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  1. Article ; Online: Microbial stars: shedding light on gut microbes' role in insulin resistance and innovative diabetes therapies.

    Zhang, Jinwei

    Gut microbes

    2024  Volume 16, Issue 1, Page(s) 2307581

    Abstract: The role of gut microbiota in insulin resistance (IR), Metabolic Syndrome (MetS), and Type 2 Diabetes Mellitus (T2DM) is rapidly gaining recognition. However, the mechanisms and implications of gut bacteria in these conditions remain enigmatic. This ... ...

    Abstract The role of gut microbiota in insulin resistance (IR), Metabolic Syndrome (MetS), and Type 2 Diabetes Mellitus (T2DM) is rapidly gaining recognition. However, the mechanisms and implications of gut bacteria in these conditions remain enigmatic. This commentary not only highlights the findings of a recent multi-omics study by Takeuchi et al. but also offers a unique perspective by integrating personal opinions and insights. The discussion revolves around the intricate connection between gut microbes and IR, suggesting novel therapeutic potential in targeting gut microbial carbohydrate metabolism for improved IR management and metabolic health.
    MeSH term(s) Humans ; Insulin Resistance ; Diabetes Mellitus, Type 2/microbiology ; Gastrointestinal Microbiome ; Insulin ; Metabolic Syndrome
    Chemical Substances Insulin
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2575755-6
    ISSN 1949-0984 ; 1949-0984
    ISSN (online) 1949-0984
    ISSN 1949-0984
    DOI 10.1080/19490976.2024.2307581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Commentaries: Lecanemab: pioneering the way as the first approved drug for Alzheimer's disease treatment.

    Zhang, Jinwei

    Inflammation research : official journal of the European Histamine Research Society ... [et al.

    2023  Volume 72, Issue 9, Page(s) 1873–1876

    Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by cognitive decline and neuronal abnormalities. Current therapies address symptoms without altering disease progression. Lecanemab, an anti-amyloid antibody, binds to amyloid- ... ...

    Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by cognitive decline and neuronal abnormalities. Current therapies address symptoms without altering disease progression. Lecanemab, an anti-amyloid antibody, binds to amyloid-beta (Aβ) protofibrils. Phase II trials revealed dose-dependent amyloid clearance and reduced clinical decline. Phase III trials demonstrated cognitive benefits with potential adverse events. Full FDA approval was granted for lecanemab due to its ability to eliminate toxic brain amyloids. However, longer trials are needed to assess its efficacy and safety. While lecanemab marks a significant advancement, further breakthroughs are essential for effective AD treatment.
    MeSH term(s) Humans ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Alzheimer Disease/psychology ; Amyloid beta-Peptides ; Brain/metabolism ; Cognitive Dysfunction
    Chemical Substances lecanemab (12PYH0FTU9) ; Amyloid beta-Peptides
    Language English
    Publishing date 2023-09-08
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 1221794-3
    ISSN 1420-908X ; 1023-3830
    ISSN (online) 1420-908X
    ISSN 1023-3830
    DOI 10.1007/s00011-023-01788-y
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 675: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Recognition of the tRNA structure: Everything everywhere but not all at once.

    Zhang, Jinwei

    Cell chemical biology

    2023  Volume 31, Issue 1, Page(s) 36–52

    Abstract: tRNAs are among the most abundant and essential biomolecules in cells. These spontaneously folding, extensively structured yet conformationally flexible anionic polymers literally bridge the worlds of RNAs and proteins, and serve as Rosetta stones that ... ...

    Abstract tRNAs are among the most abundant and essential biomolecules in cells. These spontaneously folding, extensively structured yet conformationally flexible anionic polymers literally bridge the worlds of RNAs and proteins, and serve as Rosetta stones that decipher and interpret the genetic code. Their ubiquitous presence, functional irreplaceability, and privileged access to cellular compartments and ribosomes render them prime targets for both endogenous regulation and exogenous manipulation. There is essentially no part of the tRNA that is not touched by another interaction partner, either as programmed or imposed by an external adversary. Recent progresses in genetic, biochemical, and structural analyses of the tRNA interactome produced a wealth of new knowledge into their interaction networks, regulatory functions, and molecular interfaces. In this review, I describe and illustrate the general principles of tRNA recognition by proteins and other RNAs, and discuss the underlying molecular mechanisms that deliver affinity, specificity, and functional competency.
    MeSH term(s) Nucleic Acid Conformation ; RNA, Transfer/metabolism ; RNA ; Genetic Code ; Ribosomes/metabolism
    Chemical Substances RNA, Transfer (9014-25-9) ; RNA (63231-63-0)
    Language English
    Publishing date 2023-12-29
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Intramural
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2023.12.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Hereditary causes of hypertension due to increased sodium transport.

    Zhang, Jinwei

    Current opinion in pediatrics

    2023  Volume 36, Issue 2, Page(s) 211–218

    Abstract: Purpose of review: Hypertension, commonly known as high blood pressure, is a widespread health condition affecting a large number of individuals across the globe. Although lifestyle choices and environmental factors are known to have a significant ... ...

    Abstract Purpose of review: Hypertension, commonly known as high blood pressure, is a widespread health condition affecting a large number of individuals across the globe. Although lifestyle choices and environmental factors are known to have a significant impact on its development, there is growing recognition of the influence of genetic factors in the pathogenesis of hypertension. This review specifically focuses on the hereditary causes of hypertension that are associated with increased sodium transport through the thiazide-sensitive NaCl cotransporter (NCC) or amiloride-sensitive epithelial sodium channel (ENaC), crucial mechanisms involved in regulating blood pressure in the kidneys. By examining genetic mutations and signaling molecules linked to the dysregulation of sodium transport, this review aims to deepen our understanding of the hereditary causes of hypertension and shed light on potential therapeutic targets.
    Recent findings: Liddle syndrome (LS) is a genetic disorder that typically manifests early in life and is characterized by hypertension, hypokalemic metabolic alkalosis, hyporeninemia, and suppressed aldosterone secretion. This condition is primarily caused by gain-of-function mutations in ENaC. In contrast, Pseudohypoaldosteronism type II (PHAII) is marked by hyperkalemia and hypertension, alongside other clinical features such as hyperchloremia, metabolic acidosis, and suppressed plasma renin levels. PHAII results from overactivations of NCC, brought about by gain-of-function mutations in its upstream signaling molecules, including WNK1 (with no lysine (K) 1), WNK4, Kelch-like 3 (KLHL3), and cullin3 (CUL3).
    Summary: NCC and ENaC are integral components, and their malfunctions lead to disorders like LS and PHAII, hereditary causes of hypertension. Current treatments for LS involve ENaC blockers (e.g., triamterene and amiloride) in conjunction with low-sodium diets, effectively normalizing blood pressure and potassium levels. In PHAII, thiazide diuretics, which inhibit NCC, are the mainstay treatment, albeit with some limitations and potential side effects. Ongoing research in developing alternative treatments, including small molecules targeting key regulators, holds promise for more effective and tailored hypertension solutions.
    MeSH term(s) Humans ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Amiloride/metabolism ; Hypertension/genetics ; Hypertension/complications ; Kidney/metabolism ; Pseudohypoaldosteronism/diagnosis ; Pseudohypoaldosteronism/genetics ; Pseudohypoaldosteronism/metabolism ; Sodium/metabolism
    Chemical Substances Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Amiloride (7DZO8EB0Z3) ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1049374-8
    ISSN 1531-698X ; 1040-8703
    ISSN (online) 1531-698X
    ISSN 1040-8703
    DOI 10.1097/MOP.0000000000001304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3049: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Probing RNA Structures and Interactions Using Fluorescence Lifetime Analyses.

    Zhang, Jinwei

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2568, Page(s) 13–23

    Abstract: Structural analyses of large, complex noncoding RNAs continue to lag behind their rapid discovery and functional descriptions. Site-specifically incorporated, minimally invasive fluorescent probes such as 2-aminopurine (2AP) and pyrrolo-cytosine (PyC) ... ...

    Abstract Structural analyses of large, complex noncoding RNAs continue to lag behind their rapid discovery and functional descriptions. Site-specifically incorporated, minimally invasive fluorescent probes such as 2-aminopurine (2AP) and pyrrolo-cytosine (PyC) have provided essential complementary information about local RNA structure, conformational dynamics, and interactions. Here I describe a protocol that benchmarks and correlates local RNA conformations with their respective fluorescence lifetimes, as a general technique that confers key advantages over fluorescence intensity-based methods. The observation that fluorescence lifetimes are more sensitive to local structures than sequence contexts suggests broad utility across diverse RNA and ribonucleoprotein systems.
    MeSH term(s) 2-Aminopurine/chemistry ; Fluorescence ; Fluorescent Dyes/chemistry ; Nucleic Acid Conformation ; RNA/chemistry ; Ribonucleoproteins ; Spectrometry, Fluorescence/methods
    Chemical Substances Fluorescent Dyes ; Ribonucleoproteins ; 2-Aminopurine (452-06-2) ; RNA (63231-63-0)
    Language English
    Publishing date 2022-09-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2687-0_2
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  6. Article ; Online: The long and short of it: long noncoding RNAs in neural development and diseases.

    Zhang, Jinwei

    Frontiers in bioscience (Landmark edition)

    2021  Volume 26, Issue 8, Page(s) 258–261

    Abstract: No abstract present. ...

    Abstract No abstract present.
    MeSH term(s) RNA, Long Noncoding/genetics
    Chemical Substances RNA, Long Noncoding
    Language English
    Publishing date 2021-08-27
    Publishing country Singapore
    Document type Editorial ; Research Support, N.I.H., Intramural
    ZDB-ID 2704569-9
    ISSN 2768-6698 ; 2768-6698
    ISSN (online) 2768-6698
    ISSN 2768-6698
    DOI 10.52586/4941
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  7. Article ; Online: The long and short of it

    Jinwei Zhang

    Frontiers in Bioscience-Landmark, Vol 26, Iss 8, Pp 258-

    long noncoding RNAs in neural development and diseases

    2021  Volume 261

    Abstract: No abstract present. ...

    Abstract No abstract present.
    Keywords Biochemistry ; QD415-436 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher IMR Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Editorial: New insights in the microbe-vector interaction.

    Qi, Yong / Zhang, Jinwei / André, Marcos Rogério / Qin, Tian

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1364989

    Language English
    Publishing date 2024-01-16
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1364989
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  9. Article ; Online: Interplay between Host tRNAs and HIV-1: A Structural Perspective.

    Zhang, Jinwei

    Viruses

    2021  Volume 13, Issue 9

    Abstract: The cellular metabolism of host tRNAs and life cycle of HIV-1 cross paths at several key virus-host interfaces. Emerging data suggest a multi-faceted interplay between host tRNAs and HIV-1 that plays essential roles, both structural and regulatory, in ... ...

    Abstract The cellular metabolism of host tRNAs and life cycle of HIV-1 cross paths at several key virus-host interfaces. Emerging data suggest a multi-faceted interplay between host tRNAs and HIV-1 that plays essential roles, both structural and regulatory, in viral genome replication, genome packaging, and virion biogenesis. HIV-1 not only hijacks host tRNAs and transforms them into obligatory reverse transcription primers but further commandeers tRNAs to regulate the localization of its major structural protein, Gag, via a specific interface. This review highlights recent advances in understanding tRNA-HIV-1 interactions, primarily from a structural perspective, which start to elucidate their underlying molecular mechanisms, intrinsic specificities, and biological significances. Such understanding may provide new avenues toward developing HIV/AIDS treatments and therapeutics including small molecules and RNA biologics that target these host-virus interfaces.
    MeSH term(s) HIV Seropositivity ; HIV-1/chemistry ; HIV-1/genetics ; HIV-1/metabolism ; Host Microbial Interactions ; Humans ; RNA, Transfer/chemistry ; RNA, Transfer/genetics ; RNA, Transfer/metabolism ; RNA, Viral/metabolism ; Virus Assembly/physiology ; Virus Replication ; gag Gene Products, Human Immunodeficiency Virus/metabolism
    Chemical Substances RNA, Viral ; gag Gene Products, Human Immunodeficiency Virus ; RNA, Transfer (9014-25-9)
    Language English
    Publishing date 2021-09-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13091819
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  10. Article: Editorial: Chloride homeostasis in animal cell physiology.

    Zhang, Jinwei / Hartmann, Anna-Maria / Guo, Jiangtao

    Frontiers in physiology

    2023  Volume 14, Page(s) 1227565

    Language English
    Publishing date 2023-06-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1227565
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