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Article ; Online: Derivation of Transcriptomics-Based Points of Departure for 20 Per- or Polyfluoroalkyl Substances Using a Larval Fathead Minnow (Pimephales promelas) Reduced Transcriptome Assay.

Villeneuve, Daniel L / Bush, Kendra / Hazemi, Monique / Hoang, John X / Le, Michelle / Blackwell, Brett R / Stacy, Emma / Flynn, Kevin M

Environmental toxicology and chemistry

2024

Abstract: Traditional toxicity testing has been unable to keep pace with the introduction of new chemicals into commerce. Consequently, there are limited or no toxicity data for many chemicals to which fish and wildlife may be exposed. Per- and polyfluoroalkyl ... ...

Abstract	Traditional toxicity testing has been unable to keep pace with the introduction of new chemicals into commerce. Consequently, there are limited or no toxicity data for many chemicals to which fish and wildlife may be exposed. Per- and polyfluoroalkyl substances (PFAS) are emblematic of this issue in that ecological hazards of most PFAS remain uncharacterized. The present study employed a high-throughput assay to identify the concentration at which 20 PFAS, with diverse properties, elicited a concerted gene expression response (termed a transcriptomics-based point of departure [tPOD]) in larval fathead minnows (Pimephales promelas; 5-6 days postfertilization) exposed for 24 h. Based on a reduced transcriptome approach that measured whole-body expression of 1832 genes, the median tPOD for the 20 PFAS tested was 10 µM. Longer-chain carboxylic acids (12-13 C-F); an eight-C-F dialcohol, N-alkyl sulfonamide; and telomer sulfonic acid were among the most potent PFAS, eliciting gene expression responses at concentrations <1 µM. With a few exceptions, larval fathead minnow tPODs were concordant with those based on whole-transcriptome response in human cell lines. However, larval fathead minnow tPODs were often greater than those for Daphnia magna exposed to the same PFAS. The tPODs overlapped concentrations at which other sublethal effects have been reported in fish (available for 10 PFAS). Nonetheless, fathead minnow tPODs were orders of magnitude higher than aqueous PFAS concentrations detected in tributaries of the North American Great Lakes, suggesting a substantial margin of safety. Overall, results broadly support the use of a fathead minnow larval transcriptomics assay to derive screening-level potency estimates for use in ecological risk-based prioritization. Environ Toxicol Chem 2024;00:1-16. © 2024 SETAC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	46234-2
ISSN	1552-8618 ; 0730-7268
ISSN (online)	1552-8618
ISSN	0730-7268
DOI	10.1002/etc.5825
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Article ; Online: Transcriptomics-Based Points of Departure for Daphnia magna Exposed to 18 Per- and Polyfluoroalkyl Substances.

Villeneuve, Daniel L / Blackwell, Brett R / Bush, Kendra / Harrill, Joshua / Harris, Felix / Hazemi, Monique / Le, Michelle / Stacy, Emma / Flynn, Kevin M

Environmental toxicology and chemistry

2024

Abstract: Per- and polyfluoroalkyl substances (PFAS) represent a large group of contaminants of concern based on their widespread use, environmental persistence, and potential toxicity. Many traditional models for estimating toxicity, bioaccumulation, and other ... ...

Abstract	Per- and polyfluoroalkyl substances (PFAS) represent a large group of contaminants of concern based on their widespread use, environmental persistence, and potential toxicity. Many traditional models for estimating toxicity, bioaccumulation, and other toxicological properties are not well suited for PFAS. Consequently, there is a need to generate hazard information for PFAS in an efficient and cost-effective manner. In the present study, Daphnia magna were exposed to multiple concentrations of 22 different PFAS for 24 h in a 96-well plate format. Following exposure, whole-body RNA was extracted and extracts, each representing five exposed individuals, were subjected to RNA sequencing. Following analytical measurements to verify PFAS exposure concentrations and quality control on processed cDNA libraries for sequencing, concentration-response modeling was applied to the data sets for 18 of the tested compounds, and the concentration at which a concerted molecular response occurred (transcriptomic point of departure; tPOD) was calculated. The tPODs, based on measured concentrations of PFAS, generally ranged from 0.03 to 0.58 µM (9.9-350 µg/L; interquartile range). In most cases, these concentrations were two orders of magnitude lower than similarly calculated tPODs for human cell lines exposed to PFAS. They were also lower than apical effect concentrations reported for seven PFAS for which some crustacean or invertebrate toxicity data were available, although there were a few exceptions. Despite being lower than most other available hazard benchmarks, D. magna tPODs were, on average, four orders of magnitude greater than the maximum aqueous concentrations of PFAS measured in Great Lakes tributaries. Overall, this high-throughput transcriptomics assay with D. magna holds promise as a component of a tiered hazard evaluation strategy employing new approach methodologies. Environ Toxicol Chem 2024;00:1-16. © 2024 SETAC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	46234-2
ISSN	1552-8618 ; 0730-7268
ISSN (online)	1552-8618
ISSN	0730-7268
DOI	10.1002/etc.5838
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Article ; Online: Co-use of Methamphetamine Is Associated With Lower Rates of Linkage to Outpatient Treatment for Hospitalized Patients Who Initiate Buprenorphine.

Tsui, Judith I / Stephens, Daniel / Collins, Brett / Denisiuk, Eric / Hallgren, Kevin A / Blalock, Kendra L / Klein, Jared W / Jack, Helen E / Merrill, Joseph O

Journal of addiction medicine

2023 Volume 17, Issue 4, Page(s) 491–492

MeSH term(s)	Humans ; Buprenorphine/therapeutic use ; Methamphetamine/adverse effects ; Outpatients ; Opiate Substitution Treatment ; Central Nervous System Stimulants/adverse effects ; Opioid-Related Disorders/drug therapy
Chemical Substances	Buprenorphine (40D3SCR4GZ) ; Methamphetamine (44RAL3456C) ; Central Nervous System Stimulants
Language	English
Publishing date	2023-01-17
Publishing country	Netherlands
Document type	Letter
ISSN	1935-3227
ISSN (online)	1935-3227
DOI	10.1097/ADM.0000000000001129
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Article ; Online: Peer providers and linkage with buprenorphine care after hospitalization: A retrospective cohort study.

Jack, Helen E / Denisiuk, Eric D / Collins, Brett A / Stephens, Dan / Blalock, Kendra L / Klein, Jared W / Bhatraju, Elenore P / Merrill, Joseph O / Hallgren, Kevin A / Tsui, Judith I

Substance abuse

2022 Volume 43, Issue 1, Page(s) 1308–1316

Abstract: ... ...

Abstract	Background
MeSH term(s)	Adult ; Buprenorphine/therapeutic use ; Hospitalization ; Humans ; Opiate Substitution Treatment ; Opioid-Related Disorders/drug therapy ; Retrospective Studies
Chemical Substances	Buprenorphine (40D3SCR4GZ)
Language	English
Publishing date	2022-07-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1458030-5
ISSN	1547-0164 ; 0889-7077
ISSN (online)	1547-0164
ISSN	0889-7077
DOI	10.1080/08897077.2022.2095078
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Article ; Online: Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization.

Chen, Jiajia / Laverty, Daniel J / Talele, Surabhi / Bale, Ashwin / Carlson, Brett L / Porath, Kendra A / Bakken, Katrina K / Burgenske, Danielle M / Decker, Paul A / Vaubel, Rachael A / Eckel-Passow, Jeanette E / Bhargava, Rohit / Lou, Zhenkun / Hamerlik, Petra / Harley, Brendan / Elmquist, William F / Nagel, Zachary D / Gupta, Shiv K / Sarkaria, Jann N

Science translational medicine

2024 Volume 16, Issue 734, Page(s) eadj5962

Abstract: ATM is a key mediator of radiation response, and pharmacological inhibition of ATM is a rational strategy to radiosensitize tumors. AZD1390 is a brain-penetrant ATM inhibitor and a potent radiosensitizer. This study evaluated the spectrum of ... ...

Abstract	ATM is a key mediator of radiation response, and pharmacological inhibition of ATM is a rational strategy to radiosensitize tumors. AZD1390 is a brain-penetrant ATM inhibitor and a potent radiosensitizer. This study evaluated the spectrum of radiosensitizing effects and the impact of
MeSH term(s)	Humans ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Glioblastoma/drug therapy ; Glioblastoma/genetics ; Glioblastoma/radiotherapy ; Signal Transduction ; DNA Repair/genetics ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Pyridines ; Quinolones
Chemical Substances	Tumor Suppressor Protein p53 ; AZD1390 ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1) ; ATM protein, human (EC 2.7.11.1) ; Pyridines ; Quinolones
Language	English
Publishing date	2024-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2518854-9
ISSN	1946-6242 ; 1946-6234
ISSN (online)	1946-6242
ISSN	1946-6234
DOI	10.1126/scitranslmed.adj5962
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Article: Humeral Head Replacement and Reverse Shoulder Arthroplasty for the Treatment of Proximal Humerus Fracturesm.

Frombach, Aaron Andrew / Brett, Kendra / Lapner, Peter

The open orthopaedics journal

2017 Volume 11, Page(s) 1108–1114

Abstract: Acute proximal humeral fractures in the elderly are generally treated non-operatively if alignment is acceptable and in stable fracture patterns. When operative treatment is indicated, surgical fixation is often difficult or impossible to obtain. ... ...

Abstract	Acute proximal humeral fractures in the elderly are generally treated non-operatively if alignment is acceptable and in stable fracture patterns. When operative treatment is indicated, surgical fixation is often difficult or impossible to obtain. Hemiarthroplasty has long been the standard of care. However, with its reliance on tuberosity healing, functional outcomes and patient satisfaction are often poor. Reverse shoulder arthroplasty has emerged as a new technology for treating proximal humeral fractures but the indications for its use remain uncertain. While not conclusive, the evidence suggests that reverse shoulder arthroplasty yields more consistent results, with improved forward elevation and higher functional outcome scores. The primary advantages of hemiarthroplasty are improved shoulder rotation and shorter operative time. Complication rates do not vary significantly between the two options. Although higher quality trials are needed to further define the role of reverse shoulder arthroplasty, current evidence suggests that this is a reasonable option for surgeons who are highly familiar with its use.
Language	English
Publishing date	2017-09-30
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	2395994-0
ISSN	1874-3250
ISSN	1874-3250
DOI	10.2174/1874325001711011108
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Article ; Online: Doctor of Physical Therapy Education in a Hybrid Learning Environment: A Case Report.

Gagnon, Kendra / Bachman, Teresa / Beuning, Brett / Koppenhaver, Shane / Unverzagt, Casey / Feda, Jessica / Gantt, Christy / Young, Brian

Physical therapy

2022 Volume 102, Issue 8

Abstract: Objective: The purpose of this case report is to describe the implementation and report early outcomes of a 2-year (6-trimester), hybrid doctor of physical therapy (DPT) program.: Methods: The case report describes management of (1) academic affairs, ...

Abstract	Objective: The purpose of this case report is to describe the implementation and report early outcomes of a 2-year (6-trimester), hybrid doctor of physical therapy (DPT) program. Methods: The case report describes management of (1) academic affairs, (2) student affairs, (3) faculty affairs, and (4) institutional affairs for an accredited, fully hybrid, 2-year DPT program. In the hybrid program, students from across the country participate in synchronous and asynchronous online learning and travel to campus twice per trimester for immersive blocks of in-person laboratory instruction. The case report describes how the program structures the hybrid learning environment and reports outcomes from the first 2 graduated cohorts. Results: Program outcomes assessment revealed that 97% to 98% of students/graduates reported being somewhat or very satisfied with the 2-year hybrid DPT program at the end of DPT year 1, at graduation, and at 1 year after graduation. Clinical instructors reported that 84% of students were prepared or well-prepared for clinical education. At 1 year after graduation, 20% of graduates were enrolled in or had completed residency, National Physical Therapy Examination (NPTE) pass rate was 97%, and employment rate was 99%. Conclusion: Hybrid DPT education is feasible and may provide opportunities for more flexible and accessible delivery of DPT education. Outcomes of this case report suggest high student satisfaction, increased student/graduate diversity, and graduate outcomes comparable with national averages as reported in the Commission on Accreditation in Physical Therapy Education aggregate data. Impact: This case report provides early evidence that hybrid DPT education-a type of blended learning that uses both face-to-face and online instructional strategies-is feasible, with student satisfaction and student/graduate outcomes comparable with national averages. Hybrid education may provide educators, programs, and institutions the flexibility to innovate in ways that address some of the immediate and long-term challenges facing physical therapist professional education while maintaining standards of excellence.
MeSH term(s)	Faculty ; Humans ; Learning ; Physical Therapy Modalities ; Physical Therapy Specialty/education ; Students
Language	English
Publishing date	2022-06-11
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	415886-6
ISSN	1538-6724 ; 0031-9023
ISSN (online)	1538-6724
ISSN	0031-9023
DOI	10.1093/ptj/pzac074
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Article ; Online: The origin of blinking in both mudskippers and tetrapods is linked to life on land.

Aiello, Brett R / Bhamla, M Saad / Gau, Jeff / Morris, John G L / Bomar, Kenji / da Cunha, Shashwati / Fu, Harrison / Laws, Julia / Minoguchi, Hajime / Sripathi, Manognya / Washington, Kendra / Wong, Gabriella / Shubin, Neil H / Sponberg, Simon / Stewart, Thomas A

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 18, Page(s) e2220404120

Abstract: Blinking, the transient occlusion of the eye by one or more membranes, serves several functions including wetting, protecting, and cleaning the eye. This behavior is seen in nearly all living tetrapods and absent in other extant sarcopterygian lineages ... ...

Abstract	Blinking, the transient occlusion of the eye by one or more membranes, serves several functions including wetting, protecting, and cleaning the eye. This behavior is seen in nearly all living tetrapods and absent in other extant sarcopterygian lineages suggesting that it might have arisen during the water-to-land transition. Unfortunately, our understanding of the origin of blinking has been limited by a lack of known anatomical correlates of the behavior in the fossil record and a paucity of comparative functional studies. To understand how and why blinking originates, we leverage mudskippers (Oxudercinae), a clade of amphibious fishes that have convergently evolved blinking. Using microcomputed tomography and histology, we analyzed two mudskipper species,
MeSH term(s)	Animals ; Blinking ; X-Ray Microtomography ; Fishes/anatomy & histology ; Perciformes
Language	English
Publishing date	2023-04-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2220404120
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Article: Perspectives on Quality of Care in Kidney Transplantation: A Semistructured Interview Study.

Brett, Kendra E / Ertel, Emily / Grimshaw, Jeremy / Knoll, Greg A

Transplantation direct

2018 Volume 4, Issue 9, Page(s) e383

Abstract: Background: There is currently no agreement as to what constitutes quality transplant care, and there is a lack of consistency in the approach to assessing transplantation quality. We aimed to ascertain the views of patients, clinicians, and program ... ...

Abstract	Background: There is currently no agreement as to what constitutes quality transplant care, and there is a lack of consistency in the approach to assessing transplantation quality. We aimed to ascertain the views of patients, clinicians, and program administrators about quality care for kidney transplant patients. Methods: Semistructured qualitative interviews were conducted with 20 patients, 17 physicians, and 11 program administrators. Transcripts were analyzed using inductive thematic analysis. Results: We identified 8 themes: access to treatment (standardized transplant referral, lengthy transplant evaluation process, lengthy living donor evaluation); accessibility of services (alternative access options, flexible appointment availability, appropriate amount of follow-up, barriers for accessing care); program resources (comprehensive multidisciplinary care, knowledgeable staff, peer support groups, educational resources, patient navigators/ advocates); communication of information (taking time to answer questions, clear communication about treatment, communication tailored to patients, health promotion and illness prevention); attitude of care providers (positive and supportive attitude, patient centered care); health outcomes (freedom from dialysis, Long-term health, short-term health, fear of infections); patient satisfaction (returning to normal life, patient satisfaction with care); and safety (reducing infection risk, quick response to complications, patient health status on the waitlist). Conclusions: There is a need to move beyond basic clinical outcomes and focus on increasing ease of access, the patient-provider relationship, and outcomes that are most important to the patients.
Language	English
Publishing date	2018-08-21
Publishing country	United States
Document type	Journal Article
ISSN	2373-8731
ISSN	2373-8731
DOI	10.1097/TXD.0000000000000820
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Article ; Online: Parental perceptions and childhood dietary quality.

Adamo, Kristi B / Brett, Kendra E

Maternal and child health journal

2013 Volume 18, Issue 4, Page(s) 978–995

Abstract: The early years represent a critical period of growth and development of health behaviours. While optimal child growth is associated with a complex set of factors, the importance of diet quality is undeniable. The objective of this narrative review is to ...

Abstract	The early years represent a critical period of growth and development of health behaviours. While optimal child growth is associated with a complex set of factors, the importance of diet quality is undeniable. The objective of this narrative review is to examine contributors to child diet quality and parental perception and how such perceptions might affect child diet quality. An extensive literature search was conducted, generating a variety of sources including research trials (randomized and non-randomized), lab-based studies, cohort studies, topical reviews, government or NGO reports and grey literature. In addition, reflection and opinion, accrued through regular interaction with families, regarding some of the potential links has also been included. Parental perception of diet quality is influenced by many different social, biological economical and psychological factors. Research suggests that diet quality of today's children is sub-optimal and a parent's perception of their child's diet may not accurately reflect this reality. Various parental attitudes and perceptions/misperceptions are important to address as knowledge awareness and beliefs can impact diet quality as can parental practices, and family structure. Issues related to socioeconomics and convenience, and a child's preferences and their peer and/or social environment are also potential factors impacting child diet quality. Knowing that parents play such an integral role in the development and maintenance of their child's health behaviours, addressing misconceptions and unhealthy parental beliefs about diet quality may be an important area for early intervention and prevention work in childhood obesity.
MeSH term(s)	Adult ; Canada ; Child ; Child Development/physiology ; Child Nutritional Physiological Phenomena ; Child Welfare ; Child, Preschool ; Diet ; Feeding Behavior ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Nutritional Requirements ; Parent-Child Relations ; Parenting ; Parents/psychology ; Perception ; Quality Control ; Risk Assessment ; Socioeconomic Factors ; United States
Language	English
Publishing date	2013-07-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1339905-6
ISSN	1573-6628 ; 1092-7875
ISSN (online)	1573-6628
ISSN	1092-7875
DOI	10.1007/s10995-013-1326-6
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