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  1. Article ; Online: Adrenal spindle-cell sarcoma with features of malignant peripheral nerve sheath tumor.

    Harach, H R / Laidler, P

    Endocrine pathology

    2020  Volume 4, Issue 4, Page(s) 222–225

    Abstract: An unusual malignant spindle-cell tumor of the adrenal medulla originally diagnosed as leiomyosarcoma is illustrated. On the evidence of histological and immunohistochemical findings, the neoplasm was rediagnosed as a spindle-cell sarcoma with features ... ...

    Abstract An unusual malignant spindle-cell tumor of the adrenal medulla originally diagnosed as leiomyosarcoma is illustrated. On the evidence of histological and immunohistochemical findings, the neoplasm was rediagnosed as a spindle-cell sarcoma with features of malignant peripheral nerve sheath tumor. Unlike ordinary pheochromocytoma, which may also show a spindling cell pattern, such lesions are malignant and its recognition may have implications for prognosis and management of patients.
    Language English
    Publishing date 2020-03-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1033267-4
    ISSN 1559-0097 ; 1046-3976
    ISSN (online) 1559-0097
    ISSN 1046-3976
    DOI 10.1007/BF02915465
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    Zs.A 2956: Show issues Location:
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  2. Book: Stroke rehabilitation

    Laidler, Polly

    structure and strategy

    1994  

    Author's details Polly Laidler
    Keywords Cerebrovascular Disorders / rehabilitation
    Language English
    Size VIII, 296 S. : Ill.
    Edition 1. ed.
    Publisher Chapman & Hall
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT006521041
    ISBN 0-412-46950-2 ; 978-0-412-46950-3
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1995 A 1077 order for loan Magazin

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  3. Article ; Online: Engaging the Great Circle: a qualitative study of the Confederated Tribes of Grand Ronde’s mobile medication unit

    Hoffman, Kim A / Graves, Chantell / Rowe, Kelly / Worth, Jennifer / Pertl, Kellie / Laidler, James / Korthuis, P Todd / McCarty, Dennis

    Annals of medicine

    2024  Volume 56, Issue 1, Page(s) 2306492

    Abstract: Background: The Confederated Tribes of the Grand Ronde Community of Oregon began a Mobile Medication Unit (MMU) as part of their Great Circle Recovery Opioid Treatment Program (OTP) to address elevated rates of opioid use disorder (OUD) among American ... ...

    Abstract Background: The Confederated Tribes of the Grand Ronde Community of Oregon began a Mobile Medication Unit (MMU) as part of their Great Circle Recovery Opioid Treatment Program (OTP) to address elevated rates of opioid use disorder (OUD) among American Indians and Alaska Natives in Oregon. The MMU provides methadone or buprenorphine for individuals with OUD, enrolled in the OTP, who are living either on the reservation or in surrounding rural communities. An implementation study describes the service through document review and qualitatively assesses patient and staff experiences and the perceived barriers and facilitators to mobile services.
    Methods: Semi-structured qualitative interviews with patients (
    Results: Staff themes identified two driving forces (i.e. staff desire for an inclusive approach to wellness that is accessible to all community members; the catalysts for the MMU), two steps toward MMU development (i.e. Tribal approvals and support; the construction and maintenance of community relationships) and two perspectives on MMU implementation and impact (i.e. initial implementation barriers; facilitators and observations of how the MMU reduced stigma associated with agonist therapy). Patients' themes noted the MMU's professional and 'caring' environment, accessible rural locations and general suggestions including culturally responsive ancillary services.
    Conclusion: The Great Circle MMU enhanced access to opioid agonist therapy for people with OUD (i.e. American Indians/Alaska Natives, and non-natives) living in rural communities. The Confederated Tribes of Grand Ronde operates the first Tribally owned OTP MMU, grounded in cultural humility and committed to Tribal members and the great circle of the larger community.
    MeSH term(s) Humans ; American Indian or Alaska Native ; Methadone/therapeutic use ; Opioid-Related Disorders/therapy ; Quality of Life ; Buprenorphine/therapeutic use ; Opiate Substitution Treatment
    Chemical Substances Methadone (UC6VBE7V1Z) ; Buprenorphine (40D3SCR4GZ)
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1004226-x
    ISSN 1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
    ISSN (online) 1365-2060 ; 1651-2219
    ISSN 0785-3890 ; 1743-1387
    DOI 10.1080/07853890.2024.2306492
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  4. Article: Memorandum prepared by L. B. Currie, P. T. Ellsworth, and H. D. White (Cambridge, Mass., january 1932)

    Laidler, David / Sandilands, Roger

    History of political economy Vol. 34, No. 3 , p. 533-552

    2002  Volume 34, Issue 3, Page(s) 533–552

    Author's details ed. by David Laidler
    Keywords Antizyklische Finanzpolitik ; Wirtschaftspolitik ; Wirtschaftskrise
    Language English
    Publisher Duke Univ. Press
    Publishing place Durham, NC
    Document type Article
    ZDB-ID 281073-6
    Database ECONomics Information System

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  5. Article: Synthesis of combined protein antigens. Cross-linking of Hg-(p-chloromercuribenzoate) and--SH(thiolactone) substituted proteins.

    Laidler, P

    Archivum immunologiae et therapiae experimentalis

    1978  Volume 26, Issue 1-6, Page(s) 85–87

    Abstract: The method of coupling of -Hg (p-chloromercuribenzoate) substituted proteins with protein ... Bm homopolymers. Reaction of p-chloromercuribenzoate with human serum albumin (HSA) was performed ...

    Abstract The method of coupling of -Hg (p-chloromercuribenzoate) substituted proteins with protein substituted by -SH (thiolactone) groups was designed to obtain AnBm type copolymers not associated with An or Bm homopolymers. Reaction of p-chloromercuribenzoate with human serum albumin (HSA) was performed in 1.47 M imidazole. The conjugate was treated with thiolated proteins (human immunoglobulin G or human serum albumin). Disulfide linking of thiolated proteins was negligible under the conditions used. The total yield of polymerization reached the value 35%-75% of proteins taken for the reaction. It depended on the amount of reactive groups substituted and ratio of proteins A/B, used for cross-linking. The results were confirmed by theoretical calculations based on Bernoulli distribution.
    MeSH term(s) Antigens ; Chemical Phenomena ; Chemistry ; Chloromercuribenzoates ; Humans ; Immunoglobulin G ; Organomercury Compounds ; Polymers ; Serum Albumin/immunology ; Sulfhydryl Compounds
    Chemical Substances Antigens ; Chloromercuribenzoates ; Immunoglobulin G ; Organomercury Compounds ; Polymers ; Serum Albumin ; Sulfhydryl Compounds
    Language English
    Publishing date 1978
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 282209-x
    ISSN 1661-4917 ; 0004-069X
    ISSN (online) 1661-4917
    ISSN 0004-069X
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  6. Article ; Online: The inhibition of invasion of human melanoma cells through N-cadherin knock-down.

    Ciołczyk-Wierzbicka, Dorota / Laidler, Piotr

    Medical oncology (Northwood, London, England)

    2018  Volume 35, Issue 4, Page(s) 42

    Abstract: N-cadherin seems to promote cell migration and invasion in many types of cancers. The object of this study is recognition of the possible role of N-cadherin and selected downstream protein kinases: PI3K, ERK1/2, and mTOR in cell invasion in malignant ... ...

    Abstract N-cadherin seems to promote cell migration and invasion in many types of cancers. The object of this study is recognition of the possible role of N-cadherin and selected downstream protein kinases: PI3K, ERK1/2, and mTOR in cell invasion in malignant melanoma. Melanoma cells were transfected with the small interfering RNA (siRNA) that targets human N-cadherin gene (CDH2). Inhibitors LY294002 (PI3K), U0126 (ERK1/2), and everolimus (mTOR) were used to inhibit selected kinases of signalling pathways. In vitro cell invasion was studied using Matrigel and an analysis of matrix metalloproteinases MMP-2 and MMP-9 activity by gelatinase zymogram assay. Treatment of melanoma cell with either siRNA against N-cadherin or protein kinase inhibitors led to significantly decreased MMPs expression and activity, as well as diminished invasion. Both the current and the former results suggest that activation of PI3/AKT, mTOR, and ERK kinase, following N-cadherin expression, contributes not only to increased proliferation but also invasive potential of melanoma cells. The results also indicate that N-cadherin, as well as the studied kinases, should be considered as a potential target in melanoma therapy.
    MeSH term(s) Animals ; Cadherins/metabolism ; Cell Line, Tumor ; Cell Movement/genetics ; Gene Knockdown Techniques ; Humans ; Melanoma/metabolism ; Melanoma/pathology ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Neoplasm Invasiveness/pathology ; Phosphatidylinositol 3-Kinases/metabolism ; Signal Transduction/physiology ; Skin Neoplasms/metabolism ; Skin Neoplasms/pathology ; TOR Serine-Threonine Kinases/metabolism ; Melanoma, Cutaneous Malignant
    Chemical Substances Cadherins ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Mitogen-Activated Protein Kinase 1 (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 3 (EC 2.7.11.24)
    Language English
    Publishing date 2018-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1201189-7
    ISSN 1559-131X ; 0736-0118 ; 1357-0560
    ISSN (online) 1559-131X
    ISSN 0736-0118 ; 1357-0560
    DOI 10.1007/s12032-018-1104-9
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    Zs.A 1899: Show issues Location:
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  7. Article ; Online: Inhibition Effect of Chloroquine and Integrin-Linked Kinase Knockdown on Translation in Melanoma Cells.

    Gil, Dorota / Laidler, Piotr / Zarzycka, Marta / Dulińska-Litewka, Joanna

    International journal of molecular sciences

    2021  Volume 22, Issue 7

    Abstract: The twofold role of autophagy in cancer is often the therapeutic target. Numerous regulatory pathways are shared between autophagy and other molecular processes needed in tumorigenesis, such as translation or survival signaling. Thus, we have assumed ... ...

    Abstract The twofold role of autophagy in cancer is often the therapeutic target. Numerous regulatory pathways are shared between autophagy and other molecular processes needed in tumorigenesis, such as translation or survival signaling. Thus, we have assumed that ILK knockdown should promote autophagy, and used together with chloroquine, an autophagy inhibitor, it could generate a better anticancer effect by dysregulation of common signaling pathways. Expression at the protein level was analyzed using Western Blot; siRNA transfection was done for ILK. Analysis of cell signaling pathways was monitored with phospho-specific antibodies. Melanoma cell proliferation was assessed with the crystal violet test, and migration was evaluated by scratch wound healing assays. Autophagy was monitored by the accumulation of its marker, LC3-II. Our data show that ILK knockdown by siRNA suppresses melanoma cell growth by inducing autophagy through AMPK activation, and simultaneously initiates apoptosis. We demonstrated that combinatorial treatment of melanoma cells with CQ and siILK has a stronger antitumor effect than monotherapy with either of these. It generates the synergistic antitumor effects by the decrease of translation of both global and oncogenic proteins synthesis. In our work, we point to the crosstalk between translation and autophagy regulation.
    MeSH term(s) Animals ; Antineoplastic Combined Chemotherapy Protocols ; Autophagy/drug effects ; Autophagy-Related Protein-1 Homolog/metabolism ; Cell Line, Tumor ; Chloroquine/pharmacology ; Chloroquine/therapeutic use ; Drug Screening Assays, Antitumor ; Humans ; Melanoma, Experimental/drug therapy ; Melanoma, Experimental/metabolism ; Mice ; Protein Biosynthesis/drug effects ; Protein-Serine-Threonine Kinases/antagonists & inhibitors ; RNA, Small Interfering/pharmacology ; RNA, Small Interfering/therapeutic use ; TOR Serine-Threonine Kinases/metabolism
    Chemical Substances RNA, Small Interfering ; Chloroquine (886U3H6UFF) ; integrin-linked kinase (EC 2.7.1.-) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; Autophagy-Related Protein-1 Homolog (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2021-04-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22073682
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  8. Article: Three revolutions in macroeconomics

    Laidler, David

    The European journal of the history of economic thought Vol. 22, No. 1 , p. 1-25

    their nature and influence

    2015  Volume 22, Issue 1, Page(s) 1–25

    Author's details David Laidler
    Keywords Keynesianism ; Monetarism ; rational expectations new classical economics quantity theory ; money ; velocity ; monetary policy ; inflation ; unemployment ; business cycle ; Phillips curve
    Language English
    Publisher Routledge, Taylor & Francis Group
    Publishing place Abingdon, Oxfordshire
    Document type Article
    ZDB-ID 1174455-8
    ISSN 0967-2567
    Database ECONomics Information System

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  9. Article ; Online: In vitro culture Muller cell model to study the role of inverted internal limiting membrane flap technique in macular hole closure.

    Morawski, K / Kocemba-Pilarczyk, K / Zarzycka, M / Dudzik, P / Trojan, S E / Laidler, P

    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society

    2021  Volume 72, Issue 3

    Abstract: Inverted internal limiting membrane (ILM) flap may constitute a scaffold for Muller cells whose migration and proliferation on its surface begin the process of macular hole closure. The goal of the study was to establish an in vitro model of the ... ...

    Abstract Inverted internal limiting membrane (ILM) flap may constitute a scaffold for Muller cells whose migration and proliferation on its surface begin the process of macular hole closure. The goal of the study was to establish an in vitro model of the interaction between ILM and the Muller cells. Vitrectomy with inverted ILM flap was performed in 23 patients due to a full-thickness macular hole (FTMH). After dissection of the inverted flap, the area of ILM peeling was extended and material was collected for cell culture experiments. Muller cells cultured on adherent cell plates showed significantly better growth than on suspension plates. Our results reveal that the presence of the ILM can overcome the growth inhibitory effect of the non-adhesive surface. Moreover, the ILM appears to be the optimal growth surface under normoxia conditions mimicking the microenvironment after vitrectomy and hypoxia which is natural state for Muller cells. The closure rate of FTMH was 100%. Our study revealed that in non-adhesive culture conditions patient derived ILM constitutes an optimal growth surface for Muller cells. We have demonstrated that the ILM effectively stimulates attachment, proliferation, and survival of Müller cells in conditions of normoxia which is the case after vitrectomy. The results strongly advocate for the use of inverted ILM flap method in macular hole closure surgeries.
    MeSH term(s) Basement Membrane ; Ependymoglial Cells ; Epiretinal Membrane ; Humans ; Retinal Perforations/surgery ; Retrospective Studies ; Tomography, Optical Coherence ; Visual Acuity
    Language English
    Publishing date 2021-11-19
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 1125221-2
    ISSN 1899-1505 ; 0867-5910 ; 0044-6033
    ISSN (online) 1899-1505
    ISSN 0867-5910 ; 0044-6033
    DOI 10.26402/jpp.2021.3.08
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    Zs.B 1358: Show issues Location:
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  10. Book: Rehabilitacja po udarze mózgu

    Laidler, Polly

    zasady i strategia

    2014  

    Title translation Stroke rehabilitation.
    Author's details Polly Laidler
    MeSH term(s) Stroke Rehabilitation
    Language Polish
    Dates of publication 2014-2000
    Size 243 pages :, illustrations
    Edition Wydanie II, 5 dodruk.
    Document type Book
    ISBN 9788320047349 ; 832004734X
    Database Catalogue of the US National Library of Medicine (NLM)

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