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  1. Article ; Online: Reply from Lasse Gliemann, Jakob Schmidt, Jesper Olesen, Rasmus Sjørup Biensø, Sebastian Louis Peronard, Simon Udsen Grandjean, Stefan Peter Mortensen, Michael Nyberg, Jens Bangsbo, Henriette Pilegaard and Ylva Hellsten.

    Gliemann, Lasse / Schmidt, Jakob / Olesen, Jesper / Biensø, Rasmus Sjørup / Peronard, Sebastian Louis / Grandjean, Simon Udsen / Mortensen, Stefan Peter / Nyberg, Michael / Bangsbo, Jens / Pilegaard, Henriette / Hellsten, Ylva

    The Journal of physiology

    2013  Volume 591, Issue 20, Page(s) 5253

    MeSH term(s) Cardiovascular System/drug effects ; Exercise ; Humans ; Male ; Resveratrol ; Stilbenes/pharmacology
    Chemical Substances Stilbenes ; Resveratrol (Q369O8926L)
    Language English
    Publishing date 2013-10-15
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/jphysiol.2013.264093
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.65: Show issues Location:
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  2. Article ; Online: Investigating the Pathogen Genomic Determinants of Tuberculosis Transmission.

    Grandjean, Louis

    American journal of respiratory and critical care medicine

    2017  Volume 195, Issue 11, Page(s) 1418–1420

    Language English
    Publishing date 2017-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201701-0053ED
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  3. Article ; Online: Are human-induced changes good or bad to dynamic landscape connectivity?

    Morin, Elie / Razafimbelo, Ny Tolotra / Yengué, Jean-Louis / Guinard, Yvonnick / Grandjean, Frédéric / Bech, Nicolas

    Journal of environmental management

    2024  Volume 352, Page(s) 120009

    Abstract: Land managers must find a compromise between rapidly changing landscapes and biodiversity conservation through ecological networks. Estimating ecological networks is a key approach to enhance or maintain functional connectivity by identifying the nodes ... ...

    Abstract Land managers must find a compromise between rapidly changing landscapes and biodiversity conservation through ecological networks. Estimating ecological networks is a key approach to enhance or maintain functional connectivity by identifying the nodes and links of a graph, which represent habitats and their corresponding functional corridors, respectively. To understand the current state of biodiversity, it is necessary to consider dynamic landscape connectivity while relying on relevant land cover maps. Although a current land cover map is relatively easy to produce using existing data, this is challenging for past landscapes. Here we investigated the impact of changes in landscape connectivity in an urban landscape at a fine scale on the habitat availability of two bird species: the tree pipit Anthus trivialis and the short-toed treecreeper Certhia brachydactyla. These species, exhibiting different niche ecologies, have shown contrasting population trends at a medium-term scale. The occurrences of C. brachydactyla were better correlated with resistance values that maximise the use of corridors, whereas the occurrences of A. trivialis better fitted with intermediate resistance values. The statistical approach indirectly highlighted relevant information about the ecology the capacity of both species to use urban habitats. Landscape connectivity increased for both species over the 24-year study period and may have implications for local abundances, which could explain, at the national scale, the increase in populations of C. brachydactyla, but not the decrease in populations of A. trivialis. Thus, more attention must be paid on rural habitats and their associated species that are more impacted by human activities, but efforts could also be achieved in urban areas especially for highly corridor-dependent species. Studying dynamic landscape connectivity at a fine scale is essential for estimating past and future land cover changes and their associated impacts on ecological networks, to better reconcile human and biodiversity concerns in land management.
    MeSH term(s) Animals ; Humans ; Conservation of Natural Resources ; Ecosystem ; Biodiversity ; Birds ; Human Activities
    Language English
    Publishing date 2024-01-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2023.120009
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  4. Article ; Online: Detecting Tuberculosis in Prisons: Switching Off the Disease at Its Source.

    Woodman, Marc / Grandjean, Louis

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 72, Issue 5, Page(s) 778–779

    MeSH term(s) Algorithms ; Brazil ; Humans ; Mass Screening ; Prisons ; Tuberculosis/diagnosis ; Tuberculosis/epidemiology
    Language English
    Publishing date 2020-02-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa139
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  5. Book ; Online: Which arithmetic operations can be performed in constant time in the RAM model with addition?

    Grandjean, Étienne / Jachiet, Louis

    2022  

    Abstract: In the literature of algorithms, the specific computation model is often not explicit as it is assumed that the model of computation is the RAM (Random Access Machine) model. However, the RAM model itself is ill-founded in the literature, with disparate ... ...

    Abstract In the literature of algorithms, the specific computation model is often not explicit as it is assumed that the model of computation is the RAM (Random Access Machine) model. However, the RAM model itself is ill-founded in the literature, with disparate definitions and no unified results. The ambition of this paper is to found the RAM model from scratch by exhibiting a RAM model that enjoys interesting algorithmic properties and the robustness of its complexity classes, notably LIN, the class of linear-time computable problems, or the now well-known CONST-DELAY-lin class of enumeration problems computable with constant delay after linear-time preprocessing, The computation model that we define is a RAM whose contents and addresses of registers are $O(N)$, where $N$ is the size (number of registers) of the input, and where the time cost of each instruction is 1 (unit cost criterion). The key to the foundation of our RAM model will be to prove that even if addition is the only primitive operation, such a RAM can still compute all the basic arithmetic operations in constant time after a linear-time preprocessing. Moreover, while the RAM handles only $O(N)$ integers in each register, we will show that our RAM can handle $O(N^d)$ integers, for any fixed d, by storing them on $O(d)$ registers and we will have surprising algorithms that computes many operations acting on these "polynomial" integers -- addition, subtraction, multiplication, division, exponential, integer logarithm, integer square root (or $c$-th root, for any integer $c$), bitwise logical operations, and, more generally, any operation computable in linear time on a cellular automaton -- in constant time after a linear-time preprocessing.
    Keywords Computer Science - Computational Complexity ; Computer Science - Data Structures and Algorithms ; F.1.1 ; F.1.3 ; F.2
    Subject code 511
    Publishing date 2022-06-28
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article ; Online: Mapping past land cover on Poitiers in 1993 at very high resolution using GEOBIA approach and open data.

    Morin, Elie / Razafimbelo, Ny Tolotra / Yengué, Jean-Louis / Guinard, Yvonnick / Grandjean, Frédéric / Bech, Nicolas

    Data in brief

    2023  Volume 52, Page(s) 109829

    Abstract: The land cover data presented here is a reconstruction of the past landscape (1993) at Very High Resolution (VHR) for the city of Poitiers, France. This reconstruction is based on multiple sources of images and data. We combined the strengths of both ... ...

    Abstract The land cover data presented here is a reconstruction of the past landscape (1993) at Very High Resolution (VHR) for the city of Poitiers, France. This reconstruction is based on multiple sources of images and data. We combined the strengths of both mono-temporal and multi-temporal classifications. Orthophotos were created at a spatial resolution of 0.5 m using aerial raw images from the French National Geographic Institute (IGN), taken during two aerial missions in July and August 1993. These orthophotos were merged at a spatial resolution of 5 m to conduct a first object-based classification using Landsat-5 TM images. The goal was to identify croplands, grasslands, coniferous and deciduous forests, urban areas, water bodies, and shadows. This learning-based classification employed a dataset consisting of 1371 polygons and demonstrated strong classification performances, achieving an overall accuracy of 86.31% and a kappa index of 0.832. On the other hand, mono-temporal classifications at a 0.5 m spatial resolution were carried out on each orthophoto to extract trees and herbaceous vegetation, especially in urban contexts. As mono-temporal classifications contained less information, we used a larger number of polygons for the learning step: 3849 and 5173 polygons for the northern and southern classifications, respectively. The segmentation step performed better in urban areas compared to rural areas. Consequently, the performance of classifications was evaluated separately for both contexts. Urban areas exhibited excellent performances, achieving kappa indices of 0.897 and 0.881 for the northern and southern classifications, respectively, whereas only tree vegetation was accurately detected in rural areas. To compensate for the lack of information such as buildings, railways, or roads, we modified the BD Topo
    Language English
    Publishing date 2023-11-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2786545-9
    ISSN 2352-3409 ; 2352-3409
    ISSN (online) 2352-3409
    ISSN 2352-3409
    DOI 10.1016/j.dib.2023.109829
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  7. Article ; Online: A systematic review of tuberculosis detection and prevention studies in prisons.

    Haeusler, Ilsa Louisa / Torres-Ortiz, Arturo / Grandjean, Louis

    Global public health

    2021  Volume 17, Issue 2, Page(s) 194–209

    Abstract: Many studies have demonstrated that prisons are hotspots of tuberculosis disease and transmission. Despite this, it remains unclear which interventions are most effective at controlling tuberculosis in prisons. The objective was to determine the study ... ...

    Abstract Many studies have demonstrated that prisons are hotspots of tuberculosis disease and transmission. Despite this, it remains unclear which interventions are most effective at controlling tuberculosis in prisons. The objective was to determine the study designs used to investigate tuberculosis control in prisons, and the efficacy of interventions undertaken. This systematic review included published studies which had the aim of reducing TB incidence or prevalence, or increasing the number of people screened for active pulmonary tuberculosis in incarcerated populations. 2,429 records were identified, 178 full-text articles were screened, and 17 studies included. The majority of reports were before/after or prospective non-comparative studies. The median study duration was 23 months (range 5-144). The most common intervention was the introduction of active case finding (10/17 studies) but the timing and methods varied. Comparable pre- and post intervention outcome values were infrequently reported; therefore, it was not possible to quantify the efficacy of interventions. Data from studies of tuberculosis control in prisons is limited by a lack of: controlled interventions, reporting of pre-intervention methods, and comparable pre- and post-intervention outcomes. Prospective comparative trials of adequate duration to determine trends in incidence are necessary to understand which interventions are effective in prisons.
    MeSH term(s) Humans ; Mass Screening ; Prevalence ; Prisoners ; Prisons ; Prospective Studies ; Tuberculosis/diagnosis ; Tuberculosis/epidemiology ; Tuberculosis/prevention & control
    Language English
    Publishing date 2021-01-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2234129-8
    ISSN 1744-1706 ; 1744-1692
    ISSN (online) 1744-1706
    ISSN 1744-1692
    DOI 10.1080/17441692.2020.1864753
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  8. Article: Quantifying patient- and hospital-level antimicrobial resistance dynamics in

    Leclerc, Quentin / Clements, Alastair / Dunn, Helen / Hatcher, James / Lindsay, Jodi A / Grandjean, Louis / Knight, Gwenan M

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Antimicrobial resistance (AMR) to all antibiotic classes has been found in the ... ...

    Abstract Antimicrobial resistance (AMR) to all antibiotic classes has been found in the pathogen
    Language English
    Publishing date 2023-02-16
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.15.23285946
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  9. Article ; Online: T cell responses to SARS-CoV-2 in healthy controls and primary immunodeficiency patients.

    Awuah, Arnold / Zamani, Ava / Tahami, Fariba / Davis, Mark / Grandjean, Louis / Buckland, Matthew / Gilmour, Kimberly

    Clinical and experimental immunology

    2022  

    Abstract: Understanding the T cell response to SARS-CoV-2 is key in patients who lack antibody production. We demonstrate the applicability of a functional assay to measure the T cell response in a cohort of patients with immunodeficiency. ...

    Abstract Understanding the T cell response to SARS-CoV-2 is key in patients who lack antibody production. We demonstrate the applicability of a functional assay to measure the T cell response in a cohort of patients with immunodeficiency.
    Language English
    Publishing date 2022-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 218531-3
    ISSN 1365-2249 ; 0009-9104 ; 0964-2536
    ISSN (online) 1365-2249
    ISSN 0009-9104 ; 0964-2536
    DOI 10.1093/cei/uxac001
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    Zs.B 337: Show issues Location:
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  10. Article ; Online: Quantifying patient- and hospital-level antimicrobial resistance dynamics in

    Leclerc, Quentin / Clements, Alastair / Dunn, Helen / Hatcher, James / Lindsay, Jodi A / Grandjean, Louis / Knight, Gwenan M

    Journal of medical microbiology

    2023  Volume 72, Issue 7

    Abstract: Introduction. ...

    Abstract Introduction.
    MeSH term(s) Child ; Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Staphylococcus aureus/genetics ; Methicillin ; Routinely Collected Health Data ; Drug Resistance, Bacterial ; Staphylococcal Infections/epidemiology ; Hospitals, Pediatric
    Chemical Substances Anti-Bacterial Agents ; Methicillin (Q91FH1328A)
    Language English
    Publishing date 2023-07-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 218356-0
    ISSN 1473-5644 ; 0022-2615
    ISSN (online) 1473-5644
    ISSN 0022-2615
    DOI 10.1099/jmm.0.001724
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