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  1. Article ; Online: Endometrial organoids: a reservoir of functional mitochondria for uterine repair.

    Hwang, Sun-Young / Lee, Danbi / Lee, Gaeun / Ahn, Jungho / Lee, Yu-Gyeong / Koo, Hwa Seon / Kang, Youn-Jung

    Theranostics

    2024  Volume 14, Issue 3, Page(s) 954–972

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Female ; Pregnancy ; Humans ; Animals ; Mice ; Uterus ; Endometrium ; Mitochondria ; Organoids ; Infertility
    Language English
    Publishing date 2024-01-01
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2592097-2
    ISSN 1838-7640 ; 1838-7640
    ISSN (online) 1838-7640
    ISSN 1838-7640
    DOI 10.7150/thno.90538
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Intrauterine botulinum toxin A administration promotes endometrial regeneration mediated by IGFBP3-dependent OPN proteolytic cleavage in thin endometrium.

    Lee, Danbi / Ahn, Jungho / Koo, Hwa Seon / Kang, Youn-Jung

    Cellular and molecular life sciences : CMLS

    2023  Volume 80, Issue 1, Page(s) 26

    Abstract: Adequate endometrial growth is a critical factor for successful embryo implantation and pregnancy maintenance. We previously reported the efficacy of intrauterine administration of botulinum toxin A (BoTA) in improving the endometrial angiogenesis and ... ...

    Abstract Adequate endometrial growth is a critical factor for successful embryo implantation and pregnancy maintenance. We previously reported the efficacy of intrauterine administration of botulinum toxin A (BoTA) in improving the endometrial angiogenesis and the rates of embryo implantation. Here, we further evaluated its potent therapeutic effects on the uterine structural and functional repair and elucidated underlying molecular regulatory mechanisms. This study demonstrated that a murine model of thin endometrium was successfully established by displaying dramatically decreased endometrial thickness and the rates of embryo implantation compared to normal endometrium. Interestingly, the expressions of insulin-like growth factor binding protein-3 (IGFBP3) and an active 35 kDa-form of osteopontin (OPN) were significantly reduced in thin endometrium, which were almost fully restored by intrauterine BoTA administration. Neutralization of BoTA-induced IGFBP3 subsequently suppressed proteolytic cleavage of OPN, exhibiting un-recovered endometrial thickness even in the presence of BoTA administration, suggesting that BoTA-induced endometrial regeneration might be mediated by IGFBP3-dependent OPN proteolytic cleavage. Our findings suggest that intrauterine BoTA administration improves the endometrial environment in our murine model with thin endometrium by increasing endometrial receptivity and angiogenesis in a manner dependent on the regulatory effect of IGFBP3 on OPN proteolytic cleavage, proposing BoTA as an efficient therapeutic strategy for the patients with thin endometrium.
    MeSH term(s) Animals ; Female ; Humans ; Mice ; Pregnancy ; Botulinum Toxins, Type A/pharmacology ; Disease Models, Animal ; Embryo Implantation ; Endometrium ; Insulin-Like Growth Factor Binding Protein 3/metabolism ; Osteopontin/metabolism ; Osteopontin/pharmacology
    Chemical Substances Botulinum Toxins, Type A (EC 3.4.24.69) ; Insulin-Like Growth Factor Binding Protein 3 ; Osteopontin (106441-73-0)
    Language English
    Publishing date 2023-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-022-04684-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Twin-width of subdivisions of multigraphs

    Ahn, Jungho / Chakraborti, Debsoumya / Hendrey, Kevin / Oum, Sang-il

    2023  

    Abstract: For each $d\leq3$, we construct a finite set $F_d$ of multigraphs such that for each graph $H$ of girth at least $5$ obtained from a multigraph $G$ by subdividing each edge at least two times, $H$ has twin-width at most $d$ if and only if $G$ has no ... ...

    Abstract For each $d\leq3$, we construct a finite set $F_d$ of multigraphs such that for each graph $H$ of girth at least $5$ obtained from a multigraph $G$ by subdividing each edge at least two times, $H$ has twin-width at most $d$ if and only if $G$ has no minor in $F_d$. This answers a question of Berg\'{e}, Bonnet, and D\'{e}pr\'{e}s asking for the structure of graphs $G$ such that each long subdivision of $G$ has twin-width $4$. As a corollary, we show that the $7\times7$ grid has twin-width $4$, which answers a question of Schidler and Szeider.

    Comment: 44 pages, 6 figures, 1 table
    Keywords Mathematics - Combinatorics ; Computer Science - Discrete Mathematics ; 05C35 ; 05C75
    Publishing date 2023-06-08
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Intrauterine botulinum toxin A administration promotes endometrial regeneration mediated by IGFBP3-dependent OPN proteolytic cleavage in thin endometrium

    Lee, Danbi / Ahn, Jungho / Koo, Hwa Seon / Kang, Youn-Jung

    Cell. Mol. Life Sci.. 2023 Jan., v. 80, no. 1 p.26-26

    2023  

    Abstract: Adequate endometrial growth is a critical factor for successful embryo implantation and pregnancy maintenance. We previously reported the efficacy of intrauterine administration of botulinum toxin A (BoTA) in improving the endometrial angiogenesis and ... ...

    Abstract Adequate endometrial growth is a critical factor for successful embryo implantation and pregnancy maintenance. We previously reported the efficacy of intrauterine administration of botulinum toxin A (BoTA) in improving the endometrial angiogenesis and the rates of embryo implantation. Here, we further evaluated its potent therapeutic effects on the uterine structural and functional repair and elucidated underlying molecular regulatory mechanisms. This study demonstrated that a murine model of thin endometrium was successfully established by displaying dramatically decreased endometrial thickness and the rates of embryo implantation compared to normal endometrium. Interestingly, the expressions of insulin-like growth factor binding protein-3 (IGFBP3) and an active 35 kDa-form of osteopontin (OPN) were significantly reduced in thin endometrium, which were almost fully restored by intrauterine BoTA administration. Neutralization of BoTA-induced IGFBP3 subsequently suppressed proteolytic cleavage of OPN, exhibiting un-recovered endometrial thickness even in the presence of BoTA administration, suggesting that BoTA-induced endometrial regeneration might be mediated by IGFBP3-dependent OPN proteolytic cleavage. Our findings suggest that intrauterine BoTA administration improves the endometrial environment in our murine model with thin endometrium by increasing endometrial receptivity and angiogenesis in a manner dependent on the regulatory effect of IGFBP3 on OPN proteolytic cleavage, proposing BoTA as an efficient therapeutic strategy for the patients with thin endometrium.
    Keywords angiogenesis ; animal models ; botulinum toxin ; embryo implantation ; endometrium ; intrauterine administration ; neutralization ; osteopontin ; pregnancy ; proteolysis ; somatomedins
    Language English
    Dates of publication 2023-01
    Size p. 26.
    Publishing place Springer International Publishing
    Document type Article ; Online
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-022-04684-6
    Database NAL-Catalogue (AGRICOLA)

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  5. Book ; Online: The proper conflict-free $k$-coloring problem and the odd $k$-coloring problem are NP-complete on bipartite graphs

    Ahn, Jungho / Im, Seonghyuk / Oum, Sang-il

    2022  

    Abstract: A proper coloring of a graph is \emph{proper conflict-free} if every non-isolated vertex $v$ has a neighbor whose color is unique in the neighborhood of $v$. A proper coloring of a graph is \emph{odd} if for every non-isolated vertex $v$, there is a ... ...

    Abstract A proper coloring of a graph is \emph{proper conflict-free} if every non-isolated vertex $v$ has a neighbor whose color is unique in the neighborhood of $v$. A proper coloring of a graph is \emph{odd} if for every non-isolated vertex $v$, there is a color appearing an odd number of times in the neighborhood of $v$. For an integer $k$, the \textsc{PCF $k$-Coloring} problem asks whether an input graph admits a proper conflict-free $k$-coloring and the \textsc{Odd $k$-Coloring} asks whether an input graph admits an odd $k$-coloring. We show that for every integer $k\geq3$, both problems are NP-complete, even if the input graph is bipartite. Furthermore, we show that the \textsc{PCF $4$-Coloring} problem is NP-complete when the input graph is planar.

    Comment: 13 pages, 2 figures
    Keywords Computer Science - Computational Complexity ; Mathematics - Combinatorics ; 05C15 ; 68Q17
    Publishing date 2022-08-17
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: N-3-oxododecanoyl homoserine lactone exacerbates endothelial cell death by inducing receptor-interacting protein kinase 1-dependent apoptosis.

    Shin, Jungho / Ahn, Sun Hee / Kim, Su Hyun / Oh, Dong-Jin

    American journal of physiology. Cell physiology

    2021  Volume 321, Issue 4, Page(s) C644–C653

    Abstract: Endothelial dysfunction is associated with the initiation of sepsis-associated organ failure. Bacterial quorum-sensing molecules act as pathogen-associated molecular patterns; however, the effects of quorum-sensing molecules on endothelial cells remain ... ...

    Abstract Endothelial dysfunction is associated with the initiation of sepsis-associated organ failure. Bacterial quorum-sensing molecules act as pathogen-associated molecular patterns; however, the effects of quorum-sensing molecules on endothelial cells remain less understood. This study investigated the molecular mechanisms of quorum-sensing molecule-induced cell death and their interaction with lipopolysaccharide (LPS) in human umbilical vein endothelial cells. Endothelial cells were treated with N-3-oxododecanoyl homoserine lactone (3OC12-HSL) and LPS derived from
    MeSH term(s) 4-Butyrolactone/analogs & derivatives ; 4-Butyrolactone/toxicity ; Apoptosis/drug effects ; Caspase 3/metabolism ; Caspase 8/metabolism ; Cells, Cultured ; Enzyme Activation ; Homoserine/analogs & derivatives ; Homoserine/toxicity ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/enzymology ; Human Umbilical Vein Endothelial Cells/pathology ; Humans ; Lipopolysaccharides/toxicity ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Signal Transduction
    Chemical Substances Lipopolysaccharides ; N-(3-oxododecanoyl)homoserine lactone ; Homoserine (6KA95X0IVO) ; RIPK1 protein, human (EC 2.7.11.1) ; Receptor-Interacting Protein Serine-Threonine Kinases (EC 2.7.11.1) ; CASP3 protein, human (EC 3.4.22.-) ; CASP8 protein, human (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-) ; Caspase 8 (EC 3.4.22.-) ; 4-Butyrolactone (OL659KIY4X)
    Language English
    Publishing date 2021-08-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00094.2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: Unified almost linear kernels for generalized covering and packing problems on nowhere dense classes

    Ahn, Jungho / Kim, Jinha / Kwon, O-joung

    2022  

    Abstract: Let $\mathcal{F}$ be a family of graphs, and let $p,r$ be nonnegative integers. The \textsc{$(p,r,\mathcal{F})$-Covering} problem asks whether for a graph $G$ and an integer $k$, there exists a set $D$ of at most $k$ vertices in $G$ such that $G^p\ ... ...

    Abstract Let $\mathcal{F}$ be a family of graphs, and let $p,r$ be nonnegative integers. The \textsc{$(p,r,\mathcal{F})$-Covering} problem asks whether for a graph $G$ and an integer $k$, there exists a set $D$ of at most $k$ vertices in $G$ such that $G^p\setminus N_G^r[D]$ has no induced subgraph isomorphic to a graph in $\mathcal{F}$, where $G^p$ is the $p$-th power of $G$. The \textsc{$(p,r,\mathcal{F})$-Packing} problem asks whether for a graph $G$ and an integer $k$, $G^p$ has $k$ induced subgraphs $H_1,\ldots,H_k$ such that each $H_i$ is isomorphic to a graph in $\mathcal{F}$, and for distinct $i,j\in \{1, \ldots, k\}$, the distance between $V(H_i)$ and $V(H_j)$ in $G$ is larger than $r$. We show that for every fixed nonnegative integers $p,r$ and every fixed nonempty finite family $\mathcal{F}$ of connected graphs, the \textsc{$(p,r,\mathcal{F})$-Covering} problem with $p\leq2r+1$ and the \textsc{$(p,r,\mathcal{F})$-Packing} problem with $p\leq2\lfloor r/2\rfloor+1$ admit almost linear kernels on every nowhere dense class of graphs, and admit linear kernels on every class of graphs with bounded expansion, parameterized by the solution size $k$. We obtain the same kernels for their annotated variants. As corollaries, we prove that \textsc{Distance-$r$ Vertex Cover}, \textsc{Distance-$r$ Matching}, \textsc{$\mathcal{F}$-Free Vertex Deletion}, and \textsc{Induced-$\mathcal{F}$-Packing} for any fixed finite family $\mathcal{F}$ of connected graphs admit almost linear kernels on every nowhere dense class of graphs and linear kernels on every class of graphs with bounded expansion. Our results extend the results for \textsc{Distance-$r$ Dominating Set} by Drange et al. (STACS 2016) and Eickmeyer et al. (ICALP 2017), and the result for \textsc{Distance-$r$ Independent Set} by Pilipczuk and Siebertz (EJC 2021).

    Comment: 38 pages
    Keywords Computer Science - Data Structures and Algorithms ; Mathematics - Combinatorics
    Subject code 511
    Publishing date 2022-07-14
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Unraveling the link between atopic dermatitis and autoimmune diseases in children: Insights from a large-scale cohort study with 15-year follow-up and shared gene ontology analysis.

    Ahn, Jungho / Shin, Seungyong / Lee, Gi Chun / Han, Bo Eun / Lee, Eun / Ha, Eun Kyo / Shin, Jeewon / Lee, Won Seok / Kim, Ju Hee / Han, Man Yong

    Allergology international : official journal of the Japanese Society of Allergology

    2024  Volume 73, Issue 2, Page(s) 243–254

    Abstract: Background: Atopic dermatitis and autoimmune diseases are highly heritable conditions that may co-occur from an early age.: Methods: The primary study is a national administrative cohort study involving 499,428 children born in 2002, tracked until ... ...

    Abstract Background: Atopic dermatitis and autoimmune diseases are highly heritable conditions that may co-occur from an early age.
    Methods: The primary study is a national administrative cohort study involving 499,428 children born in 2002, tracked until 2017. Atopic dermatitis was defined as five or more principal diagnoses of atopic dermatitis and two or more topical steroid prescriptions. We estimated the risks for the occurrence of 41 autoimmune diseases, controlling for risk factors. In addition, we sourced a gene library from the National Library of Medicine to conduct a comprehensive gene ontology. We used Gene Weaver to identify gene set similarity and clustering, and used GeneMania to generate a network for shared genes.
    Results: Exposed and unexposed groups included 39,832 and 159,328 children, respectively. During a mean follow-up of 12 years, the exposed group had an increased risk of autoimmune disease (hazard ratio, 1.27 [95 % confidence interval, 1.23-1.32]) compared to the unexposed group. The hazard ratios of autoimmune illnesses consistently increased with two- and five years lag times and alternative atopic dermatitis definitions. Shared genes between atopic dermatitis and autoimmune diseases were associated with comorbidities such as asthma, bronchiolitis, and specific infections. Genetic interactions of these shared genes revealed clustering in Th1, Th2, Th17, and non-classifiable pathways.
    Conclusions: Atopic dermatitis was significantly associated with an increased risk of subsequent autoimmune disease. we identified the genetically associated disease in atopic dermatitis patients comorbid with autoimmune disease and demonstrated a genetic network between atopic dermatitis and autoimmune diseases.
    MeSH term(s) Child ; Humans ; Young Adult ; Adult ; Dermatitis, Atopic/epidemiology ; Dermatitis, Atopic/genetics ; Dermatitis, Atopic/diagnosis ; Cohort Studies ; Follow-Up Studies ; Gene Ontology ; Gene Regulatory Networks ; Autoimmune Diseases/epidemiology ; Autoimmune Diseases/genetics
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1336498-4
    ISSN 1440-1592 ; 1323-8930
    ISSN (online) 1440-1592
    ISSN 1323-8930
    DOI 10.1016/j.alit.2023.12.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Development of bioinformatics and multi-omics analyses in organoids.

    Ha, Doyeon / Kong, JungHo / Kim, Donghyo / Lee, Kwanghwan / Lee, Juhun / Park, Minhyuk / Ahn, Hyunsoo / Oh, Youngchul / Kim, Sanguk

    BMB reports

    2022  Volume 56, Issue 1, Page(s) 43–48

    Abstract: Pre-clinical models are critical in gaining mechanistic and biological insights into disease progression. Recently, patient-derived organoid models have been developed to facilitate our understanding of disease development and to improve the discovery of ...

    Abstract Pre-clinical models are critical in gaining mechanistic and biological insights into disease progression. Recently, patient-derived organoid models have been developed to facilitate our understanding of disease development and to improve the discovery of therapeutic options by faithfully recapitulating in vivo tissues or organs. As technological developments of organoid models are rapidly growing, computational methods are gaining attention in organoid researchers to improve the ability to systematically analyze experimental results. In this review, we summarize the recent advances in organoid models to recapitulate human diseases and computational advancements to analyze experimental results from organoids. [BMB Reports 2023; 56(1): 43-48].
    MeSH term(s) Humans ; Multiomics ; Organoids ; Computational Biology
    Language English
    Publishing date 2022-10-22
    Publishing country Korea (South)
    Document type Review ; News
    ZDB-ID 2410389-5
    ISSN 1976-670X ; 1976-6696
    ISSN (online) 1976-670X
    ISSN 1976-6696
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: AS-CRI

    Sungho Kim / Jungho Kim / Jinyong Lee / Junmo Ahn

    Remote Sensing, Vol 11, Iss 7, p

    A New Metric of FTIR-Based Apparent Spectral-Contrast Radiant Intensity for Remote Thermal Signature Analysis

    2019  Volume 777

    Abstract: Infrared signature analysis that considers both the target and background is fundamentally important to the development of target detection systems as well as in the design of ships for thermal stealth. This paper presents the analysis results of long- ... ...

    Abstract Infrared signature analysis that considers both the target and background is fundamentally important to the development of target detection systems as well as in the design of ships for thermal stealth. This paper presents the analysis results of long-term infrared signature variations in terms of the apparent spectral-contrast radiant intensity measured using Fourier transform infrared (FTIR)-based hyperspectral images. A novel apparent spectral-contrast radiant intensity (AS-CRI) measure is proposed to evaluate the spectral infrared signature accurately at the sensor point of view. The spectral information by AS-CRI can provide the optimal band for either target detection or thermal stealth purposes, considering the background and atmospheric transmittance. In addition, the effects of seasonal and weather variations were analyzed from the long-term hyperspectral image database constructed during 2018.01–2018.08 (three times a day). A TELOPS HYPER-CAM MWE camera was adopted to acquire 374 bands in 1.5–5.5 μm. The automatic weather system (AWS) can provide 24 h weather recordings for the signature evaluation. The experimental results validate the utility of the novel AS-CRI method to find spectral bands for a range of infrared signature applications including small infrared target detection.
    Keywords infrared signature ; apparent spectral-contrast radiant intensity ; target detection ; thermal stealth ; FTIR ; spectral analysis ; weather variations ; Science ; Q
    Subject code 520
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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