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  1. Book ; Online: Modeling the Plankton - Enhancing the Integration of Biological Knowledge and Mechanistic Understanding

    Menden-Deuer, Susanne / Flynn, Kevin J. / Aksnes, Dag L. / Lindemann, Christian

    2018  

    Abstract: In light of climate change and allied changes to marine ecosystems, mathematical models have become an important tool to examine processes and predict phenomena from local through to global scales. In recent years model studies, laboratory experiments ... ...

    Abstract In light of climate change and allied changes to marine ecosystems, mathematical models have become an important tool to examine processes and predict phenomena from local through to global scales. In recent years model studies, laboratory experiments and a better ecological understanding of the pelagic ecosystem have enabled advancements on fundamental challenges in oceanography, including marine production, biodiversity and anticipation of future conditions in the ocean. This research topic presents a number of studies that investigate functionally diverse organism in a dynamic ocean through diverse and novel modeling approaches
    Keywords Science (General) ; Oceanography
    Size 1 electronic resource (228 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020097495
    ISBN 9782889453658 ; 2889453650
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Measurement and control of foam generation in a mammalian cell culture.

    Flynn, James / Breen, Laura / Narayanan, Shankara / Butler, Michael

    Biotechnology progress

    2024  , Page(s) e3450

    Abstract: Foam is generated in mammalian cell cultures by excessive agitation or gas sparging. This occurs particularly in cultures that generate recombinant proteins at high cell concentrations. Three antifoam agents were tested for their compatibility with ... ...

    Abstract Foam is generated in mammalian cell cultures by excessive agitation or gas sparging. This occurs particularly in cultures that generate recombinant proteins at high cell concentrations. Three antifoam agents were tested for their compatibility with antibody-producing Chinese hamster ovary (CHO) cells. One agent (antifoam 204) was completely inhibitory to growth at a concentration of 10 ppm, one agent (antifoam C) showed partial inhibition and a third (antifoam SE-15) showed no inhibition at this concentration. A novel foam image analyzer (LabCam) was used to evaluate two antifoams (C and SE-15) for their ability to dissipate foam generated in cell culture media by enhanced agitation. The presence of antifoam in the media reduced significantly the foam layer that was generated and this was shown to be rapidly dissipated in the presence of 10 ppm SE-15. The antifoams were also tested for foam dissipation in cultures of CHO cells at >10
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 165657-0
    ISSN 1520-6033 ; 8756-7938
    ISSN (online) 1520-6033
    ISSN 8756-7938
    DOI 10.1002/btpr.3450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A computer vision approach to the assessment of dried blood spot size and quality in newborn screening.

    Flynn, Nick / Moat, Stuart J / Hogg, Sarah L

    Clinica chimica acta; international journal of clinical chemistry

    2023  Volume 547, Page(s) 117418

    Abstract: Background: Dried blood spot (DBS) size and quality affect newborn screening (NBS) test results. Visual assessment of DBS quality is subjective.: Methods: We developed and validated a computer vision (CV) algorithm to measure DBS diameter and ... ...

    Abstract Background: Dried blood spot (DBS) size and quality affect newborn screening (NBS) test results. Visual assessment of DBS quality is subjective.
    Methods: We developed and validated a computer vision (CV) algorithm to measure DBS diameter and identify incorrectly applied blood in images from the Panthera DBS puncher. We used CV to assess historical trends in DBS quality and correlate DBS diameter to NBS analyte concentrations in 130,620 specimens.
    Results: CV estimates of DBS diameter were precise (percentage coefficient of variation < 1.3%) and demonstrated excellent agreement with digital calipers with a mean (standard deviation) difference of 0.23 mm (0.18 mm). An optimised logistic regression model showed a sensitivity of 94.3% and specificity of 96.8% for detecting incorrectly applied blood. In a validation set of images (n = 40), CV agreed with an expert panel in all acceptable specimens and identified all specimens rejected by the expert panel due to incorrect blood application or DBS diameter > 14 mm. CV identified a reduction in unsuitable NBS specimens from 25.5% in 2015 to 2% in 2021. Each mm decrease in DBS diameter decreased analyte concentrations by up to 4.3%.
    Conclusions: CV can aid assessment of DBS size and quality to harmonize specimen rejection both within and between laboratories.
    MeSH term(s) Infant, Newborn ; Humans ; Dried Blood Spot Testing/methods ; Neonatal Screening/methods ; Blood Specimen Collection/methods ; Algorithms ; Laboratories
    Language English
    Publishing date 2023-06-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cca.2023.117418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Supportive peer review: Why and how to constructively review a paper.

    Rees, Lesley / Flynn, Joseph

    Pediatric nephrology (Berlin, Germany)

    2022  Volume 37, Issue 8, Page(s) 1701–1703

    MeSH term(s) Humans ; Peer Review
    Language English
    Publishing date 2022-05-02
    Publishing country Germany
    Document type Editorial
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-022-05535-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Looking back, looking ahead.

    Flynn, Joseph / Rees, Lesley

    Pediatric nephrology (Berlin, Germany)

    2022  Volume 37, Issue 4, Page(s) 697–698

    Language English
    Publishing date 2022-02-03
    Publishing country Germany
    Document type Editorial
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-022-05466-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Immune cell interactions in tuberculosis.

    Flynn, JoAnne L / Chan, John

    Cell

    2022  Volume 185, Issue 25, Page(s) 4682–4702

    Abstract: Despite having been identified as the organism that causes tuberculosis in 1882, Mycobacterium tuberculosis has managed to still evade our understanding of the protective immune response against it, defying the development of an effective vaccine. ... ...

    Abstract Despite having been identified as the organism that causes tuberculosis in 1882, Mycobacterium tuberculosis has managed to still evade our understanding of the protective immune response against it, defying the development of an effective vaccine. Technology and novel experimental models have revealed much new knowledge, particularly with respect to the heterogeneity of the bacillus and the host response. This review focuses on certain immunological elements that have recently yielded exciting data and highlights the importance of taking a holistic approach to understanding the interaction of M. tuberculosis with the many host cells that contribute to the development of protective immunity.
    Language English
    Publishing date 2022-11-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2022.10.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Alternative lengthening of telomeres: mechanism and the pathogenesis of cancer.

    Mori, Joakin O / Keegan, Joshua / Flynn, Rachel L / Heaphy, Christopher M

    Journal of clinical pathology

    2024  Volume 77, Issue 2, Page(s) 82–86

    Abstract: Telomere maintenance and elongation allows cells to gain replicative immortality and evade cellular senescence during cancer development. While most cancers use telomerase to maintain telomere lengths, a subset of cancers engage the alternative ... ...

    Abstract Telomere maintenance and elongation allows cells to gain replicative immortality and evade cellular senescence during cancer development. While most cancers use telomerase to maintain telomere lengths, a subset of cancers engage the alternative lengthening of telomeres (ALT) pathway for telomere maintenance. ALT is present in 5%-10% of all cancers, although the prevalence is dramatically higher in certain cancer types, including complex karyotype sarcomas, isocitrate dehydrogenase-mutant astrocytoma (WHO grade II-IV), pancreatic neuroendocrine tumours, neuroblastoma and chromophobe hepatocellular carcinomas. ALT is maintained through a homology-directed DNA repair mechanism. Resembling break-induced replication, this aberrant process results in dramatic cell-to-cell telomere length heterogeneity, widespread chromosomal instability and chronic replication stress. Additionally, ALT-positive cancers frequently harbour inactivating mutations in either chromatin remodelling proteins (
    MeSH term(s) Humans ; Telomere Homeostasis ; X-linked Nuclear Protein/genetics ; Telomerase/genetics ; Telomere/genetics ; Telomere/metabolism ; Neoplasms/genetics ; DNA Helicases/genetics ; Carrier Proteins
    Chemical Substances X-linked Nuclear Protein (EC 3.6.4.12) ; Telomerase (EC 2.7.7.49) ; SMARCAL1 protein, human (EC 2.7.7.-) ; DNA Helicases (EC 3.6.4.-) ; SLX4IP protein, human ; Carrier Proteins
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 80261-x
    ISSN 1472-4146 ; 0021-9746
    ISSN (online) 1472-4146
    ISSN 0021-9746
    DOI 10.1136/jcp-2023-209005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Optimal growth and development: are teenagers getting enough micronutrients from their diet?

    Walsh, Niamh M / Flynn, Albert / Walton, Janette / Kehoe, Laura

    The Proceedings of the Nutrition Society

    2024  , Page(s) 1–9

    Abstract: The teenage years represent a crucial period of physical and cognitive growth and development with sufficient micronutrient intakes necessary to meet high nutritional requirements. This review examines current micronutrient intakes in teenagers in the ... ...

    Abstract The teenage years represent a crucial period of physical and cognitive growth and development with sufficient micronutrient intakes necessary to meet high nutritional requirements. This review examines current micronutrient intakes in teenagers in the Western world in the context of public health implications including the prevalence of inadequate intakes and risk of excessive intakes. Intakes of vitamins A, D, E and C, folate, calcium, iron, magnesium, zinc and potassium in teenagers are low when compared to generally accepted recommendations, while there is little risk of excessive micronutrient intakes based on current dietary patterns. Therefore, strategies should focus on increasing micronutrient intakes in order to decrease the risk of negative impacts resulting from these low intakes. These strategies should be mindful of guidance towards an environmentally sustainable diet whilst ensuring that nutrient intakes in teenagers are not further negatively impacted. In order to identify, implement and monitor the effectiveness of such strategies, intakes of micronutrients should be continually monitored in nationally representative samples of the population for all age groups including this vulnerable cohort of teenagers.
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 391142-1
    ISSN 1475-2719 ; 0029-6651
    ISSN (online) 1475-2719
    ISSN 0029-6651
    DOI 10.1017/S002966512400017X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Single cell analysis of Chinese hamster ovary cells during a bioprocess using a novel dynamic imaging system.

    Breen, Laura / Flynn, James / Bergin, Adam / Flampouri, Evangelia / Butler, Michael

    Biotechnology progress

    2024  , Page(s) e3469

    Abstract: Reliable monitoring of mammalian cells in bioreactors is essential to biopharmaceutical production. Trypan blue exclusion is a method of determining cell density and viability that has been used for over one hundred years to monitor cells in culture and ... ...

    Abstract Reliable monitoring of mammalian cells in bioreactors is essential to biopharmaceutical production. Trypan blue exclusion is a method of determining cell density and viability that has been used for over one hundred years to monitor cells in culture and is the current standard method in biomanufacturing. This method has many disadvantages however and there is a growing demand for more detailed and in-line measurements of cell growth in bioreactors. This article assesses a novel dynamic imaging system for single cell analysis. This data shows that comparable total cell density, viable cell density and percentage viability data shown here, generated by the imaging system, aligned well with conventional trypan blue counting methods for an industrially relevant Chinese Hamster Ovary (CHO) cell line. Furthermore, detailed statistical analysis shows that the classification system used by the PharmaFlow system can reveal trends of interest in monitoring the health of mammalian cells over a 6-day bioreactor culture. The system is also capable of sampling at-line, removing the necessity for taking samples off-line and enabling real time monitoring of cells in a bioreactor culture.
    Language English
    Publishing date 2024-04-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 165657-0
    ISSN 1520-6033 ; 8756-7938
    ISSN (online) 1520-6033
    ISSN 8756-7938
    DOI 10.1002/btpr.3469
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Service user perspectives on social prescribing services for mental health in the UK: a systematic review.

    Cooper, M / Flynn, D / Avery, L / Ashley, K / Jordan, C / Errington, L / Scott, J

    Perspectives in public health

    2023  Volume 143, Issue 3, Page(s) 135–144

    Abstract: Aim: To thematically synthesise adult service users' perspectives on how UK-based social prescribing services support them with their mental health management.: Methods: Nine databases were systematically searched up to March 2022. Eligible studies ... ...

    Abstract Aim: To thematically synthesise adult service users' perspectives on how UK-based social prescribing services support them with their mental health management.
    Methods: Nine databases were systematically searched up to March 2022. Eligible studies were qualitative or mixed methods studies involving participants aged ⩾ 18 years accessing social prescribing services primarily for mental health reasons. Thematic synthesis was applied to qualitative data to create descriptive and analytical themes.
    Results: 51,965 articles were identified from electronic searches. Six studies were included in the review (
    Conclusions: This review provides a synthesis of the qualitative evidence on service users' experiences of accessing and using social prescribing services to support their mental health management. Adherence to principles of person-centred care and addressing the holistic needs of service users (including devoting attention to the quality of the therapeutic environment) are important for design and delivery of social prescribing services. This will optimise service user satisfaction and other outcomes that matter to them.
    MeSH term(s) Adult ; Humans ; Aged ; Mental Health ; Mental Health Services ; United Kingdom ; Qualitative Research
    Language English
    Publishing date 2023-05-26
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2478358-4
    ISSN 1757-9147 ; 1757-9139
    ISSN (online) 1757-9147
    ISSN 1757-9139
    DOI 10.1177/17579139231170786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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