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  1. Article ; Online: Redox physical oncology: intersections between redox and the physical environment in cancer.

    Espey, Michael Graham

    Free radical biology & medicine

    2015  Volume 79, Page(s) 251–252

    MeSH term(s) Humans ; Neoplasms/metabolism ; Neoplasms/pathology ; Neoplasms/therapy ; Oxidation-Reduction
    Language English
    Publishing date 2015-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2014.11.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2109: Show issues Location:
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  2. Article ; Online: Role of oxygen gradients in shaping redox relationships between the human intestine and its microbiota.

    Espey, Michael Graham

    Free radical biology & medicine

    2013  Volume 55, Page(s) 130–140

    Abstract: The unique anatomy and physiology of the intestine in conjunction with its microbial content create the steepest oxygen gradients in the body, which plunge to near anoxia at the luminal midpoint. Far from static, intestinal oxygen gradients ebb and flow ... ...

    Abstract The unique anatomy and physiology of the intestine in conjunction with its microbial content create the steepest oxygen gradients in the body, which plunge to near anoxia at the luminal midpoint. Far from static, intestinal oxygen gradients ebb and flow with every meal. This in turn governs the redox effectors nitric oxide, hydrogen sulfide, and reactive oxygen species of both host and bacterial origin. This review illustrates how the intestine and microbes utilize oxygen gradients as a backdrop for mechanistically shaping redox relationships and a functional coexistence.
    MeSH term(s) Humans ; Intestines/metabolism ; Intestines/microbiology ; Microbiota ; Oxidation-Reduction ; Oxygen/metabolism
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2013-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2012.10.554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Redox relationships in gut-microbiome interactions.

    Daschner, Phillip J / Grisham, Matthew B / Espey, Michael Graham

    Free radical biology & medicine

    2017  Volume 105, Page(s) 1–2

    MeSH term(s) Bacteria/metabolism ; Gastrointestinal Microbiome ; Humans ; Oxidation-Reduction
    Language English
    Publishing date 2017-02-28
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2017.02.043
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  4. Article: Role of oxygen gradients in shaping redox relationships between the human intestine and its microbiota

    Espey, Michael Graham

    Free Radical Biology and Medicine. 2013 Feb., v. 55

    2013  

    Abstract: The unique anatomy and physiology of the intestine in conjunction with its microbial content create the steepest oxygen gradients in the body, which plunge to near anoxia at the luminal midpoint. Far from static, intestinal oxygen gradients ebb and flow ... ...

    Abstract The unique anatomy and physiology of the intestine in conjunction with its microbial content create the steepest oxygen gradients in the body, which plunge to near anoxia at the luminal midpoint. Far from static, intestinal oxygen gradients ebb and flow with every meal. This in turn governs the redox effectors nitric oxide, hydrogen sulfide, and reactive oxygen species of both host and bacterial origin. This review illustrates how the intestine and microbes utilize oxygen gradients as a backdrop for mechanistically shaping redox relationships and a functional coexistence.
    Keywords humans ; hydrogen sulfide ; hypoxia ; intestines ; microorganisms ; nitric oxide ; oxygen ; physiology ; reactive oxygen species
    Language English
    Dates of publication 2013-02
    Size p. 130-140.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2012.10.554
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: The State of Preclinical Modeling for Early Phase Cancer Trials Using Molecularly Targeted Agents with Radiation.

    Hong, Julie A / Vikram, Bhadrasian / Buchsbaum, Jeffrey / Capala, Jacek / Livinski, Alicia / Teicher, Beverly / Prasanna, Pataje / Ahmed, Mansoor M / Obcemea, Ceferino / Coleman, C Norman / Espey, Michael Graham

    Radiation research

    2022  Volume 198, Issue 6, Page(s) 625–631

    Abstract: Preclinical studies inform and guide the development of novel treatment combination strategies that bridge the laboratory with the clinic. We aimed to evaluate approaches cancer researchers used to justify advancing new combinations of molecularly ... ...

    Abstract Preclinical studies inform and guide the development of novel treatment combination strategies that bridge the laboratory with the clinic. We aimed to evaluate approaches cancer researchers used to justify advancing new combinations of molecularly targeted agents and radiation treatment into early-phase human clinical trials. Unsolicited early phase clinical trial proposals submitted to the National Cancer Institute's Cancer Therapy Evaluation Program between January 2016 and July 2020 were curated to quantify key characteristics and proportion of preclinical data provided by trialists seeking to conduct molecularly targeted agent-radiation combination studies in cancer patients. These data elucidate the current landscape for how the rationale for a molecularly targeted agent-radiation combination therapy is supported by preclinical research and illustrate unique challenges faced in translation at the intersection of precision medicine and radiation oncology.
    MeSH term(s) Humans ; Neoplasms/drug therapy ; Neoplasms/radiotherapy
    Language English
    Publishing date 2022-08-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80322-4
    ISSN 1938-5404 ; 0033-7587
    ISSN (online) 1938-5404
    ISSN 0033-7587
    DOI 10.1667/RADE-22-00077.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Tumor macrophage redox and effector mechanisms associated with hypoxia.

    Espey, Michael Graham

    Free radical biology & medicine

    2006  Volume 41, Issue 11, Page(s) 1621–1628

    Abstract: Monocytes are recruited from the circulation into solid tumors where they differentiate into macrophages with unique phenotypes. While macrophages utilize oxygen in a broad range of immune effector functions, the generation of reactive oxygen and ... ...

    Abstract Monocytes are recruited from the circulation into solid tumors where they differentiate into macrophages with unique phenotypes. While macrophages utilize oxygen in a broad range of immune effector functions, the generation of reactive oxygen and nitrogen oxide species is less clear in the setting of hypoxia, which can be a prominent feature of solid tumors. The relationships among innate immunity, redox systems, and the plasticity of phenotypic changes tumor-associated macrophages undergo in conjunction with tumor hypoxia will be examined.
    MeSH term(s) Animals ; Humans ; Hypoxia/etiology ; Hypoxia/pathology ; Immunity, Innate ; Macrophages/metabolism ; Macrophages/pathology ; Neoplasms/complications ; Neoplasms/pathology ; Neoplasms/therapy ; Oxidation-Reduction
    Language English
    Publishing date 2006-09-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2006.08.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Redox biology

    Espey, Michael Graham

    2006  

    Title variant Immunology-epidemiology
    Institution National Institutes of Health (U.S.)
    Author's details Espey and Ambs
    MeSH term(s) Neoplasms/etiology ; Immunity ; Neoplasms/immunology ; Oxidation-Reduction ; Oxidative Stress/immunology
    Language English
    Publisher National Institutes of Health
    Publishing place Bethesda, Md
    Document type Book
    Note Open-captioned. ; Title from screen banner (viewed July 13, 2007). ; Streaming video (2 hr., 2 min., 38 sec. : sd., col.).
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Article ; Online: Nutritional Interventions for Mitochondrial OXPHOS Deficiencies: Mechanisms and Model Systems.

    Kuszak, Adam J / Espey, Michael Graham / Falk, Marni J / Holmbeck, Marissa A / Manfredi, Giovanni / Shadel, Gerald S / Vernon, Hilary J / Zolkipli-Cunningham, Zarazuela

    Annual review of pathology

    2017  Volume 13, Page(s) 163–191

    Abstract: Multisystem metabolic disorders caused by defects in oxidative phosphorylation (OXPHOS) are severe, often lethal, conditions. Inborn errors of OXPHOS function are termed primary mitochondrial disorders (PMDs), and the use of nutritional interventions is ... ...

    Abstract Multisystem metabolic disorders caused by defects in oxidative phosphorylation (OXPHOS) are severe, often lethal, conditions. Inborn errors of OXPHOS function are termed primary mitochondrial disorders (PMDs), and the use of nutritional interventions is routine in their supportive management. However, detailed mechanistic understanding and evidence for efficacy and safety of these interventions are limited. Preclinical cellular and animal model systems are important tools to investigate PMD metabolic mechanisms and therapeutic strategies. This review assesses the mechanistic rationale and experimental evidence for nutritional interventions commonly used in PMDs, including micronutrients, metabolic agents, signaling modifiers, and dietary regulation, while highlighting important knowledge gaps and impediments for randomized controlled trials. Cellular and animal model systems that recapitulate mutations and clinical manifestations of specific PMDs are evaluated for their potential in determining pathological mechanisms, elucidating therapeutic health outcomes, and investigating the value of nutritional interventions for mitochondrial disease conditions.
    MeSH term(s) Animals ; Humans ; Mitochondrial Diseases/diet therapy ; Nutritional Physiological Phenomena
    Language English
    Publishing date 2017-11-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2227429-7
    ISSN 1553-4014 ; 1553-4006
    ISSN (online) 1553-4014
    ISSN 1553-4006
    DOI 10.1146/annurev-pathol-020117-043644
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Vitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries.

    Levine, Mark / Padayatty, Sebastian J / Espey, Michael Graham

    Advances in nutrition (Bethesda, Md.)

    2011  Volume 2, Issue 2, Page(s) 78–88

    Abstract: A concentration-function approach to vitamin C (ascorbate) has yielded new physiology and pharmacology discoveries. To determine the range of vitamin C concentrations possible in humans, pharmacokinetics studies were conducted. They showed that when ... ...

    Abstract A concentration-function approach to vitamin C (ascorbate) has yielded new physiology and pharmacology discoveries. To determine the range of vitamin C concentrations possible in humans, pharmacokinetics studies were conducted. They showed that when vitamin C is ingested by mouth, plasma and tissue concentrations are tightly controlled by at least 3 mechanisms in healthy humans: absorption, tissue accumulation, and renal reabsorption. A 4th mechanism, rate of utilization, may be important in disease. With ingested amounts found in foods, vitamin C plasma concentrations do not exceed 100 μmol/L. Even with supplementation approaching maximally tolerated doses, ascorbate plasma concentrations are always <250 μmol/L and frequently <150 μmol/L. By contrast, when ascorbate is i.v. injected, tight control is bypassed until excess ascorbate is eliminated by glomerular filtration and renal excretion. With i.v. infusion, pharmacologic ascorbate concentrations of 25-30 mmol/L are safely achieved. Pharmacologic ascorbate can act as a pro-drug for hydrogen peroxide (H(2)O(2)) formation, which can lead to extracellular fluid at concentrations as high as 200 μmol/L. Pharmacologic ascorbate can elicit cytotoxicity toward cancer cells and slow the growth of tumors in experimental murine models. The effects of pharmacologic ascorbate should be further studied in diseases, such as cancer and infections, which may respond to generation of reactive oxygen species via H(2)O(2).
    MeSH term(s) Absorption ; Animals ; Ascorbic Acid/administration & dosage ; Ascorbic Acid/blood ; Ascorbic Acid/pharmacokinetics ; Female ; Humans ; Hydrogen Peroxide/metabolism ; Male ; Mice ; Mice, Knockout ; Neoplasms/metabolism ; Vitamins/administration & dosage ; Vitamins/blood ; Vitamins/pharmacokinetics
    Chemical Substances Vitamins ; Hydrogen Peroxide (BBX060AN9V) ; Ascorbic Acid (PQ6CK8PD0R)
    Language English
    Publishing date 2011-03-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2583634-1
    ISSN 2156-5376 ; 2156-5376
    ISSN (online) 2156-5376
    ISSN 2156-5376
    DOI 10.3945/an.110.000109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The role of antioxidants in the era of cardio‑oncology.

    Vincent, Duncan T / Ibrahim, Yasmine F / Espey, Michael Graham / Suzuki, Yuichiro J

    Cancer chemotherapy and pharmacology

    2013  Volume 72, Issue 6, Page(s) 1157–1168

    Abstract: Although most chemotherapeutic drugs have the potential to exert cardiotoxicity, these drugs have been chosen for use in cancer treatment because survival and curability benefits outweigh the risk of these complications. Anthracyclines, for example, are ... ...

    Abstract Although most chemotherapeutic drugs have the potential to exert cardiotoxicity, these drugs have been chosen for use in cancer treatment because survival and curability benefits outweigh the risk of these complications. Anthracyclines, for example, are a powerful class of chemotherapeutic agents; however, their use is restricted by dose-related cardiotoxicity. Experimental evidence strongly supports the role of reactive oxygen species in this process, suggesting that antioxidants may be effective in protecting the heart from toxicity. Clinical use of antioxidants to protect the heart during anthracycline chemotherapy has been controversial due to the potential for reduced cytotoxic efficacy toward cancer cells. Results from randomized clinical trials addressing whether antioxidants either reduce the incidence of clinical heart failure among patients undergoing anthracycline-based chemotherapy or reduce the response rates to anthracycline-based chemotherapy have been unclear. While anthracyclines are by far the most well-studied antitumor agents with cardiotoxic properties, evidence now shows that reactive oxygen species may play roles in cardiotoxicity induced by other chemotherapeutic agents such as cyclophosphamide, cisplatin, 5-fluorouracil, and trastuzumab. Thus, in the new era of combination therapy and long-term survival of cancer patients, the use of antioxidants to support cancer therapy should be revisited.
    MeSH term(s) Animals ; Anthracyclines/adverse effects ; Anthracyclines/therapeutic use ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Antioxidants/therapeutic use ; Heart Diseases/chemically induced ; Heart Diseases/prevention & control ; Humans ; Neoplasms/drug therapy ; Reactive Oxygen Species/metabolism ; Survival Rate
    Chemical Substances Anthracyclines ; Antineoplastic Agents ; Antioxidants ; Reactive Oxygen Species
    Language English
    Publishing date 2013-08-20
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 6820-2
    ISSN 1432-0843 ; 0344-5704 ; 0943-9404
    ISSN (online) 1432-0843
    ISSN 0344-5704 ; 0943-9404
    DOI 10.1007/s00280-013-2260-4
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