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Article ; Online: Trombosis venosa cerebral e infección por SARS-CoV-2.

Dahl-Cruz, F / Guevara-Dalrymple, N / López-Hernández, N

2020 Volume 70, Issue 10, Page(s) 391–392

Title translation	Cerebral venous thrombosis and SARS-CoV-2 infection.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Sinus Thrombosis, Intracranial/epidemiology
Keywords	covid19
Language	Spanish
Publishing date	2020-05-11
Publishing country	Spain
Document type	Letter
ZDB-ID	1468278-3
ISSN	1576-6578 ; 0210-0010
ISSN (online)	1576-6578
ISSN	0210-0010
DOI	10.33588/rn.7010.2020204
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Article: [Cerebral venous thrombosis and SARS-CoV-2 infection]

Dahl-Cruz, F. / Guevara-Dalrymple, N. / Lopez-Hernandez, N.

Rev Neurol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #242047
Database	COVID19

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Article ; Online: Encefalitis multifocal como manifestación neurológica de la infección por COVID-19.

Serrano-Serrano, B / López-Hernández, N / Dahl-Cruz, F / Elvira-Soler, E / Díaz-Marín, C

Revista de neurologia

2020 Volume 71, Issue 9, Page(s) 351–352

Title translation	Multifocal encephalitis as a neurological manifestation of COVID-19 infection.
MeSH term(s)	Aged ; Antiviral Agents/therapeutic use ; Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Humans ; Infectious Encephalitis/cerebrospinal fluid ; Infectious Encephalitis/diagnostic imaging ; Infectious Encephalitis/drug therapy ; Infectious Encephalitis/etiology ; Language Disorders/etiology ; Magnetic Resonance Imaging ; Male ; Methylprednisolone/therapeutic use ; Nasopharynx/virology ; Neuroimaging ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/drug therapy ; Psychomotor Agitation/etiology ; SARS-CoV-2 ; Tremor/etiology
Chemical Substances	Antiviral Agents ; Methylprednisolone (X4W7ZR7023)
Keywords	covid19
Language	Spanish
Publishing date	2020-10-01
Publishing country	Spain
Document type	Case Reports ; Letter
ZDB-ID	1468278-3
ISSN	1576-6578 ; 0210-0010
ISSN (online)	1576-6578
ISSN	0210-0010
DOI	10.33588/rn.7109.2020226
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Article: [Multifocal encephalitis as a neurological manifestation of COVID-19 infection]

Serrano-Serrano, B. / López-Hernández, N. / Dahl-Cruz, F. / Elvira-Soler, E. / Díaz-Marín, C.

Rev Neurol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #884198
Database	COVID19

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Article ; Online: Author Correction: The axolotl genome and the evolution of key tissue formation regulators.

Nowoshilow, Sergej / Schloissnig, Siegfried / Fei, Ji-Feng / Dahl, Andreas / Pang, Andy W C / Pippel, Martin / Winkler, Sylke / Hastie, Alex R / Young, George / Roscito, Juliana G / Falcon, Francisco / Knapp, Dunja / Powell, Sean / Cruz, Alfredo / Cao, Han / Habermann, Bianca / Hiller, Michael / Tanaka, Elly M / Myers, Eugene W

Nature

2018 Volume 559, Issue 7712, Page(s) E2

Abstract: In the originally published version of this Article, the sequenced axolotl strain (the homozygous white mutant) was denoted as 'D/D' rather than 'd/d' in Fig. 1a and the accompanying legend, the main text and the Methods section. The original Article has ...

Abstract	In the originally published version of this Article, the sequenced axolotl strain (the homozygous white mutant) was denoted as 'D/D' rather than 'd/d' in Fig. 1a and the accompanying legend, the main text and the Methods section. The original Article has been corrected online.
Language	English
Publishing date	2018-07
Publishing country	England
Document type	Published Erratum
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-018-0141-z
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Article ; Online: The axolotl genome and the evolution of key tissue formation regulators.

Nature

2018 Volume 554, Issue 7690, Page(s) 50–55

Abstract: Salamanders serve as important tetrapod models for developmental, regeneration and evolutionary studies. An extensive molecular toolkit makes the Mexican axolotl (Ambystoma mexicanum) a key representative salamander for molecular investigations. Here we ... ...

Abstract	Salamanders serve as important tetrapod models for developmental, regeneration and evolutionary studies. An extensive molecular toolkit makes the Mexican axolotl (Ambystoma mexicanum) a key representative salamander for molecular investigations. Here we report the sequencing and assembly of the 32-gigabase-pair axolotl genome using an approach that combined long-read sequencing, optical mapping and development of a new genome assembler (MARVEL). We observed a size expansion of introns and intergenic regions, largely attributable to multiplication of long terminal repeat retroelements. We provide evidence that intron size in developmental genes is under constraint and that species-restricted genes may contribute to limb regeneration. The axolotl genome assembly does not contain the essential developmental gene Pax3. However, mutation of the axolotl Pax3 paralogue Pax7 resulted in an axolotl phenotype that was similar to those seen in Pax3
MeSH term(s)	Ambystoma mexicanum/genetics ; Animals ; DNA, Intergenic/genetics ; Evolution, Molecular ; Genes, Essential/genetics ; Genome/genetics ; Genomics ; Homeodomain Proteins/genetics ; Introns/genetics ; Male ; Mice ; PAX3 Transcription Factor/genetics ; PAX7 Transcription Factor/genetics ; Picea/genetics ; Pinus/genetics ; Regeneration/genetics ; Retroelements/genetics ; Terminal Repeat Sequences/genetics
Chemical Substances	DNA, Intergenic ; Homeodomain Proteins ; PAX3 Transcription Factor ; PAX7 Transcription Factor ; Retroelements ; Pax3 protein, mouse (138016-91-8) ; HoxA protein (157907-48-7)
Language	English
Publishing date	2018-01-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/nature25458
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Article ; Online: Pilot study of mobile phone technology in allergic rhinitis in European countries: the MASK-rhinitis study.

Bousquet, J / Caimmi, D P / Bedbrook, A / Bewick, M / Hellings, P W / Devillier, P / Arnavielhe, S / Bachert, C / Bergmann, K C / Canonica, G W / Chavannes, N H / Cruz, A A / Dahl, R / Demoly, P / De Vries, G / Mathieu-Dupas, E / Finkwagner, A / Fonseca, J / Guldemond, N /

Haahtela, T / Hellqvist-Dahl, B / Just, J / Keil, T / Klimek, L / Kowalski, M L / Kuitunen, M / Kuna, P / Kvedariene, V / Laune, D / Pereira, A M / Carreiro-Martins, P / Melén, E / Morais-Almeida, M / Mullol, J / Muraro, A / Murray, R / Nogueira-Silva, L / Papadopoulos, N G / Passalacqua, G / Portejoie, F / Price, D / Ryan, D / Samolinski, B / Sheikh, A / Siroux, V / Spranger, O / Todo Bom, A / Tomazic, P V / Valero, A / Valovirta, E / Valiulis, A / VandenPlas, O / van der Meulen, S / van Eerd, M / Wickman, M / Zuberbier, T

Allergy

2017 Volume 72, Issue 6, Page(s) 857–865

Abstract: Background: The use of Apps running on smartphones and tablets profoundly affects medicine. The MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) App (Allergy Diary) assesses allergic rhinitis symptoms, disease control and impact on ... ...

Abstract	Background: The use of Apps running on smartphones and tablets profoundly affects medicine. The MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) App (Allergy Diary) assesses allergic rhinitis symptoms, disease control and impact on patients' lives. It is freely available in 20 countries (iOS and Android platforms). Aims: To assess in a pilot study whether (i) Allergy Diary users were able to properly provide baseline characteristics (ii) simple phenotypic characteristics based upon data captured by the Allergy Diary could be identified and (iii) information gathered by this study could suggest novel research questions. Methods: The Allergy Diary users were classified into six groups according to the baseline data that they entered into the App: (i) asymptomatic; (ii) nasal symptoms excluding rhinorrhea; (iii) rhinorrhea; (iv) rhinorrhea plus 1-2 nasal/ocular symptoms; (v) rhinorrhea plus ≥3 nasal/ocular symptoms; and (vi) rhinorrhea plus all nasal/ocular symptoms. Results: By 1 June 2016, 3260 users had registered with the Allergy Diary and 2710 had completed the baseline questionnaire. Troublesome symptoms were found mainly in the users with the most symptoms. Around 50% of users with troublesome rhinitis and/or ocular symptoms suffered work impairment. Sleep was impaired by troublesome symptoms and nasal obstruction. Conclusions: This is the first App (iOS and Android) to have tested for allergic rhinitis and conjunctivitis. A simple questionnaire administered by cell phones enables the identification of phenotypic differences between a priori defined rhinitis groups. The results suggest novel concepts and research questions in allergic rhinitis that may not be identified using classical methods.
MeSH term(s)	Cell Phone/trends ; Conjunctivitis/diagnosis ; Europe ; Humans ; Mobile Applications/trends ; Pilot Projects ; Research/trends ; Rhinitis, Allergic/classification ; Rhinitis, Allergic/diagnosis ; Surveys and Questionnaires
Language	English
Publishing date	2017-02-21
Publishing country	Denmark
Document type	Journal Article ; Review
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.13125
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Article ; Online: Assessment of algorithms for mitosis detection in breast cancer histopathology images.

Veta, Mitko / van Diest, Paul J / Willems, Stefan M / Wang, Haibo / Madabhushi, Anant / Cruz-Roa, Angel / Gonzalez, Fabio / Larsen, Anders B L / Vestergaard, Jacob S / Dahl, Anders B / Cireşan, Dan C / Schmidhuber, Jürgen / Giusti, Alessandro / Gambardella, Luca M / Tek, F Boray / Walter, Thomas / Wang, Ching-Wei / Kondo, Satoshi / Matuszewski, Bogdan J /

Precioso, Frederic / Snell, Violet / Kittler, Josef / de Campos, Teofilo E / Khan, Adnan M / Rajpoot, Nasir M / Arkoumani, Evdokia / Lacle, Miangela M / Viergever, Max A / Pluim, Josien P W

Medical image analysis

2015 Volume 20, Issue 1, Page(s) 237–248

Abstract: The proliferative activity of breast tumors, which is routinely estimated by counting of mitotic figures in hematoxylin and eosin stained histology sections, is considered to be one of the most important prognostic markers. However, mitosis counting is ... ...

Abstract	The proliferative activity of breast tumors, which is routinely estimated by counting of mitotic figures in hematoxylin and eosin stained histology sections, is considered to be one of the most important prognostic markers. However, mitosis counting is laborious, subjective and may suffer from low inter-observer agreement. With the wider acceptance of whole slide images in pathology labs, automatic image analysis has been proposed as a potential solution for these issues. In this paper, the results from the Assessment of Mitosis Detection Algorithms 2013 (AMIDA13) challenge are described. The challenge was based on a data set consisting of 12 training and 11 testing subjects, with more than one thousand annotated mitotic figures by multiple observers. Short descriptions and results from the evaluation of eleven methods are presented. The top performing method has an error rate that is comparable to the inter-observer agreement among pathologists.
MeSH term(s)	Algorithms ; Breast Neoplasms/pathology ; Female ; Humans ; Mitosis ; Observer Variation
Language	English
Publishing date	2015-02
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1356436-5
ISSN	1361-8423 ; 1361-8431 ; 1361-8415
ISSN (online)	1361-8423 ; 1361-8431
ISSN	1361-8415
DOI	10.1016/j.media.2014.11.010
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Article ; Online: Work productivity in rhinitis using cell phones: The MASK pilot study.

Bousquet, J / Bewick, M / Arnavielhe, S / Mathieu-Dupas, E / Murray, R / Bedbrook, A / Caimmi, D P / Vandenplas, O / Hellings, P W / Bachert, C / Anto, J M / Bergmann, K C / Bindslev-Jensen, C / Bosnic-Anticevich, S / Bouchard, J / Canonica, G W / Chavannes, N H / Cruz, A A / Dahl, R /

Demoly, P / De Vries, G / Devillier, P / Fink-Wagner, A / Fokkens, W J / Fonseca, J / Guldemond, N A / Haahtela, T / Hellqvist-Dahl, B / Just, J / Keil, T / Klimek, L / Kowalski, M L / Kuna, P / Kvedariene, V / Laune, D / Larenas-Linnemann, D / Mullol, J / Pereira, A M / Carreiro-Martins, P / Melén, E / Morais-Almeida, M / Nogueira-Silva, L / O'Hehir, R E / Papadopoulos, N G / Passalacqua, G / Portejoie, F / Price, D / Ryan, D / Samolinski, B / Sheikh, A / Simons, F E R / Spranger, O / Todo Bom, A / Tomazic, P V / Triggiani, M / Valero, A / Valovirta, E / Valiulis, A / van Eerd, M / Wickman, M / Young, I / Zuberbier, T

Allergy

2017 Volume 72, Issue 10, Page(s) 1475–1484

Abstract: Allergic rhinitis often impairs social life and performance. The aim of this cross-sectional study was to use cell phone data to assess the impact on work productivity of uncontrolled rhinitis assessed by visual analogue scale (VAS). A mobile phone app ( ... ...

Abstract	Allergic rhinitis often impairs social life and performance. The aim of this cross-sectional study was to use cell phone data to assess the impact on work productivity of uncontrolled rhinitis assessed by visual analogue scale (VAS). A mobile phone app (Allergy Diary, Google Play Store and Apple App Store) collects data from daily visual analogue scales (VAS) for overall allergic symptoms (VAS-global measured), nasal (VAS-nasal), ocular (VAS-ocular) and asthma symptoms (VAS-asthma) as well as work (VAS-work). A combined nasal-ocular score is calculated. The Allergy Diary is available in 21 countries. The app includes the Work Productivity and Activity Impairment Allergic Specific Questionnaire (WPAI:AS) in six EU countries. All consecutive users who completed the VAS-work from 1 June to 31 October 2016 were included in the study. A total of 1136 users filled in 5818 days of VAS-work. Symptoms of allergic rhinitis were controlled (VAS-global <20) in approximately 60% of the days. In users with uncontrolled rhinitis, approximately 90% had some work impairment and over 50% had severe work impairment (VAS-work >50). There was a significant correlation between VAS-global calculated and VAS-work (Rho=0.83, P<0.00001, Spearman's rank test). In 144 users, there was a significant correlation between VAS-work and WPAI:AS (Rho=0.53, P<0.0001). This pilot study provides not only proof-of-concept data on the work impairment collected with the app but also data on the app itself, especially the distribution of responses for the VAS. This supports the interpretation that persons with rhinitis report both the presence and the absence of symptoms.
MeSH term(s)	Cell Phone ; Efficiency ; Humans ; Pilot Projects ; Public Health Surveillance ; Rhinitis/diagnosis ; Rhinitis/epidemiology ; Severity of Illness Index ; Surveys and Questionnaires ; Symptom Assessment ; Work Performance
Language	English
Publishing date	2017-06-09
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.13177
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Article: CHRODIS criteria applied to the MASK (MACVIA-ARIA Sentinel NetworK) Good Practice in allergic rhinitis: a SUNFRAIL report.

Bousquet, J / Onorato, G L / Bachert, C / Barbolini, M / Bedbrook, A / Bjermer, L / de Sousa, J Correia / Chavannes, N H / Cruz, A A / De Manuel Keenoy, E / Devillier, P / Fonseca, J / Hun, S / Kostka, T / Hellings, P W / Illario, M / Ivancevich, J C / Larenas-Linnemann, D / Millot-Keurinck, J /

Ryan, D / Samolinski, B / Sheikh, A / Yorgancioglu, A / Agache, I / Arnavielhe, S / Bewick, M / Annesi-Maesano, I / Anto, J M / Bergmann, K C / Bindslev-Jensen, C / Bosnic-Anticevich, S / Bouchard, J / Caimmi, D P / Camargos, P / Canonica, G W / Cardona, V / Carriazo, A M / Cingi, C / Colgan, E / Custovic, A / Dahl, R / Demoly, P / De Vries, G / Fokkens, W J / Fontaine, J F / Gemicioğlu, B / Guldemond, N / Gutter, Z / Haahtela, T / Hellqvist-Dahl, B / Jares, E / Joos, G / Just, J / Khaltaev, N / Keil, T / Klimek, L / Kowalski, M L / Kull, I / Kuna, P / Kvedariene, V / Laune, D / Louis, R / Magnan, A / Malva, J / Mathieu-Dupas, E / Melén, E / Menditto, E / Morais-Almeida, M / Mösges, R / Mullol, J / Murray, R / Neffen, H / O'Hehir, R / Palkonen, S / Papadopoulos, N G / Passalacqua, G / Pépin, J L / Portejoie, F / Price, D / Pugin, B / Raciborski, F / Simons, F E R / Sova, M / Spranger, O / Stellato, C / Todo Bom, A / Tomazic, P V / Triggiani, M / Valero, A / Valovirta, E / VandenPlas, O / Valiulis, A / van Eerd, M / Ventura, M T / Wickman, M / Young, I / Zuberbier, T / Zurkuhlen, A / Senn, A

Clinical and translational allergy

2017 Volume 7, Page(s) 37

Abstract: A Good Practice is a practice that works well, produces good results, and is recommended as a model. MACVIA-ARIA Sentinel Network (MASK), the new Allergic Rhinitis and its Impact on Asthma (ARIA) initiative, is an example of a Good Practice focusing on ... ...

Abstract	A Good Practice is a practice that works well, produces good results, and is recommended as a model. MACVIA-ARIA Sentinel Network (MASK), the new Allergic Rhinitis and its Impact on Asthma (ARIA) initiative, is an example of a Good Practice focusing on the implementation of multi-sectoral care pathways using emerging technologies with real life data in rhinitis and asthma multi-morbidity. The European Union Joint Action on Chronic Diseases and Promoting Healthy Ageing across the Life Cycle (JA-CHRODIS) has developed a checklist of 28 items for the evaluation of Good Practices. SUNFRAIL (Reference Sites Network for Prevention and Care of Frailty and Chronic Conditions in community dwelling persons of EU Countries), a European Union project, assessed whether MASK is in line with the 28 items of JA-CHRODIS. A short summary was proposed for each item and 18 experts, all members of ARIA and SUNFRAIL from 12 countries, assessed the 28 items using a Survey Monkey-based questionnaire. A visual analogue scale (VAS) from 0 (strongly disagree) to 100 (strongly agree) was used. Agreement equal or over 75% was observed for 14 items (50%). MASK is following the JA-CHRODIS recommendations for the evaluation of Good Practices.
Language	English
Publishing date	2017-10-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2630865-4
ISSN	2045-7022
ISSN	2045-7022
DOI	10.1186/s13601-017-0173-8
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