LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 302

Search options

  1. Article ; Online: Physician-scientist development: a new category for supporting all stages of the physician-scientist pipeline.

    Collins, Kathleen L

    JCI insight

    2024  Volume 9, Issue 5

    MeSH term(s) Humans ; Physicians ; Education, Medical
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Editorial
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.179940
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Resource and Technical Advance papers: expanding our resources.

    Collins, Kathleen L

    JCI insight

    2021  Volume 6, Issue 11

    MeSH term(s) Databases as Topic ; Editorial Policies ; Humans ; Information Dissemination
    Language English
    Publishing date 2021-06-08
    Publishing country United States
    Document type Editorial
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.151152
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: A year at the helm.

    Collins, Kathleen L

    JCI insight

    2020  Volume 5, Issue 17

    MeSH term(s) Biomedical Research/trends ; COVID-19/prevention & control ; Editorial Policies ; Humans ; Periodicals as Topic/statistics & numerical data ; Periodicals as Topic/trends ; SARS-CoV-2/isolation & purification
    Keywords covid19
    Language English
    Publishing date 2020-09-03
    Publishing country United States
    Document type Editorial
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.142915
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Resource and Technical Advance papers

    Kathleen L. Collins

    JCI Insight, Vol 6, Iss

    expanding our resources

    2021  Volume 11

    Keywords Medicine ; R
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher American Society for Clinical investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: A new editor and a new team for JCI Insight.

    Collins, Kathleen L

    JCI insight

    2019  Volume 4, Issue 17

    Language English
    Publishing date 2019-09-05
    Publishing country United States
    Document type Editorial
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.132119
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: A year at the helm

    Kathleen L. Collins

    JCI Insight, Vol 5, Iss

    2020  Volume 17

    Keywords Medicine ; R
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher American Society for Clinical investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Vpr Is a VIP: HIV Vpr and Infected Macrophages Promote Viral Pathogenesis.

    Lubow, Jay / Collins, Kathleen L

    Viruses

    2020  Volume 12, Issue 8

    Abstract: HIV infects several cell types in the body, including ... ...

    Abstract HIV infects several cell types in the body, including CD4
    MeSH term(s) Animals ; HIV Infections/immunology ; HIV Infections/pathology ; HIV-1/immunology ; HIV-1/pathogenicity ; Host-Pathogen Interactions/immunology ; Humans ; Macrophages/immunology ; Macrophages/virology ; Mice ; Virus Replication ; vpr Gene Products, Human Immunodeficiency Virus/immunology
    Chemical Substances vpr Gene Products, Human Immunodeficiency Virus
    Language English
    Publishing date 2020-07-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v12080809
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: The Impact of Cellular Proliferation on the HIV-1 Reservoir.

    Virgilio, Maria C / Collins, Kathleen L

    Viruses

    2020  Volume 12, Issue 2

    Abstract: Human immunodeficiency virus (HIV) is a chronic infection that destroys the immune system in infected individuals. Although antiretroviral therapy is effective at preventing infection of new cells, it is not curative. The inability to clear infection is ... ...

    Abstract Human immunodeficiency virus (HIV) is a chronic infection that destroys the immune system in infected individuals. Although antiretroviral therapy is effective at preventing infection of new cells, it is not curative. The inability to clear infection is due to the presence of a rare, but long-lasting latent cellular reservoir. These cells harboring silent integrated proviral genomes have the potential to become activated at any moment, making therapy necessary for life. Latently-infected cells can also proliferate and expand the viral reservoir through several methods including homeostatic proliferation and differentiation. The chromosomal location of HIV proviruses within cells influences the survival and proliferative potential of host cells. Proliferating, latently-infected cells can harbor proviruses that are both replication-competent and defective. Replication-competent proviral genomes contribute to viral rebound in an infected individual. The majority of available techniques can only assess the integration site or the proviral genome, but not both, preventing reliable evaluation of HIV reservoirs.
    MeSH term(s) CD4-Positive T-Lymphocytes/virology ; Cell Proliferation ; HIV Infections/virology ; HIV-1/genetics ; HIV-1/physiology ; Hematopoietic Stem Cells/virology ; Host Microbial Interactions ; Humans ; Proviruses/genetics ; Proviruses/physiology ; Viral Load ; Virus Latency ; Virus Replication
    Language English
    Publishing date 2020-01-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v12020127
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: HIV-1 Vpr combats the PU.1-driven antiviral response in primary human macrophages.

    Virgilio, Maria C / Ramnani, Barkha / Chen, Thomas / Disbennett, W Miguel / Lubow, Jay / Welch, Joshua D / Collins, Kathleen L

    bioRxiv : the preprint server for biology

    2024  

    Abstract: HIV-1 Vpr promotes efficient spread of HIV-1 from macrophages to T cells by transcriptionally downmodulating restriction factors that target HIV-1 Envelope protein (Env). Here we find that Vpr induces broad transcriptomic changes by targeting PU.1, a ... ...

    Abstract HIV-1 Vpr promotes efficient spread of HIV-1 from macrophages to T cells by transcriptionally downmodulating restriction factors that target HIV-1 Envelope protein (Env). Here we find that Vpr induces broad transcriptomic changes by targeting PU.1, a transcription factor necessary for expression of host innate immune response genes, including those that target Env. Consistent with this, we find silencing PU.1 in infected macrophages lacking Vpr rescues Env. Vpr downmodulates PU.1 through a proteasomal degradation pathway that depends on physical interactions with PU.1 and DCAF1, a component of the Cul4A E3 ubiquitin ligase. The capacity for Vpr to target PU.1 is highly conserved across primate lentiviruses. In addition to impacting infected cells, we find that Vpr suppresses expression of innate immune response genes in uninfected bystander cells, and that virion-associated Vpr can degrade PU.1. Together, we demonstrate Vpr counteracts PU.1 in macrophages to blunt antiviral immune responses and promote viral spread.
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.21.533528
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci.

    Zhang, Xiaozhu / Van Treeck, Briana / Horton, Connor A / McIntyre, Jeremy J R / Palm, Sarah M / Shumate, Justin L / Collins, Kathleen

    Nature biotechnology

    2024  

    Abstract: Current approaches for inserting autonomous transgenes into the genome, such as CRISPR-Cas9 or virus-based strategies, have limitations including low efficiency and high risk of untargeted genome mutagenesis. Here, we describe precise RNA-mediated ... ...

    Abstract Current approaches for inserting autonomous transgenes into the genome, such as CRISPR-Cas9 or virus-based strategies, have limitations including low efficiency and high risk of untargeted genome mutagenesis. Here, we describe precise RNA-mediated insertion of transgenes (PRINT), an approach for site-specifically primed reverse transcription that directs transgene synthesis directly into the genome at a multicopy safe-harbor locus. PRINT uses delivery of two in vitro transcribed RNAs: messenger RNA encoding avian R2 retroelement-protein and template RNA encoding a transgene of length validated up to 4 kb. The R2 protein coordinately recognizes the target site, nicks one strand at a precise location and primes complementary DNA synthesis for stable transgene insertion. With a cultured human primary cell line, over 50% of cells can gain several 2 kb transgenes, of which more than 50% are full-length. PRINT advantages include no extragenomic DNA, limiting risk of deleterious mutagenesis and innate immune responses, and the relatively low cost, rapid production and scalability of RNA-only delivery.
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1311932-1
    ISSN 1546-1696 ; 1087-0156
    ISSN (online) 1546-1696
    ISSN 1087-0156
    DOI 10.1038/s41587-024-02137-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2167: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 137: Show issues
    Zs.MG 43: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top