LIVIVO - Search results -

Search results

Result 1 - 10 of total 143

Search options

Article ; Online: Liposomal Bupivacaine Decreases Intravenous Opioid Use in Patients with Hip Fracture: A Modification to a Novel Pain Protocol.

Stevenson, Kimberly L / Stein, Matthew K / Fryhofer, George W / Looby, Sean / Donegan, Derek / Mehta, Samir

The Journal of the American Academy of Orthopaedic Surgeons

2023 Volume 31, Issue 5, Page(s) e246–e255

Abstract: Introduction: The aim of this study was to determine whether the administration of liposomal bupivacaine decreased opioid use and delirium in patients sustaining a hip fracture.: Methods: A retrospective review of patients with hip fracture from ... ...

Abstract	Introduction: The aim of this study was to determine whether the administration of liposomal bupivacaine decreased opioid use and delirium in patients sustaining a hip fracture. Methods: A retrospective review of patients with hip fracture from September 2018 to October 2019 was performed through our institution's hip fracture registry. A liposomal bupivacaine cocktail was administered intraoperatively. Opioid requirement was determined for postoperative days 1, 2, and 3. Delirium was identified through chart review. Visual analog scale pain scores were averaged for postoperative days 1, 2, and 3. Four groups were analyzed: patients who received liposomal bupivacaine and IV acetaminophen, patients who only received IV acetaminophen, patients who only received liposomal bupivacaine, and control patients whose data were collected before this intervention. Continuous data were compared using a one-way analysis of variance or Student t-test, as applicable. Categorical data were compared using the Fisher exact test. Significance was set at P < 0.05. Results: One hundred nine patients met the inclusion criteria for the study with a mean age of 81.2 years. Eighty-two patients (75.2%) received intraoperative liposomal bupivacaine during the study year. Intravenous opioid requirement was markedly different among all four groups in all postoperative days. Oral opioid requirement and pain scores were not different between groups on any postoperative day. A notable decrease in IV opioid requirement in all postoperative days was seen in the Intervention groups (day 1 P < 0.001, day 2 P = 0.002, and day 3 P = 0.030). There existed a trend toward decreased delirium rates in the Intervention groups compared with the No Intervention group (23.9% vs. 32.8%, P = 0.272). Conclusion: The inclusion of liposomal bupivacaine in our institution's novel pain protocol led to notable decreases in opioid requirement in all postoperative days studied with a trend toward decreased delirium rates as well.
MeSH term(s)	Humans ; Aged, 80 and over ; Analgesics, Opioid ; Bupivacaine ; Anesthetics, Local ; Pain, Postoperative/drug therapy ; Acetaminophen ; Pain Management/methods ; Opioid-Related Disorders ; Retrospective Studies ; Hip Fractures ; Delirium/chemically induced
Chemical Substances	Analgesics, Opioid ; Bupivacaine (Y8335394RO) ; Anesthetics, Local ; Acetaminophen (362O9ITL9D)
Language	English
Publishing date	2023-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200524-1
ISSN	1940-5480 ; 1067-151X
ISSN (online)	1940-5480
ISSN	1067-151X
DOI	10.5435/JAAOS-D-22-00493
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4048: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 274: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A framework for integrating young peers in recovery into adolescent substance use prevention and early intervention.

Paquette, Kristen L / Pannella Winn, Laura A / Wilkey, Catriona M / Ferreira, Kathleen N / Donegan, Laura Rose W

Addictive behaviors

2019 Volume 99, Page(s) 106080

Abstract: Substance use among adolescents is associated with a range of negative outcomes and risk-taking behaviors. Identifying and intervening early is essential to reducing associated risks in adolescence and adulthood. New approaches are needed to equip youth- ... ...

Abstract	Substance use among adolescents is associated with a range of negative outcomes and risk-taking behaviors. Identifying and intervening early is essential to reducing associated risks in adolescence and adulthood. New approaches are needed to equip youth-serving systems with tools to identify and respond to substance use. Screening, Brief Intervention, and Referral to Treatment (SBIRT) has emerged as a promising public health framework and there is a growing research interest in effective adaptations for its use with adolescents. However, healthcare settings, schools, and other community-based settings are slow to adapt SBIRT, citing gaps in knowledge and capacity to deliver evidence-based substance use prevention and early intervention. Further, these settings and the surrounding communities often lack the treatment and other prevention and recovery support resources needed for youth who screen as high-risk. Integrating young adult peers with personal lived experience of substance use recovery may meet this practical need. By drawing upon their shared experiences and skills developed in recovery, young adult peers can provide developmentally appropriate screening and intervention support to youth - while also providing urgently needed skills and time to under resourced settings. This article describes the value of young adult peer roles in expanding youth substance use prevention and early intervention, and features Project Amp as an example. Project Amp was designed as an extended, four-session brief intervention for low to moderate risk adolescents, delivered by trained young adult peers. Project Amp draws on best practices from peer recovery support and prevention and early intervention approaches such as SBIRT.
MeSH term(s)	Adolescent ; Community Health Services ; Early Medical Intervention ; Humans ; Mass Screening ; Peer Group ; Referral and Consultation ; Substance-Related Disorders/prevention & control ; Substance-Related Disorders/therapy ; Young Adult
Language	English
Publishing date	2019-08-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	197618-7
ISSN	1873-6327 ; 0306-4603
ISSN (online)	1873-6327
ISSN	0306-4603
DOI	10.1016/j.addbeh.2019.106080
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1214: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Enhancing adolescent SBIRT with a peer-delivered intervention: An implementation study.

Winn, Laura A Pannella / Paquette, Kristen L / Donegan, Laura Rose W / Wilkey, Catriona M / Ferreira, Kathleen N

Journal of substance abuse treatment

2019 Volume 103, Page(s) 14–22

Abstract: Purpose: Innovations in adolescent prevention and early intervention strategies are needed to curb early substance use and bring public health models to scale, such as Screening, Brief Intervention, and Referral to Treatment (SBIRT). Young adults in ... ...

Abstract	Purpose: Innovations in adolescent prevention and early intervention strategies are needed to curb early substance use and bring public health models to scale, such as Screening, Brief Intervention, and Referral to Treatment (SBIRT). Young adults in recovery may have an important role to play in delivering these innovations. However, clinics, schools, and community programs may face barriers when implementing new prevention and early intervention approaches in their settings. The purpose of this study is to examine the feasibility, barriers, and facilitators of Project Amp, an innovative, four-session prevention and early intervention model to enhance SBIRT for adolescents. Methods: Three school-based programs and three health clinics were selected to implement SBIRT for adolescents and refer eligible adolescents (13-17 years old, moderate risk for substance use disorder) to the study intervention. Between three and six mentors (young adults, 18-28 years old, with lived experience of substance use recovery, also known as peers), were recruited at each site and trained in core skills to deliver the intervention. Study staff communicated with each setting throughout implementation and collected quantitative and qualitative data regarding facilitators and barriers to success. The qualitative data were analyzed to identify key strategies for success when implementing Project Amp. Results: Across the six sites, 71 practitioners including physicians, nurses, social workers, and counselors, completed training in SBIRT and 30 mentors were hired and trained for the study. Twenty completed sessions with adolescent participants. A total of 1192 adolescents were screened using the CRAFFT. Of those screened, 139 (12%) were eligible, 51 eligible youth (37%) enrolled in the study, and 28 enrolled youth (55%) completed the intervention. Five of the six sites were successfully able to integrate the SBIRT-based Project Amp model into their workflow. Facilitators and barriers for implementation were identified related to three critical factors: recruitment, readiness, and sustainability. Conclusions: The Project Amp intervention can be conducted successfully in school and healthcare settings in conjunction with SBIRT, adding capacity to expand access to screening and early intervention in a developmentally appropriate way. However, the study yielded insights into adaptations for future implementation, such as a more streamlined model and centralized staff roles such as integrated roles for young peer mentors.
MeSH term(s)	Adolescent ; Adolescent Behavior ; Adult ; Community Health Services ; Early Medical Intervention ; Female ; Humans ; Male ; Mentoring ; Motivational Interviewing ; Outpatient Clinics, Hospital ; Peer Group ; Process Assessment, Health Care ; Psychotherapy, Brief ; Referral and Consultation ; Risk ; School Health Services ; Substance-Related Disorders/diagnosis ; Substance-Related Disorders/prevention & control ; Substance-Related Disorders/therapy ; Young Adult
Language	English
Publishing date	2019-05-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605923-5
ISSN	1873-6483 ; 0740-5472
ISSN (online)	1873-6483
ISSN	0740-5472
DOI	10.1016/j.jsat.2019.05.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2017: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: An open-label pilot trial assessing tolerability and feasibility of LSD microdosing in patients with major depressive disorder (LSDDEP1).

Donegan, Carina Joy / Daldegan-Bueno, Dimitri / Sumner, Rachael / Menkes, David / Evans, William / Hoeh, Nicholas / Sundram, Frederick / Reynolds, Lisa / Ponton, Rhys / Cavadino, Alana / Smith, Todd / Roop, Partha / Allen, Nathan / Abeysinghe, Binu / Svirskis, Darren / Forsyth, Anna / Bansal, Mahima / Muthukumaraswamy, Suresh

Pilot and feasibility studies

2023 Volume 9, Issue 1, Page(s) 169

Abstract: Background: Globally, an estimated 260 million people suffer from depression [1], and there is a clear need for the development of new, alternative antidepressant therapies. In light of problems with the tolerability and efficacy of available treatments ...

Abstract	Background: Globally, an estimated 260 million people suffer from depression [1], and there is a clear need for the development of new, alternative antidepressant therapies. In light of problems with the tolerability and efficacy of available treatments [2], a global trend is emerging for patients to self-treat depression with microdoses of psychedelic drugs such as lysergic acid diethylamide (LSD) and psilocybin [3]. Beyond anecdotal reports from those who self-medicate in this way, few clinical trials have evaluated this practice. In our recently published phase 1 study in healthy volunteers [4], we determined that LSD microdosing was relatively safe and well tolerated in that cohort. Furthermore, the data demonstrated that conducting such microdosing trials is broadly feasible, with excellent adherence and compliance to the regimen observed. In this open-label pilot trial of patients with major depressive disorder (LSDDEP1), we will test the tolerability and feasibility of an 8-week regimen of LSD microdosing in this patient group prior to a larger subsequent randomised controlled trial (LSDDEP2). Methods: Twenty patients meeting the DSM-5 criteria for major depressive disorder will receive an 8-week LSD microdosing treatment regimen. The treatment protocol will use a sublingual formulation of LSD (MB-22001) delivered twice per week under a titration schedule using a dose of 5-15 µg. Tolerability will be assessed by quantifying the percentage of participants who withdraw from the trial due to adverse events attributable to the treatment regimen, while feasibility will be assessed by quantifying the percentage of attended clinic visits once enrolled. To determine whether there is any antidepressant response to the LSD microdosing regimen, MADRS scores will be assessed at baseline and 2, 4, 6, and 8 weeks after the commencement of the regimen. Discussion: The results of LSDDEP1 will provide valuable information regarding the tolerability and feasibility of a proposed LSD microdosing regimen in patients with MDD. Such information is critically important to optimise trial design prior to commencing a subsequent and more resource-intensive randomised controlled trial. Trial registration: ANZCTR, ACTRN12623000486628. Registered on 12 May 2023.
Language	English
Publishing date	2023-10-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2809935-7
ISSN	2055-5784
ISSN	2055-5784
DOI	10.1186/s40814-023-01399-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Wide-waveguide high-power low-RIN single-mode distributed feedback laser diodes for optical communication.

Xiang, Minwen / Zhang, Yuanhao / Li, Guojiong / Liu, Can / Chen, Quanan / Lu, Qiaoyin / Huang, Lirong / Lu, Mingzhi / DoneGan, John / Guo, Weihua

Optics express

2022 Volume 30, Issue 17, Page(s) 30187–30197

Abstract: We present an 8-µm-wide 800-µm-long high-power, single-mode and low RIN DFB laser using a dual-waveguide structure. The introduced passive lower waveguide has weakenes the lateral optical confinement for the ridge waveguide, and thus reduces losses ... ...

Abstract	We present an 8-µm-wide 800-µm-long high-power, single-mode and low RIN DFB laser using a dual-waveguide structure. The introduced passive lower waveguide has weakenes the lateral optical confinement for the ridge waveguide, and thus reduces losses caused by the p-doped layers and maintains single mode stability of the laser. The fabricated laser exhibited an output power higher than 170 mW and a relative intensity noise (RIN) below -157 dB/Hz along with a side-mode suppression-ratio (SMSR) over 55 dB. The temperature tuning from -10°C to 60°C allows an 8.6 nm wavelength tunability with a variation coefficient of 0.12 nm/K. The relaxation oscillation frequency is around 8 GHz, and the linewidth is about 250 kHz at 100 mW output power for the fabricated laser. The characteristics of the proposed high-power laser, including high slope efficiency, single mode stability and low noise, make it a suitable candidate for optical communication.
Language	English
Publishing date	2022-10-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.464598
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Vascular remodeling in sheep implanted with endovascular neural interface.

John, Sam E / Donegan, Sam / Scordas, Theodore C / Qi, Weijie / Sharma, Prayshita / Liyanage, Kishan / Wilson, Stefan / Birchall, Ian / Ooi, Andrew / Oxley, Thomas J / May, Clive N / Grayden, David B / Opie, Nicholas L

Journal of neural engineering

2022 Volume 19, Issue 5

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Animals ; Sheep ; Vascular Remodeling ; Stents ; Superior Sagittal Sinus ; Foreign Bodies ; Endovascular Procedures
Language	English
Publishing date	2022-10-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2170901-4
ISSN	1741-2552 ; 1741-2560
ISSN (online)	1741-2552
ISSN	1741-2560
DOI	10.1088/1741-2552/ac9a77
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6071: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Menstrual cycle and breast cancer.

Donegan, W L

Journal of surgical oncology

2000 Volume 74, Issue 3, Page(s) 237

MeSH term(s)	Breast Neoplasms/pathology ; Female ; Humans ; Menstrual Cycle/physiology
Language	English
Publishing date	2000-07
Publishing country	United States
Document type	Comment ; Comparative Study ; Journal Article
ZDB-ID	82063-5
ISSN	1096-9098 ; 0022-4790
ISSN (online)	1096-9098
ISSN	0022-4790
DOI	10.1002/1096-9098(200007)74:3<237::aid-jso17>3.0.co;2-a
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 706: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Cancer of the male breast.

Donegan, W L

The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia

2000 Volume 3, Issue 4, Page(s) 55–58

Abstract: Cancer of the breast in men is an infrequent but serious problem. The epidemiology and clinical features of the disease generally parallel those of breast cancer in women, but affected men tend to be older, have subareolar tumors, and present in more ... ...

Abstract	Cancer of the breast in men is an infrequent but serious problem. The epidemiology and clinical features of the disease generally parallel those of breast cancer in women, but affected men tend to be older, have subareolar tumors, and present in more advanced stages. Treatment of men follows the trends for treatment of women, with less radical surgery and more frequent use of systemic adjuvant therapy. Stage and axillary nodal status are the most important prognostic indicators for men. Although overall survival rates of males remain inferior to those of women, the indications are that breast cancer in men is equally curable in comparable stages. Men need to be sensitive to the signs of breast cancer and seek early consultation.
MeSH term(s)	Breast Neoplasms, Male/diagnosis ; Breast Neoplasms, Male/etiology ; Breast Neoplasms, Male/therapy ; Humans ; Male ; Prognosis
Language	English
Publishing date	2000-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2083856-6
ISSN	1523-7036
ISSN	1523-7036
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5644: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: New screening guidelines for colorectal cancer.

Donegan, W L

Journal of surgical oncology

1998 Volume 68, Issue 1, Page(s) 2–4

MeSH term(s)	Colonoscopy ; Colorectal Neoplasms/diagnosis ; Humans ; Practice Guidelines as Topic ; Proctoscopy ; Sigmoidoscopy
Language	English
Publishing date	1998-05
Publishing country	United States
Document type	Editorial ; Review
ZDB-ID	82063-5
ISSN	1096-9098 ; 0022-4790
ISSN (online)	1096-9098
ISSN	0022-4790
DOI	10.1002/(sici)1096-9098(199805)68:1<2::aid-jso2>3.0.co;2-b
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 706: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Tumor-related prognostic factors for breast cancer.

Donegan, W L

CA: a cancer journal for clinicians

1997 Volume 47, Issue 1, Page(s) 28–51

Abstract: Interest in prognostic factors for breast cancer has been stimulated by the success of systemic adjuvant therapy for early-stage operable disease. Patients destined for recurrence can be selected for systemic adjuvant therapy, while patients not likely ... ...

Abstract	Interest in prognostic factors for breast cancer has been stimulated by the success of systemic adjuvant therapy for early-stage operable disease. Patients destined for recurrence can be selected for systemic adjuvant therapy, while patients not likely to recur can be spared the morbidity of unnecessary treatment. The number of tumor-related features available for prognosis has grown impressively in recent years. The purpose of this article is to review tumor-related biologic factors and relate them to prognosis and treatment objectives.
MeSH term(s)	Breast Neoplasms/blood supply ; Breast Neoplasms/diagnosis ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Female ; Humans ; Lymphatic Metastasis ; Mitosis ; Neoplasm Staging ; Neovascularization, Pathologic/pathology ; Ploidies ; Prognosis
Language	English
Publishing date	1997-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	603553-x
ISSN	1542-4863 ; 0007-9235
ISSN (online)	1542-4863
ISSN	0007-9235
DOI	10.3322/canjclin.47.1.28
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 100: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito