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  1. Article: Translating Chagasic dilating cardiomyopathy to surgical therapies: An under published global challenge.

    Groom, Zoe C / Zochios, Vasileios / Protopapas, Aristotle D

    SAGE open medicine

    2019  Volume 7, Page(s) 2050312119895927

    Abstract: Chagas disease is a neglected parasitic anthropozoonosis of the Americas linked to social deprivation with no hope of eradication in the future. Having been the most common non-ischemic cause of dilating cardiomyopathy in Latin America, it now spreads ... ...

    Abstract Chagas disease is a neglected parasitic anthropozoonosis of the Americas linked to social deprivation with no hope of eradication in the future. Having been the most common non-ischemic cause of dilating cardiomyopathy in Latin America, it now spreads beyond the geographical boundaries of its vector via imported and autochthonous transmission. We review the evidence on surgery in Chagasic heart failure and offer a brief narrative on the main aspects of translational management. There is very limited literature on surgery for Chagasic heart failure, especially assist devices and transplantation. This may be attributed to the often unsurmountable economic burden of this single-system parasymphatholytic heart failure to young sufferers who commonly have very limited access to the aforementioned procedures. Chagasic heart failure offers a so far neglected translational model of parasymphatholytic non-ischemic cardiac failure.
    Language English
    Publishing date 2019-12-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2735399-0
    ISSN 2050-3121
    ISSN 2050-3121
    DOI 10.1177/2050312119895927
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Translating Chagasic dilating cardiomyopathy to surgical therapies

    Zoe C Groom / Vasileios Zochios / Aristotle D Protopapas

    SAGE Open Medicine, Vol

    An under published global challenge

    2019  Volume 7

    Abstract: Chagas disease is a neglected parasitic anthropozoonosis of the Americas linked to social deprivation with no hope of eradication in the future. Having been the most common non-ischemic cause of dilating cardiomyopathy in Latin America, it now spreads ... ...

    Abstract Chagas disease is a neglected parasitic anthropozoonosis of the Americas linked to social deprivation with no hope of eradication in the future. Having been the most common non-ischemic cause of dilating cardiomyopathy in Latin America, it now spreads beyond the geographical boundaries of its vector via imported and autochthonous transmission. We review the evidence on surgery in Chagasic heart failure and offer a brief narrative on the main aspects of translational management. There is very limited literature on surgery for Chagasic heart failure, especially assist devices and transplantation. This may be attributed to the often unsurmountable economic burden of this single-system parasymphatholytic heart failure to young sufferers who commonly have very limited access to the aforementioned procedures. Chagasic heart failure offers a so far neglected translational model of parasymphatholytic non-ischemic cardiac failure.
    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Tropical diseases of the myocardium: a review.

    Groom, Zoe C / Protopapas, Aristotle D / Zochios, Vasileios

    International journal of general medicine

    2017  Volume 10, Page(s) 101–111

    Abstract: Cardiovascular diseases are widely distributed throughout the world. Human parasitic infections are ubiquitous. Tropical parasites are increasingly recognized as causes of cardiovascular diseases. In this review, we address the most frequently reported ... ...

    Abstract Cardiovascular diseases are widely distributed throughout the world. Human parasitic infections are ubiquitous. Tropical parasites are increasingly recognized as causes of cardiovascular diseases. In this review, we address the most frequently reported parasites that directly infect the myocardium, including
    Language English
    Publishing date 2017-04-07
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2452220-X
    ISSN 1178-7074
    ISSN 1178-7074
    DOI 10.2147/IJGM.S130828
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Rapid Identification of Novel Psychoactive and Other Controlled Substances Using Low-Field

    Antonides, Lysbeth H / Brignall, Rachel M / Costello, Andrew / Ellison, Jamie / Firth, Samuel E / Gilbert, Nicolas / Groom, Bethany J / Hudson, Samuel J / Hulme, Matthew C / Marron, Jack / Pullen, Zoe A / Robertson, Thomas B R / Schofield, Christopher J / Williamson, David C / Kemsley, E Kate / Sutcliffe, Oliver B / Mewis, Ryan E

    ACS omega

    2019  Volume 4, Issue 4, Page(s) 7103–7112

    Abstract: An automated approach to the collection ... ...

    Abstract An automated approach to the collection of
    Language English
    Publishing date 2019-04-19
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.9b00302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Rapid Identification of Novel Psychoactive and Other Controlled Substances Using Low-Field 1H NMR Spectroscopy

    Lysbeth H. Antonides / Rachel M. Brignall / Andrew Costello / Jamie Ellison / Samuel E. Firth / Nicolas Gilbert / Bethany J. Groom / Samuel J. Hudson / Matthew C. Hulme / Jack Marron / Zoe A. Pullen / Thomas B. R. Robertson / Christopher J. Schofield / David C. Williamson / E. Kate Kemsley / Oliver B. Sutcliffe / Ryan E. Mewis

    ACS Omega, Vol 4, Iss 4, Pp 7103-

    2019  Volume 7112

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: The incremental validity of a computerised assessment added to clinical rating scales to differentiate adult ADHD from autism spectrum disorder.

    Groom, Madeleine J / Young, Zoe / Hall, Charlotte L / Gillott, Alinda / Hollis, Chris

    Psychiatry research

    2016  Volume 243, Page(s) 168–173

    Abstract: There is a clinical need for objective evidence-based measures that are sensitive and specific to ADHD when compared with other neurodevelopmental disorders. This study evaluated the incremental validity of adding an objective measure of activity and ... ...

    Abstract There is a clinical need for objective evidence-based measures that are sensitive and specific to ADHD when compared with other neurodevelopmental disorders. This study evaluated the incremental validity of adding an objective measure of activity and computerised cognitive assessment to clinical rating scales to differentiate adult ADHD from Autism spectrum disorders (ASD). Adults with ADHD (n=33) or ASD (n=25) performed the QbTest, comprising a Continuous Performance Test with motion-tracker to record physical activity. QbTest parameters measuring inattention, impulsivity and hyperactivity were combined to provide a summary score ('QbTotal'). Binary stepwise logistic regression measured the probability of assignment to the ADHD or ASD group based on scores on the Conners Adult ADHD Rating Scale-subscale E (CAARS-E) and Autism Quotient (AQ10) in the first step and then QbTotal added in the second step. The model fit was significant at step 1 (CAARS-E, AQ10) with good group classification accuracy. These predictors were retained and QbTotal was added, resulting in a significant improvement in model fit and group classification accuracy. All predictors were significant. ROC curves indicated superior specificity of QbTotal. The findings present preliminary evidence that adding QbTest to clinical rating scales may improve the differentiation of ADHD and ASD in adults.
    MeSH term(s) Adolescent ; Adult ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/psychology ; Autism Spectrum Disorder/diagnosis ; Autism Spectrum Disorder/psychology ; Diagnosis, Differential ; Female ; Humans ; Hyperkinesis/diagnosis ; Hyperkinesis/psychology ; Impulsive Behavior/physiology ; Male ; Middle Aged ; Psychometrics ; Sensitivity and Specificity ; Young Adult
    Language English
    Publishing date 2016-06-25
    Publishing country Ireland
    Document type Journal Article ; Validation Studies
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2016.06.042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Tropical diseases of the myocardium

    Groom ZC / Protopapas AD / Zochios V

    International Journal of General Medicine, Vol Volume 10, Pp 101-

    a review

    2017  Volume 111

    Abstract: Zoe C Groom,1 Aristotle D Protopapas,2 Vasileios Zochios3,4 1Costello Medical Consulting Limited ...

    Abstract Zoe C Groom,1 Aristotle D Protopapas,2 Vasileios Zochios3,4 1Costello Medical Consulting Limited, Cambridge, 2Department of Surgery, Division of Surgery and Cancer, Imperial College London, London, 3Department of Intensive Care Medicine, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, 4College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK Abstract: Cardiovascular diseases are widely distributed throughout the world. Human parasitic infections are ubiquitous. Tropical parasites are increasingly recognized as causes of cardiovascular diseases. In this review, we address the most frequently reported parasites that directly infect the myocardium, including Trypanosoma cruzi, the protozoal causative agent of American trypanosomiasis (Chagas disease), and Taenia solium, the cestode causative agent of taeniasis and cysticercosis. We also discuss tropical endomyocardial fibrosis, trichinellosis and schistosomiasis. Health systems, attitudes, the perceptions of both patients and physicians as well as socioeconomic factors should all be explored and recognized as crucial factors for improving the control of cardiovascular diseases in the tropics. Clinicians throughout the world must remain aware of imported parasites as potential causes of cardiac diseases. Keywords: cardiomyopathy, Chagas disease, myocardium, parasitic infection, tropical infections
    Keywords Cardiomyopathy ; Chagas disease ; myocardium ; parasitic infection ; tropical infections ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2017-04-01T00:00:00Z
    Publisher Dove Medical Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Developing mHealth Remote Monitoring Technology for Attention Deficit Hyperactivity Disorder: A Qualitative Study Eliciting User Priorities and Needs.

    Simons, Lucy / Valentine, Althea Z / Falconer, Caroline J / Groom, Madeleine / Daley, David / Craven, Michael P / Young, Zoe / Hall, Charlotte / Hollis, Chris

    JMIR mHealth and uHealth

    2016  Volume 4, Issue 1, Page(s) e31

    Abstract: Background: Guidelines in the United Kingdom recommend that medication titration for attention deficit hyperactivity disorder (ADHD) should be completed within 4-6 weeks and include regular reviews. However, most clinicians think that weekly clinic ... ...

    Abstract Background: Guidelines in the United Kingdom recommend that medication titration for attention deficit hyperactivity disorder (ADHD) should be completed within 4-6 weeks and include regular reviews. However, most clinicians think that weekly clinic contact is infeasible, and audits have shown that this timeline is rarely achieved. Thus, a more effective monitoring and review system is needed; remote monitoring technology (RMT) may be one way to improve current practice. However, little is known about whether patients with ADHD, their families, and clinicians would be interested in using RMT.
    Objective: To explore patients', parents', and health care professionals' views and attitudes toward using digital technology for remote monitoring during titration for ADHD.
    Methods: This was a qualitative study, and data were collected through 11 focus groups with adults and young people with ADHD, parents of children with ADHD, and health care professionals (N=59).
    Results: All participant groups were positive about using RMT in the treatment of ADHD, but they were also aware of barriers to its use, especially around access to technology and integrating RMT into clinical care. They identified that RMT had the most potential for use in the ongoing management and support of ADHD, rather than during the distinct titration period. Participants identified features of RMT that could improve the quality of consultations and support greater self-management.
    Conclusions: RMT has the potential to augment support and care for ADHD, but it needs to go beyond the titration period and offer more to patients and families than monitoring through outcome measures. Developing and evaluating an mHealth app that incorporates the key features identified by end users is required.
    Language English
    Publishing date 2016-03-23
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2719220-9
    ISSN 2291-5222
    ISSN 2291-5222
    DOI 10.2196/mhealth.5009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Developing mHealth Remote Monitoring Technology for Attention Deficit Hyperactivity Disorder

    Simons, Lucy / Valentine, Althea Z / Falconer, Caroline J / Groom, Madeleine / Daley, David / Craven, Michael P / Young, Zoe / Hall, Charlotte / Hollis, Chris

    JMIR mHealth and uHealth, Vol 4, Iss 1, p e

    A Qualitative Study Eliciting User Priorities and Needs

    2016  Volume 31

    Abstract: BackgroundGuidelines in the United Kingdom recommend that medication titration for attention deficit hyperactivity disorder (ADHD) should be completed within 4-6 weeks and include regular reviews. However, most clinicians think that weekly clinic contact ...

    Abstract BackgroundGuidelines in the United Kingdom recommend that medication titration for attention deficit hyperactivity disorder (ADHD) should be completed within 4-6 weeks and include regular reviews. However, most clinicians think that weekly clinic contact is infeasible, and audits have shown that this timeline is rarely achieved. Thus, a more effective monitoring and review system is needed; remote monitoring technology (RMT) may be one way to improve current practice. However, little is known about whether patients with ADHD, their families, and clinicians would be interested in using RMT. ObjectiveTo explore patients’, parents’, and health care professionals’ views and attitudes toward using digital technology for remote monitoring during titration for ADHD. MethodsThis was a qualitative study, and data were collected through 11 focus groups with adults and young people with ADHD, parents of children with ADHD, and health care professionals (N=59). ResultsAll participant groups were positive about using RMT in the treatment of ADHD, but they were also aware of barriers to its use, especially around access to technology and integrating RMT into clinical care. They identified that RMT had the most potential for use in the ongoing management and support of ADHD, rather than during the distinct titration period. Participants identified features of RMT that could improve the quality of consultations and support greater self-management. ConclusionsRMT has the potential to augment support and care for ADHD, but it needs to go beyond the titration period and offer more to patients and families than monitoring through outcome measures. Developing and evaluating an mHealth app that incorporates the key features identified by end users is required.
    Keywords Information technology ; T58.5-58.64 ; Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2016-03-01T00:00:00Z
    Publisher JMIR Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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