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  1. Book: Mesothelioma from bench side to clinic

    Baldi, Alfonso

    (Nova biomedical)

    2008  

    Author's details Alfonso Baldi, ed
    Series title Nova biomedical
    Keywords Mesothelioma ; Mesotheliom
    Subject Mesotheltumor ; Deckzellentumor ; Zölotheliom
    Language English
    Size XII, 585 S. : Ill., graph. Darst.
    Publisher Nova Biomed. Books
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT015706913
    ISBN 978-1-60021-789-0 ; 1-60021-789-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 5056 order for loan Magazin

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  2. Book: Skin cancer

    Baldi, Alfonso / Pasquali, Paola / Spugnini, Enrico P.

    a practical approach

    (Current clinical pathology)

    2014  

    Author's details Alfonso Baldi ; Paola Pasquali ; Enrico P. Spugnini ed
    Series title Current clinical pathology
    Language English
    Size XIV, 569 S. : zahlr. Ill., graph. Darst.
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017772916
    ISBN 978-1-46147-356-5 ; 1-46147-356-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 2553 available for loan (reading room) Lesesaal EG

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  3. Article: Prototype Salivary Assay for Quantification of Two Biomarkers for In Vitro Diagnosis of Endometriosis.

    Signorile, Pietro Giulio / Dominici, Sabrina / Viceconte, Rosa / Baldi, Alfonso

    Critical reviews in eukaryotic gene expression

    2024  Volume 34, Issue 4, Page(s) 25–31

    Abstract: Endometriosis, a very common disease in women, is characterized by endometrial structures outside the uterine cavity. The lack of a reliable noninvasive diagnostic test and the often nonspecific symptoms of this pathology are responsible for the delay in ...

    Abstract Endometriosis, a very common disease in women, is characterized by endometrial structures outside the uterine cavity. The lack of a reliable noninvasive diagnostic test and the often nonspecific symptoms of this pathology are responsible for the delay in definitive diagnosis of this disease. Recently, through a proteomics approach, our research group has identified two potential diagnostic markers for endometriosis in serum (Zn-alpha2-glycoprotein and complement C3 precursor). In this article, we describe the experimental conditions of a simple ELISA for rapid quantification of these two biomarkers in the saliva of patients with endometriosis. Finally, preliminary experiments on a small cohort of patients and controls have confirmed the potential diagnostic value of this assay.
    MeSH term(s) Humans ; Female ; Endometriosis/diagnosis ; Glycoproteins ; Enzyme-Linked Immunosorbent Assay ; Biomarkers
    Chemical Substances Glycoproteins ; Biomarkers
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1071345-1
    ISSN 1045-4403
    ISSN 1045-4403
    DOI 10.1615/CritRevEukaryotGeneExpr.2023051116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3226: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Electroporation in Translational Medicine: From Veterinary Experience to Human Oncology.

    Spugnini, Enrico P / Condello, Maria / Crispi, Stefania / Baldi, Alfonso

    Cancers

    2024  Volume 16, Issue 5

    Abstract: Electroporation (EP) is a broadly accepted procedure that, through the application of electric pulses with appropriate amplitudes and waveforms, promotes the delivery of anticancer molecules in various oncology therapies. EP considerably boosts the ... ...

    Abstract Electroporation (EP) is a broadly accepted procedure that, through the application of electric pulses with appropriate amplitudes and waveforms, promotes the delivery of anticancer molecules in various oncology therapies. EP considerably boosts the absorptivity of targeted cells to anticancer molecules of different natures, thus upgrading their effectiveness. Its use in veterinary oncology has been widely explored, and some applications, such as electrochemotherapy (ECT), are currently approved as first-line treatments for several neoplastic conditions. Other applications include irreversible electroporation and EP-based cancer vaccines. In human oncology, EP is still mostly restricted to therapies for cutaneous tumors and the palliation of cutaneous and visceral metastases of malignant tumors. Fields where veterinary experience could help smooth the clinical transition to humans include intraoperative EP, interventional medicine and cancer vaccines. This article recapitulates the state of the art of EP in veterinary and human oncology, recounting the most relevant results to date.
    Language English
    Publishing date 2024-03-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16051067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Differential Expression in Endometriosis Tissue versus Endometrium of the Uterine Adenogenesis Factors PRL-R, GH, IGF1, and IGF2.

    Signorile, Pietro G / Viceconte, Rosa / Vincenzi, Bruno / Baldi, Alfonso

    Critical reviews in eukaryotic gene expression

    2023  Volume 33, Issue 3, Page(s) 39–46

    Abstract: Endometriosis is characterized by the presence of endometrial glandular and stromal structures outside the uterine cavity. It is an inflammatory estrogen dependent disease characterized by gene polymorphisms. This is a very frequent pathology and ... ...

    Abstract Endometriosis is characterized by the presence of endometrial glandular and stromal structures outside the uterine cavity. It is an inflammatory estrogen dependent disease characterized by gene polymorphisms. This is a very frequent pathology and represents one of the most important causes of infertility, as well as having an important level of morbidity in patients. Recently, an alteration of the processes of organogenesis of the uterus has been proposed as a pathogenetic mechanism of endometriosis. In this article we have compared the expression in deep endometriotic lesions and in normal endometrial tissue of some of the molecular factors known to be involved in the embryonic development of the uterine glands. In detail, we found by immunohistochemistry a significant higher expression both for epithelium and stroma in the controls respect to the endometriosis samples for insulin growth factor 1 (IGF1) and IGF2, whereas for the prolactin receptor (PRL-R), this result was detected only for the epithelium. On the other hand, we found for growth hormone (GH) a significant higher expression in the epithelium of endometriosis samples respect to the controls. The correlation data generated can give indications on some of the molecular mechanisms responsible for the adenogenesis and survival of endometriosis structures outside of the uterus.
    MeSH term(s) Pregnancy ; Female ; Humans ; Receptors, Prolactin/metabolism ; Endometriosis/genetics ; Growth Hormone/metabolism ; Insulin/metabolism ; Endometrium/metabolism ; Endometrium/pathology ; Uterus/metabolism ; Insulin-Like Growth Factor II/metabolism ; Insulin-Like Growth Factor I/metabolism
    Chemical Substances Receptors, Prolactin ; Growth Hormone (9002-72-6) ; Insulin ; IGF2 protein, human ; Insulin-Like Growth Factor II (67763-97-7) ; IGF1 protein, human ; Insulin-Like Growth Factor I (67763-96-6)
    Language English
    Publishing date 2023-03-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1071345-1
    ISSN 1045-4403
    ISSN 1045-4403
    DOI 10.1615/CritRevEukaryotGeneExpr.2022045360
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3226: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: New Insights in Pathogenesis of Endometriosis.

    Signorile, Pietro G / Viceconte, Rosa / Baldi, Alfonso

    Frontiers in medicine

    2022  Volume 9, Page(s) 879015

    Abstract: Endometriosis is a gynecological disease characterized by the growth of endometrial glands and stroma outside the uterine cavity. The incidence of the disease is very high, there are currently no reliable early diagnostic tests, the therapies are only ... ...

    Abstract Endometriosis is a gynecological disease characterized by the growth of endometrial glands and stroma outside the uterine cavity. The incidence of the disease is very high, there are currently no reliable early diagnostic tests, the therapies are only symptomatic and, consequently, the social impact of endometriosis is very important, also considering the related fertility problems. Despite this, the pathogenesis of endometriosis is still not fully defined. Retrograde menstruation and coelomic metaplasia are currently the most recognized pathogenetic hypotheses. Recent experimental evidences generated by our research group and by others have indicated an alteration of the fine-tuning of the female genital system developmental program during a critical window of time in the fetal life as the pathogenetic event prompting to the development of endometriosis later in life. Goal of this article is to present a revision of the recent literature about the different pathogenetic mechanisms proposed for endometriosis with particular emphasis on the embryologic theory. The possible clinical and pathological implications of these findings will be discussed.
    Language English
    Publishing date 2022-04-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.879015
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  7. Article: Looking for an effective and non-invasive diagnostic test for endometriosis: where are we?

    Signorile, Pietro G / Baldi, Alfonso

    Annals of translational medicine

    2019  Volume 6, Issue Suppl 2, Page(s) S106

    Language English
    Publishing date 2019-01-22
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2018.11.46
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Pathogenesis of Endometriosis: Focus on Adenogenesis-related Factors.

    Signorile, Pietro G / Baldi, Alfonso / Viceconte, Rosa / Ronchi, Andrea / Montella, Marco

    In vivo (Athens, Greece)

    2023  Volume 37, Issue 5, Page(s) 1922–1930

    Abstract: Endometriosis can be defined as the presence of the endometrium outside the uterine cavity. It affects approximately 10% of women of reproductive age and causes infertility, chronic pain, and deterioration of the quality of life. Since the identification ...

    Abstract Endometriosis can be defined as the presence of the endometrium outside the uterine cavity. It affects approximately 10% of women of reproductive age and causes infertility, chronic pain, and deterioration of the quality of life. Since the identification of the disease, various pathogenetic mechanisms have been proposed, such as retrograde menstruation, coelomic metaplasia, hormonal imbalance, stem cell involvement, and alterations in epigenetic regulation. However, the underlying pathogenesis of endometriosis remains inadequately understood. Elucidation of the precise mechanism of the development and progression of endometriosis is crucial for effective treatment. This review presents the major pathogenetic theories of endometriosis based on current research studies with a major focus on the potential role of uterine factors.
    MeSH term(s) Humans ; Female ; Endometriosis/etiology ; Epigenesis, Genetic ; Quality of Life ; Uterus/pathology ; Endometrium/pathology
    Language English
    Publishing date 2023-08-29
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.13288
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2288: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: New Insights in Pathogenesis of Endometriosis

    Pietro G. Signorile / Rosa Viceconte / Alfonso Baldi

    Frontiers in Medicine, Vol

    2022  Volume 9

    Abstract: Endometriosis is a gynecological disease characterized by the growth of endometrial glands and stroma outside the uterine cavity. The incidence of the disease is very high, there are currently no reliable early diagnostic tests, the therapies are only ... ...

    Abstract Endometriosis is a gynecological disease characterized by the growth of endometrial glands and stroma outside the uterine cavity. The incidence of the disease is very high, there are currently no reliable early diagnostic tests, the therapies are only symptomatic and, consequently, the social impact of endometriosis is very important, also considering the related fertility problems. Despite this, the pathogenesis of endometriosis is still not fully defined. Retrograde menstruation and coelomic metaplasia are currently the most recognized pathogenetic hypotheses. Recent experimental evidences generated by our research group and by others have indicated an alteration of the fine-tuning of the female genital system developmental program during a critical window of time in the fetal life as the pathogenetic event prompting to the development of endometriosis later in life. Goal of this article is to present a revision of the recent literature about the different pathogenetic mechanisms proposed for endometriosis with particular emphasis on the embryologic theory. The possible clinical and pathological implications of these findings will be discussed.
    Keywords endometriosis ; fetal life ; critical period ; adenomyosis ; coelomic metaplasia ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article: Electrochemotherapy in Translational Medicine: From Veterinary Experience to Human Oncology.

    Spugnini, Enrico P / Menditti, Dardo / De Luca, Antonio / Baldi, Alfonso

    Critical reviews in eukaryotic gene expression

    2022  Volume 33, Issue 1, Page(s) 79–90

    Abstract: Electrochemotherapy (ECT) is a tumor treatment that, through the application of electric pulses with suitable amplitude and waveforms, favors the systemic or local delivery of chemotherapy agents. This procedure significantly increases the permeability ... ...

    Abstract Electrochemotherapy (ECT) is a tumor treatment that, through the application of electric pulses with suitable amplitude and waveforms, favors the systemic or local delivery of chemotherapy agents. This procedure significantly increases the permeability of cancer cells to anticancer drugs, making them more effective and allowing their use at lower doses with less morbidity for patients. Its use in veterinary oncology is consolidated and it is currently adopted as first-line treatment for different cancers with successful results. In human oncology, ECT use is mainly in the treatment of cutaneous tumors and for the palliation of cutaneous metastases of malignant tumors. A standard operating procedure has been formulated. Currently, several preclinical and phase I and II studies are under way involving various cancers in humans to better define the efficacy and tolerability of this therapy. This review summarizes the state of the art of ECT in veterinary and human oncology, describing the most significant results achieved to date.
    MeSH term(s) Humans ; Electrochemotherapy/adverse effects ; Electrochemotherapy/methods ; Electrochemotherapy/veterinary ; Translational Science, Biomedical ; Antineoplastic Agents/therapeutic use ; Skin Neoplasms/etiology
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2022-11-14
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1071345-1
    ISSN 1045-4403
    ISSN 1045-4403
    DOI 10.1615/CritRevEukaryotGeneExpr.2022043966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3226: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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