pandemics ; Randomized Controlled Trials as Topic ; Respiration, Artificial
    Chemical Substances Adrenal Cortex Hormones ; Antiviral Agents
    Language English
    Publishing date 2021-08-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M21-3221
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  6. Article ; Online: Investigational Antiretroviral Drugs: What is Coming Down the Pipeline.

    Gulick, Roy M

    Topics in antiviral medicine

    2018  Volume 25, Issue 4, Page(s) 127–132

    Abstract: ... presentations by Roy M. Gulick, MD, MPH, at the IAS-USA continuing education program, Improving the Management ...

    Abstract Over the past 30 years, antiretroviral drug regimens for treating HIV infection have become more effective, safer, and more convenient. Despite 31 currently approved drugs, the pipeline of investigational HIV drugs remains full. Investigational antiretroviral drugs include the nucleoside analogue reverse transcriptase translocation inhibitor (NRTTI) MK-8591, a long-acting compound that could be dosed once weekly. Investigational nonnucleoside analogue reverse transcriptase inhibitors (NNRTIs) include doravirine, which is active in vitro against NNRTI-resistant HIV and was potent and well-tolerated when used in combination with a dual-nucleoside analogue RTI (nRTI) backbone in treatment-naive individuals.New integrase strand transfer inhibitors (InSTIs) include recently approved bictegravir, which is active against InSTI-resistant viral strains in vitro and was potent and well-tolerated in combination regimens in treatment-naive individuals, and investigational cabotegravir, which is being studied with monthly parenteral dosing for HIV maintenance treatment and with bimonthly dosing for HIV preexposure prophylaxis (PrEP). Investigational HIV entry inhibitors include the new CD4 attachment inhibitor fostemsavir, which targets HIV envelope glycoprotein 120, and recently approved ibalizumab, which binds the CD4 receptor. This article summarizes presentations by Roy M. Gulick, MD, MPH, at the IAS-USA continuing education program, Improving the Management of HIV Disease, held in Los Angeles, California, in April 2017, and at the 2017 Ryan White HIV/AIDS Program Clinical Conference, held in San Antonio, Texas, in August 2017.
    MeSH term(s) Anti-HIV Agents/therapeutic use ; Antiretroviral Therapy, Highly Active ; Deoxyadenosines/therapeutic use ; Drug Discovery/trends ; Drugs, Investigational/therapeutic use ; HIV Infections/drug therapy ; HIV Infections/prevention & control ; Humans ; Pre-Exposure Prophylaxis ; Reverse Transcriptase Inhibitors/therapeutic use
    Chemical Substances Anti-HIV Agents ; Deoxyadenosines ; Drugs, Investigational ; Reverse Transcriptase Inhibitors ; 4'-ethynyl-2-fluoro-2'-deoxyadenosine (QPQ082R25D)
    Language English
    Publishing date 2018-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2656632-1
    ISSN 2161-5853 ; 2161-5861
    ISSN (online) 2161-5853
    ISSN 2161-5861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Barriers to Uptake of Long-Acting Antiretroviral Products for Treatment and Prevention of Human Immunodeficiency Virus (HIV) in High-Income Countries.

    Cooper, Stanley E / Rosenblatt, Joshua / Gulick, Roy M

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2022  Volume 75, Issue Suppl 4, Page(s) S541–S548

    Abstract: Long-acting injectable antiretroviral therapy (LAI-ART) for the treatment and prevention of human immunodeficiency virus (HIV) holds great potential to shift treatment paradigms by offering an alternative to daily oral medication. However, significant ... ...

    Abstract Long-acting injectable antiretroviral therapy (LAI-ART) for the treatment and prevention of human immunodeficiency virus (HIV) holds great potential to shift treatment paradigms by offering an alternative to daily oral medication. However, significant challenges at the drug, patient, and system levels risk impeding the uptake and implementation of LAI-ART. This review aims to describe the known and anticipated barriers to uptake of LAI-ART in high-income countries, as well as the ongoing research addressing some of these barriers to improve the delivery and uptake of LAI-ART products.
    MeSH term(s) Humans ; Developed Countries ; Anti-Retroviral Agents/therapeutic use ; Income ; HIV Infections/drug therapy ; HIV Infections/prevention & control ; HIV
    Chemical Substances Anti-Retroviral Agents
    Language English
    Publishing date 2022-11-22
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciac716
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 480: Show issues

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  8. Article ; Online: Drug Costs: What Can Infectious Diseases Physicians Do?

    Kapadia, Shashi N / Gulick, Roy M

    The Journal of infectious diseases

    2019  Volume 221, Issue 5, Page(s) 681–684

    MeSH term(s) Costs and Cost Analysis ; Drugs, Generic ; Humans ; Physicians
    Chemical Substances Drugs, Generic
    Language English
    Publishing date 2019-03-18
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiz067
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  9. Article ; Online: Expectations of preventative benefits and risk behaviors in a randomized trial evaluating oral HIV preexposure prophylaxis candidates.

    Sugarman, Jeremy / Weir, Brian W / Dun, Chen / Gulick, Roy M / Wilkin, Timothy J / Mayer, Kenneth H / McCauley, Marybeth / Weinfurt, Kevin P

    AIDS care

    2024  , Page(s) 1–7

    Abstract: When participants enrolled in an HIV prevention trial hold a preventive misconception (PM) - expectations that experimental interventions will confer protection from HIV infection - they may engage in behaviors that increase their risk of acquiring HIV. ... ...

    Abstract When participants enrolled in an HIV prevention trial hold a preventive misconception (PM) - expectations that experimental interventions will confer protection from HIV infection - they may engage in behaviors that increase their risk of acquiring HIV. This can raise ethical concerns about whether those enrolled in the trial understand the nature of participation and their safety. Consequently, we systematically evaluated the prevalence of PM and its association with risk behaviors in a trial examining three candidate regimens for oral HIV pre-exposure prophylaxis in which all participants received at least one antiretroviral agent. Overall, trial participants exhibited relatively high preventive expectations that may be associated with an increase in risk behaviors among men who have sex with men. In addition, we identified substantial site variability in PM that necessitates future research to uncover its source. This will allow appropriate measures to be taken to mitigate PM and help ensure that participants have an accurate understanding of the potential risks and benefits of trial participation throughout the course of a trial.
    Language English
    Publishing date 2024-04-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1012651-x
    ISSN 1360-0451 ; 0954-0121
    ISSN (online) 1360-0451
    ISSN 0954-0121
    DOI 10.1080/09540121.2024.2332446
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Choosing Initial Antiretroviral Therapy: Current Recommendations for Initial Therapy and Newer or Investigational Agents.

    Gulick, Roy M

    Topics in antiviral medicine

    2015  Volume 23, Issue 4, Page(s) 128–131

    Abstract: ... inhibitor BMS-955176. This article summarizes a presentation by Roy M. Gulick, MD, MPH, at the IAS-USA ...

    Abstract There is general consistency among US and European guidelines regarding the initiation of antiretroviral therapy for HIV-infected individuals. Recent and ongoing trials comparing regimens may lead to reevaluation of initial treatment choices. The choice of antiretroviral regimen will also likely be affected by development, evaluation, and availability of newer drugs. This article reviews currently recommended regimens and characteristics of selected current investigational drugs, including the nucleotide analogue reverse transcriptase inhibitor tenofovir alafenamide, the nonnucleoside reverse transcriptase inhibitor doravirine, the integrase strand transfer inhibitor cabotegravir, the HIV entry inhibitor BMS-663068, and the HIV maturation inhibitor BMS-955176. This article summarizes a presentation by Roy M. Gulick, MD, MPH, at the IAS-USA continuing education program, Improving the Management of HIV Disease, held in New York, New York, in March 2015 and September 2015.
    MeSH term(s) Anti-Retroviral Agents/therapeutic use ; Antiretroviral Therapy, Highly Active/methods ; Europe ; HIV Infections/drug therapy ; Humans ; Treatment Outcome ; United States
    Chemical Substances Anti-Retroviral Agents
    Language English
    Publishing date 2015-11-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2656632-1
    ISSN 2161-5853 ; 2161-5853
    ISSN (online) 2161-5853
    ISSN 2161-5853
    Database MEDical Literature Analysis and Retrieval System OnLINE

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