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Article ; Online: Initial Investigation of a Grating Stimulus as a Visual Endpoint for Human Centrifuge Research.

Britton, Joseph / Connolly, Desmond M / Hawarden, Danielle E / Stevenson, Alec T / Harridge, Stephen D R / Green, Nicholas D C / Pollock, Ross D

Aerospace medicine and human performance

2024 Volume 94, Issue 12, Page(s) 894–901

Abstract: INTRODUCTION: ...

Abstract	INTRODUCTION:
MeSH term(s)	Humans ; Reproducibility of Results ; Aerospace Medicine ; Centrifugation ; Fatigue ; Acceleration
Language	English
Publishing date	2024-01-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2809085-8
ISSN	2375-6322 ; 2375-6314
ISSN (online)	2375-6322
ISSN	2375-6314
DOI	10.3357/AMHP.6246.2023
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Article ; Online: Triterpenoids.

Hill, Robert A / Connolly, Joseph D

Natural product reports

2020 Volume 37, Issue 7, Page(s) 962–998

Abstract: Covering 2015. Previous review: Nat. Prod. Rep., 2018, 35, 1294-1329This review covers the isolation and structure determination of triterpenoids reported during 2015 including squalene derivatives, lanostanes, holostanes, cycloartanes, cucurbitanes, ... ...

Abstract	Covering 2015. Previous review: Nat. Prod. Rep., 2018, 35, 1294-1329This review covers the isolation and structure determination of triterpenoids reported during 2015 including squalene derivatives, lanostanes, holostanes, cycloartanes, cucurbitanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, serratanes, isomalabaricanes and saponins; 320 references are cited.
MeSH term(s)	Crystallography, X-Ray ; Fungi/chemistry ; Molecular Structure ; Plants/chemistry ; Triterpenes/chemistry ; Triterpenes/pharmacology
Chemical Substances	Triterpenes
Language	English
Publishing date	2020-02-14
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2002546-4
ISSN	1460-4752 ; 0265-0568
ISSN (online)	1460-4752
ISSN	0265-0568
DOI	10.1039/c9np00067d
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Article ; Online: Triterpenoids.

Hill, Robert A / Connolly, Joseph D

Natural product reports

2018 Volume 35, Issue 12, Page(s) 1294–1329

Abstract: Covering 2014. Previous review: Nat. Prod. Rep., 2017, 34, 90-122 This review covers the isolation and structure determination of triterpenoids reported during 2014 including squalene derivatives, lanostanes, holostanes, cycloartanes, cucurbitanes, ... ...

Abstract	Covering 2014. Previous review: Nat. Prod. Rep., 2017, 34, 90-122 This review covers the isolation and structure determination of triterpenoids reported during 2014 including squalene derivatives, lanostanes, holostanes, cycloartanes, cucurbitanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, serratanes, isomalabaricanes and saponins; 374 references are cited.
MeSH term(s)	Molecular Structure ; Oleanolic Acid/analogs & derivatives ; Oleanolic Acid/chemistry ; Saponins/chemistry ; Squalene/chemistry ; Triterpenes/chemistry ; Dammaranes
Chemical Substances	Saponins ; Triterpenes ; friedelane ; oleanane ; Oleanolic Acid (6SMK8R7TGJ) ; Squalene (7QWM220FJH)
Language	English
Publishing date	2018-07-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2002546-4
ISSN	1460-4752 ; 0265-0568
ISSN (online)	1460-4752
ISSN	0265-0568
DOI	10.1039/c8np00029h
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Article ; Online: Triterpenoids.

Hill, Robert A / Connolly, Joseph D

Natural product reports

2017 Volume 34, Issue 1, Page(s) 90–122

Abstract: Covering: 2013. Previous review: Nat. Prod. Rep., 2015, 29, 1028-1065This review covers the isolation and structure determination of triterpenoids reported during 2013 including squalene derivatives, lanostanes, holostanes, cycloartanes, cucurbitanes, ... ...

Abstract	Covering: 2013. Previous review: Nat. Prod. Rep., 2015, 29, 1028-1065This review covers the isolation and structure determination of triterpenoids reported during 2013 including squalene derivatives, lanostanes, holostanes, cycloartanes, cucurbitanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, serratanes, isomalabaricanes and saponins; 350 references are cited.
MeSH term(s)	Molecular Structure ; Triterpenes
Chemical Substances	Triterpenes
Language	English
Publishing date	2017-01-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2002546-4
ISSN	1460-4752 ; 0265-0568
ISSN (online)	1460-4752
ISSN	0265-0568
DOI	10.1039/c6np00094k
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Article ; Online: Impact of Muscle Measures on Outcome in Patients Receiving Endocrine Therapy for Metastatic Breast Cancer: Analysis of ECOG-ACRIN E2112.

Ballinger, Tarah J / Marques, Helga S / Xue, Gloria / Hoffman, Richard / Gatsonis, Constantine / Zhao, Fengmin / Miller, Kathy D / Sparano, Joseph / Connolly, Roisin M

Journal of the National Comprehensive Cancer Network : JNCCN

2023 Volume 21, Issue 9, Page(s) 915–923.e1

Abstract: Background: Observational data investigating the relationship between body habitus and outcomes in breast cancer have been variable and inconsistent, largely centered in the curative setting and focused on weight-based metrics. This study evaluated the ... ...

Abstract	Background: Observational data investigating the relationship between body habitus and outcomes in breast cancer have been variable and inconsistent, largely centered in the curative setting and focused on weight-based metrics. This study evaluated the impact of muscle measures on outcomes in patients with metastatic breast cancer receiving endocrine-based therapy. Methods: Baseline CT scans were collected from ECOG-ACRIN E2112, a randomized phase III placebo-controlled study of exemestane with or without entinostat. A CT cross-sectional image at the L3 level was extracted to obtain skeletal muscle mass and attenuation. Low muscle mass (LMM) was defined as skeletal muscle index <41 cm2/m2 and low muscle attenuation (LMA) as muscle density <25 HU or <33 HU if overweight/obese by body mass index (BMI). Multivariable Cox proportional hazard models determined the association between LMM or LMA and progression-free survival (PFS) and overall survival (OS). Correlations between LMM, LMA, and patient-reported outcomes were determined using 2-sample t tests. Results: Analyzable CT scans and follow-up data were available for 540 of 608 patients. LMM was present in 39% (n=212) of patients and LMA in 56% (n=301). Those with LMA were more likely to have obesity and worse performance status. LMM was not associated with survival (PFS hazard ratio [HR]: 1.13, P=.23; OS HR: 1.05, P=.68), nor was LMA (PFS HR: 1.01, P=.93; OS HR: 1.00, P=.99). BMI was not associated with survival. LMA, but not LMM, was associated with increased frequency of patient-reported muscle aches. Conclusions: Both low muscle mass and density are prevalent in patients with hormone receptor-positive metastatic breast cancer. Muscle measures correlated with obesity and performance status; however, neither muscle mass nor attenuation were associated with prognosis. Further work is needed to refine body composition measurements and select optimal cutoffs with meaningful endpoints in specific breast cancer populations, particularly those living with metastatic disease.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/drug therapy ; Muscle, Skeletal/diagnostic imaging ; Benchmarking ; Body Mass Index ; Obesity/complications
Language	English
Publishing date	2023-09-04
Publishing country	United States
Document type	Randomized Controlled Trial ; Clinical Trial, Phase III ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2250759-0
ISSN	1540-1413 ; 1540-1405
ISSN (online)	1540-1413
ISSN	1540-1405
DOI	10.6004/jnccn.2023.7045
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Article ; Online: Optimizing radiation safety in dentistry: Clinical recommendations and regulatory considerations.

Benavides, Erika / Krecioch, Joseph R / Connolly, Roger T / Allareddy, Trishul / Buchanan, Allison / Spelic, David / O'Brien, Kelly K / Keels, Martha Ann / Mascarenhas, Ana Karina / Duong, Mai-Ly / Aerne-Bowe, Mickie J / Ziegler, Kathleen M / Lipman, Ruth D

Journal of the American Dental Association (1939)

2024 Volume 155, Issue 4, Page(s) 280–293.e4

Abstract: Background: The value of dental radiographs to oral health care decision making must be balanced with radiation safety to minimize patient exposure and occupational risk of oral health care providers. This review summarizes recommendations and ... ...

Abstract	Background: The value of dental radiographs to oral health care decision making must be balanced with radiation safety to minimize patient exposure and occupational risk of oral health care providers. This review summarizes recommendations and regulatory guidance regarding dental radiography and cone-beam computed tomography. An expert panel presents recommendations on radiation safety, appropriate imaging practices, and reducing radiation exposure. Types of studies reviewed: A systematic search run in Ovid MEDLINE, Embase, and Cochrane Database of Systematic Reviews identified relevant topical systematic reviews, organizational guidelines, and regulatory reviews published in the peer-reviewed literature since 2010. A supplemental search of the gray literature (eg, technical reports, standards, and regulations) identified topical nonindexed publications. Inclusion criteria required relevance to primary oral health care (ie, general or pediatric dentistry). Results: A total of 95 articles, guidance documents, and regulations met the inclusion criteria. Resources were characterized as applicable to all modalities, operator and occupational protection, dose reduction and optimization, and quality assurance and control. Practical implications: Understanding factors affecting imaging safety and applying fundamental principles of radiation protection consistent with federal, state, and local requirements are essential for limiting patient ionizing radiation exposure, in conjunction with implementing optimal imaging procedures to support prudent use of dental radiographs and cone-beam computed tomographic imaging. The regulatory guidance and best practice recommendations summarized in this article should be followed by dentists and other oral health care providers.
MeSH term(s)	Child ; Humans ; Systematic Reviews as Topic ; Cone-Beam Computed Tomography/methods ; Pediatric Dentistry ; Radiography, Dental/methods ; Radiation Dosage
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	220622-5
ISSN	1943-4723 ; 0002-8177 ; 1048-6364
ISSN (online)	1943-4723
ISSN	0002-8177 ; 1048-6364
DOI	10.1016/j.adaj.2023.12.002
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Article: Triterpenoids

Hill, Robert A. / Connolly, Joseph D.

Natural product reports. 2020 July 22, v. 37, no. 7

2020

Abstract: Covering 2015. Previous review: Nat. Prod. Rep., 2018, 35, 1294–1329 This review covers the isolation and structure determination of triterpenoids reported during 2015 including squalene derivatives, lanostanes, holostanes, cycloartanes, cucurbitanes, ... ...

Abstract	Covering 2015. Previous review: Nat. Prod. Rep., 2018, 35, 1294–1329 This review covers the isolation and structure determination of triterpenoids reported during 2015 including squalene derivatives, lanostanes, holostanes, cycloartanes, cucurbitanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, serratanes, isomalabaricanes and saponins; 320 references are cited.
Keywords	lupane ; saponins ; squalene
Language	English
Dates of publication	2020-0722
Size	p. 962-998.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2002546-4
ISSN	1460-4752 ; 0265-0568
ISSN (online)	1460-4752
ISSN	0265-0568
DOI	10.1039/c9np00067d
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Advancing the community health vulnerability index for wildland fire smoke exposure.

Jung, Jihoon / Wilkins, Joseph L / Schollaert, Claire L / Masuda, Yuta J / Flunker, John C / Connolly, Rachel E / D'Evelyn, Savannah M / Bonillia, Eimy / Rappold, Ana G / Haugo, Ryan D / Marlier, Miriam E / Spector, June T

The Science of the total environment

2023 Volume 906, Page(s) 167834

Abstract: Wildland fire smoke risks are not uniformly distributed across people and places, and the most vulnerable communities are often disproportionately impacted. This study develops a county level community health vulnerability index (CHVI) for the Contiguous ...

Abstract	Wildland fire smoke risks are not uniformly distributed across people and places, and the most vulnerable communities are often disproportionately impacted. This study develops a county level community health vulnerability index (CHVI) for the Contiguous United States (CONUS) using three major vulnerability components: adaptive capacity, sensitivity, and exposure at the national and regional level. We first calculated sensitivity and adaptive capacity sub-indices using nine sensitivity and twenty adaptive capacity variables. These sub-indices were then combined with an exposure sub-index, which is based on the Community Multiscale Air Quality data (2008-2018), to develop CHVI. Finally, we conducted several analyses with the derived indices to: 1) explore associations between the level of fine particulate matter from wildland fires (fire-PM
MeSH term(s)	Humans ; Air Pollutants/adverse effects ; Particulate Matter/adverse effects ; Public Health ; Smoke/adverse effects ; United States ; Wildfires ; Environmental Exposure/adverse effects
Chemical Substances	Air Pollutants ; Particulate Matter ; Smoke
Language	English
Publishing date	2023-10-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.167834
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Zs.A 949: Show issues

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Article ; Online: Triterpenoids.

Hill, Robert A / Connolly, Joseph D

Natural product reports

2015 Volume 32, Issue 2, Page(s) 273–327

Abstract: This review covers the isolation and structure determination of triterpenoids reported during 2012 including squalene derivatives, lanostanes, holostanes, cycloartanes, cucurbitanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, ...

Abstract	This review covers the isolation and structure determination of triterpenoids reported during 2012 including squalene derivatives, lanostanes, holostanes, cycloartanes, cucurbitanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, serratanes, isomalabaricanes and saponins; 348 references are cited.
MeSH term(s)	Biological Products ; Molecular Structure ; Triterpenes
Chemical Substances	Biological Products ; Triterpenes
Language	English
Publishing date	2015-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2002546-4
ISSN	1460-4752 ; 0265-0568
ISSN (online)	1460-4752
ISSN	0265-0568
DOI	10.1039/c4np00101j
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Article ; Online: High Comorbidity of Pediatric Cancers in Patients with Birth Defects: Insights from Whole Genome Sequencing Analysis of Copy Number Variations.

Qu, Hui-Qi / Glessner, Joseph T / Qu, Jingchun / Liu, Yichuan / Watson, Deborah / Chang, Xiao / Saeidian, Amir Hossein / Qiu, Haijun / Mentch, Frank D / Connolly, John J / Hakonarson, Hakon

Translational research : the journal of laboratory and clinical medicine

2023 Volume 266, Page(s) 49–56

Abstract: Background: Patients with birth defects (BD) exhibit an elevated risk of cancer. We aimed to investigate the potential link between pediatric cancers and BDs, exploring the hypothesis of shared genetic defects contributing to the coexistence of these ... ...

Abstract	Background: Patients with birth defects (BD) exhibit an elevated risk of cancer. We aimed to investigate the potential link between pediatric cancers and BDs, exploring the hypothesis of shared genetic defects contributing to the coexistence of these conditions. Methods: This study included 1454 probands with BDs (704 females and 750 males), including 619 (42.3%) with and 845 (57.7%) without co-occurrence of pediatric onset cancers. Whole genome sequencing (WGS) was done at 30X coverage through the Kids First/Gabriella Miller X01 Program. Results: 8211 CNV loci were called from the 1454 unrelated individuals. 191 CNV loci classified as pathogenic/likely pathogenic (P/LP) were identified in 309 (21.3%) patients, with 124 (40.1%) of these patients having pediatric onset cancers. The most common group of CNVs are pathogenic deletions covering the region ChrX:52,863,011-55,652,521, seen in 162 patients including 17 males. Large recurrent P/LP duplications >5MB were detected in 33 patients. Conclusions: This study revealed that P/LP CNVs were common in a large cohort of BD patients with high rate of pediatric cancers. We present a comprehensive spectrum of P/LP CNVs in patients with BDs and various cancers. Notably, deletions involving E2F target genes and genes implicated in mitotic spindle assembly and G2/M checkpoint were identified, potentially disrupting cell-cycle progression and providing mechanistic insights into the concurrent occurrence of BDs and cancers.
MeSH term(s)	Male ; Child ; Female ; Humans ; DNA Copy Number Variations/genetics ; Whole Genome Sequencing ; Neoplasms/epidemiology ; Neoplasms/genetics ; Comorbidity
Language	English
Publishing date	2023-11-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2246684-8
ISSN	1878-1810 ; 1532-6543 ; 1931-5244
ISSN (online)	1878-1810 ; 1532-6543
ISSN	1931-5244
DOI	10.1016/j.trsl.2023.11.004
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