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  1. Article ; Online: Editorial

    Chengchao Chu / Yan Zhang

    Frontiers in Chemistry, Vol

    iSensor and iMedicine for human health

    2022  Volume 10

    Keywords sensor ; wearable devices ; electrochemistry ; electroluminescence ; in vitro ; in vivo ; Chemistry ; QD1-999
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: The versatile applications of polydopamine in regenerative medicine

    Shundong Cai / Yuhang Cheng / Chenyue Qiu / Gang Liu / Chengchao Chu

    Smart Materials in Medicine, Vol 4, Iss , Pp 294-

    Progress and challenges

    2023  Volume 312

    Abstract: In recent decades, great progress has been made in regenerative medicine with the development of various functional scaffolds, many of which have been put into practical clinical applications. In this process, biomaterials with excellent properties have ... ...

    Abstract In recent decades, great progress has been made in regenerative medicine with the development of various functional scaffolds, many of which have been put into practical clinical applications. In this process, biomaterials with excellent properties have played an important role, such as medical metal materials, bioceramics, polymers, etc. Among them, melanin-like polymer polydopamine (PDA) attracts increasing scientific interest and shows good clinical application potential: i) PDA can be used as coating material to facilitate the loading of various bioactive molecules; ii) PDA can be applied as the main constituent material of scaffolds to optimize the performances. In this review, the preparation method and polymerization mechanism of PDA are first outlined, and then the advantages of PDA, including good biocompatibility, strong adhesion, antioxidant property, and excellent photothermal properties, are introduced. Next, this review highlights the significant applications of PDA in regenerative medicine, mainly focusing on wound healing, bone repair and regeneration, as well as different forms of tissue engineering. Finally, challenges and prospects on future clinical applications of PDA in regenerative medicine are discussed.
    Keywords Polydopamine ; Regenerative medicine ; Scaffolds ; Wound healing ; Bone regeneration ; Tissue engineering ; Technology ; T
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher KeAi Communications Co., Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Soluble Nanographene C

    Ma, Xiao-Hui / Gao, Xing / Chen, Jia-Ying / Cao, Maofeng / Dai, Qixuan / Jia, Zhe-Kun / Zhou, Yuan-Biao / Zhao, Xin-Jing / Chu, Chengchao / Liu, Gang / Tan, Yuan-Zhi

    Journal of the American Chemical Society

    2024  Volume 146, Issue 4, Page(s) 2411–2418

    Abstract: Nanographene ... ...

    Abstract Nanographene C
    MeSH term(s) Humans ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/therapeutic use ; Photothermal Therapy ; Nanoparticles ; Photochemotherapy/methods ; Neoplasms/drug therapy
    Chemical Substances Photosensitizing Agents
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c08822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: ICG-based laser treatments for ophthalmic diseases: Toward their safe and rapid strategy.

    Ye, Jinfa / Wu, Yiming / Pan, Jintao / Cai, Shundong / Cheng, Yuhang / Chu, Chengchao / Su, Min

    Luminescence : the journal of biological and chemical luminescence

    2023  

    Abstract: The eye is a very important organ, and keratitis, corneal neovascularization, floaters, age-related macular degeneration, and other vision problems have seriously affected people's quality of life. Among the ophthalmic treatments, laser photocoagulations ...

    Abstract The eye is a very important organ, and keratitis, corneal neovascularization, floaters, age-related macular degeneration, and other vision problems have seriously affected people's quality of life. Among the ophthalmic treatments, laser photocoagulations have been proposed and have shown therapeutic effects in clinical settings. However, corneal thinning and bleeding lesions induced by laser damage have led to limit its applications. To treat the issues of traditional hyperthermia treatments, photosensitizers [e.g., indocyanine green (ICG)] have been investigated to increase the therapeutic effects of corneal neovascularization and choroidal neovascularization. In the recent study, with the help of ICG, laser-induced nanobubble was proposed to treat vitreous opacities. The developed strategies could enlarge the effect of laser irradiation and reduce the side effects, so as to expand the scope of laser treatments in clinical ophthalmic diseases.
    Language English
    Publishing date 2023-12-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1470995-8
    ISSN 1522-7243 ; 1522-7235 ; 1099-1271
    ISSN (online) 1522-7243
    ISSN 1522-7235 ; 1099-1271
    DOI 10.1002/bio.4658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Revolutionizing eye care: the game-changing applications of nano-antioxidants in ophthalmology.

    Cheng, Yuhang / Cai, Shundong / Wu, Han / Pan, Jintao / Su, Min / Wei, Xingyuan / Ye, Jinfa / Ke, Lang / Liu, Gang / Chu, Chengchao

    Nanoscale

    2024  Volume 16, Issue 15, Page(s) 7307–7322

    Abstract: Since the theory of free radical-induced aging was proposed in 1956, it has been constantly proven that reactive oxygen species (ROS) produced by oxidative stress play a vital role in the occurrence and progression of eye diseases. However, the inherent ... ...

    Abstract Since the theory of free radical-induced aging was proposed in 1956, it has been constantly proven that reactive oxygen species (ROS) produced by oxidative stress play a vital role in the occurrence and progression of eye diseases. However, the inherent limitations of traditional drug therapy hindered the development of ophthalmic disease treatment. In recent years, great achievements have been made in the research of nanomedicine, which promotes the rapid development of safe theranostics in ophthalmology. In this review, we focus on the applications of antioxidant nanomedicine in the treatment of ophthalmology. The eye diseases were mainly classified into two categories: ocular surface diseases and posterior eye diseases. In each part, we first introduced the pathology of specific diseases about oxidative stress, and then presented the representative application examples of nano-antioxidants in eye disease therapy. Meanwhile, the nanocarriers that were used, the mechanism of function, and the therapeutic effect were also presented. Finally, we summarized the latest research progress and limitations of antioxidant nanomedicine for eye disease treatment and put forward the prospects of future development.
    MeSH term(s) Humans ; Antioxidants/pharmacology ; Ophthalmology ; Oxidative Stress ; Eye Diseases/drug therapy ; Reactive Oxygen Species/pharmacology
    Chemical Substances Antioxidants ; Reactive Oxygen Species
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d4nr00611a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Study on Spraying Construction Method of a Non-Water Reacting Polymer Layer in the Tunnel.

    Sun, Bo / Guo, Chengchao / Chen, Yu / Chu, Xuanxuan / Ma, Xue

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 12

    Abstract: Non-water reacting double-component foamed polyurethane has been increasingly used in the field of transportation. Particularly, it is recognized that a polymer damping layer between tunnel linings and surrounding rocks can improve the seismic ... ...

    Abstract Non-water reacting double-component foamed polyurethane has been increasingly used in the field of transportation. Particularly, it is recognized that a polymer damping layer between tunnel linings and surrounding rocks can improve the seismic performance of tunnels. To facilitate the application of this polymer in tunnels, a spraying construction method of polymer damping layers was proposed. The polymer damping layer was prepared with hydraulic spraying equipment, and the construction process included the pre-treatment of the tunnel base surface, the pressure control of the spraying equipment, the adjustment of the spray gun working parameters and spraying quality control. In this paper, the effects of material ratio, material temperature, environmental factors (i.e., temperature, humidity and wind speed), spraying pressure and spray gun parameters (i.e., speed, distance from the sprayed surface and spray angle) on the layer formation were investigated. Thus, spraying parameters for better spraying performance were recommended. This study will provide technical support for polymer damping layer construction in the seismic design of tunnels.
    Language English
    Publishing date 2022-06-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15124138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The threaten of typhoons to the health of residents in inland areas: a study on the vulnerability of residents to death risk during typhoon "Lekima" : In Jinan, China.

    Ma, Yiwen / Zhang, Xianhui / Zhang, Yingjian / Du, Jipei / Chu, Nan / Wei, Jinli / Cui, Liangliang / Zhou, Chengchao

    BMC public health

    2024  Volume 24, Issue 1, Page(s) 606

    Abstract: Background: Studies had suggested increased risk of death of residents was associated with typhoons, particularly coastal regions. However, these findings ignored the impact of inland typhoons on the health of residents, especially the indirect death ... ...

    Abstract Background: Studies had suggested increased risk of death of residents was associated with typhoons, particularly coastal regions. However, these findings ignored the impact of inland typhoons on the health of residents, especially the indirect death risk caused by typhoons. This study aimed to investigate the acute death risk of residents during inland typhoon Lekima in Jinan, further identify vulnerable populations and areas.
    Methods: We selected the daily death from 11 to 27th August 2019 in Jinan as case period, and conducted a time-stratified case-crossover design to match the contemporaneous data from 2016 to 2018 as control period. We used the generalized linear Poisson models to estimate the related effects of death risk during typhoon Lekima and lag days.
    Results: During the Lekima typhoon month, there were 3,366 deaths occurred in Jinan. Compared to unexposed periods, the acute death risk of non-accidental diseases (especially circulatory diseases), female and the older adults increased significantly in the second week after the typhoon. The maximum significant effect of circulatory disease deaths, female and older adult deaths were appeared on lag9, lag9, and lag13 respectively. And the typhoon-associated RR were 1.19 (95%CI:1.05,1.34), 1.28 (95%CI:1.08,1.52), and 1.22 (95%CI:1.06,1.42) respectively. The acute death risk of residents living in TQ and CQ increased significantly on Lag2 and Lag6 after the typhoon, respectively, while those living in LX, LC, HY, JY, and SH occurred from Lag 8 to Lag 13 after the typhoon. LC lasted the longest days.
    Conclusions: Typhoons would increase the vulnerability of residents living in Jinan which mainly occurred from the seventh day after the typhoon. Residents suffering from non-accidental diseases (circulatory diseases), female and the older adults were more vulnerable. The vulnerability of TQ and CQ occurred on Lag2 and Lag6 after typhoon Lekima, respectively, and the other areas except ZQ and PY occurred from Lag 8 to Lag 13. LC lasted the longest duration. Our findings emphasized the importance of the emergency response, which would help policymakers to identify vulnerable regions and populations accurately during typhoons and formulate the emergency response plan.
    MeSH term(s) Aged ; Female ; Humans ; Cardiovascular Diseases ; China/epidemiology ; Cyclonic Storms ; Male ; Cross-Over Studies
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-024-17667-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A TME-activated in situ nanogenerator for magnetic resonance/fluorescence/photoacoustic imaging.

    Xu, Shuyu / Shi, Xiaoxiao / Chu, Chengchao / Liu, Gang

    Methods in enzymology

    2021  Volume 657, Page(s) 145–156

    Abstract: With the rapid development of biomedical imaging, non-invasive imaging method particularly has been widely used in clinical diagnosis. Different imaging methods have their own advantages, such as higher resolution of optical imaging, deeper penetration ... ...

    Abstract With the rapid development of biomedical imaging, non-invasive imaging method particularly has been widely used in clinical diagnosis. Different imaging methods have their own advantages, such as higher resolution of optical imaging, deeper penetration of acoustic imaging, high resolution photoacoustic imaging (PAI), and multi-parameter guidance of magnetic resonance imaging (MRI). Recent years, multimodal MRI, fluorescence imaging, PAI and others have been verified to play an important role in the field of molecular imaging and provided detail information for accurate in vivo diagnosis. Therefore, the design of multimodal probe that can integrate the above advantages to carry out combined imaging will be more accurate to assist diagnosis and treatment. While tumor microenvironment (TME) is highly critical in validating and optimizing current therapeutic strategies. Herein, we highlight the TME-triggered supramolecular system as an in situ nano-generator for multimodal imaging-guided treatment. The experimental protocols on the PAI/fluorescence imaging/MRI-based diagnosis are described in this chapter.
    MeSH term(s) Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Optical Imaging ; Photoacoustic Techniques ; Tumor Microenvironment
    Language English
    Publishing date 2021-07-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1557-7988
    ISSN (online) 1557-7988
    DOI 10.1016/bs.mie.2021.06.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Nanosensitizer-mediated unique dynamic therapy tactics for effective inhibition of deep tumors.

    Sun, Wenjing / Chu, Chengchao / Li, Shi / Ma, Xiaoqian / Liu, Peifei / Chen, Shileng / Chen, Hongmin

    Advanced drug delivery reviews

    2022  Volume 192, Page(s) 114643

    Abstract: X-ray and ultrasound waves are widely employed for diagnostic and therapeutic purposes in clinic. Recently, they have been demonstrated to be ideal excitation sources that activate sensitizers for the dynamic therapy of deep-seated tumors due to their ... ...

    Abstract X-ray and ultrasound waves are widely employed for diagnostic and therapeutic purposes in clinic. Recently, they have been demonstrated to be ideal excitation sources that activate sensitizers for the dynamic therapy of deep-seated tumors due to their excellent tissue penetration. Here, we focused on the recent progress in five years in the unique dynamic therapy strategies for the effective inhibition of deep tumors that activated by X-ray and ultrasound waves. The concepts, mechanisms, and typical nanosensitizers used as energy transducers are described as well as their applications in oncology. The future developments and potential challenges are also discussed. These unique therapeutic methods are expected to be developed as depth-independent, minimally invasive, and multifunctional strategies for the clinic treatment of various deep malignancies.
    MeSH term(s) Humans ; Photochemotherapy/methods ; Neoplasms/diagnostic imaging ; Neoplasms/drug therapy ; Neoplasms/pathology ; X-Rays
    Language English
    Publishing date 2022-12-06
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 639113-8
    ISSN 1872-8294 ; 0169-409X
    ISSN (online) 1872-8294
    ISSN 0169-409X
    DOI 10.1016/j.addr.2022.114643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: m

    Liu, Rui / Zhong, Yuping / Chen, Rui / Chu, Chengchao / Liu, Gang / Zhou, Yong / Huang, Yazhu / Fang, Zhihong / Liu, Huan

    Theranostics

    2022  Volume 12, Issue 18, Page(s) 7760–7774

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Humans ; Multiple Myeloma/complications ; MicroRNAs/genetics ; Bone Diseases ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B/genetics ; Osteogenesis
    Chemical Substances MicroRNAs ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B
    Language English
    Publishing date 2022-11-14
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2592097-2
    ISSN 1838-7640 ; 1838-7640
    ISSN (online) 1838-7640
    ISSN 1838-7640
    DOI 10.7150/thno.76852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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