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  1. Article ; Online: Using EM data to understand COVID-19 pathophysiology - Authors' reply.

    Dittmayer, Carsten / Meinhardt, Jenny / Radbruch, Helena / Radke, Josefine / Heppner, Barbara Ingold / Heppner, Frank L / Stenzel, Werner / Holland, Gudrun / Laue, Michael

    Lancet (London, England)

    2021  Volume 397, Issue 10270, Page(s) 197–198

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-01-08
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(21)00032-5
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  2. Article ; Online: Geriatrische Intensivpatienten : Perspektiven und Grenzen der geriatrischen Intensivmedizin.

    Müller-Werdan, U / Heppner, H-J / Michels, G

    Medizinische Klinik, Intensivmedizin und Notfallmedizin

    2018  Volume 113, Issue 4, Page(s) 256–259

    Abstract: Critically ill geriatric patients are vitally endangered due to the aging processes of organs, the frequently existing multimorbidity with subsequent polypharmacy and the typical geriatric syndrome of functional impairments. Aging processes in organs ... ...

    Title translation Geriatric intensive care patients : Perspectives and limits of geriatric intensive care medicine.
    Abstract Critically ill geriatric patients are vitally endangered due to the aging processes of organs, the frequently existing multimorbidity with subsequent polypharmacy and the typical geriatric syndrome of functional impairments. Aging processes in organs lower the clinical threshold for organ dysfunction and organ failure. Physiological organ aging processes with practical consequences for intensive care medicine are atypical manifestion of sepsis in immunosenescence, altered pharmacokinetics, reduced tolerance to hypovolemia due to proportionally reduced water compartment of the body in old age, the frequently only apparently normal function of the kidneys and the continuous reduction in pulmonary function in old age. The main reasons for changes in therapeutic targets are the will of the patient and risk-benefit considerations. The guidelines of the ethics section of the German Interdisciplinary Association for Intensive Care and Emergency Medicine (DIVI) provide assistance and suggestions for a structured decision-making process.
    MeSH term(s) Aged ; Critical Care ; Critical Illness ; Delivery of Health Care ; Humans ; Sepsis
    Language German
    Publishing date 2018-04-18
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2636018-4
    ISSN 2193-6226 ; 1435-1420 ; 0723-5003 ; 2193-6218 ; 0175-3851
    ISSN (online) 2193-6226 ; 1435-1420
    ISSN 0723-5003 ; 2193-6218 ; 0175-3851
    DOI 10.1007/s00063-018-0440-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Radiation Therapy in Alzheimer's Disease: A Systematic Review.

    Kaul, David / Ehret, Felix / Roohani, Siyer / Jendrach, Marina / Buthut, Maria / Acker, Güliz / Anwar, Muneeba / Zips, Daniel / Heppner, Frank / Prüss, Harald

    International journal of radiation oncology, biology, physics

    2023  Volume 119, Issue 1, Page(s) 23–41

    Abstract: Purpose: Pathophysiological hallmarks of Alzheimer's disease (AD) include extracellular amyloid plaques and intracellular neurofibrillary tangles. Recent studies also demonstrated a role of neuroinflammation in the progression of the disease. Clinical ... ...

    Abstract Purpose: Pathophysiological hallmarks of Alzheimer's disease (AD) include extracellular amyloid plaques and intracellular neurofibrillary tangles. Recent studies also demonstrated a role of neuroinflammation in the progression of the disease. Clinical trials and animal studies using low-dose radiation therapy (LDRT) have shown therapeutic potential for AD. This systematic review summarizes the current evidence on the use of LDRT for the treatment of AD, outlines potential mechanisms of action, and discusses current challenges in the planning of future trials.
    Methods and materials: A systematic review of human and animal studies as well as registered clinical trials describing outcomes for RT in the treatment of AD was conducted. We followed the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Articles published until July 1, 2023, were included.
    Results: The initial search yielded 993 articles. After the removal of duplicates and ineligible publications, a total of 16 (12 animal, 4 human) studies were included. Various dose regimens were utilized in both animal and human trials. The results revealed that LDRT reduced the number of amyloid plaques and neurofibrillary tangles, and it has a role in the regulation of genes and protein expression involved in the pathological progression of AD. LDRT has demonstrated reduced astro- and microgliosis, anti-inflammatory and neuroprotective effects, and an alleviation of symptoms of cognitive deficits in animal models. Most studies in humans suggested improvements in cognition and behavior. None of the trials or studies described significant (>grade 2) toxicity.
    Conclusions: Preclinical studies, animal studies, and early clinical trials in humans have shown a promising role for LDRT in the treatment of AD pathologies, although the underlying mechanisms are yet to be fully explored. Phase I/II/III trials are needed to assess the long-term safety, efficacy, and optimal treatment parameters of LDRT in AD treatment.
    MeSH term(s) Animals ; Humans ; Alzheimer Disease ; Plaque, Amyloid/drug therapy ; Cognition ; Anti-Inflammatory Agents/pharmacology ; Models, Animal ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Peptides/pharmacology ; Amyloid beta-Peptides/therapeutic use ; Disease Models, Animal
    Chemical Substances Anti-Inflammatory Agents ; Amyloid beta-Peptides
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2023.11.044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Why misinterpretation of electron micrographs in SARS-CoV-2-infected tissue goes viral.

    Dittmayer, Carsten / Meinhardt, Jenny / Radbruch, Helena / Radke, Josefine / Heppner, Barbara Ingold / Heppner, Frank L / Stenzel, Werner / Holland, Gudrun / Laue, Michael

    Lancet (London, England)

    2020  Volume 396, Issue 10260, Page(s) e64–e65

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Microscopy, Electron ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Washington
    Keywords covid19
    Language English
    Publishing date 2020-10-05
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)32079-1
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  5. Article ; Online: Using EM data to understand COVID-19 pathophysiology – Authors' reply

    Dittmayer, Carsten / Meinhardt, Jenny / Radbruch, Helena / Radke, Josefine / Heppner, Barbara Ingold / Heppner, Frank L / Stenzel, Werner / Holland, Gudrun / Laue, Michael

    2021  

    Abstract: ... Peer ... ...

    Abstract Peer Reviewed
    Keywords 610 Medizin und Gesundheit ; ddc:610
    Language English
    Publishing date 2021-01-14
    Publisher Robert Koch-Institut
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: COVID-19 im Alter – Die geriatrische Perspektive.

    Wirth, R / Becker, C / Djukic, M / Drebenstedt, C / Heppner, H J / Jacobs, A H / Meisel, M / Michels, G / Nau, R / Pantel, J / Bauer, J M

    Zeitschrift fur Gerontologie und Geriatrie

    2021  Volume 54, Issue 2, Page(s) 152–160

    Abstract: Predominantly the older population is affected by a severe course of COVID-19. The mortality of hospitalized patients with COVID-19 above the age of 80 years is up to 54% in international studies. These observations indicate the necessity to highlight ... ...

    Title translation COVID-19 in old age-The geriatric perspective.
    Abstract Predominantly the older population is affected by a severe course of COVID-19. The mortality of hospitalized patients with COVID-19 above the age of 80 years is up to 54% in international studies. These observations indicate the necessity to highlight the geriatric perspective on this disease. The diagnostics and treatment of COVID-19 do not differ between younger and older patients but atypical symptoms should be expected more frequently in old age. Older subjects show an increased need for rehabilitation after COVID-19. Paradoxically, increasing rehabilitation demands go along with a reduced availability of geriatric rehabilitation options, the latter being a consequence of closure or downsizing of rehabilitation departments during the pandemic. In general, measures of isolation and quarantine should be diligently balanced as the health and emotional consequences of such measures may be severe in older persons. In light of the poor prognosis of older COVID-19 patients, advanced care planning becomes even more relevant. Caregivers and physicians should be encouraged to compose advanced care directives that also reflect the specific circumstances of COVID-19. Fortunately, current data suggest that the effectiveness of the vaccination with the mRNA-vaccines approved in Germany may be equally high in older compared to younger persons.
    MeSH term(s) Aged ; Aged, 80 and over ; COVID-19 ; Germany ; Humans ; Pandemics ; SARS-CoV-2
    Language German
    Publishing date 2021-02-17
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1227032-5
    ISSN 1435-1269 ; 0044-281X ; 0948-6704
    ISSN (online) 1435-1269
    ISSN 0044-281X ; 0948-6704
    DOI 10.1007/s00391-021-01864-0
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    Zs.A 497: Show issues Location:
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  7. Article: Why misinterpretation of electron micrographs in SARS-CoV-2-infected tissue goes viral

    Dittmayer, Carsten / Meinhardt, Jenny / Radbruch, Helena / Radke, Josefine / Heppner, Barbara Ingold / Heppner, Frank L / Stenzel, Werner / Holland, Gudrun / Laue, Michael

    Lancet

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #813929
    Database COVID19

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  8. Article ; Online: Why misinterpretation of electron micrographs in SARS-CoV-2-infected tissue goes viral

    Dittmayer, Carsten / Meinhardt, Jenny / Radbruch, Helena / Radke, Josefine / Heppner, Barbara Ingold / Heppner, Frank L / Stenzel, Werner / Holland, Gudrun / Laue, Michael

    The Lancet

    2020  Volume 396, Issue 10260, Page(s) e64–e65

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/s0140-6736(20)32079-1
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors.

    Beyett, Tyler S / To, Ciric / Heppner, David E / Rana, Jaimin K / Schmoker, Anna M / Jang, Jaebong / De Clercq, Dries J H / Gomez, Gabriel / Scott, David A / Gray, Nathanael S / Jänne, Pasi A / Eck, Michael J

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 2530

    Abstract: Lung cancer is frequently caused by activating mutations in the epidermal growth factor receptor (EGFR). Allosteric EGFR inhibitors offer promise as the next generation of therapeutics, as they are unaffected by common ATP-site resistance mutations and ... ...

    Abstract Lung cancer is frequently caused by activating mutations in the epidermal growth factor receptor (EGFR). Allosteric EGFR inhibitors offer promise as the next generation of therapeutics, as they are unaffected by common ATP-site resistance mutations and synergize with the drug osimertinib. Here, we examine combinations of ATP-competitive and allosteric inhibitors to better understand the molecular basis for synergy. We identify a subset of irreversible EGFR inhibitors that display positive binding cooperativity and synergy with the allosteric inhibitor JBJ-04-125-02 in several EGFR variants. Structural analysis of these complexes reveals conformational changes occur mainly in the phosphate-binding loop (P-loop). Mutation of F723 in the P-loop reduces cooperative binding and synergy, supporting a mechanism in which F723-mediated contacts between the P-loop and the allosteric inhibitor are critical for synergy. These structural and mechanistic insights will aid in the identification and development of additional inhibitor combinations with potential clinical value.
    MeSH term(s) Adenosine Triphosphate ; Aniline Compounds ; Drug Resistance, Neoplasm/genetics ; ErbB Receptors/metabolism ; Humans ; Lung Neoplasms ; Mutation ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology
    Chemical Substances Aniline Compounds ; Protein Kinase Inhibitors ; Adenosine Triphosphate (8L70Q75FXE) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2022-05-09
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-30258-y
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  10. Article ; Online: Intraluminaler Verlauf des femoro-femoralen Cross-over-Bypasses imitiert Blasenstein.

    Sonak, I / Wiedemann, A / Heppner, H J

    Aktuelle Urologie

    2016  Volume 47, Issue 2, Page(s) 148–151

    Abstract: ... of a vascular prosthesis, e.g. a femoro-femoral cross-over bypass graft, is extremely rare. This is emphasised ...

    Title translation Intraluminal Aspect of Femoro-femoral Cross-over Bypass Graft Mimics Bladder Stone.
    Abstract Iatrogenic bladder perforation with delayed diagnosis and treatment in the context of the placement of a vascular prosthesis, e.g. a femoro-femoral cross-over bypass graft, is extremely rare. This is emphasised by the present publication, which is the second published case study worldwide. To identify such a situation is very important because there is a risk of inappropriate treatment if such a bypass complication remains undetected, and the potential complications of an improperly intended "treatment of a bladder stone" may be deleterious or even lethal. Therefore, the involved disciplines should be aware of this possibility in order to initiate relevant diagnostic measures, especially diagnostic cystoscopy, without any delay if symptoms such as voiding disorders or alguria coincide with vascular bypass grafting.
    MeSH term(s) Aged ; Blood Vessel Prosthesis/adverse effects ; Cystoscopy ; Delayed Diagnosis ; Diagnosis, Differential ; Femoral Artery/surgery ; Foreign Bodies/diagnosis ; Foreign Bodies/surgery ; Humans ; Iatrogenic Disease ; Lithotripsy, Laser ; Male ; Peripheral Arterial Disease/surgery ; Postoperative Complications/diagnosis ; Postoperative Complications/surgery ; Reoperation ; Surgical Flaps ; Ureteroscopy ; Urinary Bladder/injuries ; Urinary Bladder/surgery ; Urinary Bladder Calculi/diagnosis ; Urinary Bladder Calculi/surgery ; Urography
    Language German
    Publishing date 2016-04
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 124847-9
    ISSN 1438-8820 ; 0001-7868
    ISSN (online) 1438-8820
    ISSN 0001-7868
    DOI 10.1055/s-0041-109727
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