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  1. Article ; Online: Immunometabolism as predictor of frailty.

    Gostner, Johanna M / Laffon, Blanca / Felder, Thomas K

    Aging

    2021  Volume 13, Issue 23, Page(s) 24917–24918

    MeSH term(s) Aged ; Aging/immunology ; Aging/metabolism ; Frailty/etiology ; Frailty/immunology ; Humans ; Immune System/metabolism ; Immune System/physiology ; Immunosenescence ; Tryptophan/metabolism
    Chemical Substances Tryptophan (8DUH1N11BX)
    Language English
    Publishing date 2021-11-30
    Publishing country United States
    Document type Editorial
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.203737
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  2. Article: Metabolic Stress and Immunity: Nutrient-Sensing Kinases and Tryptophan Metabolism.

    Gostner, Johanna M / Fuchs, Dietmar / Kurz, Katharina

    Advances in experimental medicine and biology

    2021  Volume 1275, Page(s) 395–405

    Abstract: The tryptophan catabolizing enzyme indoleamine 2,3-dioxygenase (IDO-1) has gained major attention due the immunoregulatory nature of this pathway. Both depletion of tryptophan concentrations as well as the accumulation of downstream metabolites are ... ...

    Abstract The tryptophan catabolizing enzyme indoleamine 2,3-dioxygenase (IDO-1) has gained major attention due the immunoregulatory nature of this pathway. Both depletion of tryptophan concentrations as well as the accumulation of downstream metabolites are relevant for the mediation of the manifold consequences of increased tryptophan metabolism. Increased tryptophan catabolism is indicative for several chronic inflammatory disorders such as infections, autoimmune diseases or cancer. Low tryptophan availability is likely to be involved in the manifestation of a variety of comorbidities such as anemia, cachexia, depression and neurocognitive disturbances.Several nutrient sensing kinases are implicated in the downstream effects of dysregulated tryptophan metabolism. These include mechanisms that were conserved during evolution but have gained special features in multicellular eukaryotes, such as pathways regulated by eukaryotic translation initiation factor 2 (eIF-2)-alpha kinase (GCN2, also named general control nonderepressible 2 kinase), 5'-adenosine monophosphate (AMP)-activated protein kinase (AMPK) and target of rapamycin (TOR).The interplay between IDO-1 and above-mentioned pathway seems to be highly context dependent. A better understanding of the crosstalk is necessary to support the search for druggable targets for the treatment of inflammatory and autoimmune disorders.
    MeSH term(s) Indoleamine-Pyrrole 2,3,-Dioxygenase/genetics ; Kynurenine ; Nutrients ; Protein-Serine-Threonine Kinases ; Stress, Physiological ; Tryptophan
    Chemical Substances Indoleamine-Pyrrole 2,3,-Dioxygenase ; Kynurenine (343-65-7) ; Tryptophan (8DUH1N11BX) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2021-02-04
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-49844-3_16
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  3. Article ; Online: Cardioprotective effect of polyamine spermidine.

    Gostner, Johanna M / Fuchs, Dietmar

    The American journal of clinical nutrition

    2018  Volume 109, Issue 1, Page(s) 218

    MeSH term(s) Kinetics ; Polyamines ; Prospective Studies ; Spermidine
    Chemical Substances Polyamines ; Spermidine (U87FK77H25)
    Language English
    Publishing date 2018-12-04
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 280048-2
    ISSN 1938-3207 ; 0002-9165
    ISSN (online) 1938-3207
    ISSN 0002-9165
    DOI 10.1093/ajcn/nqy221
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  4. Article ; Online: Oxidative Stress Reaction to Hypobaric-Hyperoxic Civilian Flight Conditions.

    Netzer, Nikolaus C / Jaekel, Heidelinde / Popp, Roland / Gostner, Johanna M / Decker, Michael / Eisendle, Frederik / Turner, Rachel / Netzer, Petra / Patzelt, Carsten / Steurer, Christian / Cavalli, Marco / Forstner, Florian / Pramsohler, Stephan

    Biomolecules

    2024  Volume 14, Issue 4

    Abstract: ... conditions equivalent to higher than 3048 m altitude, and has made it mandatory for conditions equivalent ... to more than 3657 m altitude.: Aim: We hypothesized that hypobaric-hyperoxic civilian commercial and ... private flight conditions with supplemental oxygen in a flight simulation in a hypobaric chamber at 2500 m ...

    Abstract Background: In military flight operations, during flights, fighter pilots constantly work under hyperoxic breathing conditions with supplemental oxygen in varying hypobaric environments. These conditions are suspected to cause oxidative stress to neuronal organ tissues. For civilian flight operations, the Federal Aviation Administration (FAA) also recommends supplemental oxygen for flying under hypobaric conditions equivalent to higher than 3048 m altitude, and has made it mandatory for conditions equivalent to more than 3657 m altitude.
    Aim: We hypothesized that hypobaric-hyperoxic civilian commercial and private flight conditions with supplemental oxygen in a flight simulation in a hypobaric chamber at 2500 m and 4500 m equivalent altitude would cause significant oxidative stress in healthy individuals.
    Methods: Twelve healthy, COVID-19-vaccinated (third portion of vaccination 15 months before study onset) subjects (six male, six female, mean age 35.7 years) from a larger cohort were selected to perform a 3 h flight simulation in a hypobaric chamber with increasing supplemental oxygen levels (35%, 50%, 60%, and 100% fraction of inspired oxygen, FiO
    Results: Eleven subjects finished the study without adverse events. Whereas the partial pressure of oxygen (PO
    Conclusion: Supplemental oxygen of 60% FiO
    MeSH term(s) Humans ; Male ; Oxidative Stress ; Female ; Adult ; Altitude ; Oxygen/metabolism ; COVID-19 ; Hyperoxia/blood ; Aircraft ; Hyperbaric Oxygenation
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2024-04-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14040481
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  5. Article ; Online: Biomarkers for the role of macrophages in the development and progression of atherosclerosis.

    Gostner, Johanna M / Fuchs, Dietmar

    Atherosclerosis

    2016  Volume 255, Page(s) 117–118

    MeSH term(s) Atherosclerosis ; Biomarkers ; Humans ; Macrophages ; Neopterin
    Chemical Substances Biomarkers ; Neopterin (670-65-5)
    Language English
    Publishing date 2016
    Publishing country Ireland
    Document type Editorial ; Comment
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2016.10.046
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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Comprehensive mapping of the AOP-Wiki database: identifying biological and disease gaps.

    Jaylet, Thomas / Coustillet, Thibaut / Smith, Nicola M / Viviani, Barbara / Lindeman, Birgitte / Vergauwen, Lucia / Myhre, Oddvar / Yarar, Nurettin / Gostner, Johanna M / Monfort-Lanzas, Pablo / Jornod, Florence / Holbech, Henrik / Coumoul, Xavier / Sarigiannis, Dimosthenis A / Antczak, Philipp / Bal-Price, Anna / Fritsche, Ellen / Kuchovska, Eliska / Stratidakis, Antonios K /
    Barouki, Robert / Kim, Min Ji / Taboureau, Olivier / Wojewodzic, Marcin W / Knapen, Dries / Audouze, Karine

    Frontiers in toxicology

    2024  Volume 6, Page(s) 1285768

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-03-08
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-3080
    ISSN (online) 2673-3080
    DOI 10.3389/ftox.2024.1285768
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  7. Article ; Online: Physical activity to counteract the impact of alcohol intake on overall mortality risks.

    Gostner, Johanna M / Fuchs, Dietmar / Strasser, Barbara

    British journal of sports medicine

    2017  Volume 51, Issue 8, Page(s) 692

    MeSH term(s) Alcohol Drinking ; Exercise ; Risk ; Risk Factors
    Language English
    Publishing date 2017-02-21
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 600592-5
    ISSN 1473-0480 ; 0306-3674
    ISSN (online) 1473-0480
    ISSN 0306-3674
    DOI 10.1136/bjsports-2016-097241
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    Zs.B 1893: Show issues Location:
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  8. Article: A Chlorophyll-Derived Phylloxanthobilin Is a Potent Antioxidant That Modulates Immunometabolism in Human PBMC.

    Karg, Cornelia A / Parráková, Lucia / Fuchs, Dietmar / Schennach, Harald / Kräutler, Bernhard / Moser, Simone / Gostner, Johanna M

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 10

    Abstract: Phyllobilins are natural products derived from the degradation of chlorophyll, which proceeds via a common and strictly controlled pathway in higher plants. The resulting tetrapyrrolic catabolites-the phyllobilins-are ubiquitous in nature; despite their ... ...

    Abstract Phyllobilins are natural products derived from the degradation of chlorophyll, which proceeds via a common and strictly controlled pathway in higher plants. The resulting tetrapyrrolic catabolites-the phyllobilins-are ubiquitous in nature; despite their high abundance, there is still a lack of knowledge about their physiological properties. Phyllobilins are part of human nutrition and were shown to be potent antioxidants accounting with interesting physiological properties. Three different naturally occurring types of phyllobilins-a phylloleucobilin, a dioxobilin-type phylloleucobilin and a phylloxanthobilin (PxB)-were compared regarding potential antioxidative properties in a cell-free and in a cell-based antioxidant activity test system, demonstrating the strongest effect for the PxB. Moreover, the PxB was investigated for its capacity to interfere with immunoregulatory metabolic pathways of tryptophan breakdown in human blood peripheral mononuclear cells. A dose-dependent inhibition of tryptophan catabolism to kynurenine was observed, suggesting a suppressive effect on pathways of cellular immune activation. Although the exact mechanisms of immunomodulatory effects are yet unknown, these prominent bioactivities point towards health-relevant effects, which warrant further mechanistic investigations and the assessment of the in vivo extrapolatability of results. Thus, phyllobilins are a still surprisingly unexplored family of natural products that merit further investigation.
    Language English
    Publishing date 2022-10-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11102056
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  9. Article: Persistent Symptoms and IFN-γ-Mediated Pathways after COVID-19.

    Piater, Talia / Gietl, Mario / Hofer, Stefanie / Gostner, Johanna M / Sahanic, Sabina / Tancevski, Ivan / Sonnweber, Thomas / Pizzini, Alex / Egger, Alexander / Schennach, Harald / Loeffler-Ragg, Judith / Weiss, Guenter / Kurz, Katharina

    Journal of personalized medicine

    2023  Volume 13, Issue 7

    Abstract: After COVID-19, patients have reported various complaints such as fatigue, neurological symptoms, and insomnia. Immune-mediated changes in amino acid metabolism might contribute to the development of these symptoms. Patients who had had acute, PCR- ... ...

    Abstract After COVID-19, patients have reported various complaints such as fatigue, neurological symptoms, and insomnia. Immune-mediated changes in amino acid metabolism might contribute to the development of these symptoms. Patients who had had acute, PCR-confirmed COVID-19 infection about 60 days earlier were recruited within the scope of the prospective CovILD study. We determined the inflammatory parameters and alterations in tryptophan and phenylalanine metabolism in 142 patients cross-sectionally. Symptom persistence (pain, gastrointestinal symptoms, anosmia, sleep disturbance, and neurological symptoms) and patients' physical levels of functioning were recorded. Symptoms improved in many patients after acute COVID-19 (
    Language English
    Publishing date 2023-06-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13071055
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  10. Article ; Online: Correction to: Knock-on effect of periodontitis to the pathogenesis of Alzheimer's disease?

    Leblhuber, Friedrich / Huemer, Julia / Steiner, Kostja / Gostner, Johanna M / Fuchs, Dietmar

    Wiener klinische Wochenschrift

    2020  Volume 132, Issue 17-18, Page(s) 549–550

    Abstract: The original version of this article unfortunately contained a mistake. There was an error in Fig. 2. The original article has been corrected. We apologize for the mistake.The correct Fig. 2 is given …. ...

    Abstract The original version of this article unfortunately contained a mistake. There was an error in Fig. 2. The original article has been corrected. We apologize for the mistake.The correct Fig. 2 is given ….
    Language English
    Publishing date 2020-04-06
    Publishing country Austria
    Document type Published Erratum
    ZDB-ID 200462-8
    ISSN 1613-7671 ; 0043-5325 ; 0300-5178
    ISSN (online) 1613-7671
    ISSN 0043-5325 ; 0300-5178
    DOI 10.1007/s00508-020-01647-4
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