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Article ; Online: Nutrition in Children with Cancer

Gönül Dinler

Güncel Pediatri, Vol 7, Iss 1, Pp 31-

2009 Volume 36

Abstract: Malnutrition is a common event in children with cancer. Both cancer and its therapies contribute to malnutrition in different proportion. Malnutrition predisposes the child to increased morbidity, poorer outcome and reduction in quality of life. To ... ...

Abstract	Malnutrition is a common event in children with cancer. Both cancer and its therapies contribute to malnutrition in different proportion. Malnutrition predisposes the child to increased morbidity, poorer outcome and reduction in quality of life. To prevent and/or treat malnutrition, children with cancer need to be evaluated their nutritional status and need to be supported nutritionally. (Journal of Current Pediatrics 2009; 7: 31-6)
Keywords	Cancer ; malnutrition ; child ; nutrition ; Pediatrics ; RJ1-570 ; Medicine ; R ; DOAJ:Pediatrics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	Turkish
Publishing date	2009-06-01T00:00:00Z
Publisher	Galenos Yayincilik
Document type	Article ; Online
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Article ; Online: Çölyak Hastalığının Genetik Allel Dağılımının Değerlendirilmesi ve Türkiye Literatür Taraması

Fatma Demirbaş / Aslıhan Sanrı / Gönül Dinler Çaltepe / Atakan Comba / Ayhan Gazi Kalaycı

Kocaeli Üniversitesi Sağlık Bilimleri Dergisi, Vol 7, Iss 1, Pp 22-

2021 Volume 26

Abstract: Amaç: Çölyak hastalığı (ÇH), genetik yatkınlığı olan bireylerde, glutene kalıcı duyarlılık sonucu gelişen, otoimmün, sistemik hastalıktır. Bu çalışmanın amacı, ÇH’nin klinik, laboratuar özellikleri ve HLA doku tiplerinin geriye dönük değerlendirilmesidir. ...

Abstract	Amaç: Çölyak hastalığı (ÇH), genetik yatkınlığı olan bireylerde, glutene kalıcı duyarlılık sonucu gelişen, otoimmün, sistemik hastalıktır. Bu çalışmanın amacı, ÇH’nin klinik, laboratuar özellikleri ve HLA doku tiplerinin geriye dönük değerlendirilmesidir.Ayrıca lieratür taramasıyla HLA doku tipleri açısından Türkiye’de bölgelere göre farklılık ve benzerliklerin incelenmesidir. Yöntem: Çalışmaya, Temmuz 2017- Ekim 2018 tarihleri arasında ÇH tanısıyla izlenen ve genetik çalışması uygulanan 104 çocuk alındı. Google Scholarda Türkiye’de ÇH ve HLA genotiplendirme ile yapılan çalışmalar tarandı (n=11 çalışma) ve bölgelere ayrıldı. Bulgular: Çalışmaya alınan 104 hastanın 67’si kız (,4) ve ortalama tanı yaşı 7,9±2,38 yıl(10ay-17,2yıl) idi. Hastalarımızın HLA grupları ,6 DQ2, ,9 DQ8 ve ,4 DQ2+DQ8 saptandı. Literatürdeki çalışmalar bölgeler göre değerlendirildiğinde bizim de içinde bulunduğumuz Karadeniz bölgesinde HLADQ2 ,7 ve HLADQ8 ,1 sıklıkla görülürken, bölgemize benzer oranlarda genotip sıklığı Akdeniz ve Doğu Anadolu bölgelerinde görülmektedir. İç Anadolu HLADQ2 ,4 ve Marmara bölgesinde ,6 ile daha yüksek frekansta görülmektedir. Çalışmamızda, DQA105 ,4 ve DQB102 ,5 oranında bulundu. Türkiye’deki diğer çalışmalarda (Marmara, Karadeniz, İç, Doğu ve Güneydoğu Anadolu Bölgeleri) görülme sıklığı DQA105,8 ve DQB102 ,7 idi. Çalışmamızda HLA DQB1*02 homozigot olan hastalarda (,5) boy kısalığı, ishal, demir eksikliği anemisi, Marsh3 evre ve akrabalarında ÇH daha yüksekti. Sonuç: Çölyak hastalığında HLA-DQ analizi bölgesel sıklığın belirlenmesi genetik analiz maliyetini azaltmak ve bölgesel dağılıma göre özellikle semptomsuz tarama hastalarında genotiplenme yapılması erken tanı kolaylığı sağlayabilir.
Keywords	celiac disease ; genotyping ; hla ; turkey ; çölyak hastalığı ; genotiplendirme ; türkiye ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Kocaeli University
Document type	Article ; Online
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Article ; Online: The relationship between body mass index and renal length in obese children.

Parmaksız, Gönül / Kekeç, Şenay Demir / Cengiz, Nurcan Dinler / Noyan, Aytül

Pediatric nephrology (Berlin, Germany)

2020 Volume 35, Issue 5, Page(s) 901–905

Abstract: Background: Obesity in the pediatric population is a severe public health problem and is associated with various comorbidities. Renal length is an important clinical parameter for the diagnosis and follow-up of renal diseases. The aim of this study was ... ...

Abstract	Background: Obesity in the pediatric population is a severe public health problem and is associated with various comorbidities. Renal length is an important clinical parameter for the diagnosis and follow-up of renal diseases. The aim of this study was to determine the relationship between renal length (measured ultrasonographically) and body mass index (BMI) in obese children, and to develop nomograms for renal length according to BMI. Methods: Renal ultrasound was performed in 368 children without renal disease. Each child's age, gender, weight, height, and BMI (kg/m Results: Weight, height, BMI, and right and left renal length differed significantly between the three groups (p = 0.001). There were significant correlations between renal length with age, weight, height, and BMI. Measurement of renal length was independently associated with BMI, age, and height. BMI was used to create renal length nomograms for obese children, based on multiple regression analysis (R Conclusions: Ultrasonographic measurement of the renal length according to BMI in children can be a useful method in evaluating these children. Smaller-than-normal kidneys can easily remain undiagnosed in obese and overweight children and this nomogram offers an additional method to evaluate the renal size in obese children.
MeSH term(s)	Adolescent ; Body Mass Index ; Body Weight/physiology ; Child ; Child, Preschool ; Female ; Humans ; Kidney/anatomy & histology ; Kidney/diagnostic imaging ; Male ; Nomograms ; Organ Size/physiology ; Overweight/complications ; Overweight/physiopathology ; Pediatric Obesity/complications ; Pediatric Obesity/physiopathology ; Reference Values ; Renal Insufficiency, Chronic/etiology ; Renal Insufficiency, Chronic/prevention & control ; Retrospective Studies ; Sex Factors ; Ultrasonography ; Urogenital Abnormalities/complications ; Urogenital Abnormalities/diagnosis
Language	English
Publishing date	2020-01-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-019-04464-8
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Article ; Online: Evaluation of the relationship between non-alcoholic fatty liver disease and serum c-peptide, c-peptide to glucose and c-peptide to HbA1C ratio in obese children

Hasan Abbasguliyev / Ayhan Gazi Kalaycı / Atakan Comba / Gönül Dinler Çaltepe / Fatma Demirbaş

Journal of Surgery and Medicine, Vol 4, Iss 12, Pp 1128-

2020 Volume 1132

Abstract: Aim: Obesity-related complications such as metabolic syndrome, insulin resistance and non-alcoholic fatty liver disease (NAFLD) have increased in childhood. The aim of this study is to investigate the fasting c-peptide, c-peptide to glucose and c-peptide ...

Abstract	Aim: Obesity-related complications such as metabolic syndrome, insulin resistance and non-alcoholic fatty liver disease (NAFLD) have increased in childhood. The aim of this study is to investigate the fasting c-peptide, c-peptide to glucose and c-peptide to HbA1C ratios in obese children with NAFLD. Methods: This case-control study was conducted from August through November 2018. A total of 60 obese children, 40 with and 20 without NAFLD, were included in the study. Patients with BMI > 2 z-score were considered obese. The ultrasonographic characteristics of NAFLD were identified with liver contrast and brightness in echogenicity. Serum fasting c-peptide levels of patients were compared. Results: Of the 60 patients included in the study, 37 (61.7%) were male and the mean age was 11.9 (2.9) years. The mean ALT, weight BMI, waist circumference, waist to height ratio, serum c-peptide, fasting c-peptide to glucose ratio, fasting c-peptide to HbA1C ratio and insulin levels were considerably higher in patients with NAFLD (P
Keywords	childhood ; c-peptide ; c-peptide-to-glucose ratio ; c-peptide-to-hba1c ratio ; non-alcoholic fatty liver disease ; obesity ; çocukluk çağı ; c-peptit ; c-peptit-glikoz oranı ; c-peptit-hba1c oranı ; non-alkolik yağlı karaciğer hastalığı ; obezite ; Medicine ; R ; Medicine (General) ; R5-920 ; Surgery ; RD1-811
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	Journal of Surgery and Medicine
Document type	Article ; Online
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Article ; Online: Duodenal nodularity in children: a clinical and pathologic study of 17 cases.

Gonul, Caltepe Dinler / Bilge, Can / Gazi, Kalayci Ayhan / Filiz, Karagoz

Indian journal of pathology & microbiology

2011 Volume 54, Issue 2, Page(s) 312–317

Abstract: Aims: Duodenal nodularity is an uncommon endoscopic appearance of numerous visible mucosal nodules in the proximal duodenum. In this retrospective study we aimed to determine the clinical significance and histopathologic features of duodenal nodularity ... ...

Abstract	Aims: Duodenal nodularity is an uncommon endoscopic appearance of numerous visible mucosal nodules in the proximal duodenum. In this retrospective study we aimed to determine the clinical significance and histopathologic features of duodenal nodularity in children. Materials and methods: The medical records of the patients who were defined to have duodenal nodularity by endoscopy were reviewed. Statistical analysis used: The data were expressed as mean ± SD and percentages (%). Results: Seventeen patients with endoscopically defined duodenal nodularity were chosen. The mean age at diagnosis was 12.1 years (range: 6-17 years), 9 males. Abdominal pain (47%) was the most common clinical symptom and antral nodularity (41%) was the most common endoscopic finding in children with duodenal nodularity. Histopathologic evaluation of duodenal nodules revealed chronic inflammation in all patients, increased intercryptal and intraepithelial numbers of eosinophils in 70.5%, and villous atrophy in 47% of patients. Giardia infestation was demonstrated in 6 patients by histologic examination and/or Giardia lamblia-specific antigen positivity in stools. The clinical diagnoses of the patients have shown variations, such as celiac disease, giardiasis, secretory IgA deficiency, and Helicobacter pylori gastritis, and some of them were associated with the others. Conclusions: Although the endoscopic appearance is similar, clinical spectrum and pathologic features are not so similar and there are no specific histomorphologic findings for nodularity. The most demonstrative findings we observed in children were increased lymphocyte and/or eosinophil infiltration in the duodenal mucosa. We suggested that care should be taken in the evaluation of microbiological and immunologic etiologies causing this prominent inflammatory reaction.
MeSH term(s)	Adolescent ; Child ; Duodenum/pathology ; Endoscopy, Gastrointestinal ; Eosinophils/cytology ; Female ; Histocytochemistry ; Humans ; Intestinal Mucosa/pathology ; Lymphocytes/cytology ; Male ; Retrospective Studies
Language	English
Publishing date	2011-04
Publishing country	India
Document type	Case Reports ; Journal Article
ZDB-ID	197621-7
ISSN	0974-5130 ; 0377-4929
ISSN (online)	0974-5130
ISSN	0377-4929
DOI	10.4103/0377-4929.81611
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Article ; Online: Inflammatory bowel disease in Turkish children.

Cakir, Murat / Unal, Fatih / Dinler, Gonul / Baran, Masallah / Yuksekkaya, Hasan Ali / Tumgor, Gokhan / Kasirga, Erhun / Kalayci, Ayhan Gazi / Aydogdu, Sema

World journal of pediatrics : WJP

2015 Volume 11, Issue 4, Page(s) 331–337

Abstract: Background: This study was undertaken to evaluate demographics, clinical manifestations, laboratory findings and outcomes of children with inflammatory bowel disease (IBD) in Turkey.: Methods: We analyzed the medical records of 127 children diagnosed ...

Abstract	Background: This study was undertaken to evaluate demographics, clinical manifestations, laboratory findings and outcomes of children with inflammatory bowel disease (IBD) in Turkey. Methods: We analyzed the medical records of 127 children diagnosed with IBD (under 18 years old) between January 2004 and January 2012 in 8 pediatric gastroenterology centers. Results: Of the 127 patients, 90 (70.9%) suffered from ulcerative colitis (UC), 29 (22.8%) from Crohn's disease (CD), and 8 (6.3%) from IBD unclassified. The mean age of the 127 patients was 11.6 ± 4.1 years, and 11.8% of the patients were below 5 years old. Of the patients, 49.6% were male, and males were more predominant in patients with CD than in those with UC (72.4% vs. 42.2%, P = 0.008; a male/female ratio of 2.62 in CD, P = 0.0016). Approximately one fifth of the patients had extra-intestinal manifestations and 13.3% of the patients had associated diseases. Extraintestinal manifestations and associated diseases were more common in early onset disease [P = 0.017, odds ratio (OR) = 4.02; P = 0.03, OR = 4.1]. Of the patients, 15% had normal laboratory parameters including anemia, high platelet count, hypoalbuminemia, hypoferritinemia, and high sedimentation rate. Area under receiver operation characteristics was used to predict pancolitis in patients with UC. The values of C-reactive protein, sedimentation rate and pediatric ulcerative colitis activity were 0.61 (P = 0.06), 0.66 (P = 0.01) and 0.76 (P = 0.0001), respectively. Four (4.4%) patients with UC underwent colectomy, and finally two (1.5%, 95% confidence interval: 0-3.7%) patients died from primary disease or complications. Conclusions: IBD is an increasing clinical entity in Turkey. Features of IBD are similar to those in other populations, but prospective multicenter studies are needed to analyze the true incidence of IBD in Turkish children.
MeSH term(s)	Adolescent ; Biopsy ; Child ; Child, Preschool ; Colonoscopy ; Female ; Humans ; Infant ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/diagnosis ; Inflammatory Bowel Diseases/epidemiology ; Inflammatory Bowel Diseases/therapy ; Male ; Retrospective Studies ; Turkey/epidemiology
Language	English
Publishing date	2015-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2236681-7
ISSN	1867-0687 ; 1708-8569
ISSN (online)	1867-0687
ISSN	1708-8569
DOI	10.1007/s12519-015-0042-2
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Article ; Online: Tuberculous Peritonitis in Childhood

Gönül Dinler / Gülnar Şensoy

Cocuk Enfeksiyon Dergisi, Vol 03, Iss 05, Pp 182-

2009 Volume 186

Abstract: Tuberculous peritonitis is an uncommon presentation of tuberculosis especially in children. The diagnosis of tuberculous peritonitis is difficult because of the variability of presentation, the protean nature of the manifestation and the limitation of ... ...

Abstract	Tuberculous peritonitis is an uncommon presentation of tuberculosis especially in children. The diagnosis of tuberculous peritonitis is difficult because of the variability of presentation, the protean nature of the manifestation and the limitation of diagnostic tests. Therefore, the diagnosis is often delayed and the rate of complications and mortality increases. High level of suspicion is required for early diagnosis especially in a high-risk population. In this article, we reviewed the symptoms, diagnostic tests, differential diagnosis and treatment of infection based on a systematic review of the literature.
Keywords	Tuberculous peritonitis ; child ; antituberculous therapy ; Pediatrics ; RJ1-570 ; Medicine ; R ; DOAJ:Pediatrics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Infectious and parasitic diseases ; RC109-216 ; Internal medicine ; RC31-1245 ; DOAJ:Internal medicine
Language	Turkish
Publishing date	2009-12-01T00:00:00Z
Publisher	Aves Yayincilik
Document type	Article ; Online
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Article ; Online: Gluconeogenesis defect presenting with resistant hyperglycemia and acidosis mimicking diabetic ketoacidosis.

Paksu, Muhammet Şükrü / Kalkan, Gokhan / Asilioglu, Nazik / Paksu, Sule / Dinler, Gonul

Pediatric emergency care

2011 Volume 27, Issue 12, Page(s) 1180–1181

Abstract: Fructose-1,6-diphosphatase (FDPase) enzyme deficiency is a rare inherited metabolic disease. Affected patients usually present with metabolic crisis including hypoglycemia, acidosis, ketonuria, and hyperuricemia. A previously healthy 8-month-old male ... ...

Abstract	Fructose-1,6-diphosphatase (FDPase) enzyme deficiency is a rare inherited metabolic disease. Affected patients usually present with metabolic crisis including hypoglycemia, acidosis, ketonuria, and hyperuricemia. A previously healthy 8-month-old male infant presented with fever, vomiting, and hypoactivity. He had tachycardia, tachypnea, and a tendency to sleep. The patient had signs of severe dehydration and shock. Laboratory findings revealed significant lactic acidosis, hyperuricemia, hyperglycemia, elevated liver enzyme level, and hyperlipidemia. The urine analysis had evidence of glycosuria and ketonuria. Hyperuricemia, lactic acidemia, and hyperglycemia persisted despite insulin infusion, adequate hydration, and perfusion. Consequently, peritoneal dialysis was started. About 12 hours after dialysis, his metabolic derangements were normalized, and clinical status was improved dramatically. His metabolic disease workup was compatible with FDPase deficiency. Here, we described a metabolic attack of FDPase deficiency presented with hyperglycemia mimicking diabetic ketoacidosis.
MeSH term(s)	Acidosis, Lactic/diagnosis ; Alanine Transaminase/blood ; Aspartate Aminotransferases/blood ; Dehydration/etiology ; Diabetic Ketoacidosis/diagnosis ; Diagnosis, Differential ; Fever/etiology ; Fructose-1,6-Diphosphatase Deficiency/blood ; Fructose-1,6-Diphosphatase Deficiency/complications ; Fructose-1,6-Diphosphatase Deficiency/diagnosis ; Fructose-1,6-Diphosphatase Deficiency/diet therapy ; Fructose-1,6-Diphosphatase Deficiency/urine ; Gluconeogenesis ; Glycosuria/etiology ; Hepatomegaly/blood ; Hepatomegaly/etiology ; Humans ; Hyperglycemia/diagnosis ; Hyperlipidemias/etiology ; Hyperuricemia/etiology ; Infant ; Male ; Peritoneal Dialysis ; Shock, Septic/complications
Chemical Substances	Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2)
Language	English
Publishing date	2011-12
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	632588-9
ISSN	1535-1815 ; 0749-5161
ISSN (online)	1535-1815
ISSN	0749-5161
DOI	10.1097/PEC.0b013e31823b412d
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Article ; Online: Pancreatitis in childhood

Gönül Dinler Çaltepe / Özlem Kırmemiş / Ayhan Gazi Kalaycı

Turk Pediatri Arşivi, Vol 46, Iss 1, Pp 49-

Clinical analysis of 20 cases - Original Article

2011 Volume 54

Abstract: Aim: Pancreatitis rarely occurs in childhood and the underlying causes differ from adults. The aim of this study is to evaluate the documentation of characteristics of our cases diagnosed as pancreatitis.Material and Method: Of the 20 patients (19 acute, ...

Abstract	Aim: Pancreatitis rarely occurs in childhood and the underlying causes differ from adults. The aim of this study is to evaluate the documentation of characteristics of our cases diagnosed as pancreatitis.Material and Method: Of the 20 patients (19 acute, one chronic) who diagnosed as pancreatitis in our clinic during a five year period were analyzed retrospectively, considering clinical and laboratory findings, underlying risk factors and outcome of the illness. Data were analysed with SPSS 16.0 computer package programme.Results: Of the 20 patients 14 were female and 6 were male. The mean age was 11.4±3.62 (2-18) years. The most common risk factors were systemic diseases (15%), drugs (15%), biliary diseases (15%) and trauma (10%). Nine of cases (45%) were idiopathic. One patient with chronic pancreatitis was defined as cystic fibrosis. Two patients had acute recurrent pancreatitis (one with mumps infection). Twenty-two episodes of 19 patients with acute pancreatitis were documented. The serum amylase and lipase were elevated in 81.8% and 90.9% of patients respectively. Pseudocysts (10%), venous thrombosis (10%) and necrotising pancreatitis (5%) were the major complications. None of the patients died. Conclusions: Systemic illnesses, drugs, biliary diseases and trauma are the major risk factors in childhood pancreatitis. Although the mortality rate is low in children, the patients should be considered by means of complication such as pseudocyst and venous thrombosis, especially in severe pancreatitis. (Turk Arch Ped 2011; 46: 49-54)
Keywords	Childhood ; L-asparaginase ; necrotising pancreatitis ; pancreatitis ; pseudocyst ; valproic acid ; venous thrombosis ; Pediatrics ; RJ1-570 ; Medicine ; R ; DOAJ:Pediatrics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	610
Language	Turkish
Publishing date	2011-03-01T00:00:00Z
Publisher	Galenos Yayincilik
Document type	Article ; Online
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Article: Celiac disease in 87 children with typical and atypical symptoms in Black Sea region of Turkey.

Dinler, Gönül / Atalay, Erdal / Kalayci, Ayhan Gazi

World journal of pediatrics : WJP

2009 Volume 5, Issue 4, Page(s) 282–286

Abstract: Background: Celiac disease presents with a spectrum of clinical disorders. The variety of clinical presentations largely depends on age and extraintestinal findings. This study aimed to determine typical and atypical cases according to presenting ... ...

Abstract	Background: Celiac disease presents with a spectrum of clinical disorders. The variety of clinical presentations largely depends on age and extraintestinal findings. This study aimed to determine typical and atypical cases according to presenting symptoms and to evaluate their biochemical and pathological parameters. Methods: Eighty-seven patients with celiac disease in our unit between 2000 and 2007 were reviewed. Their diagnosis was made by serological and histological examination. The patients were divided into two groups according to their typical or atypical symptoms. Results: The mean age of the patients at diagnosis was 8.2 years (range, 1-18 years), but patients presenting with typical symptoms were younger than those presenting with atypical symptoms. The patients in the two groups did not differ significantly in sex, weight and height Z scores except age. Diarrhea (96.3%), abdominal distention (65.4%) and failure to thrive (60%) were the most common clinical presentations in the typical group, and short stature (62.5%) and anemia (31.2%) were the most common in the atypical group. Total/subtotal villous atrophy was significantly higher in the typical group than in the atypical group. Conclusions: Many children with celiac disease show an atypical form. The understanding of presentations of celiac disease may prevent delayed diagnosis. Celiac disease should be specially investigated in patients with recurrent iron deficiency anemia, short stature and autoimmune disorders.
MeSH term(s)	Age Factors ; Anemia, Iron-Deficiency/epidemiology ; Celiac Disease/diagnosis ; Celiac Disease/epidemiology ; Child ; Child, Preschool ; Comorbidity ; Diabetes Mellitus, Type 1/epidemiology ; Diarrhea/epidemiology ; Failure to Thrive/epidemiology ; Female ; Humans ; Male ; Retrospective Studies ; Sex Factors ; Turkey
Language	English
Publishing date	2009-11-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2236681-7
ISSN	1867-0687 ; 1708-8569
ISSN (online)	1867-0687
ISSN	1708-8569
DOI	10.1007/s12519-009-0053-y
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