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  1. Article ; Online: In Regard to Nam et al.

    Brown, J Martin

    International journal of radiation oncology, biology, physics

    2021  Volume 109, Issue 4, Page(s) 1124

    Language English
    Publishing date 2021-02-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2020.11.028
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1218: Show issues Location:
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  2. Article: Can the Cans: Determinants of Container Deposit Behavior before and after Introduction of a Container Refund Scheme.

    Phipps, Daniel J / Brown, Daniel J / Hagger, Martin S / Hamilton, Kyra

    Behavioral sciences (Basel, Switzerland)

    2024  Volume 14, Issue 2

    Abstract: Objective: Container deposit schemes are often hailed as a useful avenue to increase consumer recycling rates. Yet, there is little research investigating within-person changes in people's beliefs and behavior following the implementation of these ... ...

    Abstract Objective: Container deposit schemes are often hailed as a useful avenue to increase consumer recycling rates. Yet, there is little research investigating within-person changes in people's beliefs and behavior following the implementation of these schemes, or tests of the mechanisms by which such change has occurred.
    Methods: The current study fills this knowledge gap and assessed container recycling behavior and habits as well as the social cognition factors of attitudes, subjective norms, perceived behavioral control, and intentions in a sample of 90 Queenslanders before the implementation of the container deposit scheme and one and three months post-implementation.
    Results: Analysis of variance indicated more frequent recycling behavior following the implementation of the scheme, as well as stronger habits, intentions, and perceived behavioral control.
    Conclusions: Such a concomitant change in behavior, beliefs, and habits provides support for behavior change theory, while also flagging potential targets for strategies that can be paired with container deposit schemes to enhance their efficacy and uptake.
    Language English
    Publishing date 2024-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651997-5
    ISSN 2076-328X
    ISSN 2076-328X
    DOI 10.3390/bs14020112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Radiation Damage to Tumor Vasculature Initiates a Program That Promotes Tumor Recurrences.

    Brown, J Martin

    International journal of radiation oncology, biology, physics

    2020  Volume 108, Issue 3, Page(s) 734–744

    Abstract: This review, mostly of preclinical data, summarizes the evidence that radiation at doses relevant to radiation therapy initiates a pathway that promotes the reconstitution of the tumor vasculature leading to tumor recurrence. The pathway is not specific ... ...

    Abstract This review, mostly of preclinical data, summarizes the evidence that radiation at doses relevant to radiation therapy initiates a pathway that promotes the reconstitution of the tumor vasculature leading to tumor recurrence. The pathway is not specific to tumors; it promotes repair of damaged and ischemic normal tissues by attracting proangiogenic cells from the bone marrow. For irradiated tumors the pathway comprises: (1) loss of endothelial cells and reduced tumor blood perfusion leading to increased tumor hypoxia and increased levels of hypoxia inducible factor-1 (HIF-1). Alternatively, increased HIF-1 levels may arise by reactive oxygen species (ROS) production caused by tumor reoxygenation. (2) Increased HIF-1 levels lead to increased levels in the tumor of the chemokine stromal cell-derived factor-1 (SDF-1, CXCL12), which captures monocytes/macrophages expressing the CXCR4 receptor of CXCL12. (3) The increased levels of tumor-associated macrophages (TAMs) become highly proangiogenic (M2 polarized) and restore the tumor vasculature, thereby promoting tumor recurrence. The relevance of this pathway for radiation therapy is that it can be blocked in a number of different ways including by inhibitors of monocytes/macrophages, of HIF-1, of CXCL12, of CXCR4, and of CSF-1R, the latter of which is responsible for the M2 polarization of the TAMs. All of these inhibitors produce a robust enhancement of the radiation response of a wide variety of preclinical tumor models. Further, the same inhibitors actually provide protection against radiation damage of several normal tissues. Some of these pathway inhibitors are available clinically, and a first-in-human trial of the CXCR4 inhibitor, plerixafor, with radiation therapy of glioblastoma has yielded promising results, including an impressive increase in local tumor control. Further clinical trials are warranted.
    MeSH term(s) Benzylamines/pharmacology ; Blood Vessels/radiation effects ; Bone Marrow Cells ; Cell Polarity ; Chemokine CXCL12/metabolism ; Cyclams/pharmacology ; Endothelial Cells/radiation effects ; Humans ; Hypoxia-Inducible Factor 1/genetics ; Hypoxia-Inducible Factor 1/metabolism ; Neoplasm Recurrence, Local/blood supply ; Neoplasm Recurrence, Local/etiology ; Neoplasms/blood supply ; Neoplasms/metabolism ; Neoplasms/radiotherapy ; Radiotherapy Dosage ; Reactive Oxygen Species/metabolism ; Receptors, CXCR4/antagonists & inhibitors ; Receptors, CXCR4/metabolism ; Tumor Hypoxia ; Tumor-Associated Macrophages/cytology ; Tumor-Associated Macrophages/metabolism ; Tumor-Associated Macrophages/radiation effects
    Chemical Substances Benzylamines ; CXCL12 protein, human ; CXCR4 protein, human ; Chemokine CXCL12 ; Cyclams ; Hypoxia-Inducible Factor 1 ; Reactive Oxygen Species ; Receptors, CXCR4 ; plerixafor (S915P5499N)
    Language English
    Publishing date 2020-05-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2020.05.028
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1218: Show issues Location:
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  4. Article: Spinal Robotics in Adult Spinal Deformity Surgery: A Systematic Review.

    Khalifeh, Kareem / Brown, Nolan J / Pennington, Zach / Pham, Martin H

    Neurospine

    2024  Volume 21, Issue 1, Page(s) 20–29

    Abstract: Spinal robotics have the potential to improve the consistency of outcomes in adult spinal deformity (ASD) surgery. The objective of this paper is to assess the accuracy of pedicle and S2 alar-iliac (S2AI) screws placed with robotic guidance in ASD ... ...

    Abstract Spinal robotics have the potential to improve the consistency of outcomes in adult spinal deformity (ASD) surgery. The objective of this paper is to assess the accuracy of pedicle and S2 alar-iliac (S2AI) screws placed with robotic guidance in ASD patients. PubMed Central, Google Scholar, and an institutional library database were queried until May 2023. Articles were included if they described ASD correction via robotic guidance and pedicle and/or S2AI screw accuracy. Articles were excluded if they described pediatric/adolescent spinal deformity or included outcomes for both ASD and non-ASD patients without separating the data. Methodological quality was assessed using the Newcastle-Ottawa scale. Primary endpoints were pedicle screw accuracy based on the Gertzbein-Robbins Scale and self-reported accuracy percentages for S2AI screws. Data were extracted for patient demographics, operative details, and perioperative outcomes and assessed using descriptive statistics. Five studies comprising 138 patients were included (mean age 66.0 years; 85 females). A total of 1,508 screws were inserted using robotic assistance (51 S2AI screws). Two studies assessing pedicle screws reported clinically acceptable trajectory rates of 98.7% and 96.0%, respectively. Another study reported a pedicle screw accuracy rate of 95.5%. Three studies reported 100% accuracy across 51 total S2AI screws. Eight total complications and 4 reoperations were reported. Current evidence supports the application of robotics in ASD surgery as safe and effective for placement of both screw types. However, due to the paucity of data, a comprehensive assessment of its incremental benefit over other techniques cannot be made. Further work using expanded cohorts is merited.
    Language English
    Publishing date 2024-02-01
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3031654-6
    ISSN 2586-6591 ; 2586-6583
    ISSN (online) 2586-6591
    ISSN 2586-6583
    DOI 10.14245/ns.2347138.569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Nurses' Utilization of Information Resources for Patient Care Tasks: A Survey of Critical Care Nurses in an Urban Hospital Setting.

    Brown, Rebecca J L / Michalowski, Martin

    Computers, informatics, nursing : CIN

    2022  Volume 40, Issue 10, Page(s) 691–698

    Abstract: Critical care nurses manage complex patient care interventions under dynamic, time-sensitive and constrained conditions, yet clinical decision support systems for nurses are limited compared with advanced practice healthcare providers. In this work, we ... ...

    Abstract Critical care nurses manage complex patient care interventions under dynamic, time-sensitive and constrained conditions, yet clinical decision support systems for nurses are limited compared with advanced practice healthcare providers. In this work, we study and analyze nurses' information-seeking behaviors to inform the development of a clinical decision support system that supports nurses. Nurses from an urban midwestern hospital were recruited to complete an online survey containing eight open-ended questions about resource utilization for various nursing tasks and open space for additional insights. Frequencies and percentages were calculated for resource type, bivariate analyses using Pearson's χ2 test were conducted for differences in resources utilization by years of experience, and content analysis of free text was completed. Forty-five nurses (response rate, 19.6%) identified 38 unique resources, which we organized into a resource taxonomy. Institutional applications were the most common type of resource used (35.6% of all responses) but accounted for only 15.4% of respondents' "go-to resources," suggesting potential areas for improvement. Our findings highlight that knowing where to look for information, the existence of comprehensive information, and fast and easy retrieval of information are key resource seeking attributes that must be considered when designing a clinical decision support system.
    MeSH term(s) Attitude of Health Personnel ; Critical Care ; Hospitals, Urban ; Humans ; Nurses ; Surveys and Questionnaires
    Language English
    Publishing date 2022-10-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2078463-6
    ISSN 1538-9774 ; 1538-2931
    ISSN (online) 1538-9774
    ISSN 1538-2931
    DOI 10.1097/CIN.0000000000000908
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: In Regard to Song et al.

    Brown, J Martin / Carlson, David J

    International journal of radiation oncology, biology, physics

    2020  Volume 110, Issue 1, Page(s) 251–252

    Language English
    Publishing date 2020-11-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2020.06.075
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    Zs.A 1218: Show issues Location:
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  7. Article ; Online: Oblique anterior column realignment with a mini-open posterior column osteotomy for minimally invasive adult spinal deformity correction: illustrative case.

    Pennington, Zach / Brown, Nolan J / Pishva, Seyedamirhossein / González, Hernán F J / Pham, Martin H

    Journal of neurosurgery. Case lessons

    2024  Volume 7, Issue 11

    Abstract: Background: Adult spinal deformity (ASD) occurs from progressive anterior column collapse due to disc space desiccation, compression fractures, and autofusion across disc spaces. Anterior column realignment (ACR) is increasingly recognized as a powerful ...

    Abstract Background: Adult spinal deformity (ASD) occurs from progressive anterior column collapse due to disc space desiccation, compression fractures, and autofusion across disc spaces. Anterior column realignment (ACR) is increasingly recognized as a powerful tool to address ASD by progressively lengthening the anterior column through the release of the anterior longitudinal ligament during lateral interbody approaches. Here, we describe the application of minimally invasive ACR through an oblique antepsoas corridor for deformity correction in a patient with adult degenerative scoliosis and significant sagittal imbalance.
    Observations: A 65-year-old female with a prior history of L4-5 transforaminal lumbar interbody fusion and morbid obesity presented with refractory, severe low-back and lower-extremity pain. Preoperative radiographs showed significant sagittal imbalance. Computed tomography showed a healed L4-5 fusion and a vacuum disc at L3-4 and L5-S1, whereas magnetic resonance imaging was notable for central canal stenosis at L3-4. The patient was treated with a first-stage L5-S1 lateral anterior lumbar interbody fusion with oblique L2-4 ACR. The second-stage posterior approach consisted of a robot-guided minimally invasive T10-ilium posterior instrumented fusion with a mini-open L2-4 posterior column osteotomy (PCO). Postoperative radiographs showed the restoration of her sagittal balance. There were no complications.
    Lessons: Oblique ACR is a powerful minimally invasive tool for sagittal plane correction. When combined with a mini-open PCO, substantial segmental lordosis can be achieved while eliminating the need for multilevel PCO or invasive three-column osteotomies.
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ISSN 2694-1902
    ISSN (online) 2694-1902
    DOI 10.3171/CASE23680
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  8. Article ; Online: The Biology of SBRT: LQ or Something New?

    Brown, J Martin

    International journal of radiation oncology, biology, physics

    2018  Volume 101, Issue 4, Page(s) 964

    MeSH term(s) Brain Neoplasms/radiotherapy ; Brain Neoplasms/secondary ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Dose Fractionation, Radiation ; Humans ; Linear Models ; Lung Neoplasms/radiotherapy ; Radiosurgery/statistics & numerical data ; Wit and Humor as Topic
    Language English
    Publishing date 2018-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2018.02.038
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  9. Article ; Online: Beware of Clinical Trials of DNA Repair Inhibitors.

    Brown, J Martin

    International journal of radiation oncology, biology, physics

    2018  Volume 103, Issue 5, Page(s) 1182–1183

    MeSH term(s) Animals ; Clinical Trials as Topic ; DNA Repair/drug effects ; DNA-Activated Protein Kinase/antagonists & inhibitors ; DNA-Activated Protein Kinase/genetics ; Enzyme Inhibitors/adverse effects ; Humans ; Mice ; Neoplasms/radiotherapy ; Organs at Risk/radiation effects ; Radiation Tolerance/drug effects ; Radiation Tolerance/physiology ; Radiation-Sensitizing Agents/adverse effects ; Radiotherapy Dosage
    Chemical Substances Enzyme Inhibitors ; Radiation-Sensitizing Agents ; DNA-Activated Protein Kinase (EC 2.7.11.1)
    Language English
    Publishing date 2018-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2018.11.063
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  10. Article ; Online: Addendum: Agrochemicals interact synergistically to increase bee mortality.

    Siviter, Harry / Bailes, Emily J / Martin, Callum D / Oliver, Thomas R / Koricheva, Julia / Leadbeater, Ellouise / Brown, Mark J F

    Nature

    2023  Volume 617, Issue 7960, Page(s) E7–E9

    MeSH term(s) Animals ; Bees ; Agrochemicals
    Chemical Substances Agrochemicals
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-05997-7
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