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Article: Determination of the Allelic Composition of the

Lukina, Kseniia A / Porotnikov, Igor V / Antonova, Olga Yu / Kovaleva, Olga N

2024 Volume 13, Issue 3

Abstract: The lodging of barley significantly limits its potential yield, leads to the deterioration of grain quality, and complicates mechanized harvesting. More than 30 dwarfness and semi-dwarfness genes and loci are known for barley, and their involvement in ... ...

Abstract	The lodging of barley significantly limits its potential yield, leads to the deterioration of grain quality, and complicates mechanized harvesting. More than 30 dwarfness and semi-dwarfness genes and loci are known for barley, and their involvement in breeding can solve the problem of lodging. The most common dwarfing alleles are of the genes
Language	English
Publishing date	2024-01-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants13030376
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Role of macrophages in progression of colorectal cancer: a contrast with the traditional paradigm.

Konstantinov, Aleksei S / Kovaleva, Olga V / Samoilova, Daria V / Shelekhova, Ksenya V

International journal of clinical and experimental pathology

2022 Volume 15, Issue 10, Page(s) 403–411

Abstract: The phenotype of tumor-associated macrophages may be critical for tumor immunity, angiogenesis, and clinical disease outcome. Here, we elucidated the prognostic significance of the neovasculature and macrophages in colorectal cancer. We analyzed the ... ...

Abstract	The phenotype of tumor-associated macrophages may be critical for tumor immunity, angiogenesis, and clinical disease outcome. Here, we elucidated the prognostic significance of the neovasculature and macrophages in colorectal cancer. We analyzed the effect of M2 macrophage density on the clinical behavior of 151 primary colorectal carcinomas using CD206 as a marker for type 2 macrophages. Triple immunohistochemical staining (ERG, SMA, and podoplanin) was used for microvessel evaluation. We found that M2 macrophages in colorectal cancer did not have a direct association with metastatic behavior. However, high numbers of CD206 tumor-associated macrophages correlated positively with recurrence-free interval duration (P=0.005). Fewer macrophages in the tumor microenvironment resulted in insufficient coverage of newly formed vessels by pericytes (P=0.011), and a high number of pericyte-impaired microvessels correlated with metastatic behavior (P<0.001). These results suggested that type 2 macrophages had a role in limiting the metastatic process by affecting vascular maturity and normalization. These findings contribute to understanding complex interactions in the tumor microenvironment and the clinical behavior of colorectal cancer.
Language	English
Publishing date	2022-10-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2418306-4
ISSN	1936-2625 ; 1936-2625
ISSN (online)	1936-2625
ISSN	1936-2625
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Article ; Online: Targeted Sequencing in Gastric Cancer: Association with Tumor Molecular Characteristics and FLOT Therapy Effectiveness.

Spirina, Liudmila V / Avgustinovich, Alexandra V / Bakina, Olga V / Afanas'ev, Sergey G / Volkov, Maxim Yu / Vtorushin, Sergey V / Kovaleva, Irina V / Klyushina, Tatyana S / Munkuev, Igor O

Current issues in molecular biology

2024 Volume 46, Issue 2, Page(s) 1281–1290

Abstract: Heterogeneity of gastric cancer (GC) is the main trigger of the disease's relapse. The aim of this study was to investigate the connections between targeted genes, cancer clinical features, and the effectiveness of FLOT chemotherapy. Twenty-one patients ... ...

Abstract	Heterogeneity of gastric cancer (GC) is the main trigger of the disease's relapse. The aim of this study was to investigate the connections between targeted genes, cancer clinical features, and the effectiveness of FLOT chemotherapy. Twenty-one patients with gastric cancers (GCs) were included in this study. Tumor-targeted sequencing was conducted, and real-time PCR was used to assess the expression of molecular markers in tumors. Seven patients with stabilization had mutations that were related to their response to therapy and were relevant to the tumor phenotype. Two patients had two mutations. The number of patients with TP53 mutations increased in HER2-positive tumor status. PD-L1-positive cancers had mutations in
Language	English
Publishing date	2024-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2000024-8
ISSN	1467-3045 ; 1467-3037
ISSN (online)	1467-3045
ISSN	1467-3037
DOI	10.3390/cimb46020081
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Article ; Online: Macrophage cytotoxic activity and its role in the tumor pathogenesis

Olga V. Kovaleva / Polina A. Podlesnaya / Alexei N. Gratchev

Alʹmanah Kliničeskoj Mediciny, Vol 50, Iss 1, Pp 13-

2022 Volume 20

Abstract: Macrophages, natural killers and T cells play the central role in tumor cells destruction. The purpose of this review is to summarize the state-of-the-art perspectives of the interplay between tumor cells and tumor stroma leading both to the formation of ...

Abstract	Macrophages, natural killers and T cells play the central role in tumor cells destruction. The purpose of this review is to summarize the state-of-the-art perspectives of the interplay between tumor cells and tumor stroma leading both to the formation of a macrophage population incapable of effective antitumor activity and to the selection of tumor cells resistant to macrophage cytotoxicity. Macrophages are highly versatile cells that can both stimulate the inflammatory response (type 1 macrophages, M1) and suppress it (type 2 macrophages, M2). Tumor-associated macrophages (TAMs) are considered the main regulator of the antitumor immune response and usually have anti-inflammatory properties, that is, they belong to M2 type. Tumor cells are able to affect macrophages, "reprogramming" them to perform an immunosuppressive function. In addition, TAMs stimulate angiogenesis and remodelling of the extracellular matrix necessary for metastasis. Recently, more and more studies have been published describing a mixed TAMs phenotype with characteristics of both M2 and M1. M1 is characterized by production of pro-inflammatory cytokines, reactive oxygen species, bactericidal and cytotoxic activity. M1 can destroy tumor cells both directly and indirectly by attracting other cells. Despite the mechanisms of direct cytotoxic activity are quite variable, their effectiveness is largely dependent on the properties of a particular tumor. The cytotoxic activity of macrophages is a powerful factor that inhibits tumor initiation and progression. However, in some cases, it is not sufficient to control the tumor process. Activation of the cytotoxic activity of TAMs is one of the strategies to use macrophages for cancer treatment. Understanding the mechanisms of macrophage cytotoxic activity and specific patterns of its manifestation in a tumor environment is of critical importance for better effectiveness of existing cancer treatments and development of promising methods for tumor immunotherapy.
Keywords	macrophage ; immunity ; cytokine ; tumor ; Medicine ; R
Subject code	610
Language	Russian
Publishing date	2022-04-01T00:00:00Z
Publisher	MONIKI
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Prognostic signature based on mitochondria quality control proteins for the prediction of lung adenocarcinoma patients survival.

Gorbunova, Anna S / Zamaraev, Alexey V / Yapryntseva, Maria A / Kovaleva, Olga V / Tchevkina, Elena M / Turkina, Maria V / Zhivotovsky, Boris / Kopeina, Gelina S

Cell death discovery

2023 Volume 9, Issue 1, Page(s) 352

Abstract: Lung cancer is the leading cause of cancer mortality worldwide. In recent years, the incidence of lung cancer subtype lung adenocarcinoma (LUAD) has steadily increased. Mitochondria, as a pivotal site of cell bioenergetics, metabolism, cell signaling, ... ...

Abstract	Lung cancer is the leading cause of cancer mortality worldwide. In recent years, the incidence of lung cancer subtype lung adenocarcinoma (LUAD) has steadily increased. Mitochondria, as a pivotal site of cell bioenergetics, metabolism, cell signaling, and cell death, are often dysregulated in lung cancer cells. Mitochondria maintenance and integrity depend on mitochondrial quality control proteins (MQCPs). During lung cancer progression, the levels of MQCPs could change and promote cancer cell adaptation to the microenvironment and stresses. Here, univariate and multivariate proportional Cox regression analyses were applied to develop a signature based on the level of MQCPs (dimeric form of BNIP3, DRP1, and SIRT3) in tumorous and non-tumorous samples of 80 patients with LUAD. The MQCP signature could be used to separate the patients with LUAD into high- and low-risk groups. Survival analysis indicated that patients in the high-risk group had dramatically shorter overall survival compared with the low-risk patients. Moreover, a nomogram combining clinicopathologic features and the MQCP signature was constructed and validated to predict 1-, 3-, and 5-year overall survival of the patients. Thus, this study presents a novel signature based on MQCPs as a reliable prognostic tool to predict overall survival for patients with LUAD.
Language	English
Publishing date	2023-09-25
Publishing country	United States
Document type	Journal Article
ISSN	2058-7716
ISSN	2058-7716
DOI	10.1038/s41420-023-01649-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effect of Poly(methacrylic acid) on the Cytokine Level in an In Vivo Tumor Model.

Zhukova, Olga V / Arkhipova, Evgenia V / Kovaleva, Tatiana F / Zykova, Daria A / Dubovskaya, Natalya A

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 14

Abstract: Cancer is a leading cause of mortality globally. Despite remarkable improvements in cancer-treatment approaches, disease recurrence and progression remain major obstacles to therapy. While chemotherapy is still a first-line treatment for a variety of ... ...

Abstract	Cancer is a leading cause of mortality globally. Despite remarkable improvements in cancer-treatment approaches, disease recurrence and progression remain major obstacles to therapy. While chemotherapy is still a first-line treatment for a variety of cancers, the focus has shifted to the development and application of new approaches to therapy. Nevertheless, the relationship between immune response, neoplastic diseases and treatment efficiency is not fully understood. Therefore, the aim of the study was to investigate the immunopharmacological effects of methacrylic acid homopolymer in an in vivo tumor model. Materials and methods: Monomeric methacrylic acid was used to synthesize polymers. Methacrylic acid was polymerized in dioxane in the presence of 4-Cyano-4-[(dodecylsulfanylthiocarbonyl)sulfanyl]pentanoic acid. To study the molecular weight characteristics of PMAA by GPC, carboxyl groups were preliminarily methylated with diazomethane. An experimental cancer model was obtained by grafting RMK1 breast cancer cells. The serum levels of IL-6, IL-10, IL-17, transforming growth factor β1 (TGF-β1), and tumor necrosis factor α (TNF-α) were measured by ELISA. Results: The effect of PMAA on the serum concentrations of several cytokines was studied upon its single administration to laboratory animals in early neoplastic process. The IL-6, IL-17 and TGF-β1 concentrations were found to change significantly and reach the level observed in intact rats. The IL-10 concentration tended to normalize. Conclusion: The positive results obtained are the basis for further studies on the effect of methacrylic-acid polymers with different molecular-weight characteristics on the neoplastic process.
MeSH term(s)	Animals ; Cytokines ; Interleukin-10 ; Interleukin-17 ; Interleukin-6 ; Neoplasms, Experimental/drug therapy ; Poly A ; Polymers ; Polymethacrylic Acids/pharmacology ; Rats ; Transforming Growth Factor beta1 ; Tumor Necrosis Factor-alpha
Chemical Substances	Cytokines ; Interleukin-17 ; Interleukin-6 ; Polymers ; Polymethacrylic Acids ; Transforming Growth Factor beta1 ; Tumor Necrosis Factor-alpha ; Interleukin-10 (130068-27-8) ; Poly A (24937-83-5) ; polymethacrylic acid (25087-26-7)
Language	English
Publishing date	2022-07-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27144572
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Article ; Online: Optimization of Extraction of Phlorotannins from the Arctic

Obluchinskaya, Ekaterina D / Pozharitskaya, Olga N / Shevyrin, Vadim A / Kovaleva, Elena G / Flisyuk, Elena V / Shikov, Alexander N

Marine drugs

2023 Volume 21, Issue 5

Abstract: Phlorotannins are secondary metabolites produced mainly by brown seaweeds (Phaeophyceae) and belong to the class of polyphenolic compounds with diverse bioactivities. The key factors in the extraction of polyphenols are the selection of a suitable ... ...

Abstract	Phlorotannins are secondary metabolites produced mainly by brown seaweeds (Phaeophyceae) and belong to the class of polyphenolic compounds with diverse bioactivities. The key factors in the extraction of polyphenols are the selection of a suitable solvent, method of extraction and selection of optimal conditions. Ultrasonic-assisted extraction (UAE) is one of the advanced energy-saving methods suitable for the extraction of labile compounds. Methanol, acetone, ethanol and ethyl acetate are the most commonly used solvents for polyphenol extraction. As alternatives to toxic organic solvents, a new class of green solvents, natural deep eutectic solvents (NADES), has been proposed for the efficient extraction of a wide range of natural compounds including polyphenols. Several NADES were screened previously for the extraction of phlorotannins; however, the extraction conditions were not optimized and chemical profiling of NADES extract was not performed. The purpose of this work was to study the effect of selected extraction parameters on the phlorotannin content in NADES extract from
MeSH term(s)	Tandem Mass Spectrometry ; Deep Eutectic Solvents ; Fucus/chemistry ; Chromatography, High Pressure Liquid/methods ; Plant Extracts/chemistry ; Solvents/chemistry
Chemical Substances	Deep Eutectic Solvents ; Plant Extracts ; Solvents
Language	English
Publishing date	2023-04-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md21050263
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Article ; Online: Conjugates of amiridine and thiouracil derivatives as effective inhibitors of butyrylcholinesterase with the potential to block β-amyloid aggregation.

Khudina, Olga G / Grishchenko, Maria V / Makhaeva, Galina F / Kovaleva, Nadezhda V / Boltneva, Natalia P / Rudakova, Elena V / Lushchekina, Sofya V / Shchegolkov, Evgeny V / Borisevich, Sophia S / Burgart, Yanina V / Saloutin, Victor I / Charushin, Valery N

Archiv der Pharmazie

2023 Volume 357, Issue 2, Page(s) e2300447

Abstract: New amiridine-thiouracil conjugates with different substituents in the pyrimidine fragment (R = ... ...

Abstract	New amiridine-thiouracil conjugates with different substituents in the pyrimidine fragment (R = CH
MeSH term(s)	Humans ; Butyrylcholinesterase/metabolism ; Acetylcholinesterase/metabolism ; Molecular Docking Simulation ; Structure-Activity Relationship ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/chemistry ; Amyloid beta-Peptides/metabolism ; Pyrimidines ; Alzheimer Disease ; Aminoquinolines
Chemical Substances	Butyrylcholinesterase (EC 3.1.1.8) ; Acetylcholinesterase (EC 3.1.1.7) ; amiridine (CV71VTP0VN) ; Cholinesterase Inhibitors ; Amyloid beta-Peptides ; Pyrimidines ; Aminoquinolines
Language	English
Publishing date	2023-12-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	6381-2
ISSN	1521-4184 ; 0365-6233 ; 1437-1014
ISSN (online)	1521-4184
ISSN	0365-6233 ; 1437-1014
DOI	10.1002/ardp.202300447
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Article ; Online: Synthesis of Norabietyl and Nordehydroabietyl Imidazolidine-2,4,5-Triones and Their Activity against Tyrosyl-DNA Phosphodiesterase 1

Kseniya S. Kovaleva / Olga I. Yarovaya / Irina A. Chernyshova / Alexandra L. Zakharenko / Sergey V. Cheresiz / Amirhossein Azimirad / Andrey G. Pokrovsky / Olga I. Lavrik / Nariman F. Salakhutdinov

Molbank, Vol 2023, Iss 4, p M

2023 Volume 1743

Abstract: New imidazolidine-2,4,5-triones with norabietic, nordehydroabietic, and adamantane substituents were synthesized by reacting oxalyl chloride and the corresponding ureas, providing good yields. Bioisosteric replacement of the ureide group with a parabanic ...

Abstract	New imidazolidine-2,4,5-triones with norabietic, nordehydroabietic, and adamantane substituents were synthesized by reacting oxalyl chloride and the corresponding ureas, providing good yields. Bioisosteric replacement of the ureide group with a parabanic acid fragment made it possible to increase the solubility of compounds and conduct biological studies. The compounds inhibit the DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 in submicromolar concentrations. Cytotoxic concentrations were also studied on the glioblastoma cell line SNB19.
Keywords	resin acids ; TDP1 inhibitors ; heterocyclic compounds ; DNA repair ; parabanic acid ; adamantane ; Inorganic chemistry ; QD146-197
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Zonal Patterns of Changes in the Taxonomic Composition of Culturable Microfungi Isolated from Permafrost Peatlands of the European Northeast

Vinogradova, Yulia A. / Kovaleva, Vera A. / Perminova, Evgenia M. / Shakhtarova, Olga V. / Lapteva, Elena M.

Diversity. 2023 May 09, v. 15, no. 5

2023

Abstract: This paper provides the results of a study on fungal species diversity in the active and permafrost layers of peatlands within frozen peatbogs in the flatland areas of the cryolitozone, European Northeast of Russia (forest-tundra zone, southern and ... ...

Abstract	This paper provides the results of a study on fungal species diversity in the active and permafrost layers of peatlands within frozen peatbogs in the flatland areas of the cryolitozone, European Northeast of Russia (forest-tundra zone, southern and northern tundra subzones). Fungal taxonomic list includes eighty-three species from seventeen genera and two forms of Mycelia sterilia. The phylum Mucoromycota is represented by fifteen species (18% of total isolate number), and these species exhibit the following distribution by genus: Mucor (four), Mortierella (seven), Umbelopsis (three), Podila (one). Ascomycota is represented by sixty-eight species from thirteen genera. The genus Penicillium dominates the species saturation (thirty-seven species, 44%). Soil microfungal complex is represented by rare species (51%), random species (32%), frequent species (15%), and dominant species (2%). In peat soils, dominant species are Penicillium canescens (72%) and non-pigmented (albino) Mycelia sterilia (61%); abundant species are Talaromyces funiculosus (41%), Pseudogymnoascus pannorum (36%), albino Mycelia sterilia (29%), Umbelopsis vinacea (25%), Mortierella alpina (17%), Penicillium decumbens (21%), P. spinulosum (20%), and P. canescens (17%). In active layers of peat soils, abundant species are Penicillium thomii (14%), Mycelia sterilia (13%), Penicillium spinulosum (13%), Penicillium simplicissimum (13%) in forest-tundra; Talaromyces funiculosus (21%), albino Mycelia sterilia (15%), Umbelopsis vinacea (14%) in southern tundra; Penicillium decumbens (23%), P. canescens (17%), P. thomii (13%) in northern tundra. In permafrost peat layers, abundant species are Penicillium spinulosum (17%), Talaromyces funiculosus (34%), and Umbelopsis vinacea (15%) in forest-tundra; Pseudogymnoascus pannorum (30%) and Mortierella alpina (28%) in southern tundra; Pseudogymnoascus pannorum (80%) in northern tundra.
Keywords	Agonomycetes ; Mortierella alpina ; Mucor ; Penicillium decumbens ; Penicillium simplicissimum ; Pseudogymnoascus pannorum ; Russia ; Talaromyces funiculosus ; Umbelopsis ; albino ; dominant species ; fungi ; peat ; peatlands ; permafrost ; rare species ; species diversity ; taxonomy ; tundra
Language	English
Dates of publication	2023-0509
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2518137-3
ISSN	1424-2818
ISSN	1424-2818
DOI	10.3390/d15050639
Database	NAL-Catalogue (AGRICOLA)

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