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  1. Book ; Online ; E-Book: Frozen section pathology

    Borczuk, Alain C. / Yantiss, Rhonda K. / Robinson, Brian D. / Scognamiglio, Theresa / D'Alfonso, Timothy M.

    diagnostic challenges

    2021  

    Author's details Alain C. Borczuk, Rhonda K. Yantiss, Brian D. Robinson, Theresa Scognamiglio, Timothy M. D'Alfonso
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (x, 453 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020935385
    ISBN 978-3-030-71308-9 ; 9783030713072 ; 3-030-71308-3 ; 3030713075
    DOI 10.1007/978-3-030-71308-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book ; Online ; E-Book: Precision molecular pathology of prostate cancer

    Robinson, Brian D. / Mosquera, Juan Miguel / Ro, Jae Y. / Divatia, Mukul

    (Molecular pathology library)

    2018  

    Author's details Brian D. Robinson, Juan Miguel Mosquera, Jae Y. Ro, Mukul Divatia editors
    Series title Molecular pathology library
    Keywords Medicine ; Oncology ; Pathology ; Urology
    Subject code 616.07
    Language English
    Size 1 Online-Ressource (xiv, 570 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019634020
    ISBN 978-3-319-64096-9 ; 9783319640645 ; 3-319-64096-8 ; 331964064X
    DOI 10.1007/978-3-319-64096-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  3. Article ; Online: Modeling Biphasic, Non-Sigmoidal Dose-Response Relationships: Comparison of Brain-Cousens and Cedergreen Models for a Biochemical Dataset.

    Abbaraju, Venkat D / Robinson, Tamaraty L / Weiser, Brian P

    ArXiv

    2023  

    Abstract: Biphasic, non-sigmoidal dose-response relationships are frequently observed in biochemistry and pharmacology, but they are not always analyzed with appropriate statistical methods. Here, we examine curve fitting methods for "hormetic" dose-response ... ...

    Abstract Biphasic, non-sigmoidal dose-response relationships are frequently observed in biochemistry and pharmacology, but they are not always analyzed with appropriate statistical methods. Here, we examine curve fitting methods for "hormetic" dose-response relationships where low and high doses of an effector produce opposite responses. We provide the full dataset used for modeling, and we provide the code for analyzing the dataset in SAS using two established mathematical models of hormesis, the Brain-Cousens model and the Cedergreen model. We show how to obtain and interpret curve parameters such as the
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Preprint
    ISSN 2331-8422
    ISSN (online) 2331-8422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Leveraging individual differences to understand grounded procedures.

    Fetterman, Adam K / Robinson, Michael D / Meier, Brian P

    The Behavioral and brain sciences

    2021  Volume 44, Page(s) e6

    Abstract: We applaud the goals and execution of the target article, but note that individual differences do not receive much attention. This is a shortcoming because individual differences can play a vital role in theory testing. In our commentary, we describe ... ...

    Abstract We applaud the goals and execution of the target article, but note that individual differences do not receive much attention. This is a shortcoming because individual differences can play a vital role in theory testing. In our commentary, we describe programs of research of this type and also apply similar thinking to the mechanisms proposed in the target article.
    MeSH term(s) Humans ; Individuality
    Language English
    Publishing date 2021-02-18
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 423721-3
    ISSN 1469-1825 ; 0140-525X
    ISSN (online) 1469-1825
    ISSN 0140-525X
    DOI 10.1017/S0140525X20000382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1470: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Erythropoietin-secreting metanephric adenoma presenting as erythrocytosis.

    Liu, Angela / Kremyanskaya, Marina / Mehrazin, Reza / Si, Qiusheng / Robinson, Brian D / Cushing, Melissa M / Hoffman, Ronald / Ginzburg, Yelena Z

    American journal of hematology

    2023  Volume 98, Issue 11, Page(s) 1808–1813

    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Case Reports
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.27047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1251: Show issues Location:
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  6. Article ; Online: Primary anterior cruciate ligament repair: Current concepts.

    Robinson, John D / Williamson, Tyler / Carson, Taylor / Whelan, Ryan J / Abelow, Stephen P / Gilmer, Brian B

    Journal of ISAKOS : joint disorders & orthopaedic sports medicine

    2023  Volume 8, Issue 6, Page(s) 456–466

    Abstract: The renewed interest in ACL repair over the last two decades stems from advances in modern arthroscopic techniques and clinical studies that have provided evidence that the ACL can reliably heal, and patients can return to sport at a comparable rate to ... ...

    Abstract The renewed interest in ACL repair over the last two decades stems from advances in modern arthroscopic techniques and clinical studies that have provided evidence that the ACL can reliably heal, and patients can return to sport at a comparable rate to ACL reconstruction patients. The ability to maintain and utilize native ACL tissue, with proprioceptive capabilities, and the smaller drill tunnels needed to repair an ACL leads to an overall less invasive procedure and improved early rehabilitation. Additionally, repair avoids a variety of comorbidities associated with autograft harvest. This current concept review details modern techniques of ACL repair and their current studies, a review on the use of biologic enhancement in ACL repair, and other considerations to appropriately integrate ACL repair into the sports medicine orthopaedic surgeon's practice.
    MeSH term(s) Humans ; Anterior Cruciate Ligament/surgery ; Anterior Cruciate Ligament Injuries/surgery ; Anterior Cruciate Ligament Reconstruction/methods ; Transplantation, Autologous ; Sports
    Language English
    Publishing date 2023-08-24
    Publishing country England
    Document type Review ; Journal Article
    ISSN 2059-7762
    ISSN (online) 2059-7762
    DOI 10.1016/j.jisako.2023.08.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Multi-omic profiling of simultaneous ductal carcinoma in situ and invasive breast cancer.

    Kaplan, Henry G / Dowdell, Alexa K / Berry, Anna B / Shimol, Racheli Ben / Robinson, Fred L / Carney, Christopher A / Piening, Brian D

    Breast cancer research and treatment

    2024  

    Abstract: Purpose: The progression of ductal carcinoma in situ (DCIS) to invasive breast carcinoma (IBC) in humans is highly variable. To better understand the relationship between them, we performed a multi-omic characterization of co-occurring DCIS and IBC ... ...

    Abstract Purpose: The progression of ductal carcinoma in situ (DCIS) to invasive breast carcinoma (IBC) in humans is highly variable. To better understand the relationship between them, we performed a multi-omic characterization of co-occurring DCIS and IBC lesions in a cohort of individuals.
    Methods: Formalin-fixed paraffin-embedded tissue samples from 50 patients with co-occurring DCIS and IBC lesions were subjected to DNA-seq and whole transcriptome RNA-seq. Paired DCIS and IBC multi-omics profiles were then interrogated for DNA mutations, gene expression profiles and pathway analysis.
    Results: Most small variants and copy number variations were shared between co-occurring DCIS and IBC lesions, with IBC exhibiting on average a higher degree of additional mutations. However, 36% of co-occurring lesions shared no common mutations and 49% shared no common copy number variations. The most frequent genomic variants in both DCIS and IBC were PIK3CA, TP53, KMT2C, MAP3K1, GATA3 and SF3B1, with KMT2C being more frequent in DCIS and TP53 and MAP3K1 more frequent in IBC, though the numbers are too small for definitive conclusions. The most frequent copy number variations were seen in MCL1, CKSB1 and ERBB2. ERBB2 changes were not seen in IBC unless present in the corresponding DCIS. Transcriptional profiles were highly distinct between DCIS and IBC, with DCIS exhibiting upregulation of immune-related signatures, while IBC showed significant overexpression in genes and pathways associated with cell division and proliferation. Interestingly, DCIS and IBC exhibited significant differential expression of different components of extracellular matrix (ECM) formation and regulation, with DCIS showing overexpression of ECM-membrane interaction components while IBC showed upregulation of genes associated with fibronectin and invadopodia.
    Conclusion: While most co-occurring DCIS and IBC were mutationally similar and suggestive of a common clonal progenitor, transcriptionally the lesions are highly distinct, with IBC expressing key pathways that facilitate invasion and proliferation. These results are suggestive of additional levels of regulation, epigenetic or other, that facilitate the acquisition of invasive properties during tumor evolution.
    Language English
    Publishing date 2024-03-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604563-7
    ISSN 1573-7217 ; 0167-6806
    ISSN (online) 1573-7217
    ISSN 0167-6806
    DOI 10.1007/s10549-024-07270-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1655: Show issues Location:
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  8. Article: Conducting research with Indigenous Peoples in Canada: ethical and policy considerations.

    Morisano, Dominique / Robinson, Margaret / Rush, Brian / Linklater, Renee

    Frontiers in psychology

    2024  Volume 14, Page(s) 1214121

    Abstract: The international context of Indigenous mental health and wellbeing has been shaped by a number of key works recognizing Indigenous rights. Despite international recognitions, the mental health and wellness of Indigenous Peoples continues to be ... ...

    Abstract The international context of Indigenous mental health and wellbeing has been shaped by a number of key works recognizing Indigenous rights. Despite international recognitions, the mental health and wellness of Indigenous Peoples continues to be negatively affected by policies that ignore Indigenous rights, that frame colonization as historical rather than ongoing, or that minimize the impact of assimilation. Research institutions have a responsibility to conduct ethical research; yet institutional guidelines, principles, and policies often serve Indigenous Peoples poorly by enveloping them into Western knowledge production. To counter epistemological domination, Indigenous Peoples assert their research sovereignty, which for the purposes of this paper we define as autonomous control over research conducted on Indigenous territory or involving Indigenous Peoples. Indigenous sovereignty might also be applied to research impacting the landscape and the web of animal and spiritual lives evoked in a phrase such as "all my relations." This narrative review of material developed in the Canadian context examines the alignment with similar work in the international context to offer suggestions and a practice-based implementation tool to support Indigenous sovereignty in research related to wellness, mental health, and substance use. The compilation of key guidelines and principles in this article is only a start; addressing deeper issues requires a research paradigm shift.
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1214121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Evaluating the Learning Curve for In-office Freehand Cognitive Fusion Transperineal Prostate Biopsy.

    Gereta, Sofia / Hung, Michael / Alexanderani, Mohammad K / Robinson, Brian D / Hu, Jim C

    Urology

    2023  Volume 181, Page(s) 31–37

    Abstract: Objective: To define the learning curve of the in-office, freehand MRI-ultrasound cognitive fusion transperineal prostate biopsy (CTPB) by assessing cancer detection, biopsy core quantity and quality, procedure times, and complications over the initial ... ...

    Abstract Objective: To define the learning curve of the in-office, freehand MRI-ultrasound cognitive fusion transperineal prostate biopsy (CTPB) by assessing cancer detection, biopsy core quantity and quality, procedure times, and complications over the initial experience.
    Methods: We reviewed 110 consecutive CTPB performed March 2021-September 2022 by a urologist inexperienced with the PrecisionPoint platform. The study period was divided into quarters to assess for temporal variation in outcomes. Univariable and multivariable analysis modeled the learning curve.
    Results: Across quarters, there were no differences in the detection of clinically significant prostate cancer (Q1:50%, Q2:52%, Q3:50%, Q4:48%, P > .9) or Gleason grade group upgrading by targeted vs systematic biopsy (P = .6). Median procedure times improved with experience (Q1:17 minutes, Q2:14 minutes, Q3:12 minutes, Q4:13 minutes, P = .018). On multivariable analysis, procedure times decreased by 1minute per 20 cases (P < .001). On linear regression, CTPB procedure times approximated transrectal biopsy times after 90 cases (P < .001). The histopathologic core quality did not differ, as evidenced by consistent core length (P = .13) and presence of minimal fibromuscular tissue (P > .9). The most common complications, hematuria and hematospermia, were similar across quarters (P = .7, P = .3, respectively). There was a single episode of urinary retention and no reported infections.
    Conclusion: There is no evidence of a learning curve for CTPB as shown by consistent clinically significant prostate cancer detection, high-quality biopsy cores, and low complications. However, CTPB procedural times begin to approximate cognitive targeted transrectal biopsy times after 90 cases.
    MeSH term(s) Male ; Humans ; Prostate ; Learning Curve ; Prostatic Neoplasms/diagnosis ; Image-Guided Biopsy ; Cognition
    Language English
    Publishing date 2023-08-12
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2023.08.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1142: Show issues Location:
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    Zs.MO 275: Show issues

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  10. Article: Canonical AREs are tumor suppressive regulatory elements in the prostate.

    Augello, Michael A / Chen, Xuanrong / Liu, Deli / Lin, Kevin / Hakansson, Alex / Sjöström, Martin / Khani, Francesca / Deonarine, Lesa D / Liu, Yang / Travascio-Green, Jaida / Wu, Jiansheng / Loda, Massimo / Feng, Felix Y / Robinson, Brian D / Davicioni, Elai / Sboner, Andrea / Barbieri, Christopher E

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The androgen receptor (AR) is the central determinant of prostate tissue identity and differentiation, controlling normal, growth-suppressive prostate-specific gene ... ...

    Abstract The androgen receptor (AR) is the central determinant of prostate tissue identity and differentiation, controlling normal, growth-suppressive prostate-specific gene expression
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.23.581466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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